TPD52L3 (TPD52 like 3)

Gene

• Entrez ID: 89882
• Gene name: TPD52 like 3
• Gene symbol: TPD52L3
• Synonyms (NCBI Gene): D55, NYDSP25, TPD55, hD55
• Chromosome: 9
• Chromosome location: 9p24.1
• Summary: This gene encodes a member of the tumor protein D52-like family of proteins. These proteins are characterized by an N-terminal coiled-coil motif that is used to form homo- and heteromeric complexes with other tumor protein D52-like proteins. The encoded p

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT048915	hsa-miR-92a-3p	CLASH	23622248
MIRT652257	hsa-miR-1255b-2-3p	HITS-CLIP	23824327
MIRT652256	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT652255	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT652254	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT652253	hsa-miR-4303	HITS-CLIP	23824327
MIRT652252	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT652251	hsa-miR-4762-3p	HITS-CLIP	23824327
MIRT652250	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT529493	hsa-miR-4796-3p	PAR-CLIP	22012620
MIRT529492	hsa-miR-6805-5p	PAR-CLIP	22012620
MIRT529491	hsa-miR-6758-3p	PAR-CLIP	22012620
MIRT529490	hsa-miR-29b-1-5p	PAR-CLIP	22012620
MIRT529488	hsa-miR-4683	PAR-CLIP	22012620
MIRT529489	hsa-miR-4437	PAR-CLIP	22012620
MIRT529487	hsa-miR-4283	PAR-CLIP	22012620
MIRT529486	hsa-miR-6846-5p	PAR-CLIP	22012620
MIRT529485	hsa-miR-6848-5p	PAR-CLIP	22012620
MIRT529484	hsa-miR-520a-5p	PAR-CLIP	22012620
MIRT529483	hsa-miR-525-5p	PAR-CLIP	22012620
MIRT529482	hsa-miR-1270	PAR-CLIP	22012620
MIRT529480	hsa-miR-620	PAR-CLIP	22012620
MIRT529481	hsa-miR-218-1-3p	PAR-CLIP	22012620
MIRT529479	hsa-miR-3180-5p	PAR-CLIP	22012620
MIRT652257	hsa-miR-1255b-2-3p	HITS-CLIP	23824327
MIRT652256	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT652255	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT652254	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT652253	hsa-miR-4303	HITS-CLIP	23824327
MIRT652252	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT652251	hsa-miR-4762-3p	HITS-CLIP	23824327
MIRT652250	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT529493	hsa-miR-4796-3p	PAR-CLIP	22012620
MIRT529492	hsa-miR-6805-5p	PAR-CLIP	22012620
MIRT529491	hsa-miR-6758-3p	PAR-CLIP	22012620
MIRT529490	hsa-miR-29b-1-5p	PAR-CLIP	22012620
MIRT529488	hsa-miR-4683	PAR-CLIP	22012620
MIRT529489	hsa-miR-4437	PAR-CLIP	22012620
MIRT529487	hsa-miR-4283	PAR-CLIP	22012620
MIRT529486	hsa-miR-6846-5p	PAR-CLIP	22012620
MIRT529485	hsa-miR-6848-5p	PAR-CLIP	22012620
MIRT529484	hsa-miR-520a-5p	PAR-CLIP	22012620
MIRT529483	hsa-miR-525-5p	PAR-CLIP	22012620
MIRT529482	hsa-miR-1270	PAR-CLIP	22012620
MIRT529480	hsa-miR-620	PAR-CLIP	22012620
MIRT529481	hsa-miR-218-1-3p	PAR-CLIP	22012620
