Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	8972
Gene name Gene Name - the full gene name approved by the HGNC.	Maltase-glucoamylase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MGAM
Synonyms (NCBI Gene) Gene synonyms aliases	MG, MGA
Chromosome Chromosome number	7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	7q34
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes maltase-glucoamylase, which is a brush border membrane enzyme that plays a role in the final steps of digestion of starch. The protein has two catalytic sites identical to those of sucrase-isomaltase, but the proteins are only 59% homolo

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miRTarBase ID	miRNA	Experiments	Reference
MIRT672536	hsa-miR-3929	HITS-CLIP	23824327
MIRT672537	hsa-miR-4419b	HITS-CLIP	23824327
MIRT672535	hsa-miR-4478	HITS-CLIP	23824327
MIRT672534	hsa-miR-5588-3p	HITS-CLIP	23824327
MIRT672533	hsa-miR-2114-5p	HITS-CLIP	23824327
MIRT672532	hsa-miR-5690	HITS-CLIP	23824327
MIRT672531	hsa-miR-1203	HITS-CLIP	23824327
MIRT672530	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT672529	hsa-miR-20b-3p	HITS-CLIP	23824327
MIRT672528	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT672527	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT672526	hsa-miR-6720-3p	HITS-CLIP	23824327
MIRT672525	hsa-miR-566	HITS-CLIP	23824327
MIRT672524	hsa-miR-7977	HITS-CLIP	23824327
MIRT672523	hsa-miR-4750-5p	HITS-CLIP	23824327
MIRT672522	hsa-miR-665	HITS-CLIP	23824327
MIRT672536	hsa-miR-3929	HITS-CLIP	23824327
MIRT672537	hsa-miR-4419b	HITS-CLIP	23824327
MIRT672535	hsa-miR-4478	HITS-CLIP	23824327
MIRT672534	hsa-miR-5588-3p	HITS-CLIP	23824327
MIRT672533	hsa-miR-2114-5p	HITS-CLIP	23824327
MIRT672532	hsa-miR-5690	HITS-CLIP	23824327
MIRT672531	hsa-miR-1203	HITS-CLIP	23824327
MIRT672530	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT672529	hsa-miR-20b-3p	HITS-CLIP	23824327
MIRT672528	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT672527	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT672526	hsa-miR-6720-3p	HITS-CLIP	23824327
MIRT672525	hsa-miR-566	HITS-CLIP	23824327
MIRT672524	hsa-miR-7977	HITS-CLIP	23824327
MIRT672523	hsa-miR-4750-5p	HITS-CLIP	23824327
MIRT672522	hsa-miR-665	HITS-CLIP	23824327
MIRT1146784	hsa-miR-1244	CLIP-seq
MIRT1146785	hsa-miR-3130-5p	CLIP-seq
MIRT1146786	hsa-miR-4482	CLIP-seq
MIRT1146787	hsa-miR-496	CLIP-seq
MIRT1146788	hsa-miR-562	CLIP-seq
MIRT1146789	hsa-miR-711	CLIP-seq
MIRT2041779	hsa-miR-153	CLIP-seq
MIRT2041780	hsa-miR-3152-5p	CLIP-seq
MIRT2041781	hsa-miR-4330	CLIP-seq
MIRT2041782	hsa-miR-4763-5p	CLIP-seq
MIRT2041783	hsa-miR-4774-3p	CLIP-seq
MIRT2041784	hsa-miR-548ag	CLIP-seq
MIRT2041785	hsa-miR-548ai	CLIP-seq
MIRT2041786	hsa-miR-767-3p	CLIP-seq
MIRT2271365	hsa-miR-1273f	CLIP-seq
MIRT2271366	hsa-miR-143	CLIP-seq
MIRT2271367	hsa-miR-4708-5p	CLIP-seq
MIRT2271368	hsa-miR-4728-3p	CLIP-seq
MIRT2271369	hsa-miR-4770	CLIP-seq
MIRT2271370	hsa-miR-526b	CLIP-seq
MIRT2438583	hsa-miR-1224-3p	CLIP-seq
MIRT2438584	hsa-miR-331-5p	CLIP-seq
MIRT2438585	hsa-miR-4678	CLIP-seq
MIRT2442359	hsa-miR-3146	CLIP-seq
MIRT2442360	hsa-miR-3167	CLIP-seq
MIRT2442361	hsa-miR-4521	CLIP-seq
MIRT2442362	hsa-miR-4639-5p	CLIP-seq
MIRT2442363	hsa-miR-491-3p	CLIP-seq
MIRT2442364	hsa-miR-513c	CLIP-seq
MIRT2442365	hsa-miR-514b-5p	CLIP-seq
MIRT2442366	hsa-miR-876-5p	CLIP-seq
MIRT2442359	hsa-miR-3146	CLIP-seq
MIRT2442360	hsa-miR-3167	CLIP-seq
MIRT2570523	hsa-miR-3667-5p	CLIP-seq
MIRT2442361	hsa-miR-4521	CLIP-seq
MIRT2442362	hsa-miR-4639-5p	CLIP-seq
MIRT2442363	hsa-miR-491-3p	CLIP-seq
MIRT2442364	hsa-miR-513c	CLIP-seq
MIRT2442365	hsa-miR-514b-5p	CLIP-seq
MIRT2442366	hsa-miR-876-5p	CLIP-seq
MIRT2442359	hsa-miR-3146	CLIP-seq
MIRT2442360	hsa-miR-3167	CLIP-seq
MIRT2570523	hsa-miR-3667-5p	CLIP-seq
MIRT2442361	hsa-miR-4521	CLIP-seq
MIRT2442362	hsa-miR-4639-5p	CLIP-seq
MIRT2442363	hsa-miR-491-3p	CLIP-seq
MIRT2442364	hsa-miR-513c	CLIP-seq
MIRT2442365	hsa-miR-514b-5p	CLIP-seq
MIRT2442366	hsa-miR-876-5p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000025	Process	Maltose catabolic process	IDA	18036614, 22058037, 27480812
GO:0003824	Function	Catalytic activity	IEA
GO:0003824	Function	Catalytic activity	TAS	9446624
GO:0004339	Function	Glucan 1,4-alpha-glucosidase activity	IEA
GO:0004553	Function	Hydrolase activity, hydrolyzing O-glycosyl compounds	IEA
GO:0004558	Function	Alpha-1,4-glucosidase activity	IBA
GO:0004558	Function	Alpha-1,4-glucosidase activity	IDA	18036614, 22058037, 27480812
GO:0004558	Function	Alpha-1,4-glucosidase activity	IEA
GO:0004574	Function	Oligo-1,6-glucosidase activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183, 36968271
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005975	Process	Carbohydrate metabolic process	IEA
GO:0005983	Process	Starch catabolic process	TAS	9446624
GO:0016020	Component	Membrane	IEA
GO:0016160	Function	Amylase activity	IEA
GO:0016324	Component	Apical plasma membrane	IDA	3143729
GO:0016324	Component	Apical plasma membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016798	Function	Hydrolase activity, acting on glycosyl bonds	IEA
GO:0030246	Function	Carbohydrate binding	IEA
GO:0046352	Process	Disaccharide catabolic process	IEA
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0070821	Component	Tertiary granule membrane	TAS
GO:0090599	Function	Alpha-glucosidase activity	IEA
GO:0101003	Component	Ficolin-1-rich granule membrane	TAS
GO:1901027	Process	Dextrin catabolic process	IDA	18036614

MIM	HGNC	e!Ensembl
154360	7043	ENSG00000257335

Protein

UniProt ID

O43451

Protein name

Maltase-glucoamylase (Alpha-1,4-glucosidase) (EC 3.2.1.20)

Protein function

Alpha-(1,4) exo-glucosidase involved in breakdown of dietary starch oligosaccharides in small intestine. Cleaves the non-reducing alpha-(1,4)-linked glucose residue in linear dextrins with retention of anomeric center stereochemistry (PubMed:125

PDB

2QLY , 2QMJ , 3CTT , 3L4T , 3L4U , 3L4V , 3L4W , 3L4X , 3L4Y , 3L4Z , 3TON , 3TOP

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00088	Trefoil	90 → 133	Trefoil (P-type) domain	Domain
PF16863	NtCtMGAM_N	150 → 259	N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase	Domain
PF01055	Glyco_hydro_31	349 → 821	Glycosyl hydrolases family 31	Family
PF00088	Trefoil	957 → 999	Trefoil (P-type) domain	Domain
PF16863	NtCtMGAM_N	1014 → 1127	N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase	Domain
PF01055	Glyco_hydro_31	1215 → 1717	Glycosyl hydrolases family 31	Family

Tissue specificity

TISSUE SPECIFICITY: Broadly expressed. Highly expressed in small intestine. Expressed in granulocytes. {ECO:0000269|PubMed:24309898, ECO:0000269|PubMed:9446624}.

Sequence

MARKKLKKFTTLEIVLSVLLLVLFIISIVLIVLLAKESLKSTAPDPGTTGTPDPGTTGTP
DPGTTGTTHARTTGPPDPGTTGTTPVSAECPVVNELERINCIPDQPPTKATCDQRGCCWN
PQGAVSVPWCYYSKNHSYHVEGNLVNTNAGFTARLKNLPSSPVFGSNVDNVLLTAEYQTS
NRFHFKLTDQTNNRFEVPHEHVQSFSGNAAASLTYQVEISRQPFSIKVTRRSNNRVLFDS
SIGPLLFADQFLQLSTRLPSTNVYGLGEHVHQQYRHDMNWKTWPIFNRDTTPNGNGTNLY
GAQTFFLCLEDASGLSFGVFLMNSNAMEVVLQPAPAITYRTIGGILDFYVFLGNTPEQVV
QEYLELIGRPALPSYWALGFHLSRYEYGTLDNMREVVERNRAAQLPYDVQHADIDYMDER
RDFTYDSVDFKGFPEFVNELHNNGQKLVIIVDPAISNNSSSSKPYGPYDRGSDMKIWVNS
SDGVTPLIGEVWPGQTVFPDYTNPNCAVWWTKEFELFHNQVEFDGIWIDMNEVSNFVDGS
VSGCSTNNLNNPPFTPRILDGYLFCKTLCMDAVQHWGKQYDIHNLYGYSMAVATAEAAKT
VFPNKRSFILTRSTFAGSGKFAAHWLGDNTATWDDLRWSIPGVLEFNLFGIPMVGPDICG
FALDTPEELCRRWMQLGAFYPFSRNHNGQGYKDQDPASFGADSLLLNSSRHYLNIRYTLL
PYLYTLFFRAHSRGDTVARPLLHEFYEDNSTWDVHQQFLWGPGLLITPVLDEGAEKVMAY
VPDAVWYDYETGSQVRWRKQKVEMELPGDKIGLHLRGGYIFPTQQPNTTTLASRKNPLGL
IIALDENKEAKGELFWDNGETKDTVANKVYLLCEFSVTQNRLEVNISQSTYKDPNNLAFN
EIKILGTEEPSNVTVKHNGVPSQTSPTVTYDSNLKVAIITDIDLLLGEAYTVEWSIKIRD
EEKIDCYPDENGASAENCTARGCIWEASNSSGVPFCYFVNDLYSVSDVQYNSHGATADIS
LKSSVYANAFPSTPVNPLRLDVTYHKNEMLQFKIYDPNKNRYEVPVPLNIPSMPSSTPEG
QLYDVLIKKNPFGIEIRRKSTGTIIWDSQLLGFTFSDMFIRISTRLPSKYLYGFGETEHR
SYRRDLEWHTWGMFSRDQPPGYKKNSYGVHPYYMGLEEDGSAHGVLLLNSNAMDVTFQPL
PALTYRTTGGVLDFYVFLGPTPELVTQQYTELIGRPVMVPYWSLGFQLCRYGYQNDSEIA
SLYDEMVAAQIPYDVQYSDIDYMERQLDFTLSPKFAGFPALINRMKADGMRVILILDPAI
SGNETQPYPAFTRGVEDDVFIKYPNDGDIVWGKVWPDFPDVVVNGSLDWDSQVELYRAYV
AFPDFFRNSTAKWWKREIEELYNNPQNPERSLKFDGMWIDMNEPSSFVNGAVSPGCRDAS
LNHPPYMPHLESRDRGLSSKTLCMESQQILPDGSLVQHYNVHNLYGWSQTRPTYEAVQEV
TGQRGVVITRSTFPSSGRWAGHWLGDNTAAWDQLKKSIIGMMEFSLFGISYTGADICGFF
QDAEYEMCVRWMQLGAFYPFSRNHNTIGTRRQDPVSWDVAFVNISRTVLQTRYTLLPYLY
TLMHKAHTEGVTVVRPLLHEFVSDQVTWDIDSQFLLGPAFLVSPVLERNARNVTAYFPRA
RWYDYYTGVDINARGEWKTLPAPLDHINLHVRGGYILPWQEPALNTHLSRQKFMGFKIAL
DDEGTAGGWLFWDDGQSIDTYGKGLYYLASFSASQNTMQSHIIFNNYITGTNPLKLGYIE
IWGVGSVPVTSVSISVSGMVITPSFNNDPTTQVLSIDVTDRNISLHNFTSLTWISTL

Sequence length

1857

Interactions

View interactions

	KEGG		Reactome
	Galactose metabolism Starch and sucrose metabolism Metabolic pathways Carbohydrate digestion and absorption		Digestion of dietary carbohydrate Neutrophil degranulation

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Metabolic Syndrome	Bitter taste perception (phenylthiocarbamide) in obesity with metabolic syndrome, Bitter taste perception (6-n-propylthiouracil) in obesity with metabolic syndrome	N/A	N/A	GWAS

Show/Hide Text Mining Associations (10)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Aortic Aneurysm Abdominal	Associate	29439675
Behcet Syndrome	Associate	34040049
Bronchopulmonary Dysplasia	Associate	40244055
Cleft Lip	Associate	25776870
Diabetes Mellitus Type 2	Associate	22058037
Glycogen Storage Disease Type II	Associate	16702880
Idiopathic Interstitial Pneumonias	Associate	25058599
Irritable Bowel Syndrome	Associate	31557950
Obesity	Associate	22058037
Squamous Cell Carcinoma of Head and Neck	Associate	23405089

MGAM (maltase-glucoamylase)