Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	89832
Gene name Gene Name - the full gene name approved by the HGNC.	CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CHRFAM7A
Synonyms (NCBI Gene) Gene synonyms aliases	CHRNA7, CHRNA7-DR1, D-10, NACHRA7
Chromosome Chromosome number	15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	15q13.2
Summary Summary of gene provided in NCBI Entrez Gene.	The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neu

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miRTarBase ID	miRNA	Experiments	Reference
MIRT017997	hsa-miR-335-5p	Microarray	18185580
MIRT025040	hsa-miR-181a-5p	Microarray	17612493
MIRT704706	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT704705	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT704704	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT704703	hsa-miR-4521	HITS-CLIP	23313552
MIRT704702	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT704701	hsa-miR-4486	HITS-CLIP	23313552
MIRT704700	hsa-miR-661	HITS-CLIP	23313552
MIRT704699	hsa-miR-4649-5p	HITS-CLIP	23313552
MIRT704698	hsa-miR-6729-5p	HITS-CLIP	23313552
MIRT704696	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT704697	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT704695	hsa-miR-7703	HITS-CLIP	23313552
MIRT668989	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT648163	hsa-miR-148a-3p	HITS-CLIP	23824327
MIRT648162	hsa-miR-148b-3p	HITS-CLIP	23824327
MIRT648161	hsa-miR-152-3p	HITS-CLIP	23824327
MIRT648160	hsa-miR-1825	HITS-CLIP	23824327
MIRT648159	hsa-miR-199a-5p	HITS-CLIP	23824327
MIRT648158	hsa-miR-199b-5p	HITS-CLIP	23824327
MIRT629791	hsa-miR-3925-3p	HITS-CLIP	23824327
MIRT629790	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT629789	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT629788	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT629787	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT648157	hsa-miR-759	HITS-CLIP	23824327
MIRT628338	hsa-miR-8485	HITS-CLIP	23824327
MIRT628337	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT628336	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT628335	hsa-miR-603	HITS-CLIP	23824327
MIRT668988	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT628334	hsa-miR-3941	HITS-CLIP	23824327
MIRT628333	hsa-miR-4672	HITS-CLIP	23824327
MIRT628332	hsa-miR-466	HITS-CLIP	23824327
MIRT648163	hsa-miR-148a-3p	HITS-CLIP	23824327
MIRT648162	hsa-miR-148b-3p	HITS-CLIP	23824327
MIRT648161	hsa-miR-152-3p	HITS-CLIP	23824327
MIRT648160	hsa-miR-1825	HITS-CLIP	23824327
MIRT648159	hsa-miR-199a-5p	HITS-CLIP	23824327
MIRT648158	hsa-miR-199b-5p	HITS-CLIP	23824327
MIRT629791	hsa-miR-3925-3p	HITS-CLIP	23824327
MIRT629790	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT629789	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT629788	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT629787	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT648157	hsa-miR-759	HITS-CLIP	23824327
MIRT629791	hsa-miR-3925-3p	HITS-CLIP	23824327
MIRT629790	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT629789	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT629788	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT629787	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT628338	hsa-miR-8485	HITS-CLIP	23824327
MIRT628337	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT628336	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT628335	hsa-miR-603	HITS-CLIP	23824327
MIRT628334	hsa-miR-3941	HITS-CLIP	23824327
MIRT628333	hsa-miR-4672	HITS-CLIP	23824327
MIRT628332	hsa-miR-466	HITS-CLIP	23824327
MIRT629791	hsa-miR-3925-3p	HITS-CLIP	23824327
MIRT629790	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT629789	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT629788	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT629787	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT629791	hsa-miR-3925-3p	HITS-CLIP	23824327
MIRT629790	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT629789	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT629788	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT629787	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT628338	hsa-miR-8485	HITS-CLIP	23824327
