SERPINB11 (serpin family B member 11)

Gene

• Entrez ID: 89778
• Gene name: Serpin family B member 11
• Gene symbol: SERPINB11
• Synonyms (NCBI Gene): EPIPIN, SERPIN11
• Chromosome: 18
• Chromosome location: 18q21.33

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1338634	hsa-miR-1207-3p	CLIP-seq
MIRT1338635	hsa-miR-129-3p	CLIP-seq
MIRT1338636	hsa-miR-300	CLIP-seq
MIRT1338637	hsa-miR-342-3p	CLIP-seq
MIRT1338638	hsa-miR-381	CLIP-seq
MIRT1338639	hsa-miR-4503	CLIP-seq
MIRT1338639	hsa-miR-4503	CLIP-seq
MIRT2100123	hsa-miR-4756-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004867	Function	Serine-type endopeptidase inhibitor activity	IBA
GO:0004867	Function	Serine-type endopeptidase inhibitor activity	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0030414	Function	Peptidase inhibitor activity	IEA

Other IDs

• MIM: 615682
• HGNC: 14221
• e!Ensembl: ENSG00000206072

Protein

• UniProt ID: Q96P15
• Protein name: Serpin B11
• Protein function: Has no serine protease inhibitory activity, probably due to variants in the scaffold impairing conformational change.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00079	Serpin	6 → 392	Serpin (serine protease inhibitor)	Domain

• Tissue specificity: TISSUE SPECIFICITY: Detected in a restricted number of tissues, including lung, placenta, prostate, and tonsil. {ECO:0000269|PubMed:17562709}.
• Sequence:

  MGSLSTANVEFCLDVFKELNSNNIGDNIFFSSLSLLYALSMVLLGARGETAEQLEKVLHF
  SHTVDSLKPGFKDSPKCSQAGRIHSEFGVEFSQINQPDSNCTLSIANRLYGTKTMAFHQQ
  YLSCSEKWYQARLQTVDFEQSTEETRKMINAWVENKTNGKVANLFGKSTIDPSSVMVLVN
  IIYFKGQRQNKFQVRETVKSPFQLSEGKNVTVEMMYQIGTFKLAFVKEPQMQVLELPYVN
  NKLSMIILLPVGIANLKQIEKQLNSGTFHEWTSSSNMMEREVEVHLPRFKLEIKYELNSL
  LKPLGVTDLFNQVKADLSGMSPTKGLYLSKAIHKSYLDVSEEGTEAAAATGDSIAVKSLP
  MRAQFKANHPFLFFIRHTHTNTILFCGKLASP

• Sequence length: 392

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
IRON METABOLISM DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MALIGNANT EPITHELIAL TUMOR OF OVARY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Liver Failure Acute	Associate	31609742	★☆☆☆☆ Found in Text Mining only
Lymphoma Non Hodgkin	Associate	34410952	★☆☆☆☆ Found in Text Mining only
Mouth Neoplasms	Associate	25029526	★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Associate	34410952	★☆☆☆☆ Found in Text Mining only