Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	9045
Gene name Gene Name - the full gene name approved by the HGNC.	Ribosomal protein L14
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	RPL14
Synonyms (NCBI Gene) Gene synonyms aliases	CAG-ISL-7, CTG-B33, L14, RL14, eL14, hRL14
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3p22.1
Summary Summary of gene provided in NCBI Entrez Gene.	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

Show/Hide all(134)

miRTarBase ID	miRNA	Experiments	Reference
MIRT031990	hsa-miR-16-5p	Proteomics	18668040
MIRT048582	hsa-miR-100-5p	CLASH	23622248
MIRT047311	hsa-miR-181a-5p	CLASH	23622248
MIRT045056	hsa-miR-186-5p	CLASH	23622248
MIRT039154	hsa-miR-769-5p	CLASH	23622248
MIRT654129	hsa-miR-4763-5p	HITS-CLIP	19536157
MIRT721211	hsa-miR-4479	HITS-CLIP	19536157
MIRT721210	hsa-miR-3960	HITS-CLIP	19536157
MIRT721209	hsa-miR-8072	HITS-CLIP	19536157
MIRT721208	hsa-miR-6847-3p	HITS-CLIP	19536157
MIRT721207	hsa-miR-6894-3p	HITS-CLIP	19536157
MIRT700070	hsa-miR-548an	HITS-CLIP	23313552
MIRT700069	hsa-miR-6768-3p	HITS-CLIP	23313552
MIRT700068	hsa-miR-4484	HITS-CLIP	23313552
MIRT700067	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT700066	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT700065	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT700064	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT700063	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT700062	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT700061	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT700060	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT700059	hsa-miR-3910	HITS-CLIP	23313552
MIRT700058	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT700057	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT654134	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT700056	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT700055	hsa-miR-302e	HITS-CLIP	23313552
MIRT700054	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT700053	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT700052	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT700051	hsa-miR-520b	HITS-CLIP	23313552
MIRT700050	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT700049	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT700048	hsa-miR-520e	HITS-CLIP	23313552
MIRT700047	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT700046	hsa-miR-520h	HITS-CLIP	23313552
MIRT700045	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT700044	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT700043	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT700041	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT700042	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT700040	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT700039	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT700038	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT539902	hsa-miR-15a-5p	HITS-CLIP	23824327
MIRT539901	hsa-miR-15b-5p	HITS-CLIP	23824327
MIRT031990	hsa-miR-16-5p	HITS-CLIP	23824327
MIRT539900	hsa-miR-195-5p	HITS-CLIP	23824327
MIRT539899	hsa-miR-424-5p	HITS-CLIP	23824327
MIRT539898	hsa-miR-497-5p	HITS-CLIP	23824327
MIRT539896	hsa-miR-6838-5p	HITS-CLIP	23824327
MIRT654135	hsa-miR-512-3p	HITS-CLIP	23824327
MIRT654134	hsa-miR-302c-3p	HITS-CLIP	23824327
MIRT654133	hsa-miR-520f-3p	HITS-CLIP	23824327
MIRT654131	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT654132	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT654130	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT654129	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT654128	hsa-miR-4473	HITS-CLIP	23824327
MIRT539902	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT539901	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT031990	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT539900	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT539899	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT539898	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT539896	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT539897	hsa-miR-624-5p	PAR-CLIP	21572407
MIRT654129	hsa-miR-4763-5p	HITS-CLIP	19536157
MIRT721211	hsa-miR-4479	HITS-CLIP	19536157
MIRT721210	hsa-miR-3960	HITS-CLIP	19536157
MIRT721209	hsa-miR-8072	HITS-CLIP	19536157
MIRT721208	hsa-miR-6847-3p	HITS-CLIP	19536157
MIRT721207	hsa-miR-6894-3p	HITS-CLIP	19536157
MIRT700070	hsa-miR-548an	HITS-CLIP	23313552
MIRT700069	hsa-miR-6768-3p	HITS-CLIP	23313552
MIRT700068	hsa-miR-4484	HITS-CLIP	23313552
MIRT700067	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT700066	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT700065	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT700064	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT700063	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT700062	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT700061	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT700060	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT700059	hsa-miR-3910	HITS-CLIP	23313552
MIRT700058	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT700057	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT654134	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT700056	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT700055	hsa-miR-302e	HITS-CLIP	23313552
MIRT700054	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT700053	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT700052	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT700051	hsa-miR-520b	HITS-CLIP	23313552
MIRT700050	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT700049	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT700048	hsa-miR-520e	HITS-CLIP	23313552
MIRT700047	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT700046	hsa-miR-520h	HITS-CLIP	23313552
MIRT700045	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT700044	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT700043	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT700041	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT700042	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT700040	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT700039	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT700038	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT539902	hsa-miR-15a-5p	HITS-CLIP	23824327
MIRT539901	hsa-miR-15b-5p	HITS-CLIP	23824327
MIRT031990	hsa-miR-16-5p	HITS-CLIP	23824327
MIRT539900	hsa-miR-195-5p	HITS-CLIP	23824327
MIRT539899	hsa-miR-424-5p	HITS-CLIP	23824327
MIRT539898	hsa-miR-497-5p	HITS-CLIP	23824327
MIRT539896	hsa-miR-6838-5p	HITS-CLIP	23824327
MIRT654135	hsa-miR-512-3p	HITS-CLIP	23824327
MIRT654134	hsa-miR-302c-3p	HITS-CLIP	23824327
MIRT654133	hsa-miR-520f-3p	HITS-CLIP	23824327
MIRT654131	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT654132	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT654130	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT654129	hsa-miR-4763-5p	HITS-CLIP	23824327
MIRT654128	hsa-miR-4473	HITS-CLIP	23824327
MIRT539902	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT539901	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT031990	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT539900	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT539899	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT539898	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT539896	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT539897	hsa-miR-624-5p	PAR-CLIP	21572407
MIRT1315987	hsa-miR-3064-3p	CLIP-seq
MIRT1315988	hsa-miR-4715-3p	CLIP-seq
MIRT1315989	hsa-miR-556-3p	CLIP-seq

Show/Hide all(22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000184	Process	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IBA	21873635
GO:0003735	Function	Structural constituent of ribosome	IBA	21873635
GO:0003735	Function	Structural constituent of ribosome	IMP	18697920
GO:0003735	Function	Structural constituent of ribosome	NAS	12962325
GO:0005515	Function	Protein binding	IPI	11369516, 24725412, 28514442, 30021884
GO:0005829	Component	Cytosol	TAS
GO:0006364	Process	RRNA processing	IMP	18697920
GO:0006412	Process	Translation	NAS	12962325
GO:0006413	Process	Translational initiation	TAS
GO:0006614	Process	SRP-dependent cotranslational protein targeting to membrane	TAS
GO:0014069	Component	Postsynaptic density	EXP	21170055
GO:0014069	Component	Postsynaptic density	IDA	21170055
GO:0016020	Component	Membrane	HDA	19946888
GO:0019083	Process	Viral transcription	TAS
GO:0022625	Component	Cytosolic large ribosomal subunit	HDA	12962325
GO:0022625	Component	Cytosolic large ribosomal subunit	IBA	21873635
GO:0042273	Process	Ribosomal large subunit biogenesis	IBA	21873635
GO:0042273	Process	Ribosomal large subunit biogenesis	IMP	18697920
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0070062	Component	Extracellular exosome	HDA	20458337

MIM	HGNC	e!Ensembl
617414	10305	ENSG00000188846

Protein

UniProt ID

P50914

Protein name

Large ribosomal subunit protein eL14 (60S ribosomal protein L14) (CAG-ISL 7)

Protein function

Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669

PDB

4UG0 , 4V6X , 5AJ0 , 5LKS , 5T2C , 6IP5 , 6IP6 , 6IP8 , 6LQM , 6LSR , 6LSS , 6LU8 , 6OLE , 6OLF , 6OLG , 6OLI , 6OLZ , 6OM0 , 6OM7 , 6QZP , 6W6L , 6XA1 , 6Y0G , 6Y2L , 6Y57 , 6Y6X , 6Z6L , 6Z6M , 6Z6N , 6ZM7 , 6ZME , 6ZMI , 6ZMO , 7BHP , 7F5S , 7QVP , 7XNX , 7XNY , 8A3D , 8FKP , 8FKQ , 8FKR , 8FKS , 8FKT , 8FKU , 8FKV , 8FKW , 8FKX , 8FKY , 8FKZ , 8FL0

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01929	Ribosomal_L14e	46 → 120	Ribosomal protein L14	Family

Sequence

MVFRRFVEVGRVAYVSFGPHAGKLVAIVDVIDQNRALVDGPCTQVRRQAMPFKCMQLTDF
ILKFPHSAHQKYVRQAWQKADINTKWAATRWAKKIEARERKAKMTDFDRFKVMKAKKMRN
RIIKNEVKKLQKAALLKASPKKAPGTKGTAAAAAAAAAAKVPAKKITAASKKAPAQKVPA
QKATGQKAAPAPKAQKGQKAPAQKAPAPKASGKKA

Sequence length

215

Interactions

View interactions

	KEGG		Reactome
	Ribosome Coronavirus disease - COVID-19		L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Show/Hide Causal Diseases (3)

Disease term	Disease name	dbSNP ID	References
Causal
Papillary renal carcinoma	Papillary Renal Cell Carcinoma	rs5030823, rs2137087134, rs121913668, rs121913669, rs121913670, rs121913671, rs121913673, rs121913243, rs786202724	23797736
Parkinson disease	Parkinson Disease	rs33939927, rs35801418, rs34805604, rs35870237, rs34995376, rs74315355, rs28940284, rs74315356, rs74315357, rs28940285, rs730880302, rs750664040, rs74315359, rs74315360, rs45539432 View all (84 more)	18353766
Renal carcinoma	Renal Cell Carcinoma, Conventional (Clear Cell) Renal Cell Carcinoma, Sarcomatoid Renal Cell Carcinoma, Collecting Duct Carcinoma of the Kidney	rs121913668, rs121913670, rs121913243, rs786202724	23797736

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Chromophobe carcinoma	Chromophobe Renal Cell Carcinoma		23797736	ClinVar

Show/Hide Text Mining Associations (9)

Disease Name	Relationship Type	References
Associations from Text Mining
Alzheimer Disease	Associate	35766008
Breast Neoplasms	Associate	33305312
Lymphatic Metastasis	Associate	34057029
Microsatellite Instability	Associate	30664178
Nasopharyngeal Carcinoma	Inhibit	34057029
Nasopharyngeal Carcinoma	Associate	39744943
Neoplasms	Associate	34057029
Non alcoholic Fatty Liver Disease	Associate	26845596
Triple Negative Breast Neoplasms	Associate	33305312

RPL14 (ribosomal protein L14)