MIRT628337	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT628336	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT628335	hsa-miR-603	HITS-CLIP	23824327
MIRT628334	hsa-miR-3941	HITS-CLIP	23824327
MIRT628333	hsa-miR-4672	HITS-CLIP	23824327
MIRT628332	hsa-miR-466	HITS-CLIP	23824327
MIRT704706	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT704705	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT704704	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT704703	hsa-miR-4521	HITS-CLIP	23313552
MIRT704702	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT704701	hsa-miR-4486	HITS-CLIP	23313552
MIRT704700	hsa-miR-661	HITS-CLIP	23313552
MIRT704699	hsa-miR-4649-5p	HITS-CLIP	23313552
MIRT704698	hsa-miR-6729-5p	HITS-CLIP	23313552
MIRT704696	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT704697	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT704695	hsa-miR-7703	HITS-CLIP	23313552
MIRT668989	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT648163	hsa-miR-148a-3p	HITS-CLIP	23824327
MIRT648162	hsa-miR-148b-3p	HITS-CLIP	23824327
MIRT648161	hsa-miR-152-3p	HITS-CLIP	23824327
MIRT648160	hsa-miR-1825	HITS-CLIP	23824327
MIRT648159	hsa-miR-199a-5p	HITS-CLIP	23824327
MIRT648158	hsa-miR-199b-5p	HITS-CLIP	23824327
MIRT629791	hsa-miR-3925-3p	HITS-CLIP	23824327
MIRT629790	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT629789	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT629788	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT629787	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT648157	hsa-miR-759	HITS-CLIP	23824327
MIRT628338	hsa-miR-8485	HITS-CLIP	23824327
MIRT628337	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT628336	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT628335	hsa-miR-603	HITS-CLIP	23824327
MIRT668988	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT628334	hsa-miR-3941	HITS-CLIP	23824327
MIRT628333	hsa-miR-4672	HITS-CLIP	23824327
MIRT628332	hsa-miR-466	HITS-CLIP	23824327
MIRT648163	hsa-miR-148a-3p	HITS-CLIP	23824327
MIRT648162	hsa-miR-148b-3p	HITS-CLIP	23824327
MIRT648161	hsa-miR-152-3p	HITS-CLIP	23824327
MIRT648160	hsa-miR-1825	HITS-CLIP	23824327
MIRT648159	hsa-miR-199a-5p	HITS-CLIP	23824327
MIRT648158	hsa-miR-199b-5p	HITS-CLIP	23824327
MIRT629791	hsa-miR-3925-3p	HITS-CLIP	23824327
MIRT629790	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT629789	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT629788	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT629787	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT648157	hsa-miR-759	HITS-CLIP	23824327
MIRT629791	hsa-miR-3925-3p	HITS-CLIP	23824327
MIRT629790	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT629789	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT629788	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT629787	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT628338	hsa-miR-8485	HITS-CLIP	23824327
MIRT628337	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT628336	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT628335	hsa-miR-603	HITS-CLIP	23824327
MIRT628334	hsa-miR-3941	HITS-CLIP	23824327
MIRT628333	hsa-miR-4672	HITS-CLIP	23824327
MIRT628332	hsa-miR-466	HITS-CLIP	23824327
MIRT629791	hsa-miR-3925-3p	HITS-CLIP	23824327
MIRT629790	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT629789	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT629788	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT629787	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT629791	hsa-miR-3925-3p	HITS-CLIP	23824327
MIRT629790	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT629789	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT629788	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT629787	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT628338	hsa-miR-8485	HITS-CLIP	23824327
MIRT628337	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT628336	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT628335	hsa-miR-603	HITS-CLIP	23824327
MIRT628334	hsa-miR-3941	HITS-CLIP	23824327
MIRT628333	hsa-miR-4672	HITS-CLIP	23824327
MIRT628332	hsa-miR-466	HITS-CLIP	23824327
MIRT891606	hsa-miR-409-3p	CLIP-seq
MIRT891607	hsa-miR-4452	CLIP-seq
MIRT891608	hsa-miR-548p	CLIP-seq
MIRT891609	hsa-miR-653	CLIP-seq
MIRT2200379	hsa-miR-629	CLIP-seq