MIRT529479	hsa-miR-3180-5p	PAR-CLIP	22012620
MIRT1449253	hsa-miR-1182	CLIP-seq
MIRT1449254	hsa-miR-1252	CLIP-seq
MIRT1449255	hsa-miR-298	CLIP-seq
MIRT1449256	hsa-miR-330-3p	CLIP-seq
MIRT1449257	hsa-miR-3613-3p	CLIP-seq
MIRT1449258	hsa-miR-4330	CLIP-seq
MIRT1449259	hsa-miR-4797-5p	CLIP-seq
MIRT1449260	hsa-miR-526b	CLIP-seq
MIRT1449261	hsa-miR-548p	CLIP-seq
MIRT1449262	hsa-miR-122	CLIP-seq
MIRT1449263	hsa-miR-183	CLIP-seq
MIRT1449264	hsa-miR-193a-5p	CLIP-seq
MIRT1449265	hsa-miR-194	CLIP-seq
MIRT1449266	hsa-miR-2355-5p	CLIP-seq
MIRT1449267	hsa-miR-302a	CLIP-seq
MIRT1449268	hsa-miR-302b	CLIP-seq
MIRT1449269	hsa-miR-302c	CLIP-seq
MIRT1449270	hsa-miR-302d	CLIP-seq
MIRT1449271	hsa-miR-302e	CLIP-seq
MIRT1449272	hsa-miR-3154	CLIP-seq
MIRT1449273	hsa-miR-3198	CLIP-seq
MIRT1449274	hsa-miR-3616-5p	CLIP-seq
MIRT1449275	hsa-miR-3647-5p	CLIP-seq
MIRT1449276	hsa-miR-372	CLIP-seq
MIRT1449277	hsa-miR-373	CLIP-seq
MIRT1449278	hsa-miR-4286	CLIP-seq
MIRT1449279	hsa-miR-4309	CLIP-seq
MIRT1449280	hsa-miR-432	CLIP-seq
MIRT1449281	hsa-miR-4436b-3p	CLIP-seq
MIRT1449282	hsa-miR-4481	CLIP-seq
MIRT1449283	hsa-miR-4745-5p	CLIP-seq
MIRT1449284	hsa-miR-4771	CLIP-seq
MIRT1449285	hsa-miR-4795-5p	CLIP-seq
MIRT1449286	hsa-miR-499a-5p	CLIP-seq
MIRT1449287	hsa-miR-512-3p	CLIP-seq
MIRT1449288	hsa-miR-516b	CLIP-seq
MIRT1449289	hsa-miR-520a-3p	CLIP-seq
MIRT1449290	hsa-miR-520b	CLIP-seq
MIRT1449291	hsa-miR-520c-3p	CLIP-seq
MIRT1449292	hsa-miR-520d-3p	CLIP-seq
MIRT1449293	hsa-miR-520e	CLIP-seq
MIRT1449294	hsa-miR-573	CLIP-seq
MIRT1449295	hsa-miR-656	CLIP-seq
MIRT1449296	hsa-miR-890	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16631610, 25416956, 33961781
GO:0005737	Component	Cytoplasm	IBA

Other IDs

• MIM: 617567
• HGNC: 23382
• e!Ensembl: ENSG00000170777

Protein

• UniProt ID: Q96J77
• Protein name: Tumor protein D55 (hD55) (Testis development protein NYD-SP25) (Tumor protein D52-like 3)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04201	TPD52	1 → 139	Tumour protein D52 family	Family

• Tissue specificity: TISSUE SPECIFICITY: Specifically expressed in testis. Expressed at 5.6-fold higher levels in adult testis than in fetal testis. {ECO:0000269|PubMed:16631610}.
• Sequence:

  MPHARTETSVGTYESHSTSELEDLTEPEQRELKTKLTKLEAEIVTLRHVLAAKERRCGEL
  KRKLGLTALVGLRQNLSKSWLDVQVSNTYVKQKTSAALSTMGTLICRKLGGVKKSATFRS
  FEGLMGTIKSKVSGGKRAWP

• Sequence length: 140

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ASTHMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATOPIC ASTHMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CYSTIC KIDNEY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
KIDNEY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations