TSPAN18 (tetraspanin 18)

Gene

• Entrez ID: 90139
• Gene name: Tetraspanin 18
• Gene symbol: TSPAN18
• Synonyms (NCBI Gene): TSPAN
• Chromosome: 11
• Chromosome location: 11p11.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT049631	hsa-miR-92a-3p	CLASH	23622248
MIRT040497	hsa-miR-597-5p	CLASH	23622248
MIRT439384	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439384	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1459669	hsa-miR-1197	CLIP-seq
MIRT1459670	hsa-miR-1264	CLIP-seq
MIRT1459671	hsa-miR-1265	CLIP-seq
MIRT1459672	hsa-miR-182	CLIP-seq
MIRT1459673	hsa-miR-202	CLIP-seq
MIRT1459674	hsa-miR-2682	CLIP-seq
MIRT1459675	hsa-miR-31	CLIP-seq
MIRT1459676	hsa-miR-3184	CLIP-seq
MIRT1459677	hsa-miR-331-3p	CLIP-seq
MIRT1459678	hsa-miR-370	CLIP-seq
MIRT1459679	hsa-miR-3940-5p	CLIP-seq
MIRT1459680	hsa-miR-423-5p	CLIP-seq
MIRT1459681	hsa-miR-4269	CLIP-seq
MIRT1459682	hsa-miR-4308	CLIP-seq
MIRT1459683	hsa-miR-431	CLIP-seq
MIRT1459684	hsa-miR-4434	CLIP-seq
MIRT1459685	hsa-miR-4468	CLIP-seq
MIRT1459686	hsa-miR-449c	CLIP-seq
MIRT1459687	hsa-miR-4507	CLIP-seq
MIRT1459688	hsa-miR-4514	CLIP-seq
MIRT1459689	hsa-miR-4516	CLIP-seq
MIRT1459690	hsa-miR-4531	CLIP-seq
MIRT1459691	hsa-miR-4688	CLIP-seq
MIRT1459692	hsa-miR-4692	CLIP-seq
MIRT1459693	hsa-miR-4696	CLIP-seq
MIRT1459694	hsa-miR-4709-3p	CLIP-seq
MIRT1459695	hsa-miR-4728-5p	CLIP-seq
MIRT1459696	hsa-miR-4738-3p	CLIP-seq
MIRT1459697	hsa-miR-4742-5p	CLIP-seq
MIRT1459698	hsa-miR-4749-3p	CLIP-seq
MIRT1459699	hsa-miR-4757-5p	CLIP-seq
MIRT1459700	hsa-miR-564	CLIP-seq
MIRT1459701	hsa-miR-653	CLIP-seq
MIRT1459702	hsa-miR-661	CLIP-seq
MIRT1555209	hsa-miR-1253	CLIP-seq
MIRT1555210	hsa-miR-185	CLIP-seq
MIRT1555211	hsa-miR-3175	CLIP-seq
MIRT1555212	hsa-miR-3911	CLIP-seq
MIRT1555213	hsa-miR-4254	CLIP-seq
MIRT1555214	hsa-miR-4292	CLIP-seq
MIRT1555215	hsa-miR-4306	CLIP-seq
MIRT1555216	hsa-miR-4644	CLIP-seq
MIRT1459695	hsa-miR-4728-5p	CLIP-seq
MIRT1555217	hsa-miR-485-5p	CLIP-seq
MIRT1555209	hsa-miR-1253	CLIP-seq
MIRT1555210	hsa-miR-185	CLIP-seq
MIRT2137954	hsa-miR-2110	CLIP-seq
MIRT2137955	hsa-miR-3126-5p	CLIP-seq
MIRT2137956	hsa-miR-3140-5p	CLIP-seq
MIRT1555215	hsa-miR-4306	CLIP-seq
MIRT1555216	hsa-miR-4644	CLIP-seq
MIRT2137957	hsa-miR-4659a-3p	CLIP-seq
MIRT2137958	hsa-miR-4659b-3p	CLIP-seq
MIRT1459694	hsa-miR-4709-3p	CLIP-seq
MIRT2358868	hsa-miR-147	CLIP-seq
MIRT2358869	hsa-miR-2113	CLIP-seq
MIRT2358870	hsa-miR-2278	CLIP-seq
MIRT1459677	hsa-miR-331-3p	CLIP-seq
MIRT2358871	hsa-miR-3919	CLIP-seq
MIRT2358872	hsa-miR-4274	CLIP-seq
MIRT1555214	hsa-miR-4292	CLIP-seq
MIRT2358873	hsa-miR-4756-3p	CLIP-seq
MIRT2358874	hsa-miR-4793-5p	CLIP-seq
MIRT2358875	hsa-miR-592	CLIP-seq
MIRT2358876	hsa-miR-597	CLIP-seq
MIRT2358877	hsa-miR-599	CLIP-seq
MIRT1555217	hsa-miR-485-5p	CLIP-seq
MIRT2358870	hsa-miR-2278	CLIP-seq
MIRT2652087	hsa-miR-3670	CLIP-seq
MIRT2358872	hsa-miR-4274	CLIP-seq
MIRT2652088	hsa-miR-455-3p	CLIP-seq
MIRT2652089	hsa-miR-556-5p	CLIP-seq
MIRT2358870	hsa-miR-2278	CLIP-seq
MIRT2694352	hsa-miR-29a	CLIP-seq
MIRT2694353	hsa-miR-29b	CLIP-seq
MIRT2694354	hsa-miR-29c	CLIP-seq
MIRT2694355	hsa-miR-3663-3p	CLIP-seq
MIRT2694356	hsa-miR-3922-5p	CLIP-seq
MIRT2358872	hsa-miR-4274	CLIP-seq
MIRT2652088	hsa-miR-455-3p	CLIP-seq
MIRT2694357	hsa-miR-4650-5p	CLIP-seq
MIRT2694358	hsa-miR-4753-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	28514442, 30573509, 33961781
GO:0005886	Component	Plasma membrane	IBA
GO:0006954	Process	Inflammatory response	IEA
GO:0007599	Process	Hemostasis	IEA
GO:0016020	Component	Membrane	IEA
GO:0017156	Process	Calcium-ion regulated exocytosis	IEA
GO:0051649	Process	Establishment of localization in cell	IEA
GO:1903670	Process	Regulation of sprouting angiogenesis	IMP	32694189

Other IDs

• MIM: 619399
• HGNC: 20660
• e!Ensembl: ENSG00000157570

Protein

• UniProt ID: Q96SJ8
• Protein name: Tetraspanin-18 (Tspan-18)
• Protein function: Plays a role in the cell surface localization of ORAI1 and may participate in the regulation of Ca(2+) signaling and the VWF release in response to inflammatory stimuli.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00335	Tetraspanin	9 → 246	Tetraspanin family	Family

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in primary endothelial cells (PubMed:30573509, PubMed:32694189). Expressed in the embryo heart (PubMed:32694189). Weakly expressed the embryo skeletal muscle (PubMed:32694189). {ECO:0000269|PubMed:30573509, ECO:0000269
• Sequence:

  MEGDCLSCMKYLMFVFNFFIFLGGACLLAIGIWVMVDPTGFREIVAANPLLLTGAYILLA
  MGGLLFLLGFLGCCGAVRENKCLLLFFFLFILIIFLAELSAAILAFIFRENLTREFFTKE
  LTKHYQGNNDTDVFSATWNSVMITFGCCGVNGPEDFKFASVFRLLTLDSEEVPEACCRRE
  PQSRDGVLLSREECLLGRSLFLNKQGCYTVILNTFETYVYLAGALAIGVLAIELFAMIFA
  MCLFRGIQ

• Sequence length: 248

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Ovarian serous cystadenocarcinoma	Likely benign	rs142957647	RCV005933233
TSPAN18-related disorder	Benign; Likely benign	rs2291334, rs1217918419, rs11038214, rs200276331, rs755992011, rs142957647	RCV003974484 RCV003911745 RCV003964455 RCV003909654 RCV003951872 RCV003942205

Associations from Text Mining
Disease Name	Relationship Type	References
Ablepharon macrostomia syndrome	Associate	26637991
Carcinoma Squamous Cell	Associate	34065085
Neoplasm Metastasis	Stimulate	37542345
Prostatic Neoplasms	Associate	37542345
Schizophrenia	Associate	30941828
Vascular Diseases	Associate	28258189