Show/Hide all(15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005230	Function	Extracellular ligand-gated ion channel activity	IEA
GO:0005515	Function	Protein binding	IPI	28750690
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0005892	Component	Acetylcholine-gated channel complex	IBA	21873635
GO:0007165	Process	Signal transduction	IBA	21873635
GO:0007268	Process	Chemical synaptic transmission	IBA	21873635
GO:0007271	Process	Synaptic transmission, cholinergic	IBA	21873635
GO:0015464	Function	Acetylcholine receptor activity	IBA	21873635
GO:0030594	Function	Neurotransmitter receptor activity	IBA	21873635
GO:0034220	Process	Ion transmembrane transport	IBA	21873635
GO:0042166	Function	Acetylcholine binding	IBA	21873635
GO:0042391	Process	Regulation of membrane potential	IBA	21873635
GO:0043005	Component	Neuron projection	IBA	21873635
GO:0045202	Component	Synapse	IBA	21873635
GO:0050877	Process	Nervous system process	IBA	21873635

MIM	HGNC	e!Ensembl
609756	15781	ENSG00000166664

Protein

UniProt ID

Q494W8

Protein name

CHRNA7-FAM7A fusion protein (CHRNA7-DR1) (D-10)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02931	Neur_chan_LBD	15 → 140	Neurotransmitter-gated ion-channel ligand binding domain	Family
PF02932	Neur_chan_memb	147 → 397	Neurotransmitter-gated ion-channel transmembrane region	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in hippocampus. {ECO:0000269|PubMed:9782083}.

Sequence

MQKYCIYQHFQFQLLIQHLWIAANCDIADERFDATFHTNVLVNSSGHCQYLPPGIFKSSC
YIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFY
ECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLL
SLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKW
TRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFR
GLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQ
DESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA

Sequence length

412

Interactions

View interactions

	KEGG		Reactome
	Calcium signaling pathway Neuroactive ligand-receptor interaction Cholinergic synapse Alzheimer disease Pathways of neurodegeneration - multiple diseases Nicotine addiction Chemical carcinogenesis - receptor activation		Highly calcium permeable postsynaptic nicotinic acetylcholine receptors

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	19631623

Show/Hide Text Mining Associations (30)

Disease Name	Relationship Type	References
Associations from Text Mining
AIDS Associated Nephropathy	Associate	26567012
Alzheimer Disease	Associate	22486522, 24787912, 27565651, 32818803
Autism Spectrum Disorder	Associate	21996756, 27565651
Autosomal Dominant Nocturnal Frontal Lobe Epilepsy	Associate	23553139
Bipolar Disorder	Associate	17192894
Breast Neoplasms	Associate	28077796
Colorectal Neoplasms	Associate	37828429
COVID 19	Associate	34088975
Cytokine Release Syndrome	Associate	34088975
Epilepsy	Associate	24024466
Epilepsy Idiopathic Generalized	Associate	24024466
Genetic Diseases Inborn	Associate	27565651
Heredodegenerative Disorders Nervous System	Associate	23553139, 24024466
HIV Infections	Associate	26567012
Inflammation	Associate	22441542, 33956875, 34088975
Lung Diseases	Associate	34088975
Lymphopenia	Associate	34088975
Mental Disorders	Associate	25681457, 25906356
Migraine Disorders	Associate	34563047
Neoplasms	Associate	9389974
Neoplasms Squamous Cell	Associate	24089524
Neuralgia	Associate	28901507, 33956875
Polyradiculoneuropathy Chronic Inflammatory Demyelinating	Associate	28901507
Pressure Ulcer	Associate	33956875
Psychotic Disorders	Associate	17192894
Schizophrenia	Associate	25681457, 25906356, 27565651, 29784875
Signs and Symptoms	Associate	23553139
Spinal Cord Injuries	Associate	33956875
Stomach Neoplasms	Stimulate	9389974
Uterine Cervical Neoplasms	Associate	16803519

CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion)