Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	89870
Gene name Gene Name - the full gene name approved by the HGNC.	Tripartite motif containing 15
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TRIM15
Synonyms (NCBI Gene) Gene synonyms aliases	RNF93, ZNF178, ZNFB7
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6p22.1
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. Alternativ

Show/Hide all(18)

miRTarBase ID	miRNA	Experiments
MIRT1453174	hsa-miR-1321	CLIP-seq
MIRT1453175	hsa-miR-24	CLIP-seq
MIRT1453176	hsa-miR-2467-5p	CLIP-seq
MIRT1453177	hsa-miR-3664-3p	CLIP-seq
MIRT1453178	hsa-miR-4270	CLIP-seq
MIRT1453179	hsa-miR-4436a	CLIP-seq
MIRT1453180	hsa-miR-4441	CLIP-seq
MIRT1453181	hsa-miR-4739	CLIP-seq
MIRT1453182	hsa-miR-4756-5p	CLIP-seq
MIRT1453183	hsa-miR-513a-5p	CLIP-seq
MIRT1453174	hsa-miR-1321	CLIP-seq
MIRT1453176	hsa-miR-2467-5p	CLIP-seq
MIRT1453178	hsa-miR-4270	CLIP-seq
MIRT1453180	hsa-miR-4441	CLIP-seq
MIRT1453181	hsa-miR-4739	CLIP-seq
MIRT1453182	hsa-miR-4756-5p	CLIP-seq
MIRT1453183	hsa-miR-513a-5p	CLIP-seq
MIRT2356894	hsa-miR-494	CLIP-seq

Show/Hide all(26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003713	Function	Transcription coactivator activity	IDA	23077300
GO:0005515	Function	Protein binding	IPI	25416956, 26871637, 32296183
GO:0005634	Component	Nucleus	IDA	34871740
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005925	Component	Focal adhesion	IEA
GO:0007249	Process	Canonical NF-kappaB signal transduction	IDA	27995356, 34871740
GO:0007500	Process	Mesodermal cell fate determination	TAS	10207104
GO:0008270	Function	Zinc ion binding	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0032481	Process	Positive regulation of type I interferon production	IMP	23077300
GO:0044790	Process	Suppression of viral release by host	IDA	18248090
GO:0044790	Process	Suppression of viral release by host	IMP	18248090
GO:0045087	Process	Innate immune response	IBA
GO:0045087	Process	Innate immune response	IEA
GO:0045087	Process	Innate immune response	IMP	18248090
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0070161	Component	Anchoring junction	IEA
GO:0070534	Process	Protein K63-linked ubiquitination	IDA	27995356
GO:0140313	Function	Molecular sequestering activity	IDA	34871740
GO:1900246	Process	Positive regulation of RIG-I signaling pathway	IMP	23077300
GO:1901223	Process	Negative regulation of non-canonical NF-kappaB signal transduction	IDA	34871740
GO:1901253	Process	Negative regulation of intracellular transport of viral material	IMP	18248090

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Protein

UniProt ID

Q9C019

Protein name

E3 ubiquitin-protein ligase TRIM15 (EC 2.3.2.27) (RING finger protein 93) (Zinc finger protein 178) (Zinc finger protein B7)

Protein function

E3 ubiquitin ligase that plays a role in several processes including innate antiviral immnity, cell migration and chemotaxis (PubMed:23077300, PubMed:34142270). Acts as a 'Lys-63'-specific ubiquitin ligase for MAPK1/ERK2 and MAPK3/ERK1, promotin

PDB

7QS2

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00097	zf-C3HC4	16 → 60	Zinc finger, C3HC4 type (RING finger)	Domain
PF00643	zf-B_box	79 → 120	B-box zinc finger	Domain
PF13765	PRY	296 → 344	SPRY-associated domain	Family
PF00622	SPRY	348 → 465	SPRY domain	Family

Sequence

MPATPSLKVVHELPACTLCAGPLEDAVTIPCGHTFCRLCLPALSQMGAQSSGKILLCPLC
QEEEQAETPMAPVPLGPLGETYCEEHGEKIYFFCENDAEFLCVFCREGPTHQAHTVGFLD
EAIQPYRDRLRSRLEALSTERDEIEDVKCQEDQKLQVLLTQIESKKHQVETAFERLQQEL
EQQRCLLLARLRELEQQIWKERDEYITKVSEEVTRLGAQVKELEEKCQQPASELLQDVRV
NQSRCEMKTFVSPEAISPDLVKKIRDFHRKILTLPEMMRMFSENLAHHLEIDSGVITLDP
QTASRSLVLSEDRKSVRYTRQKKSLPDSPLRFDGLPAVLGFPGFSSGRHRWQVDLQLGDG
GGCTVGVAGEGVRRKGEMGLSAEDGVWAVIISHQQCWASTSPGTDLPLSEIPRGVRVALD
YEAGQVTLHNAQTQEPIFTFTASFSGKVFPFFAVWKKGSCLTLKG

Sequence length

465

Interactions

View interactions

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Insomnia	Insomnia	N/A	N/A	GWAS
Ulcerative colitis	Ulcerative colitis	N/A	N/A	GWAS

Show/Hide Text Mining Associations (13)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Arthritis Rheumatoid	Associate	34867944
Carcinoma Hepatocellular	Associate	36670097
Carcinoma Non Small Cell Lung	Stimulate	35534896
Colitis Ulcerative	Associate	29562276
Kidney Neoplasms	Associate	36189312
Lupus Nephritis	Associate	29953444
Lymphatic Metastasis	Stimulate	31906745
Melanoma	Associate	34497368
Neoplasm Metastasis	Stimulate	31906745
Neoplasm Metastasis	Associate	35534896
Neoplasms	Inhibit	30412518
Neoplasms	Associate	31906745, 35534896, 36189312
Stomach Neoplasms	Associate	30412518, 31906745, 36661663

TRIM15 (tripartite motif containing 15)