Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	9020
Gene name Gene Name - the full gene name approved by the HGNC.	Mitogen-activated protein kinase kinase kinase 14
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MAP3K14
Synonyms (NCBI Gene) Gene synonyms aliases	FTDCR1B, HS, HSNIK, IMD112, NIK
Disease Acronyms (UniProt) Disease acronyms from UniProt database	IMD112
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17q21.31
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates

Show/Hide all(203)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020850	hsa-miR-155-5p	Reporter assay	20584899
MIRT052929	hsa-miR-520e	5.0	22105365
MIRT052929	hsa-miR-520e	5.0	22105365
MIRT440287	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT020850	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT440286	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT440287	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT020850	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT727256	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT727255	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT727254	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT727253	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT727252	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT727251	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT440286	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT1128496	hsa-miR-106a	CLIP-seq
MIRT1128497	hsa-miR-106b	CLIP-seq
MIRT1128498	hsa-miR-1203	CLIP-seq
MIRT1128499	hsa-miR-1207-5p	CLIP-seq
MIRT1128500	hsa-miR-1228	CLIP-seq
MIRT1128501	hsa-miR-1245b-3p	CLIP-seq
MIRT1128502	hsa-miR-1248	CLIP-seq
MIRT1128503	hsa-miR-1304	CLIP-seq
MIRT1128504	hsa-miR-133a	CLIP-seq
MIRT1128505	hsa-miR-133b	CLIP-seq
MIRT1128506	hsa-miR-146a	CLIP-seq
MIRT1128507	hsa-miR-146b-5p	CLIP-seq
MIRT1128508	hsa-miR-17	CLIP-seq
MIRT1128509	hsa-miR-20a	CLIP-seq
MIRT1128510	hsa-miR-20b	CLIP-seq
MIRT1128511	hsa-miR-223	CLIP-seq
MIRT1128512	hsa-miR-302a	CLIP-seq
MIRT1128513	hsa-miR-302b	CLIP-seq
MIRT1128514	hsa-miR-302c	CLIP-seq
MIRT1128515	hsa-miR-302d	CLIP-seq
MIRT1128516	hsa-miR-302e	CLIP-seq
MIRT1128517	hsa-miR-3117-5p	CLIP-seq
MIRT1128518	hsa-miR-3126-5p	CLIP-seq
MIRT1128519	hsa-miR-3138	CLIP-seq
MIRT1128520	hsa-miR-3151	CLIP-seq
MIRT1128521	hsa-miR-3176	CLIP-seq
MIRT1128522	hsa-miR-3180	CLIP-seq
MIRT1128523	hsa-miR-3180-3p	CLIP-seq
MIRT1128524	hsa-miR-3189-3p	CLIP-seq
MIRT1128525	hsa-miR-3195	CLIP-seq
MIRT1128526	hsa-miR-3196	CLIP-seq
MIRT1128527	hsa-miR-329	CLIP-seq
MIRT1128528	hsa-miR-342-3p	CLIP-seq
MIRT1128529	hsa-miR-345	CLIP-seq
MIRT1128530	hsa-miR-362-3p	CLIP-seq
MIRT1128531	hsa-miR-3659	CLIP-seq
MIRT1128532	hsa-miR-371-3p	CLIP-seq
MIRT1128533	hsa-miR-372	CLIP-seq
MIRT1128534	hsa-miR-373	CLIP-seq
MIRT1128535	hsa-miR-3922-3p	CLIP-seq
MIRT1128536	hsa-miR-3941	CLIP-seq
MIRT1128537	hsa-miR-4274	CLIP-seq
MIRT1128538	hsa-miR-4283	CLIP-seq
MIRT1128539	hsa-miR-4302	CLIP-seq
MIRT1128540	hsa-miR-4419a	CLIP-seq
MIRT1128541	hsa-miR-4435	CLIP-seq
MIRT1128542	hsa-miR-4436b-3p	CLIP-seq
MIRT1128543	hsa-miR-4471	CLIP-seq
MIRT1128544	hsa-miR-4488	CLIP-seq
MIRT1128545	hsa-miR-4489	CLIP-seq
MIRT1128546	hsa-miR-4491	CLIP-seq
MIRT1128547	hsa-miR-4492	CLIP-seq
MIRT1128548	hsa-miR-4498	CLIP-seq
MIRT1128549	hsa-miR-4505	CLIP-seq
MIRT1128550	hsa-miR-4508	CLIP-seq
MIRT1128551	hsa-miR-4510	CLIP-seq
MIRT1128552	hsa-miR-4520a-3p	CLIP-seq
MIRT1128553	hsa-miR-455-5p	CLIP-seq
MIRT1128554	hsa-miR-4639-3p	CLIP-seq
MIRT1128555	hsa-miR-4657	CLIP-seq
MIRT1128556	hsa-miR-4658	CLIP-seq
MIRT1128557	hsa-miR-466	CLIP-seq
MIRT1128558	hsa-miR-4672	CLIP-seq
MIRT1128559	hsa-miR-4688	CLIP-seq
MIRT1128560	hsa-miR-4697-3p	CLIP-seq
MIRT1128561	hsa-miR-4697-5p	CLIP-seq
MIRT1128562	hsa-miR-4707-5p	CLIP-seq
MIRT1128563	hsa-miR-4727-3p	CLIP-seq
MIRT1128564	hsa-miR-4728-3p	CLIP-seq
MIRT1128565	hsa-miR-4731-5p	CLIP-seq
MIRT1128566	hsa-miR-4763-3p	CLIP-seq
MIRT1128567	hsa-miR-4800-5p	CLIP-seq
MIRT1128568	hsa-miR-486-3p	CLIP-seq
MIRT1128569	hsa-miR-514	CLIP-seq
MIRT1128570	hsa-miR-514b-3p	CLIP-seq
MIRT1128571	hsa-miR-519d	CLIP-seq
MIRT1128572	hsa-miR-520a-3p	CLIP-seq
MIRT1128573	hsa-miR-520b	CLIP-seq
MIRT1128574	hsa-miR-520c-3p	CLIP-seq
MIRT1128575	hsa-miR-520d-3p	CLIP-seq
MIRT1128576	hsa-miR-520f	CLIP-seq
MIRT1128577	hsa-miR-574-5p	CLIP-seq
MIRT1128578	hsa-miR-589	CLIP-seq
MIRT1128579	hsa-miR-603	CLIP-seq
MIRT1128580	hsa-miR-622	CLIP-seq
MIRT1128581	hsa-miR-637	CLIP-seq
MIRT1128582	hsa-miR-759	CLIP-seq
MIRT1128583	hsa-miR-762	CLIP-seq
MIRT1128584	hsa-miR-9	CLIP-seq
MIRT1128585	hsa-miR-93	CLIP-seq
MIRT1128586	hsa-miR-938	CLIP-seq
MIRT1128503	hsa-miR-1304	CLIP-seq
MIRT2036495	hsa-miR-146b-3p	CLIP-seq
MIRT1128520	hsa-miR-3151	CLIP-seq
MIRT2036496	hsa-miR-3173-5p	CLIP-seq
MIRT2036497	hsa-miR-3616-3p	CLIP-seq
MIRT1128542	hsa-miR-4436b-3p	CLIP-seq
MIRT2036498	hsa-miR-4722-3p	CLIP-seq
MIRT1128568	hsa-miR-486-3p	CLIP-seq
MIRT2036499	hsa-miR-874	CLIP-seq
MIRT1128496	hsa-miR-106a	CLIP-seq
MIRT1128497	hsa-miR-106b	CLIP-seq
MIRT1128499	hsa-miR-1207-5p	CLIP-seq
MIRT2266774	hsa-miR-125a-3p	CLIP-seq
MIRT1128503	hsa-miR-1304	CLIP-seq
MIRT1128508	hsa-miR-17	CLIP-seq
MIRT2266775	hsa-miR-182	CLIP-seq
MIRT1128509	hsa-miR-20a	CLIP-seq
MIRT1128510	hsa-miR-20b	CLIP-seq
MIRT2266776	hsa-miR-2110	CLIP-seq
MIRT2266777	hsa-miR-24	CLIP-seq
