Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8986
Gene name Gene Name - the full gene name approved by the HGNC.
Ribosomal protein S6 kinase A4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RPS6KA4
Synonyms (NCBI Gene) Gene synonyms aliases
MSK2, RSK-B, S6K-alpha-4
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11q13.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and ATF1. The encoded protein can also pho
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT022283 hsa-miR-124-3p Microarray 18668037
MIRT468925 hsa-miR-302c-3p PAR-CLIP 23592263
MIRT468926 hsa-miR-520f-3p PAR-CLIP 23592263
MIRT468924 hsa-miR-6750-3p PAR-CLIP 23592263
MIRT468923 hsa-miR-6085 PAR-CLIP 23592263
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000287 Function Magnesium ion binding IEA
GO:0001818 Process Negative regulation of cytokine production TAS 18508628
GO:0004674 Function Protein serine/threonine kinase activity IBA 21873635
GO:0004674 Function Protein serine/threonine kinase activity IDA 9792677
GO:0004674 Function Protein serine/threonine kinase activity IMP 12773393
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
603606 10433 ENSG00000162302
Protein
UniProt ID O75676
Protein name Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB)
Protein function Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by hi
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 33 301 Protein kinase domain Domain
PF00433 Pkinase_C 322 361 Protein kinase C terminal domain Family
PF00069 Pkinase 412 674 Protein kinase domain Domain
Sequence
Sequence length 772
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  MAPK signaling pathway
TNF signaling pathway
 
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Leprosy Leprosy GWAS
Biliary Cholangitis Biliary Cholangitis GWAS
Inflammatory Bowel Disease Inflammatory Bowel Disease GWAS
Psoriasis Psoriasis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 23675462
Heart Diseases Associate 35942506
Inflammation Associate 35942506
Leukemia Myeloid Acute Associate 37462338
Multiple Sclerosis Relapsing Remitting Associate 32386505
Squamous Cell Carcinoma of Head and Neck Associate 24192080
Stiff Skin Syndrome Associate 35942506
Tarlov Cysts Stimulate 38287071
Uterine Cervical Neoplasms Associate 17504382
Wilms Tumor Associate 28930610