Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	8973
Gene name	Cholinergic receptor nicotinic alpha 6 subunit
Gene symbol	CHRNA6
Synonyms (NCBI Gene)	CHNRA6
Chromosome	8
Chromosome location	8p11.21
Summary	This gene encodes an alpha subunit of neuronal nicotinic acetylcholine receptors. These receptors consist of five subunits and function as ion channels involved in neurotransmission. The encoded protein is a subunit of neuronal nicotinic acetylcholine rec

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miRTarBase ID	miRNA	Experiments	Reference
MIRT450394	hsa-miR-648	PAR-CLIP	22100165
MIRT450393	hsa-miR-644a	PAR-CLIP	22100165
MIRT450392	hsa-miR-142-3p	PAR-CLIP	22100165
MIRT450391	hsa-miR-4474-3p	PAR-CLIP	22100165
MIRT450390	hsa-miR-3591-5p	PAR-CLIP	22100165
MIRT450394	hsa-miR-648	PAR-CLIP	22100165
MIRT450393	hsa-miR-644a	PAR-CLIP	22100165
MIRT450392	hsa-miR-142-3p	PAR-CLIP	22100165
MIRT450391	hsa-miR-4474-3p	PAR-CLIP	22100165
MIRT450390	hsa-miR-3591-5p	PAR-CLIP	22100165
MIRT891877	hsa-miR-200b	CLIP-seq
MIRT891878	hsa-miR-200c	CLIP-seq
MIRT891879	hsa-miR-3622a-3p	CLIP-seq
MIRT891880	hsa-miR-3622b-3p	CLIP-seq
MIRT891881	hsa-miR-369-3p	CLIP-seq
MIRT891882	hsa-miR-429	CLIP-seq
MIRT891883	hsa-miR-4717-3p	CLIP-seq
MIRT891884	hsa-miR-1229	CLIP-seq
MIRT891885	hsa-miR-1914	CLIP-seq
MIRT891886	hsa-miR-4713-5p	CLIP-seq
MIRT2200451	hsa-miR-323-3p	CLIP-seq
MIRT2200452	hsa-miR-4797-5p	CLIP-seq
MIRT2503248	hsa-miR-155	CLIP-seq
MIRT2503249	hsa-miR-3150b-3p	CLIP-seq
MIRT2503250	hsa-miR-4424	CLIP-seq
MIRT2503251	hsa-miR-4663	CLIP-seq
MIRT2503252	hsa-miR-4689	CLIP-seq
MIRT2503253	hsa-miR-4728-3p	CLIP-seq
MIRT2503254	hsa-miR-4779	CLIP-seq
MIRT2503255	hsa-miR-4784	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0005216	Function	Monoatomic ion channel activity	IEA
GO:0005230	Function	Extracellular ligand-gated monoatomic ion channel activity	IEA
GO:0005515	Function	Protein binding	IPI	27344019
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005892	Component	Acetylcholine-gated channel complex	IBA
GO:0005892	Component	Acetylcholine-gated channel complex	IDA	16835356
GO:0005892	Component	Acetylcholine-gated channel complex	IEA
GO:0005892	Component	Acetylcholine-gated channel complex	TAS	8906617
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0007165	Process	Signal transduction	TAS	8906617
GO:0007268	Process	Chemical synaptic transmission	TAS	8906617
GO:0007271	Process	Synaptic transmission, cholinergic	IBA
GO:0007274	Process	Neuromuscular synaptic transmission	IBA
GO:0014059	Process	Regulation of dopamine secretion	IEA
GO:0014059	Process	Regulation of dopamine secretion	ISS
GO:0015464	Function	Acetylcholine receptor activity	IBA
GO:0015464	Function	Acetylcholine receptor activity	IEA
GO:0015464	Function	Acetylcholine receptor activity	TAS	8906617
GO:0016020	Component	Membrane	IEA
GO:0022848	Function	Acetylcholine-gated monoatomic cation-selective channel activity	IBA
GO:0022848	Function	Acetylcholine-gated monoatomic cation-selective channel activity	IEA
GO:0022848	Function	Acetylcholine-gated monoatomic cation-selective channel activity	ISS
GO:0022848	Function	Acetylcholine-gated monoatomic cation-selective channel activity	TAS	8906617
GO:0034220	Process	Monoatomic ion transmembrane transport	IBA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0034703	Component	Cation channel complex	IDA	16835356
GO:0035094	Process	Response to nicotine	IBA
GO:0035095	Process	Behavioral response to nicotine	IEA
GO:0035095	Process	Behavioral response to nicotine	ISS
GO:0042734	Component	Presynaptic membrane	IEA
GO:0042734	Component	Presynaptic membrane	ISS
GO:0043005	Component	Neuron projection	IBA
GO:0045202	Component	Synapse	IBA
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0051899	Process	Membrane depolarization	IBA
GO:0051899	Process	Membrane depolarization	IEA
GO:0060078	Process	Regulation of postsynaptic membrane potential	IEA
GO:0060079	Process	Excitatory postsynaptic potential	IEA
GO:0095500	Process	Acetylcholine receptor signaling pathway	IBA
GO:0097060	Component	Synaptic membrane	IEA
GO:0098691	Component	Dopaminergic synapse	IEA
GO:0098691	Component	Dopaminergic synapse	ISS
GO:0098878	Component	Neurotransmitter receptor complex	IDA	16835356
GO:0099171	Process	Presynaptic modulation of chemical synaptic transmission	IBA
GO:0099171	Process	Presynaptic modulation of chemical synaptic transmission	IEA

MIM	HGNC	e!Ensembl
606888	15963	ENSG00000147434

Q15825

Protein name

Neuronal acetylcholine receptor subunit alpha-6

Protein function

Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nA

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02931	Neur_chan_LBD	34 → 240	Neurotransmitter-gated ion-channel ligand binding domain	Family
PF02932	Neur_chan_memb	247 → 483	Neurotransmitter-gated ion-channel transmembrane region	Family

Sequence

MLTSKGQGFLHGGLCLWLCVFTPFFKGCVGCATEERLFHKLFSHYNQFIRPVENVSDPVT
VHFEVAITQLANVDEVNQIMETNLWLRHIWNDYKLRWDPMEYDGIETLRVPADKIWKPDI
VLYNNAVGDFQVEGKTKALLKYNGMITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWT
YDKAEIDLLIIGSKVDMNDFWENSEWEIIDASGYKHDIKYNCCEEIYTDITYSFYIRRLP
MFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVV
PLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPTTHTMPRWVKTVFLKLLPQVLLMRWPLD
KTRGTGSDAVPRGLARRPAKGKLASHGEPRHLKECFHCHKSNELATSKRRLSHQPLQWVV
ENSEHSPEVEDVINSVQFIAENMKSHNETKEVEDDWKYVAMVVDRVFLWVFIIVCVFGTA
GLFLQPLLGNTGKS

Sequence length

494

Interactions

View interactions

	KEGG		Reactome
	Neuroactive ligand-receptor interaction Cholinergic synapse Nicotine addiction		Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors

CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit)