Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	9013
Gene name Gene Name - the full gene name approved by the HGNC.	TATA-box binding protein associated factor, RNA polymerase I subunit C
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TAF1C
Synonyms (NCBI Gene) Gene synonyms aliases	MGC:39976, SL1, TAFI110, TAFI95
Chromosome Chromosome number	16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	16q24.1
Summary Summary of gene provided in NCBI Entrez Gene.	Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of

Show/Hide all(88)

miRTarBase ID	miRNA	Experiments	Reference
MIRT047782	hsa-miR-30d-5p	CLASH	23622248
MIRT1409248	hsa-miR-124	CLIP-seq
MIRT1409249	hsa-miR-1294	CLIP-seq
MIRT1409250	hsa-miR-1305	CLIP-seq
MIRT1409251	hsa-miR-1827	CLIP-seq
MIRT1409252	hsa-miR-2355-5p	CLIP-seq
MIRT1409253	hsa-miR-3190	CLIP-seq
MIRT1409254	hsa-miR-3194-3p	CLIP-seq
MIRT1409255	hsa-miR-3202	CLIP-seq
MIRT1409256	hsa-miR-3677-5p	CLIP-seq
MIRT1409257	hsa-miR-3679-3p	CLIP-seq
MIRT1409258	hsa-miR-4286	CLIP-seq
MIRT1409259	hsa-miR-4294	CLIP-seq
MIRT1409260	hsa-miR-4316	CLIP-seq
MIRT1409261	hsa-miR-4318	CLIP-seq
MIRT1409262	hsa-miR-4533	CLIP-seq
MIRT1409263	hsa-miR-4677-3p	CLIP-seq
MIRT1409264	hsa-miR-4679	CLIP-seq
MIRT1409265	hsa-miR-4723-5p	CLIP-seq
MIRT1409266	hsa-miR-4757-5p	CLIP-seq
MIRT1409267	hsa-miR-506	CLIP-seq
MIRT1409268	hsa-miR-513c	CLIP-seq
MIRT1409269	hsa-miR-514b-5p	CLIP-seq
MIRT1409270	hsa-miR-570	CLIP-seq
MIRT1409271	hsa-miR-22	CLIP-seq
MIRT1409272	hsa-miR-4485	CLIP-seq
MIRT1409273	hsa-miR-646	CLIP-seq
MIRT1920953	hsa-miR-1224-3p	CLIP-seq
MIRT1920954	hsa-miR-214	CLIP-seq
MIRT1409271	hsa-miR-22	CLIP-seq
MIRT1409254	hsa-miR-3194-3p	CLIP-seq
MIRT1920955	hsa-miR-330-3p	CLIP-seq
MIRT1920956	hsa-miR-3619-5p	CLIP-seq
MIRT1920957	hsa-miR-4291	CLIP-seq
MIRT1409272	hsa-miR-4485	CLIP-seq
MIRT1920958	hsa-miR-4660	CLIP-seq
MIRT1409273	hsa-miR-646	CLIP-seq
MIRT1920959	hsa-miR-761	CLIP-seq
MIRT1920960	hsa-miR-922	CLIP-seq
MIRT1920953	hsa-miR-1224-3p	CLIP-seq
MIRT1920954	hsa-miR-214	CLIP-seq
MIRT1409271	hsa-miR-22	CLIP-seq
MIRT1409254	hsa-miR-3194-3p	CLIP-seq
MIRT1920956	hsa-miR-3619-5p	CLIP-seq
MIRT1920957	hsa-miR-4291	CLIP-seq
MIRT1409272	hsa-miR-4485	CLIP-seq
MIRT1920958	hsa-miR-4660	CLIP-seq
MIRT1409273	hsa-miR-646	CLIP-seq
MIRT1920959	hsa-miR-761	CLIP-seq
MIRT1920960	hsa-miR-922	CLIP-seq
MIRT2122724	hsa-miR-147	CLIP-seq
MIRT2122725	hsa-miR-1587	CLIP-seq
MIRT2122726	hsa-miR-3591-3p	CLIP-seq
MIRT2122727	hsa-miR-4287	CLIP-seq
MIRT2122728	hsa-miR-4302	CLIP-seq
MIRT2122729	hsa-miR-4469	CLIP-seq
MIRT2122730	hsa-miR-4674	CLIP-seq
MIRT2122731	hsa-miR-4685-3p	CLIP-seq
MIRT2122732	hsa-miR-4697-3p	CLIP-seq
MIRT2122733	hsa-miR-4717-3p	CLIP-seq
MIRT2122734	hsa-miR-509-3p	CLIP-seq
MIRT2122735	hsa-miR-599	CLIP-seq
MIRT2345101	hsa-miR-4476	CLIP-seq
MIRT2395502	hsa-miR-128	CLIP-seq
MIRT2395503	hsa-miR-27a	CLIP-seq
MIRT2395504	hsa-miR-27b	CLIP-seq
MIRT1409256	hsa-miR-3677-5p	CLIP-seq
MIRT1409266	hsa-miR-4757-5p	CLIP-seq
MIRT2461065	hsa-miR-3670	CLIP-seq
MIRT2122728	hsa-miR-4302	CLIP-seq
MIRT2461066	hsa-miR-556-5p	CLIP-seq
MIRT2461065	hsa-miR-3670	CLIP-seq
MIRT2122728	hsa-miR-4302	CLIP-seq
MIRT2461066	hsa-miR-556-5p	CLIP-seq
MIRT2638167	hsa-miR-3616-3p	CLIP-seq
MIRT2638168	hsa-miR-4257	CLIP-seq
MIRT2638169	hsa-miR-4690-3p	CLIP-seq
MIRT2638170	hsa-miR-4725-5p	CLIP-seq
MIRT2638171	hsa-miR-504	CLIP-seq
MIRT2638172	hsa-miR-552	CLIP-seq
MIRT2638173	hsa-miR-764	CLIP-seq
MIRT2638174	hsa-miR-767-3p	CLIP-seq
MIRT2638167	hsa-miR-3616-3p	CLIP-seq
MIRT2638168	hsa-miR-4257	CLIP-seq
MIRT2638169	hsa-miR-4690-3p	CLIP-seq
MIRT2638170	hsa-miR-4725-5p	CLIP-seq
MIRT2638171	hsa-miR-504	CLIP-seq
MIRT2638174	hsa-miR-767-3p	CLIP-seq

