Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8976
Gene name Gene Name - the full gene name approved by the HGNC.
WASP like actin nucleation promoting factor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
WASL
Synonyms (NCBI Gene) Gene synonyms aliases
N-WASP, NWASP, WASPB
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7q31.32
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the Wiskott-Aldrich syndrome (WAS) protein family. Wiskott-Aldrich syndrome proteins share similar domain structure, and associate with a variety of signaling molecules to alter the actin cytoskeleton. The encoded protein is
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT051960 hsa-let-7b-5p CLASH 23622248
MIRT051048 hsa-miR-17-5p CLASH 23622248
MIRT049810 hsa-miR-92a-3p CLASH 23622248
MIRT437604 hsa-miR-142-3p Microarray, qRT-PCR 22815788
MIRT520215 hsa-miR-548c-3p HITS-CLIP 21572407
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003779 Function Actin binding IEA
GO:0005515 Function Protein binding IPI 11231575, 11331876, 12732638, 14732713, 15296718, 15527496, 16253999, 16293614, 16483316, 16531231, 16582881, 16595635, 16767080, 17015620, 17474147, 18388313, 18650809, 18662323, 20936779, 21516116, 21706016, 22921828, 23414517, 24332715, 25416956, 26496610, 26871637, 27107012, 285
GO:0005634 Component Nucleus IDA 16767080
GO:0005829 Component Cytosol IDA 18388313
GO:0005829 Component Cytosol TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605056 12735 ENSG00000106299
Protein
UniProt ID O00401
Protein name Actin nucleation-promoting factor WASL (Neural Wiskott-Aldrich syndrome protein) (N-WASP)
Protein function Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex (PubMed:16767080, PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828, PubMed:9422512). Involved in various processes, such as mitos
PDB 2FF3 , 2LNH , 2VCP , 4CC2 , 4CC7 , 9DLX
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00568 WH1 31 138 WH1 domain Domain
PF00786 PBD 202 261 P21-Rho-binding domain Domain
PF02205 WH2 403 428 WH2 motif Family
PF02205 WH2 430 455 WH2 motif Family
Sequence
MSSVQQQPPPPRRVTNVGSLLLTPQENESLFTFLGKKCVTMSSAVVQLYAADRNCMWSKK
CSGVACLVKDNPQRSYFLRIFDIKDGKLLWEQELYNNFVYNSPRGYFHTFAGDTCQVALN
FANEEEAKKFRKAVTDLL
GRRQRKSEKRRDPPNGPNLPMATVDIKNPEITTNRFYGPQVN
NISHTKEKKKGKAKKKRLTKADIGTPSNFQHIGHVGWDPNTGFDLNNLDPELKNLFDMCG
ISEAQLKDRETSKVIYDFIEK
TGGVEAVKNELRRQAPPPPPPSRGGPPPPPPPPHNSGPP
PPPARGRGAPPPPPSRAPTAAPPPPPPSRPSVAVPPPPPNRMYPPPPPALPSSAPSGPPP
PPPSVLGVGPVAPPPPPPPPPPPGPPPPPGLPSDGDHQVPTTAGNKAALLDQIREGAQLK
KVEQNSRP
VSCSGRDALLDQIRQGIQLKSVADGQESTPPTPAPTSGIVGALMEVMQKRSK
AIHSSDEDEDEDDEEDFEDDDEWED
Sequence length 505
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Endocytosis
Adherens junction
Regulation of actin cytoskeleton
Bacterial invasion of epithelial cells
Pathogenic Escherichia coli infection
Shigellosis
Salmonella infection
Yersinia infection
  Regulation of actin dynamics for phagocytic cup formation
NOSTRIN mediated eNOS trafficking
Nephrin family interactions
EPHB-mediated forward signaling
DCC mediated attractive signaling
RHO GTPases Activate WASPs and WAVEs
Clathrin-mediated endocytosis
FCGR3A-mediated phagocytosis
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Migraine Migraine Disorders rs794727411 23793025
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 32733636
Breast Neoplasms Associate 26657485
Carcinoma Hepatocellular Associate 28475688, 29621773
Esophageal Neoplasms Associate 19360286, 23874846
Glioma Associate 26305187
Infections Associate 23230296
Lung Neoplasms Associate 28351346
Lung Neoplasms Inhibit 37980468
Menkes Kinky Hair Syndrome Associate 27685868
Myopia Associate 35586671