TMEM116 (transmembrane protein 116)

Gene

• Entrez ID: 89894
• Gene name: Transmembrane protein 116
• Gene symbol: TMEM116
• Synonyms (NCBI Gene): -
• Chromosome: 12
• Chromosome location: 12q24.13

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT439445	hsa-miR-127-5p	HITS-CLIP	24374217
MIRT439445	hsa-miR-127-5p	HITS-CLIP	24374217
MIRT1430036	hsa-miR-1184	CLIP-seq
MIRT1430037	hsa-miR-1205	CLIP-seq
MIRT1430038	hsa-miR-1296	CLIP-seq
MIRT1430039	hsa-miR-2909	CLIP-seq
MIRT1430040	hsa-miR-3158-5p	CLIP-seq
MIRT1430041	hsa-miR-3945	CLIP-seq
MIRT1430042	hsa-miR-4436b-3p	CLIP-seq
MIRT1430043	hsa-miR-4761-3p	CLIP-seq
MIRT1430044	hsa-miR-544	CLIP-seq
MIRT1430036	hsa-miR-1184	CLIP-seq
MIRT1430037	hsa-miR-1205	CLIP-seq
MIRT1430038	hsa-miR-1296	CLIP-seq
MIRT1430039	hsa-miR-2909	CLIP-seq
MIRT1430040	hsa-miR-3158-5p	CLIP-seq
MIRT1430041	hsa-miR-3945	CLIP-seq
MIRT1430042	hsa-miR-4436b-3p	CLIP-seq
MIRT1430043	hsa-miR-4761-3p	CLIP-seq
MIRT2350453	hsa-miR-543	CLIP-seq
MIRT1430044	hsa-miR-544	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003674	Function	Molecular_function	ND
GO:0005575	Component	Cellular_component	ND
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	37293153
GO:0007165	Process	Signal transduction	IEA
GO:0008150	Process	Biological_process	ND
GO:0016020	Component	Membrane	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q8NCL8
• Protein name: Transmembrane protein 116
• Sequence:

  MKHTQSGQSTSPLVIDYTCRVCQMAFVFSSLIPLLLMTPVFCLGNTSECFQNFSQSHKCI
  LMHSPPSAMAELPPSANTSVCSTLYFYGIAIFLGSFVLSLLTIMVLLIRAQTLYKKFVKS
  TGFLGSEQWAVIHIVDQRVRFYPVAFFCCWGPAVILMIIKLTKPQDTKLHMALYVLQALT
  ATSQGLLNCGVYGWTQHKFHQLKQEARRDADTQTPLLCSQKRFYSRGLNSLESTLTFPAS
  TSTIF

• Sequence length: 245

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL INFARCTION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC LUPUS ERYTHEMATOSUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UPPER AERODIGESTIVE TRACT NEOPLASM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Carcinoma Renal Cell	Associate	26169495	★☆☆☆☆ Found in Text Mining only