Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	90102
Gene name Gene Name - the full gene name approved by the HGNC.	Pleckstrin homology like domain family B member 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PHLDB2
Synonyms (NCBI Gene) Gene synonyms aliases	LL5b, LL5beta
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3q13.2

Show/Hide all(81)

miRTarBase ID	miRNA	Experiments	Reference
MIRT001432	hsa-miR-16-5p	pSILAC	18668040
MIRT023789	hsa-miR-1-3p	Proteomics	18668040
MIRT001432	hsa-miR-16-5p	Proteomics	18668040
MIRT439984	hsa-miR-382-3p	HITS-CLIP	24374217
MIRT439983	hsa-miR-376a-5p	HITS-CLIP	24374217
MIRT439981	hsa-miR-432-5p	HITS-CLIP	24374217
MIRT439984	hsa-miR-382-3p	HITS-CLIP	24374217
MIRT439983	hsa-miR-376a-5p	HITS-CLIP	24374217
MIRT439981	hsa-miR-432-5p	HITS-CLIP	24374217
MIRT1232102	hsa-miR-124	CLIP-seq
MIRT1232103	hsa-miR-1323	CLIP-seq
MIRT1232104	hsa-miR-3662	CLIP-seq
MIRT1232105	hsa-miR-3714	CLIP-seq
MIRT1232106	hsa-miR-3910	CLIP-seq
MIRT1232107	hsa-miR-506	CLIP-seq
MIRT1232108	hsa-miR-548o	CLIP-seq
MIRT1232109	hsa-miR-1208	CLIP-seq
MIRT1232110	hsa-miR-1297	CLIP-seq
MIRT1232111	hsa-miR-205	CLIP-seq
MIRT1232112	hsa-miR-2355-3p	CLIP-seq
MIRT1232113	hsa-miR-26a	CLIP-seq
MIRT1232114	hsa-miR-26b	CLIP-seq
MIRT1232115	hsa-miR-4420	CLIP-seq
MIRT1232116	hsa-miR-4465	CLIP-seq
MIRT1232117	hsa-miR-4668-3p	CLIP-seq
MIRT1232118	hsa-miR-676	CLIP-seq
MIRT2068117	hsa-miR-1272	CLIP-seq
MIRT2068118	hsa-miR-1322	CLIP-seq
MIRT2068119	hsa-miR-197	CLIP-seq
MIRT2068120	hsa-miR-2964a-5p	CLIP-seq
MIRT2068121	hsa-miR-3119	CLIP-seq
MIRT2068122	hsa-miR-338-5p	CLIP-seq
MIRT2068123	hsa-miR-4263	CLIP-seq
MIRT2068124	hsa-miR-4517	CLIP-seq
MIRT2068125	hsa-miR-4799-5p	CLIP-seq
MIRT2068126	hsa-miR-490-3p	CLIP-seq
MIRT2068127	hsa-miR-5096	CLIP-seq
MIRT2068128	hsa-miR-576-5p	CLIP-seq
MIRT2068129	hsa-miR-649	CLIP-seq
MIRT2068130	hsa-miR-759	CLIP-seq
MIRT1232109	hsa-miR-1208	CLIP-seq
MIRT1232110	hsa-miR-1297	CLIP-seq
MIRT1232111	hsa-miR-205	CLIP-seq
MIRT1232112	hsa-miR-2355-3p	CLIP-seq
MIRT1232113	hsa-miR-26a	CLIP-seq
MIRT1232114	hsa-miR-26b	CLIP-seq
MIRT1232115	hsa-miR-4420	CLIP-seq
MIRT1232116	hsa-miR-4465	CLIP-seq
MIRT1232117	hsa-miR-4668-3p	CLIP-seq
MIRT1232118	hsa-miR-676	CLIP-seq
MIRT2392492	hsa-miR-3692	CLIP-seq
MIRT2456398	hsa-miR-2116	CLIP-seq
MIRT2456399	hsa-miR-4255	CLIP-seq
MIRT2456400	hsa-miR-4677-5p	CLIP-seq
MIRT2456401	hsa-miR-4698	CLIP-seq
MIRT2456402	hsa-miR-570	CLIP-seq
MIRT2456403	hsa-miR-9	CLIP-seq
MIRT2593127	hsa-miR-1283	CLIP-seq
MIRT2593128	hsa-miR-1285	CLIP-seq
MIRT2593129	hsa-miR-1343	CLIP-seq
MIRT2593130	hsa-miR-3074-5p	CLIP-seq
MIRT2593131	hsa-miR-3117-5p	CLIP-seq
MIRT2593132	hsa-miR-3187-5p	CLIP-seq
MIRT2593133	hsa-miR-3945	CLIP-seq
MIRT2593134	hsa-miR-4253	CLIP-seq
MIRT2593135	hsa-miR-450a	CLIP-seq
MIRT2593136	hsa-miR-518a-5p	CLIP-seq
MIRT2593137	hsa-miR-527	CLIP-seq
MIRT2593138	hsa-miR-579	CLIP-seq
MIRT2593139	hsa-miR-612	CLIP-seq
MIRT2593140	hsa-miR-616	CLIP-seq
MIRT2593128	hsa-miR-1285	CLIP-seq
MIRT2593129	hsa-miR-1343	CLIP-seq
MIRT2593130	hsa-miR-3074-5p	CLIP-seq
MIRT2593131	hsa-miR-3117-5p	CLIP-seq
MIRT2593132	hsa-miR-3187-5p	CLIP-seq
MIRT2593133	hsa-miR-3945	CLIP-seq
MIRT2593134	hsa-miR-4253	CLIP-seq
MIRT2593136	hsa-miR-518a-5p	CLIP-seq
MIRT2593137	hsa-miR-527	CLIP-seq
MIRT2593139	hsa-miR-612	CLIP-seq

