Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	90353
Gene name	Cytosolic thiouridylase subunit 1
Gene symbol	CTU1
Synonyms (NCBI Gene)	ATPBD3NCS6
Chromosome	19
Chromosome location	19q13.41

117

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miRTarBase ID	miRNA	Experiments	Reference
MIRT618039	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT618038	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT618037	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT618036	hsa-miR-4421	HITS-CLIP	23824327
MIRT618035	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT618034	hsa-miR-6870-3p	HITS-CLIP	23824327
MIRT643734	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT618033	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT618032	hsa-miR-6895-3p	HITS-CLIP	23824327
MIRT618031	hsa-miR-593-3p	HITS-CLIP	23824327
MIRT618029	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT618028	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT618027	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT618039	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT618038	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT618037	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT618036	hsa-miR-4421	HITS-CLIP	23824327
MIRT618035	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT618034	hsa-miR-6870-3p	HITS-CLIP	23824327
MIRT618033	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT618032	hsa-miR-6895-3p	HITS-CLIP	23824327
MIRT618031	hsa-miR-593-3p	HITS-CLIP	23824327
MIRT618030	hsa-miR-4775	HITS-CLIP	23824327
MIRT618029	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT618028	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT618027	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT618039	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT618038	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT618037	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT618036	hsa-miR-4421	HITS-CLIP	23824327
MIRT618035	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT618034	hsa-miR-6870-3p	HITS-CLIP	23824327
MIRT643734	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT618033	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT618032	hsa-miR-6895-3p	HITS-CLIP	23824327
MIRT618031	hsa-miR-593-3p	HITS-CLIP	23824327
MIRT618029	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT618028	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT618027	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT618039	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT618038	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT618037	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT618036	hsa-miR-4421	HITS-CLIP	23824327
MIRT618035	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT618034	hsa-miR-6870-3p	HITS-CLIP	23824327
MIRT618033	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT618032	hsa-miR-6895-3p	HITS-CLIP	23824327
MIRT618031	hsa-miR-593-3p	HITS-CLIP	23824327
MIRT618030	hsa-miR-4775	HITS-CLIP	23824327
MIRT618029	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT618028	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT618027	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT916236	hsa-miR-1275	CLIP-seq
MIRT916237	hsa-miR-1293	CLIP-seq
MIRT916238	hsa-miR-3155	CLIP-seq
MIRT916239	hsa-miR-3155b	CLIP-seq
MIRT916240	hsa-miR-3943	CLIP-seq
MIRT916241	hsa-miR-4438	CLIP-seq
MIRT916242	hsa-miR-4447	CLIP-seq
MIRT916243	hsa-miR-4472	CLIP-seq
MIRT916244	hsa-miR-4483	CLIP-seq
MIRT916245	hsa-miR-4514	CLIP-seq
MIRT916246	hsa-miR-4525	CLIP-seq
MIRT916247	hsa-miR-4665-5p	CLIP-seq
MIRT916248	hsa-miR-4676-5p	CLIP-seq
MIRT916249	hsa-miR-4692	CLIP-seq
MIRT916250	hsa-miR-4723-5p	CLIP-seq
MIRT916251	hsa-miR-4751	CLIP-seq
MIRT916252	hsa-miR-484	CLIP-seq
MIRT916253	hsa-miR-5095	CLIP-seq
MIRT916254	hsa-miR-548v	CLIP-seq
MIRT916255	hsa-miR-575	CLIP-seq
MIRT916256	hsa-miR-625	CLIP-seq
MIRT1971723	hsa-miR-125a-3p	CLIP-seq
MIRT1971724	hsa-miR-296-5p	CLIP-seq
MIRT1971725	hsa-miR-3127-5p	CLIP-seq
MIRT1971726	hsa-miR-3145-3p	CLIP-seq
MIRT1971727	hsa-miR-3689a-5p	CLIP-seq
MIRT1971728	hsa-miR-3689b	CLIP-seq
MIRT1971729	hsa-miR-3689e	CLIP-seq
MIRT1971730	hsa-miR-3689f	CLIP-seq
MIRT1971731	hsa-miR-3934	CLIP-seq
MIRT1971732	hsa-miR-4679	CLIP-seq
MIRT1971733	hsa-miR-4711-3p	CLIP-seq
MIRT1971734	hsa-miR-4778-3p	CLIP-seq
MIRT1971735	hsa-miR-764	CLIP-seq
MIRT1971723	hsa-miR-125a-3p	CLIP-seq
MIRT2207431	hsa-miR-128	CLIP-seq
MIRT2207432	hsa-miR-1912	CLIP-seq
MIRT2207433	hsa-miR-27a	CLIP-seq
MIRT2207434	hsa-miR-27b	CLIP-seq
MIRT1971725	hsa-miR-3127-5p	CLIP-seq
MIRT2207435	hsa-miR-3173-3p	CLIP-seq
MIRT2207436	hsa-miR-339-3p	CLIP-seq
MIRT2207437	hsa-miR-3619-3p	CLIP-seq
MIRT2207438	hsa-miR-3663-3p	CLIP-seq
MIRT2207439	hsa-miR-3921	CLIP-seq
MIRT1971731	hsa-miR-3934	CLIP-seq
MIRT2207440	hsa-miR-4436a	CLIP-seq
MIRT2207441	hsa-miR-4461	CLIP-seq
MIRT2207442	hsa-miR-4502	CLIP-seq
MIRT2207443	hsa-miR-4653-5p	CLIP-seq
MIRT2207444	hsa-miR-4663	CLIP-seq
MIRT2207445	hsa-miR-4728-3p	CLIP-seq
MIRT2207446	hsa-miR-4729	CLIP-seq
MIRT1971734	hsa-miR-4778-3p	CLIP-seq
MIRT2207447	hsa-miR-4779	CLIP-seq
MIRT916253	hsa-miR-5095	CLIP-seq
MIRT2207448	hsa-miR-513a-5p	CLIP-seq
MIRT2207449	hsa-miR-591	CLIP-seq
MIRT2207450	hsa-miR-616	CLIP-seq
MIRT2207451	hsa-miR-629	CLIP-seq
MIRT1971735	hsa-miR-764	CLIP-seq
MIRT2207452	hsa-miR-942	CLIP-seq
MIRT2207439	hsa-miR-3921	CLIP-seq
MIRT2207443	hsa-miR-4653-5p	CLIP-seq
MIRT2207452	hsa-miR-942	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000049	Function	TRNA binding	IBA
GO:0000049	Function	TRNA binding	IEA
GO:0002098	Process	TRNA wobble uridine modification	IEA
GO:0002098	Process	TRNA wobble uridine modification	NAS	19017811
GO:0002143	Process	TRNA wobble position uridine thiolation	IBA
GO:0002144	Component	Cytosolic tRNA wobble base thiouridylase complex	IBA
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	19017811, 21209336
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	ISS
GO:0005829	Component	Cytosol	TAS
GO:0008033	Process	TRNA processing	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016779	Function	Nucleotidyltransferase activity	IEA
GO:0032447	Process	Protein urmylation	IEA
GO:0034227	Process	TRNA thio-modification	IEA
GO:0034227	Process	TRNA thio-modification	NAS	19017811

MIM	HGNC	e!Ensembl
612694	29590	ENSG00000142544

Q7Z7A3

Protein name

Cytoplasmic tRNA 2-thiolation protein 1 (EC 2.7.7.-) (ATP-binding domain-containing protein 3) (Cancer-associated gene protein) (Cytoplasmic tRNA adenylyltransferase 1)

Protein function

Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is uncle

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01171	ATP_bind_3	53 → 250	PP-loop family	Family
PF16503	zn-ribbon_14	285 → 316	Zinc-ribbon	Family

Sequence

MPAPPCASCHAARAALRRPLSGQALCGACFCAAFEAEVLHTVLAGRLLPPGAVVAVGASG
GKDSTVLAHVLRALAPRLGISLQLVAVDEGIGGYRDAALAAVRRQAARWELPLTVVAYED
LFGGWTMDAVARSTAGSGRSRSCCTFCGVLRRRALEEGARRVGATHIVTGHNADDMAETV
LMNFLRGDAGRLARGGGLGSPGEGGALPRCRPLQFASQKEVVLYAHFRRLDYFSEECVYA
PEAFRGHARDLLKRLEAARPSAVLDLVHSAERLALAPAARPPRPGACSRCGALASRALCQ
ACALLDGLNRGRPRLAIGKGRRGLDEEATPGTPGDPARPPASKAVPTF

Sequence length

348

Interactions

View interactions

	KEGG		Reactome
	Sulfur relay system		tRNA modification in the nucleus and cytosol

CTU1 (cytosolic thiouridylase subunit 1)