Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
89780
Gene name Gene Name - the full gene name approved by the HGNC.
Wnt family member 3A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
WNT3A
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q42.13
Summary Summary of gene provided in NCBI Entrez Gene.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryog
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT000282 hsa-miR-15a-5p Luciferase reporter assay 18931683
MIRT003430 hsa-miR-16-5p Luciferase reporter assay 18931683
MIRT003430 hsa-miR-16-5p Review 20130964
MIRT000282 hsa-miR-15a-5p Luciferase reporter assay, qRT-PCR 21106054
MIRT000282 hsa-miR-15a-5p Luciferase reporter assay, qRT-PCR 21106054
Transcription factors
Transcription factor Regulation Reference
FOXQ1 Activation 20145154
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001649 Process Osteoblast differentiation IEA
GO:0001701 Process In utero embryonic development IEA
GO:0001756 Process Somitogenesis IEA
GO:0001819 Process Positive regulation of cytokine production IEA
GO:0001947 Process Heart looping IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
606359 15983 ENSG00000154342
Protein
UniProt ID P56704
Protein name Protein Wnt-3a
Protein function Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:20093360, PubMed:21244856,
PDB 7DRT , 7URD , 7URE , 8TZR
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00110 wnt 44 352 wnt family Family
Tissue specificity TISSUE SPECIFICITY: Moderately expressed in placenta and at low levels in adult lung, spleen, and prostate. {ECO:0000269|PubMed:11414706}.
Sequence
Sequence length 352
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  mTOR signaling pathway
Wnt signaling pathway
Hippo signaling pathway
Signaling pathways regulating pluripotency of stem cells
Melanogenesis
Cushing syndrome
Alzheimer disease
Pathways of neurodegeneration - multiple diseases
Human papillomavirus infection
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Basal cell carcinoma
Breast cancer
Hepatocellular carcinoma
Gastric cancer
  TCF dependent signaling in response to WNT
WNT ligand biogenesis and trafficking
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Regulation of FZD by ubiquitination
RNF mutants show enhanced WNT signaling and proliferation
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Hypertension Hypertension, Hypertension (confirmatory factor analysis Factor 12) N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Inhibit 30841855
Adenocarcinoma of Lung Associate 27610375
Adenomatous Polyposis Coli Associate 30072583
Alopecia Associate 19141591
Anorectal Malformations Associate 23127126
Asthma Associate 31683769
Astrocytoma Stimulate 26708597
Barrett Esophagus Associate 26297437, 30841855
Bone Diseases Associate 25999350, 32413029
Bone Diseases Metabolic Associate 24584697