Show/Hide all(20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000226	Process	Microtubule cytoskeleton organization	IMP	24859005
GO:0005515	Function	Protein binding	IPI	20236936, 26496610
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IDA
GO:0005925	Component	Focal adhesion	IDA	24859005
GO:0010470	Process	Regulation of gastrulation	IMP	23940118
GO:0010717	Process	Regulation of epithelial to mesenchymal transition	IMP	23940118
GO:0031252	Component	Cell leading edge	IDA	24859005
GO:0045111	Component	Intermediate filament cytoskeleton	IDA
GO:0045180	Component	Basal cortex	IBA	21873635
GO:0045180	Component	Basal cortex	IDA	23940118
GO:0045184	Process	Establishment of protein localization	IMP	24859005
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0051497	Process	Negative regulation of stress fiber assembly	IMP	24859005
GO:0051895	Process	Negative regulation of focal adhesion assembly	IMP	24859005
GO:0070507	Process	Regulation of microtubule cytoskeleton organization	IBA	21873635
GO:0070507	Process	Regulation of microtubule cytoskeleton organization	IGI	23940118
GO:1903690	Process	Negative regulation of wound healing, spreading of epidermal cells	IMP	24859005
GO:1904261	Process	Positive regulation of basement membrane assembly involved in embryonic body morphogenesis	IGI	23940118
GO:1904261	Process	Positive regulation of basement membrane assembly involved in embryonic body morphogenesis	IMP	23940118

MIM	HGNC	e!Ensembl
610298	29573	ENSG00000144824

Protein

UniProt ID

Q86SQ0

Protein name

Pleckstrin homology-like domain family B member 2 (Protein LL5-beta)

Protein function

Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity).

PDB

8WHJ , 8WHK , 8WHM

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00169	PH	1144 → 1245	PH domain	Domain

Sequence

MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYL
TLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSG
YPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMW
NGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRK
YSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDN
YLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYV
GTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSIS
GRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKIN
KELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRN
DELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNN
LEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKN
IVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESK
HFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQ
REQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEP
CGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLP
RKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYN
HQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACS
PDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKR
LQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVS
ITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYD
HLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL

Sequence length

1253

Interactions

View interactions

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Atrial fibrillation	Atrial Fibrillation	rs120074192, rs121908590, rs121908593, rs121434558, rs587776851, rs387906612, rs387906613, rs387906614, rs387906615, rs199472687, rs199472705, rs199473324, rs587777336, rs587777339, rs587777557 View all (6 more)	29892015, 30061737

Show/Hide Unknown Diseases (2)

Disease term	Disease name	References	Source
Unknown
Paroxysmal atrial fibrillation	Paroxysmal atrial fibrillation	29892015	ClinVar
Atrial Fibrillation	Atrial Fibrillation		GWAS

Show/Hide Text Mining Associations (8)

Disease Name	Relationship Type	References
Associations from Text Mining
Carcinogenesis	Stimulate	33452458
Carcinoma Renal Cell	Associate	33320958
Colorectal Neoplasms	Associate	34526059
Glioma	Associate	37614011
Neoplasm Metastasis	Associate	37614011
Neoplasms	Associate	37437062
Squamous Cell Carcinoma of Head and Neck	Associate	35655921
Stomach Neoplasms	Associate	33452458

PHLDB2 (pleckstrin homology like domain family B member 2)