Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8975
Gene name Gene Name - the full gene name approved by the HGNC.
Ubiquitin specific peptidase 13
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
USP13
Synonyms (NCBI Gene) Gene synonyms aliases
ISOT3, IsoT-3
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q26.33
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT049674 hsa-miR-92a-3p CLASH 23622248
MIRT651843 hsa-miR-4778-3p HITS-CLIP 23824327
MIRT651842 hsa-miR-4659a-3p HITS-CLIP 23824327
MIRT651841 hsa-miR-4659b-3p HITS-CLIP 23824327
MIRT651840 hsa-miR-1305 HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004197 Function Cysteine-type endopeptidase activity IBA 21873635
GO:0004197 Function Cysteine-type endopeptidase activity IMP 21811243
GO:0004843 Function Thiol-dependent ubiquitin-specific protease activity IBA 21873635
GO:0004843 Function Thiol-dependent ubiquitin-specific protease activity IDA 21811243, 21962518, 22216260, 26280536
GO:0005515 Function Protein binding IPI 21811243, 21962518, 31391242, 32296183, 32814053
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
603591 12611 ENSG00000058056
Protein
UniProt ID Q92995
Protein name Ubiquitin carboxyl-terminal hydrolase 13 (EC 3.4.19.12) (Deubiquitinating enzyme 13) (Isopeptidase T-3) (ISOT-3) (Ubiquitin thioesterase 13) (Ubiquitin-specific-processing protease 13)
Protein function Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy, endoplasmic reticulum-associated degradation (ERAD), cell cycle progression or DNA damag
PDB 2L80 , 2LBC
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF17807 zf-UBP_var 35 98 Variant UBP zinc finger Domain
PF02148 zf-UBP 211 284 Zn-finger in ubiquitin-hydrolases and other protein Domain
PF00443 UCH 336 858 Ubiquitin carboxyl-terminal hydrolase Family
PF00627 UBA 653 690 UBA/TS-N domain Domain
PF00627 UBA 728 764 UBA/TS-N domain Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in ovary and testes.
Sequence
MQRRGALFGMPGGSGGRKMAAGDIGELLVPHMPTIRVPRSGDRVYKNECAFSYDSPNSEG
GLYVCMNTFLAFGREHVERHFRKTGQSVYMHLKRHVRE
KVRGASGGALPKRRNSKIFLDL
DTDDDLNSDDYEYEDEAKLVIFPDHYEIALPNIEELPALVTIACDAVLSSKSPYRKQDPD
TWENELPVSKYANNLTQLDNGVRIPPSGWKCARCDLRENLWLNLTDGSVLCGKWFFDSSG
GNGHALEHYRDMGYPLAVKLGTITPDGADVYSFQEEEPVLDPHL
AKHLAHFGIDMLHMHG
TENGLQDNDIKLRVSEWEVIQESGTKLKPMYGPGYTGLKNLGNSCYLSSVMQAIFSIPEF
QRAYVGNLPRIFDYSPLDPTQDFNTQMTKLGHGLLSGQYSKPPVKSELIEQVMKEEHKPQ
QNGISPRMFKAFVSKSHPEFSSNRQQDAQEFFLHLVNLVERNRIGSENPSDVFRFLVEER
IQCCQTRKVRYTERVDYLMQLPVAMEAATNKDELIAYELTRREAEANRRPLPELVRAKIP
FSACLQAFSEPENVDDFWSSALQAKSAGVKTSRFASFPEYLVVQIKKFTFGLDWVPKKFD
VSIDMPDLLDINHLRARGLQPGEEELPDISPPIVIPDDSKDRLMNQLIDPSD
IDESSVMQ
LAEMGFPLEACRKAVYFTGNMGAEVAFNWI
IVHMEEPDFAEPLTMPGYGGAASAGASVFG
ASGLDNQPPEEIVAIITSMGFQRNQAIQALRATNNNLERALDWIFSHPEFEEDSDFVIEM
ENNANANIISEAKPEGPRVKDGSGTYELFAFISHMGTSTMSGHYICHIKKEGRWVIYNDH
KVCASERPPKDLGYMYFY
RRIPS
Sequence length 863
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Ub-specific processing proteases
Regulation of PTEN stability and activity
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Leukemia Leukemia, Myelocytic, Acute rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297 27903959
Associations from Text Mining
Disease Name Relationship Type References
Anorchia Inhibit 26625006
Breast Neoplasms Associate 32735883
Carcinogenesis Associate 36037364
Carcinoma Embryonal Inhibit 26625006
Carcinoma Non Small Cell Lung Associate 38043062
Carcinoma Renal Cell Associate 36037364
Cell Transformation Neoplastic Associate 27923907
Cholangiocarcinoma Associate 32453420
COVID 19 Associate 32735883
Esophageal Neoplasms Associate 29396516