Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
899
Gene name Gene Name - the full gene name approved by the HGNC.
Cyclin F
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CCNF
Synonyms (NCBI Gene) Gene synonyms aliases
FBX1, FBXO1, FTDALS5
Chromosome Chromosome number
16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16p13.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characte
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT000653 hsa-miR-424-5p Luciferase reporter assay 19956200
MIRT000643 hsa-miR-503-5p Luciferase reporter assay 19956200
MIRT005061 hsa-let-7b-5p Microarray 17699775
MIRT027780 hsa-miR-98-5p Microarray 19088304
MIRT005061 hsa-let-7b-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000082 Process G1/S transition of mitotic cell cycle IBA
GO:0000307 Component Cyclin-dependent protein kinase holoenzyme complex IBA
GO:0000320 Process Re-entry into mitotic cell cycle IEA
GO:0001890 Process Placenta development IEA
GO:0005515 Function Protein binding IPI 20596027, 22441691, 22632967, 25557911, 27653696, 33961781
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
600227 1591 ENSG00000162063
Protein
UniProt ID P41002
Protein name Cyclin-F (F-box only protein 1)
Protein function Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:20596027, PubMed:22632967, PubMed:26818844
PDB 9CB3
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00646 F-box 30 72 F-box domain Domain
PF00134 Cyclin_N 281 406 Cyclin, N-terminal domain Domain
PF02984 Cyclin_C 408 531 Cyclin, C-terminal domain Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed, with expression detected in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:7813445}.
Sequence
MGSGGVVHCRCAKCFCYPTKRRIRRRPRNLTILSLPEDVLFHILKWLSVEDILAVRAVHS
QLKDLVDNHASV
WACASFQELWPSPGNLKLFERAAEKGNFEAAVKLGIAYLYNEGLSVSD
EARAEVNGLKASRFFSLAERLNVGAAPFIWLFIRPPWSVSGSCCKAVVHESLRAECQLQR
THKASILHCLGRVLSLFEDEEKQQQAHDLFEEAAHQGCLTSSYLLWESDRRTDVSDPGRC
LHSFRKLRDYAAKGCWEAQLSLAKACANANQLGLEVRASSEIVCQLFQASQAVSKQQVFS
VQKGLNDTMRYILIDWLVEVATMKDFTSLCLHLTVECVDRYLRRRLVPRYRLQLLGIACM
VICTRFISKEILTIREAVWLTDNTYKYEDLVRMMGEIVSALEGKIR
VPTVVDYKEVLLTL
VPVELRTQHLCSFLCELSLLHTSLSAYAPARLAAAALLLARLTHGQTQPWTTQLWDLTGF
SYEDLIPCVLSLHKKCFHDDAPKDYRQVSLTAVKQRFEDKRYGEISQEEVL
SYSQLCAAL
GVTQDSPDPPTFLSTGEIHAFLSSPSGRRTKRKRENSLQEDRGSFVTTPTAELSSQEETL
LGSFLDWSLDCCSGYEGDQESEGEKEGDVTAPSGILDVTVVYLNPEQHCCQESSDEEACP
EDKGPQDPQALALDTQIPATPGPKPLVRTSREPGKDVTTSGYSSVSTASPTSSVDGGLGA
LPQPTSVLSLDSDSHTQPCHHQARKSCLQCRPPSPPESSVPQQQVKRINLCIHSEEEDMN
LGLVRL
Sequence length 786
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Neddylation
Antigen processing: Ubiquitination & Proteasome degradation
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Amyotrophic Lateral Sclerosis amyotrophic lateral sclerosis N/A N/A GenCC
Amyotrophic lateral sclerosis frontotemporal dementia and/or amyotrophic lateral sclerosis 5 N/A N/A GenCC
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Amyotrophic Lateral Sclerosis Associate 28852778, 29021214, 31164693, 31445393, 33670299, 35231559, 36114006, 36674783, 37208601, 37220877, 37243816, 37993492
Amyotrophic lateral sclerosis 1 Associate 29021214, 31445393
Burkitt Lymphoma Associate 26468873
Carcinoma Hepatocellular Inhibit 23305207
Carcinoma Hepatocellular Associate 34397798
Carcinoma Pancreatic Ductal Stimulate 35046938
Carcinoma Renal Cell Associate 31739630
Colorectal Neoplasms Associate 31087508, 34308980
Frontotemporal Dementia Associate 28852778, 29021214, 35231559, 37220877, 37243816, 37993492
HIV Infections Associate 28184007