Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	89832
Gene name	CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion
Gene symbol	CHRFAM7A
Synonyms (NCBI Gene)	CHRNA7CHRNA7-DR1D-10NACHRA7
Chromosome	15
Chromosome location	15q13.2
Summary	The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neu

155

Show/Hide all (155)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017997	hsa-miR-335-5p	Microarray	18185580
MIRT025040	hsa-miR-181a-5p	Microarray	17612493
MIRT704706	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT704705	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT704704	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT704703	hsa-miR-4521	HITS-CLIP	23313552
MIRT704702	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT704701	hsa-miR-4486	HITS-CLIP	23313552
MIRT704700	hsa-miR-661	HITS-CLIP	23313552
MIRT704699	hsa-miR-4649-5p	HITS-CLIP	23313552
MIRT704698	hsa-miR-6729-5p	HITS-CLIP	23313552
MIRT704696	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT704697	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT704695	hsa-miR-7703	HITS-CLIP	23313552
MIRT668989	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT648163	hsa-miR-148a-3p	HITS-CLIP	23824327
MIRT648162	hsa-miR-148b-3p	HITS-CLIP	23824327
MIRT648161	hsa-miR-152-3p	HITS-CLIP	23824327
MIRT648160	hsa-miR-1825	HITS-CLIP	23824327
MIRT648159	hsa-miR-199a-5p	HITS-CLIP	23824327
MIRT648158	hsa-miR-199b-5p	HITS-CLIP	23824327
MIRT629791	hsa-miR-3925-3p	HITS-CLIP	23824327
MIRT629790	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT629789	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT629788	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT629787	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT648157	hsa-miR-759	HITS-CLIP	23824327
MIRT628338	hsa-miR-8485	HITS-CLIP	23824327
MIRT628337	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT628336	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT628335	hsa-miR-603	HITS-CLIP	23824327
MIRT668988	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT628334	hsa-miR-3941	HITS-CLIP	23824327
MIRT628333	hsa-miR-4672	HITS-CLIP	23824327
MIRT628332	hsa-miR-466	HITS-CLIP	23824327
MIRT648163	hsa-miR-148a-3p	HITS-CLIP	23824327
MIRT648162	hsa-miR-148b-3p	HITS-CLIP	23824327
MIRT648161	hsa-miR-152-3p	HITS-CLIP	23824327
MIRT648160	hsa-miR-1825	HITS-CLIP	23824327
MIRT648159	hsa-miR-199a-5p	HITS-CLIP	23824327
MIRT648158	hsa-miR-199b-5p	HITS-CLIP	23824327
MIRT629791	hsa-miR-3925-3p	HITS-CLIP	23824327
MIRT629790	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT629789	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT629788	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT629787	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT648157	hsa-miR-759	HITS-CLIP	23824327
MIRT629791	hsa-miR-3925-3p	HITS-CLIP	23824327
MIRT629790	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT629789	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT629788	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT629787	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT628338	hsa-miR-8485	HITS-CLIP	23824327
MIRT628337	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT628336	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT628335	hsa-miR-603	HITS-CLIP	23824327
MIRT628334	hsa-miR-3941	HITS-CLIP	23824327
MIRT628333	hsa-miR-4672	HITS-CLIP	23824327
MIRT628332	hsa-miR-466	HITS-CLIP	23824327
MIRT629791	hsa-miR-3925-3p	HITS-CLIP	23824327
MIRT629790	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT629789	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT629788	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT629787	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT629791	hsa-miR-3925-3p	HITS-CLIP	23824327
MIRT629790	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT629789	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT629788	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT629787	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT628338	hsa-miR-8485	HITS-CLIP	23824327
MIRT628337	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT628336	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT628335	hsa-miR-603	HITS-CLIP	23824327
MIRT628334	hsa-miR-3941	HITS-CLIP	23824327
MIRT628333	hsa-miR-4672	HITS-CLIP	23824327
MIRT628332	hsa-miR-466	HITS-CLIP	23824327
MIRT704706	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT704705	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT704704	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT704703	hsa-miR-4521	HITS-CLIP	23313552
MIRT704702	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT704701	hsa-miR-4486	HITS-CLIP	23313552
MIRT704700	hsa-miR-661	HITS-CLIP	23313552
MIRT704699	hsa-miR-4649-5p	HITS-CLIP	23313552
MIRT704698	hsa-miR-6729-5p	HITS-CLIP	23313552
MIRT704696	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT704697	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT704695	hsa-miR-7703	HITS-CLIP	23313552
MIRT668989	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT648163	hsa-miR-148a-3p	HITS-CLIP	23824327
MIRT648162	hsa-miR-148b-3p	HITS-CLIP	23824327
MIRT648161	hsa-miR-152-3p	HITS-CLIP	23824327
MIRT648160	hsa-miR-1825	HITS-CLIP	23824327
MIRT648159	hsa-miR-199a-5p	HITS-CLIP	23824327
MIRT648158	hsa-miR-199b-5p	HITS-CLIP	23824327
MIRT629791	hsa-miR-3925-3p	HITS-CLIP	23824327
MIRT629790	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT629789	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT629788	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT629787	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT648157	hsa-miR-759	HITS-CLIP	23824327
MIRT628338	hsa-miR-8485	HITS-CLIP	23824327
MIRT628337	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT628336	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT628335	hsa-miR-603	HITS-CLIP	23824327
MIRT668988	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT628334	hsa-miR-3941	HITS-CLIP	23824327
MIRT628333	hsa-miR-4672	HITS-CLIP	23824327
MIRT628332	hsa-miR-466	HITS-CLIP	23824327
MIRT648163	hsa-miR-148a-3p	HITS-CLIP	23824327
MIRT648162	hsa-miR-148b-3p	HITS-CLIP	23824327
MIRT648161	hsa-miR-152-3p	HITS-CLIP	23824327
MIRT648160	hsa-miR-1825	HITS-CLIP	23824327
MIRT648159	hsa-miR-199a-5p	HITS-CLIP	23824327
MIRT648158	hsa-miR-199b-5p	HITS-CLIP	23824327
MIRT629791	hsa-miR-3925-3p	HITS-CLIP	23824327
MIRT629790	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT629789	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT629788	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT629787	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT648157	hsa-miR-759	HITS-CLIP	23824327
MIRT629791	hsa-miR-3925-3p	HITS-CLIP	23824327
MIRT629790	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT629789	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT629788	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT629787	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT628338	hsa-miR-8485	HITS-CLIP	23824327
MIRT628337	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT628336	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT628335	hsa-miR-603	HITS-CLIP	23824327
MIRT628334	hsa-miR-3941	HITS-CLIP	23824327
MIRT628333	hsa-miR-4672	HITS-CLIP	23824327
MIRT628332	hsa-miR-466	HITS-CLIP	23824327
MIRT629791	hsa-miR-3925-3p	HITS-CLIP	23824327
MIRT629790	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT629789	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT629788	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT629787	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT629791	hsa-miR-3925-3p	HITS-CLIP	23824327
MIRT629790	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT629789	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT629788	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT629787	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT628338	hsa-miR-8485	HITS-CLIP	23824327
MIRT628337	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT628336	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT628335	hsa-miR-603	HITS-CLIP	23824327
MIRT628334	hsa-miR-3941	HITS-CLIP	23824327
MIRT628333	hsa-miR-4672	HITS-CLIP	23824327
MIRT628332	hsa-miR-466	HITS-CLIP	23824327
MIRT891606	hsa-miR-409-3p	CLIP-seq
MIRT891607	hsa-miR-4452	CLIP-seq
MIRT891608	hsa-miR-548p	CLIP-seq
MIRT891609	hsa-miR-653	CLIP-seq
MIRT2200379	hsa-miR-629	CLIP-seq

Show/Hide all (18)

GO ID	Ontology	Definition	Evidence
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0005216	Function	Monoatomic ion channel activity	IEA
GO:0005230	Function	Extracellular ligand-gated monoatomic ion channel activity	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005892	Component	Acetylcholine-gated channel complex	IBA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0007268	Process	Chemical synaptic transmission	IBA
GO:0016020	Component	Membrane	IEA
GO:0022848	Function	Acetylcholine-gated monoatomic cation-selective channel activity	IBA
GO:0034220	Process	Monoatomic ion transmembrane transport	IBA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0042391	Process	Regulation of membrane potential	IBA
GO:0043005	Component	Neuron projection	IBA
GO:0045202	Component	Synapse	IBA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0050890	Process	Cognition	IEA
GO:0060078	Process	Regulation of postsynaptic membrane potential	IEA
GO:0060079	Process	Excitatory postsynaptic potential	IEA

MIM	HGNC	e!Ensembl
609756	15781	ENSG00000166664

Q494W8

Protein name

CHRNA7-FAM7A fusion protein (CHRNA7-DR1) (D-10)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02931	Neur_chan_LBD	15 → 140	Neurotransmitter-gated ion-channel ligand binding domain	Family
PF02932	Neur_chan_memb	147 → 397	Neurotransmitter-gated ion-channel transmembrane region	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in hippocampus. {ECO:0000269|PubMed:9782083}.

Sequence

MQKYCIYQHFQFQLLIQHLWIAANCDIADERFDATFHTNVLVNSSGHCQYLPPGIFKSSC
YIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFY
ECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLL
SLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKW
TRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFR
GLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQ
DESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA

Sequence length

412

Interactions

View interactions

	KEGG		Reactome
	Calcium signaling pathway Neuroactive ligand-receptor interaction Cholinergic synapse Alzheimer disease Pathways of neurodegeneration - multiple diseases Nicotine addiction Chemical carcinogenesis - receptor activation		Highly calcium permeable postsynaptic nicotinic acetylcholine receptors

CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion)