Gene Gene information from NCBI Gene database.
Entrez ID 8986
Gene name Ribosomal protein S6 kinase A4
Gene symbol RPS6KA4
Synonyms (NCBI Gene)
MSK2RSK-BS6K-alpha-4
Chromosome 11
Chromosome location 11q13.1
Summary This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and ATF1. The encoded protein can also pho
miRNA miRNA information provided by mirtarbase database.
266
miRTarBase ID miRNA Experiments Reference
MIRT022283 hsa-miR-124-3p Microarray 18668037
MIRT468925 hsa-miR-302c-3p PAR-CLIP 23592263
MIRT468926 hsa-miR-520f-3p PAR-CLIP 23592263
MIRT468924 hsa-miR-6750-3p PAR-CLIP 23592263
MIRT468923 hsa-miR-6085 PAR-CLIP 23592263
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
41
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0000287 Function Magnesium ion binding IEA
GO:0001818 Process Negative regulation of cytokine production IEA
GO:0001818 Process Negative regulation of cytokine production TAS 18508628
GO:0004672 Function Protein kinase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603606 10433 ENSG00000162302
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O75676
Protein name Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB)
Protein function Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by hi
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 33 301 Protein kinase domain Domain
PF00433 Pkinase_C 322 361 Protein kinase C terminal domain Family
PF00069 Pkinase 412 674 Protein kinase domain Domain
Sequence
Sequence length 772
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  MAPK signaling pathway
TNF signaling pathway
 
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Malignant lymphoma, large B-cell, diffuse Uncertain significance rs568222796 RCV005932439
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Breast Neoplasms Associate 23675462
Heart Diseases Associate 35942506
Inflammation Associate 35942506
Leukemia Myeloid Acute Associate 37462338
Multiple Sclerosis Relapsing Remitting Associate 32386505
Squamous Cell Carcinoma of Head and Neck Associate 24192080
Stiff Skin Syndrome Associate 35942506
Tarlov Cysts Stimulate 38287071
Uterine Cervical Neoplasms Associate 17504382
Wilms Tumor Associate 28930610