Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	89845
Gene name Gene Name - the full gene name approved by the HGNC.	ATP binding cassette subfamily C member 10
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ABCC10
Synonyms (NCBI Gene) Gene synonyms aliases	EST182763, MRP7, SIMRP7
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6p21.1
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, M

Show/Hide all(87)

miRTarBase ID	miRNA	Experiments	Reference
MIRT047155	hsa-miR-183-5p	CLASH	23622248
MIRT758254	hsa-let-7a	CLIP-seq
MIRT758255	hsa-let-7b	CLIP-seq
MIRT758256	hsa-let-7c	CLIP-seq
MIRT758257	hsa-let-7d	CLIP-seq
MIRT758258	hsa-let-7e	CLIP-seq
MIRT758259	hsa-let-7f	CLIP-seq
MIRT758260	hsa-let-7g	CLIP-seq
MIRT758261	hsa-let-7i	CLIP-seq
MIRT758262	hsa-miR-1225-3p	CLIP-seq
MIRT758263	hsa-miR-185	CLIP-seq
MIRT758264	hsa-miR-30a	CLIP-seq
MIRT758265	hsa-miR-30b	CLIP-seq
MIRT758266	hsa-miR-30c	CLIP-seq
MIRT758267	hsa-miR-30d	CLIP-seq
MIRT758268	hsa-miR-30e	CLIP-seq
MIRT758269	hsa-miR-3150b-3p	CLIP-seq
MIRT758270	hsa-miR-3911	CLIP-seq
MIRT758271	hsa-miR-3927	CLIP-seq
MIRT758272	hsa-miR-4306	CLIP-seq
MIRT758273	hsa-miR-4323	CLIP-seq
MIRT758274	hsa-miR-4451	CLIP-seq
MIRT758275	hsa-miR-4458	CLIP-seq
MIRT758276	hsa-miR-4495	CLIP-seq
MIRT758277	hsa-miR-4500	CLIP-seq
MIRT758278	hsa-miR-4644	CLIP-seq
MIRT758279	hsa-miR-4685-5p	CLIP-seq
MIRT758280	hsa-miR-4732-5p	CLIP-seq
MIRT758281	hsa-miR-4765	CLIP-seq
MIRT758282	hsa-miR-4784	CLIP-seq
MIRT758283	hsa-miR-595	CLIP-seq
MIRT758284	hsa-miR-98	CLIP-seq
MIRT758262	hsa-miR-1225-3p	CLIP-seq
MIRT1923634	hsa-miR-1237	CLIP-seq
MIRT1923635	hsa-miR-204	CLIP-seq
MIRT1923636	hsa-miR-211	CLIP-seq
MIRT1923637	hsa-miR-2110	CLIP-seq
MIRT1923638	hsa-miR-4271	CLIP-seq
MIRT1923639	hsa-miR-4314	CLIP-seq
MIRT1923640	hsa-miR-4446-5p	CLIP-seq
MIRT1923641	hsa-miR-4667-5p	CLIP-seq
MIRT1923642	hsa-miR-4700-5p	CLIP-seq
MIRT1923643	hsa-miR-4725-3p	CLIP-seq
MIRT758280	hsa-miR-4732-5p	CLIP-seq
MIRT1923644	hsa-miR-4755-5p	CLIP-seq
MIRT758283	hsa-miR-595	CLIP-seq
MIRT1923645	hsa-miR-623	CLIP-seq
MIRT1923646	hsa-miR-637	CLIP-seq
MIRT1923634	hsa-miR-1237	CLIP-seq
MIRT1923635	hsa-miR-204	CLIP-seq
MIRT1923636	hsa-miR-211	CLIP-seq
MIRT1923637	hsa-miR-2110	CLIP-seq
MIRT2165151	hsa-miR-3664-3p	CLIP-seq
MIRT758270	hsa-miR-3911	CLIP-seq
MIRT1923638	hsa-miR-4271	CLIP-seq
MIRT1923639	hsa-miR-4314	CLIP-seq
MIRT1923640	hsa-miR-4446-5p	CLIP-seq
MIRT1923641	hsa-miR-4667-5p	CLIP-seq
MIRT2165152	hsa-miR-4680-5p	CLIP-seq
MIRT758279	hsa-miR-4685-5p	CLIP-seq
MIRT1923642	hsa-miR-4700-5p	CLIP-seq
MIRT1923643	hsa-miR-4725-3p	CLIP-seq
MIRT1923644	hsa-miR-4755-5p	CLIP-seq
MIRT758281	hsa-miR-4765	CLIP-seq
MIRT758283	hsa-miR-595	CLIP-seq
MIRT1923645	hsa-miR-623	CLIP-seq
MIRT1923646	hsa-miR-637	CLIP-seq
MIRT2165153	hsa-miR-671-5p	CLIP-seq
MIRT2165154	hsa-miR-938	CLIP-seq
MIRT758254	hsa-let-7a	CLIP-seq
MIRT758255	hsa-let-7b	CLIP-seq
MIRT758256	hsa-let-7c	CLIP-seq
MIRT758257	hsa-let-7d	CLIP-seq
MIRT758258	hsa-let-7e	CLIP-seq
MIRT758259	hsa-let-7f	CLIP-seq
MIRT758260	hsa-let-7g	CLIP-seq
MIRT758261	hsa-let-7i	CLIP-seq
MIRT758262	hsa-miR-1225-3p	CLIP-seq
MIRT758269	hsa-miR-3150b-3p	CLIP-seq
MIRT758271	hsa-miR-3927	CLIP-seq
MIRT758273	hsa-miR-4323	CLIP-seq
MIRT758274	hsa-miR-4451	CLIP-seq
MIRT758275	hsa-miR-4458	CLIP-seq
MIRT758277	hsa-miR-4500	CLIP-seq
MIRT758280	hsa-miR-4732-5p	CLIP-seq
MIRT758282	hsa-miR-4784	CLIP-seq
MIRT758284	hsa-miR-98	CLIP-seq

Show/Hide all(18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005524	Function	ATP binding	IEA
GO:0005765	Component	Lysosomal membrane	HDA	17897319
GO:0005886	Component	Plasma membrane	IDA	28112518
GO:0005886	Component	Plasma membrane	TAS
GO:0006691	Process	Leukotriene metabolic process	IDA	23087055
GO:0008559	Function	ABC-type xenobiotic transporter activity	IDA	23087055
GO:0015431	Function	ABC-type glutathione S-conjugate transporter activity	IDA	23087055
GO:0016020	Component	Membrane	IBA	21873635
GO:0016021	Component	Integral component of membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	IDA	23087055
GO:0016887	Function	ATPase activity	IEA
GO:0042626	Function	ATPase-coupled transmembrane transporter activity	IBA	21873635
GO:0042908	Process	Xenobiotic transport	IEA
GO:0055085	Process	Transmembrane transport	IBA	21873635
GO:0055085	Process	Transmembrane transport	TAS
GO:0071716	Process	Leukotriene transport	IDA	23087055
GO:0098656	Process	Anion transmembrane transport	IEA
GO:0140359	Function	ABC-type transporter activity	IDA	23087055

MIM	HGNC	e!Ensembl
612509	52	ENSG00000124574

Protein

UniProt ID

Q5T3U5

Protein name

ATP-binding cassette sub-family C member 10 (EC 7.6.2.2) (EC 7.6.2.3) (Multidrug resistance-associated protein 7)

Protein function

ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Lipophilic anion transporter that mediates ATP-dependent transport of glucuronide conjugates such as e

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00664	ABC_membrane	285 → 551	ABC transporter transmembrane region	Family
PF00005	ABC_tran	618 → 754	ABC transporter	Domain
PF00664	ABC_membrane	885 → 1198	ABC transporter transmembrane region	Family
PF00005	ABC_tran	1263 → 1410	ABC transporter	Domain

Tissue specificity

TISSUE SPECIFICITY: In testis, localized to peritubular myoid cells, Leydig cells, along the basal membrane of Sertoli cells, moderately in the adluminal compartment of the seminiferous tubules, and in vascular endothelial cells. {ECO:0000269|PubMed:35307

Sequence

MERLLAQLCGSSAAWPLPLWEGDTTGHCFTQLVLSALPHALLAVLSACYLGTPRSPDYIL
PCSPGWRLRLAASFLLSVFPLLDLLPVALPPGAGPGPIGLEVLAGCVAAVAWISHSLALW
VLAHSPHGHSRGPLALALVALLPAPALVLTVLWHCQRGTLLPPLLPGPMARLCLLILQLA
ALLAYALGWAAPGGPREPWAQEPLLPEDQEPEVAEDGESWLSRFSYAWLAPLLARGACGE
LRQPQDICRLPHRLQPTYLARVFQAHWQEGARLWRALYGAFGRCYLALGLLKLVGTMLGF
SGPLLLSLLVGFLEEGQEPLSHGLLYALGLAGGAVLGAVLQNQYGYEVYKVTLQARGAVL
NILYCKALQLGPSRPPTGEALNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVG
VAFVGGLILALLLVPVNKVIATRIMASNQEMLQHKDARVKLVTELLSGIRVIKFCGWEQA
LGARVEACRARELGRLRVIKYLDAACVYLWAALPVVISIVIFITYVLMGHQLTATKVFTA
LALVRMLILPLNNFPWVINGLLEAKVSLDRIQLFLDLPNHNPQAYYSPDPPAEPSTVLEL
HGALFSWDPVGTSLETFISHLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVR
GLSKGFGLATQEPWIQFATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVG
EKGVTLSGGQRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLL
CTHRTEYLERADAVLLMEAGRLIRAGPPSEILPLVQAVPKAWAENGQESDSATAQSVQNP
EKTKEGLEEEQSTSGRLLQEESKKEGAVALHVYQAYWKAVGQGLALAILFSLLLMQATRN
AADWWLSHWISQLKAENSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNG
SSDIRFYLTVYATIAGVNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATP
TGRILNRFSSDVACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYH
VQRHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRC
QFATSATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSG
LVSSFTQTEAMLVSVERLEEYTCDLPQEPQGQPLQLGTGWLTQGGVEFQDVVLAYRPGLP
NALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLR
SQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITSMGGLDGELGEGGR
SLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKTVLTIAHRL
NTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLLQSSQQGVPASLGGP

Sequence length

1492

Interactions

View interactions

	KEGG		Reactome
	ABC transporters		ABC-family proteins mediated transport

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Coronary artery disease	Coronary Artery Disease	rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs1555800701, rs1215189537	29212778

Show/Hide Unknown Diseases (4)

Disease term	Disease name	Source
Unknown
Schizophrenia	Schizophrenia	GWAS
Hypertension	Hypertension	GWAS
Pulmonary Fibrosis	Pulmonary Fibrosis	GWAS
Heart Failure	Heart Failure	GWAS

Show/Hide Text Mining Associations (14)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma of Lung	Associate	33879658
Breast Neoplasms	Associate	26372358
Carcinoma Hepatocellular	Associate	35363194
Carcinoma Non Small Cell Lung	Associate	23393594
Colorectal Neoplasms	Associate	36585626
Drug Resistant Epilepsy	Associate	24903205
Kidney Diseases	Associate	21628669
Neoplasm Metastasis	Stimulate	36585626
Neoplasm Metastasis	Associate	36982681
Neoplasms	Associate	19841739, 33879658
Neutropenia	Associate	30890141
Prostatic Neoplasms	Associate	26459268, 28612064
Stomach Neoplasms	Associate	31852133
Tuberculosis Multidrug Resistant	Associate	22578167, 23393594, 24726739, 24939447

ABCC10 (ATP binding cassette subfamily C member 10)