Gene Gene information from NCBI Gene database.
Entrez ID 8975
Gene name Ubiquitin specific peptidase 13
Gene symbol USP13
Synonyms (NCBI Gene)
ISOT3IsoT-3
Chromosome 3
Chromosome location 3q26.33
miRNA miRNA information provided by mirtarbase database.
510
miRTarBase ID miRNA Experiments Reference
MIRT049674 hsa-miR-92a-3p CLASH 23622248
MIRT651843 hsa-miR-4778-3p HITS-CLIP 23824327
MIRT651842 hsa-miR-4659a-3p HITS-CLIP 23824327
MIRT651841 hsa-miR-4659b-3p HITS-CLIP 23824327
MIRT651840 hsa-miR-1305 HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
45
GO ID Ontology Definition Evidence Reference
GO:0004197 Function Cysteine-type endopeptidase activity IEA
GO:0004197 Function Cysteine-type endopeptidase activity IMP 21811243
GO:0004197 Function Cysteine-type endopeptidase activity TAS 9827704
GO:0004843 Function Cysteine-type deubiquitinase activity IBA
GO:0004843 Function Cysteine-type deubiquitinase activity IDA 21811243, 21962518, 22216260, 26280536
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603591 12611 ENSG00000058056
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q92995
Protein name Ubiquitin carboxyl-terminal hydrolase 13 (EC 3.4.19.12) (Deubiquitinating enzyme 13) (Isopeptidase T-3) (ISOT-3) (Ubiquitin thioesterase 13) (Ubiquitin-specific-processing protease 13)
Protein function Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy, endoplasmic reticulum-associated degradation (ERAD), cell cycle progression or DNA damag
PDB 2L80 , 2LBC
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF17807 zf-UBP_var 35 98 Variant UBP zinc finger Domain
PF02148 zf-UBP 211 284 Zn-finger in ubiquitin-hydrolases and other protein Domain
PF00443 UCH 336 858 Ubiquitin carboxyl-terminal hydrolase Family
PF00627 UBA 653 690 UBA/TS-N domain Domain
PF00627 UBA 728 764 UBA/TS-N domain Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in ovary and testes.
Sequence
MQRRGALFGMPGGSGGRKMAAGDIGELLVPHMPTIRVPRSGDRVYKNECAFSYDSPNSEG
GLYVCMNTFLAFGREHVERHFRKTGQSVYMHLKRHVRE
KVRGASGGALPKRRNSKIFLDL
DTDDDLNSDDYEYEDEAKLVIFPDHYEIALPNIEELPALVTIACDAVLSSKSPYRKQDPD
TWENELPVSKYANNLTQLDNGVRIPPSGWKCARCDLRENLWLNLTDGSVLCGKWFFDSSG
GNGHALEHYRDMGYPLAVKLGTITPDGADVYSFQEEEPVLDPHL
AKHLAHFGIDMLHMHG
TENGLQDNDIKLRVSEWEVIQESGTKLKPMYGPGYTGLKNLGNSCYLSSVMQAIFSIPEF
QRAYVGNLPRIFDYSPLDPTQDFNTQMTKLGHGLLSGQYSKPPVKSELIEQVMKEEHKPQ
QNGISPRMFKAFVSKSHPEFSSNRQQDAQEFFLHLVNLVERNRIGSENPSDVFRFLVEER
IQCCQTRKVRYTERVDYLMQLPVAMEAATNKDELIAYELTRREAEANRRPLPELVRAKIP
FSACLQAFSEPENVDDFWSSALQAKSAGVKTSRFASFPEYLVVQIKKFTFGLDWVPKKFD
VSIDMPDLLDINHLRARGLQPGEEELPDISPPIVIPDDSKDRLMNQLIDPSD
IDESSVMQ
LAEMGFPLEACRKAVYFTGNMGAEVAFNWI
IVHMEEPDFAEPLTMPGYGGAASAGASVFG
ASGLDNQPPEEIVAIITSMGFQRNQAIQALRATNNNLERALDWIFSHPEFEEDSDFVIEM
ENNANANIISEAKPEGPRVKDGSGTYELFAFISHMGTSTMSGHYICHIKKEGRWVIYNDH
KVCASERPPKDLGYMYFY
RRIPS
Sequence length 863
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Ub-specific processing proteases
Regulation of PTEN stability and activity
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Ovarian serous cystadenocarcinoma Uncertain significance rs200979122 RCV005939301
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Anorchia Inhibit 26625006
Breast Neoplasms Associate 32735883
Carcinogenesis Associate 36037364
Carcinoma Embryonal Inhibit 26625006
Carcinoma Non Small Cell Lung Associate 38043062
Carcinoma Renal Cell Associate 36037364
Cell Transformation Neoplastic Associate 27923907
Cholangiocarcinoma Associate 32453420
COVID 19 Associate 32735883
Esophageal Neoplasms Associate 29396516