RPS6KA4 (ribosomal protein S6 kinase A4)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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8986 |
Gene name
Gene Name - the full gene name approved by the HGNC.
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Ribosomal protein S6 kinase A4 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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RPS6KA4 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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MSK2, RSK-B, S6K-alpha-4 |
Chromosome
Chromosome number
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11 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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11q13.1 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and ATF1. The encoded protein can also pho |
miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein | |||||||||||||||||||||
UniProt ID | O75676 | ||||||||||||||||||||
Protein name | Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB) | ||||||||||||||||||||
Protein function | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by hi | ||||||||||||||||||||
Family and domains |
Pfam
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Sequence |
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Sequence length | 772 | ||||||||||||||||||||
Interactions | View interactions |
Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease information provided by ClinVar, GenCC, and GWAS databases.
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