MIRT2266778	hsa-miR-2467-5p	CLIP-seq
MIRT2266779	hsa-miR-299-3p	CLIP-seq
MIRT2266780	hsa-miR-31	CLIP-seq
MIRT1128520	hsa-miR-3151	CLIP-seq
MIRT2266781	hsa-miR-3166	CLIP-seq
MIRT2266782	hsa-miR-3188	CLIP-seq
MIRT2266783	hsa-miR-3194-3p	CLIP-seq
MIRT2266784	hsa-miR-326	CLIP-seq
MIRT2266785	hsa-miR-330-5p	CLIP-seq
MIRT2266786	hsa-miR-3934	CLIP-seq
MIRT2266787	hsa-miR-3975	CLIP-seq
MIRT2266788	hsa-miR-4271	CLIP-seq
MIRT2266789	hsa-miR-431	CLIP-seq
MIRT1128542	hsa-miR-4436b-3p	CLIP-seq
MIRT2266790	hsa-miR-4437	CLIP-seq
MIRT2266791	hsa-miR-4640-3p	CLIP-seq
MIRT2266792	hsa-miR-4667-5p	CLIP-seq
MIRT1128559	hsa-miR-4688	CLIP-seq
MIRT2266793	hsa-miR-4700-5p	CLIP-seq
MIRT2266794	hsa-miR-4725-3p	CLIP-seq
MIRT2266795	hsa-miR-4732-3p	CLIP-seq
MIRT1128566	hsa-miR-4763-3p	CLIP-seq
MIRT2266796	hsa-miR-485-5p	CLIP-seq
MIRT1128568	hsa-miR-486-3p	CLIP-seq
MIRT1128571	hsa-miR-519d	CLIP-seq
MIRT2266797	hsa-miR-576-3p	CLIP-seq
MIRT2266798	hsa-miR-621	CLIP-seq
MIRT2266799	hsa-miR-626	CLIP-seq
MIRT2266800	hsa-miR-634	CLIP-seq
MIRT1128581	hsa-miR-637	CLIP-seq
MIRT2266801	hsa-miR-654-3p	CLIP-seq
MIRT2266802	hsa-miR-764	CLIP-seq
MIRT1128585	hsa-miR-93	CLIP-seq
MIRT1128500	hsa-miR-1228	CLIP-seq
MIRT1128502	hsa-miR-1248	CLIP-seq
MIRT2566343	hsa-miR-1254	CLIP-seq
MIRT1128504	hsa-miR-133a	CLIP-seq
MIRT1128505	hsa-miR-133b	CLIP-seq
MIRT2566344	hsa-miR-3116	CLIP-seq
MIRT1128517	hsa-miR-3117-5p	CLIP-seq
MIRT1128524	hsa-miR-3189-3p	CLIP-seq
MIRT1128527	hsa-miR-329	CLIP-seq
MIRT1128528	hsa-miR-342-3p	CLIP-seq
MIRT1128530	hsa-miR-362-3p	CLIP-seq
MIRT2566345	hsa-miR-3664-3p	CLIP-seq
MIRT1128536	hsa-miR-3941	CLIP-seq
MIRT2566346	hsa-miR-4254	CLIP-seq
MIRT2566347	hsa-miR-4257	CLIP-seq
MIRT2566348	hsa-miR-4436a	CLIP-seq
MIRT1128554	hsa-miR-4639-3p	CLIP-seq
MIRT1128557	hsa-miR-466	CLIP-seq
MIRT1128558	hsa-miR-4672	CLIP-seq
MIRT2566349	hsa-miR-4684-3p	CLIP-seq
MIRT2566350	hsa-miR-4710	CLIP-seq
MIRT2566351	hsa-miR-492	CLIP-seq
MIRT2566352	hsa-miR-510	CLIP-seq
MIRT1128579	hsa-miR-603	CLIP-seq
MIRT2566353	hsa-miR-647	CLIP-seq
MIRT1128584	hsa-miR-9	CLIP-seq
MIRT1128500	hsa-miR-1228	CLIP-seq
MIRT1128502	hsa-miR-1248	CLIP-seq
MIRT1128504	hsa-miR-133a	CLIP-seq
MIRT1128505	hsa-miR-133b	CLIP-seq
MIRT1128524	hsa-miR-3189-3p	CLIP-seq
MIRT1128527	hsa-miR-329	CLIP-seq
MIRT1128530	hsa-miR-362-3p	CLIP-seq
MIRT2566345	hsa-miR-3664-3p	CLIP-seq
MIRT1128536	hsa-miR-3941	CLIP-seq
MIRT2566347	hsa-miR-4257	CLIP-seq
MIRT2566348	hsa-miR-4436a	CLIP-seq
MIRT1128557	hsa-miR-466	CLIP-seq
MIRT1128558	hsa-miR-4672	CLIP-seq
MIRT2566351	hsa-miR-492	CLIP-seq
MIRT2566352	hsa-miR-510	CLIP-seq
MIRT1128579	hsa-miR-603	CLIP-seq
MIRT2566353	hsa-miR-647	CLIP-seq
MIRT1128584	hsa-miR-9	CLIP-seq

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
HSF1	Unknown	19381566

Show/Hide all(23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	IEA
GO:0000186	Process	Activation of MAPKK activity	IEA
GO:0001650	Component	Fibrillar center	IDA
GO:0004672	Function	Protein kinase activity	IDA	15001576
GO:0004674	Function	Protein serine/threonine kinase activity	EXP	9520446
GO:0004704	Function	NF-kappaB-inducing kinase activity	ISS
GO:0004709	Function	MAP kinase kinase kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	9020361, 9520446, 10733566, 12884866, 14743216, 15208311, 16286467, 16498412, 17158868, 17237370, 22939624, 25036637, 25241761, 25416956, 28514442, 30833792, 31980649, 32296183, 32814053
GO:0005524	Function	ATP binding	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006468	Process	Protein phosphorylation	IEA
GO:0006955	Process	Immune response	ISS
GO:0007249	Process	I-kappaB kinase/NF-kappaB signaling	ISS
GO:0016301	Function	Kinase activity	TAS
GO:0033209	Process	Tumor necrosis factor-mediated signaling pathway	TAS
GO:0038061	Process	NIK/NF-kappaB signaling	TAS
GO:0043123	Process	Positive regulation of I-kappaB kinase/NF-kappaB signaling	IBA	21873635
GO:0043123	Process	Positive regulation of I-kappaB kinase/NF-kappaB signaling	IMP	10094049
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0051607	Process	Defense response to virus	IDA	21478870
GO:0071260	Process	Cellular response to mechanical stimulus	IEP	19593445

MIM	HGNC	e!Ensembl
604655	6853	ENSG00000006062

Protein

UniProt ID

Q99558

Protein name

Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (HsNIK) (Serine/threonine-protein kinase NIK)

Protein function

Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Phosphorylates CHUK/IKKA, thereby promoting proteolytic processing of NFKB2/P100, which leads to NF-kappa-

PDB

4DN5 , 4G3D , 4IDT , 4IDV , 6WPP , 6Z1Q , 6Z1T , 8YHW

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	401 → 649	Protein kinase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Weakly expressed in testis, small intestine, spleen, thymus, peripheral blood leukocytes, prostate, ovary and colon. {ECO:0000269|PubMed:9020361}.

Sequence

MAVMEMACPGAPGSAVGQQKELPKAKEKTPPLGKKQSSVYKLEAVEKSPVFCGKWEILND
VITKGTAKEGSEAGPAAISIIAQAECENSQEFSPTFSERIFIAGSKQYSQSESLDQIPNN
VAHATEGKMARVCWKGKRRSKARKKRKKKSSKSLAHAGVALAKPLPRTPEQESCTIPVQE
DESPLGAPYVRNTPQFTKPLKEPGLGQLCFKQLGEGLRPALPRSELHKLISPLQCLNHVW
KLHHPQDGGPLPLPTHPFPYSRLPHPFPFHPLQPWKPHPLESFLGKLACVDSQKPLPDPH
LSKLACVDSPKPLPGPHLEPSCLSRGAHEKFSVEEYLVHALQGSVSSGQAHSLTSLAKTW
AARGSRSREPSPKTEDNEGVLLTEKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDK
QTGFQCAVKKVRLEVFRAEELMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQL
VKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVC
LQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFF
RGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNRALQQVGG
LKSPWRGEYKEPRHPPPNQANYHQTLHAQPRELSPRAPGPRPAEETTGRAPKLQPPLPPE
PPEPNKSPPLTLSKEESGMWEPLPLSSLEPAPARNPSSPERKATVPEQELQQLEIELFLN
SLSQPFSLEEQEQILSCLSIDSLSLSDDSEKNPSKASQSSRDTLSSGVHSWSSQAEARSS
SWNMVLARGRPTDTPSYFNGVKVQIQSLNGEHLHIREFHRVKVGDIATGISSQIPAAAFS
LVTKDGQPVRYDMEVPDSGIDLQCTLAPDGSFAWSWRVKHGQLENRP

Sequence length

947

Interactions

View interactions

	KEGG		Reactome
	MAPK signaling pathway NF-kappa B signaling pathway Apoptosis Osteoclast differentiation C-type lectin receptor signaling pathway T cell receptor signaling pathway TNF signaling pathway Intestinal immune network for IgA production Alcoholic liver disease Epithelial cell signaling in Helicobacter pylori infection Human T-cell leukemia virus 1 infection Epstein-Barr virus infection Chemical carcinogenesis - reactive oxygen species		CD28 dependent PI3K/Akt signaling Dectin-1 mediated noncanonical NF-kB signaling TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

Show/Hide Unknown Diseases (5)

Disease term	Disease name	Source
Unknown
Nik deficiency	NIK deficiency	ClinVar
NIK Deficiency	NIK deficiency	GenCC
Asthma	Asthma	GWAS
Multiple Sclerosis	Multiple Sclerosis	GWAS
Dermatitis	Dermatitis	GWAS

Show/Hide Text Mining Associations (67)

Disease Name	Relationship Type	References
Associations from Text Mining
Agammaglobulinemia	Associate	25406581
Anti Neutrophil Cytoplasmic Antibody Associated Vasculitis	Associate	37931331
Arthritis Rheumatoid	Associate	25963989
Atherosclerosis	Associate	29407886
Autoimmune Diseases	Associate	37931331, 39766197
Breast Neoplasms	Associate	19538528, 20735436, 26823811
Carcinogenesis	Associate	32000390
Carcinoma Hepatocellular	Associate	17711513
Carcinoma Non Small Cell Lung	Associate	30195659, 31586084
Carcinoma Pancreatic Ductal	Associate	23301098, 33525943
Carcinoma Renal Cell	Associate	37455213
Chronic Disease	Stimulate	29407886
Colorectal Neoplasms	Associate	25812680, 28982739, 34573430, 39379942
Constriction Pathologic	Stimulate	29407886
Corneal Endothelial Cell Loss	Associate	34894925
COVID 19	Associate	37938781
Cryptosporidiosis	Associate	25406581
Diabetes Mellitus	Associate	21846802
Drug Related Side Effects and Adverse Reactions	Inhibit	24980832
Endometrial Neoplasms	Associate	25811593
Gastritis	Stimulate	29329668
Glioblastoma	Associate	33723235, 37567906
Glioma	Associate	22745752
Head and Neck Neoplasms	Associate	30488488
Hematologic Neoplasms	Associate	31870133
Hepatitis C	Associate	31363036
Hepatitis C Chronic	Stimulate	31363036
Hereditary leiomyomatosis and renal cell cancer	Associate	22469134
Hodgkin Disease	Associate	20339089, 22469134, 22968463
Immunologic Deficiency Syndromes	Associate	27416764
Infections	Stimulate	23797008
Inflammation	Associate	21700900, 21820422, 21846802, 29329668, 33741083, 34894925, 39766197
Insulin Resistance	Associate	21846802
Intellectual Disability	Associate	20004765
Kotzot Richter syndrome	Associate	39596634
Leukemia	Associate	21820422
Leukemia Lymphocytic Chronic B Cell	Associate	36550750, 39596634
Leukemia Lymphoma Adult T Cell	Associate	22264793, 26269411
Leukoencephalopathies	Associate	20004765
Lymphatic Metastasis	Stimulate	26823811
Lymphoma B Cell Marginal Zone	Associate	21273489, 24349473
Lymphoma Large Cell Anaplastic	Associate	33184494
Lymphoma Mantle Cell	Associate	35263985
Lymphopenia	Associate	25406581
Melanoma	Associate	11773061, 18347013, 34638912
Mental Retardation X Linked Nonsyndromic	Associate	20004765
Metabolic Diseases	Associate	39766197
Microcephaly	Associate	20004765
Multiple Myeloma	Associate	17692804, 17692805, 24980832, 29654269
Neoplasms	Associate	11510478, 23301098, 25774687, 27348585, 28982739, 30488488, 34573430, 34638912, 34738714, 39766197
Nephrotic Syndrome	Associate	35173708
Netherton Syndrome	Associate	20004765
Nonsyndromic Deafness	Associate	20004765
Pancreatic Neoplasms	Associate	19502791, 22078386, 23301098
Pancreatitis	Associate	38273351
Polycystic Ovary Syndrome	Associate	33224973
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	25079338
Primary Immunodeficiency Diseases	Associate	25406581, 27416764
Prostatic Neoplasms	Associate	33509203
Rhabdomyosarcoma	Associate	23797008
Schizophrenia	Associate	35027554
Squamous Cell Carcinoma of Head and Neck	Associate	30488488, 40650045
Stomach Neoplasms	Associate	32000390
Urinary Bladder Neoplasms	Associate	35711565
Vascular Diseases	Associate	34894925
Weight Loss	Inhibit	21846802
X Linked Combined Immunodeficiency Diseases	Associate	39812688

MAP3K14 (mitogen-activated protein kinase kinase kinase 14)