Show/Hide all(19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001164	Function	RNA polymerase I core promoter sequence-specific DNA binding	IBA
GO:0001164	Function	RNA polymerase I core promoter sequence-specific DNA binding	IDA	22368283
GO:0001181	Function	RNA polymerase I general transcription initiation factor activity	IDA	12498690
GO:0001188	Process	RNA polymerase I preinitiation complex assembly	IEA
GO:0001650	Component	Fibrillar center	IBA
GO:0001650	Component	Fibrillar center	IDA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	11250903, 17268553, 17318177, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005668	Component	RNA polymerase transcription factor SL1 complex	IDA	11250903
GO:0005668	Component	RNA polymerase transcription factor SL1 complex	IEA
GO:0005730	Component	Nucleolus	IDA	12498690
GO:0005730	Component	Nucleolus	IEA
GO:0006360	Process	Transcription by RNA polymerase I	IEA
GO:0006360	Process	Transcription by RNA polymerase I	TAS	7801123
GO:0006361	Process	Transcription initiation at RNA polymerase I promoter	NAS	12498690
GO:0006366	Process	Transcription by RNA polymerase II	TAS	7801123

MIM	HGNC	e!Ensembl
604905	11534	ENSG00000103168

Protein

UniProt ID

Q15572

Protein name

TATA box-binding protein-associated factor RNA polymerase I subunit C (RNA polymerase I-specific TBP-associated factor 110 kDa) (TAFI110) (TATA box-binding protein-associated factor 1C) (TBP-associated factor 1C) (Transcription initiation factor SL1/TIF-I

Protein function

Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rat

Family and domains

Sequence

MDFPSSLRPALFLTGPLGLSDVPDLSFMCSWRDALTLPEAQPQNSENGALHVTKDLLWEP
ATPGPLPMLPPLIDPWDPGLTARDLLFRGGCRYRKRPRVVLDVTEQISRFLLDHGDVAFA
PLGKLMLENFKLEGAGSRTKKKTVVSVKKLLQDLGGHQPWGCPWAYLSNRQRRFSILGGP
ILGTSVASHLAELLHEELVLRWEQLLLDEACTGGALAWVPGRTPQFGQLVYPAGGAQDRL
HFQEVVLTPGDNPQFLGKPGRIQLQGPVRQVVTCTVQGESKALIYTFLPHWLTCYLTPGP
FHPSSALLAVRSDYHCAVWKFGKQWQPTLLQAMQVEKGATGISLSPHLPGELAICSRSGA
VCLWSPEDGLRQIYRDPETLVFRDSSSWRWADFTAHPRVLTVGDRTGVKMLDTQGPPGCG
LLLFRLGAEASCQKGERVLLTQYLGHSSPKCLPPTLHLVCTQFSLYLVDERLPLVPMLKW
NHGLPSPLLLARLLPPPRPSCVQPLLLGGQGGQLQLLHLAGEGASVPRLAGPPQSLPSRI
DSLPAFPLLEPKIQWRLQERLKAPTIGLAAVVPPLPSAPTPGLVLFQLSAAGDVFYQQLR
PQVDSSLRRDAGPPGDTQPDCHAPTASWTSQDTAGCSQWLKALLKVPLAPPVWTAPTFTH
RQMLGSTELRREEEEGQRLGVLRKAMARGQLLLQRDLGSLPAAEPPPAPESGLEDKLSER
LGEAWAGRGAAWWERQQGRTSEPGRQTRRPKRRTQLSSSFSLSGHVDPSEDTSSPHSPEW
PPADALPLPPTTPPSQELTPDACAQGVPSEQRQMLRDYMAKLPPQRDTPGCATTPPHSQA
SSVRATRSQQHTPVLSSSQPLRKKPRMGF

Sequence length

869

Interactions

View interactions

	Reactome
			B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Neurodevelopmental Disorders	complex neurodevelopmental disorder	N/A	N/A	GenCC

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Carcinoma Intraductal Noninfiltrating	Associate	22887771
Multiple Myeloma	Associate	30353654
Neoplasms	Associate	30353654

TAF1C (TATA-box binding protein associated factor, RNA polymerase I subunit C)