Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	8942
Gene name	Kynureninase
Gene symbol	KYNU
Synonyms (NCBI Gene)	KYNUUVCRL2
Chromosome	2
Chromosome location	2q22.2
Summary	Kynureninase is a pyridoxal-5`-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NA

Show/Hide all (4)

SNP ID	Visualize variation	Clinical significance	Consequence
rs606231307	A>G	Pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs758865880	T>A	Pathogenic, likely-pathogenic	Stop gained, coding sequence variant, non coding transcript variant
rs770642379	TTTAAGC>-	Pathogenic	Genic downstream transcript variant, frameshift variant, non coding transcript variant, coding sequence variant
rs1135401744	G>T	Pathogenic	Splice acceptor variant, genic upstream transcript variant

188

Show/Hide all (188)

miRTarBase ID	miRNA	Experiments	Reference
MIRT519031	hsa-miR-3074-3p	HITS-CLIP	21572407
MIRT519030	hsa-miR-2115-3p	HITS-CLIP	21572407
MIRT519029	hsa-miR-4494	HITS-CLIP	21572407
MIRT519027	hsa-miR-499b-5p	HITS-CLIP	21572407
MIRT519028	hsa-miR-361-5p	HITS-CLIP	21572407
MIRT616831	hsa-miR-8485	HITS-CLIP	21572407
MIRT552019	hsa-miR-4789-3p	HITS-CLIP	21572407
MIRT616827	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT616825	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT616824	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT616831	hsa-miR-8485	HITS-CLIP	23313552
MIRT616830	hsa-miR-329-3p	HITS-CLIP	23313552
MIRT616829	hsa-miR-362-3p	HITS-CLIP	23313552
MIRT616828	hsa-miR-603	HITS-CLIP	23313552
MIRT552019	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT616827	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT616826	hsa-miR-3941	HITS-CLIP	23313552
MIRT695997	hsa-miR-4789-5p	HITS-CLIP	23313552
MIRT616825	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT616824	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT616831	hsa-miR-8485	HITS-CLIP	23824327
MIRT552019	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT616827	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT616825	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT616824	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT519031	hsa-miR-3074-3p	HITS-CLIP	23824327
MIRT519030	hsa-miR-2115-3p	HITS-CLIP	23824327
MIRT519029	hsa-miR-4494	HITS-CLIP	23824327
MIRT519027	hsa-miR-499b-5p	HITS-CLIP	23824327
MIRT519028	hsa-miR-361-5p	HITS-CLIP	23824327
MIRT519031	hsa-miR-3074-3p	HITS-CLIP	23824327
MIRT519030	hsa-miR-2115-3p	HITS-CLIP	23824327
MIRT519029	hsa-miR-4494	HITS-CLIP	23824327
MIRT519027	hsa-miR-499b-5p	HITS-CLIP	23824327
MIRT519028	hsa-miR-361-5p	HITS-CLIP	23824327
MIRT616824	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT616831	hsa-miR-8485	HITS-CLIP	23824327
MIRT552019	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT616827	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT616825	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT616824	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT616831	hsa-miR-8485	HITS-CLIP	23824327
MIRT552019	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT616824	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT519031	hsa-miR-3074-3p	HITS-CLIP	23824327
MIRT519030	hsa-miR-2115-3p	HITS-CLIP	23824327
MIRT519029	hsa-miR-4494	HITS-CLIP	23824327
MIRT519027	hsa-miR-499b-5p	HITS-CLIP	23824327
MIRT519028	hsa-miR-361-5p	HITS-CLIP	23824327
MIRT616824	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT616831	hsa-miR-8485	HITS-CLIP	23824327
MIRT616830	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT616829	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT616828	hsa-miR-603	HITS-CLIP	23824327
MIRT552019	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT616827	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT616826	hsa-miR-3941	HITS-CLIP	23824327
MIRT616825	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT616824	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT552019	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT519031	hsa-miR-3074-3p	PAR-CLIP	21572407
MIRT519030	hsa-miR-2115-3p	PAR-CLIP	21572407
MIRT519029	hsa-miR-4494	PAR-CLIP	21572407
MIRT519027	hsa-miR-499b-5p	PAR-CLIP	21572407
MIRT519028	hsa-miR-361-5p	PAR-CLIP	21572407
MIRT519031	hsa-miR-3074-3p	PAR-CLIP	23446348
MIRT519030	hsa-miR-2115-3p	PAR-CLIP	23446348
MIRT519029	hsa-miR-4494	PAR-CLIP	23446348
MIRT519027	hsa-miR-499b-5p	PAR-CLIP	23446348
MIRT519028	hsa-miR-361-5p	PAR-CLIP	23446348
MIRT616824	hsa-miR-1277-5p	HITS-CLIP	27418678
MIRT616824	hsa-miR-1277-5p	HITS-CLIP	27418678
MIRT616825	hsa-miR-190a-3p	HITS-CLIP	27418678
MIRT616825	hsa-miR-190a-3p	HITS-CLIP	27418678
MIRT616830	hsa-miR-329-3p	HITS-CLIP	27418678
MIRT616830	hsa-miR-329-3p	HITS-CLIP	27418678
MIRT616829	hsa-miR-362-3p	HITS-CLIP	27418678
MIRT616829	hsa-miR-362-3p	HITS-CLIP	27418678
MIRT616826	hsa-miR-3941	HITS-CLIP	27418678
MIRT616826	hsa-miR-3941	HITS-CLIP	27418678
MIRT552019	hsa-miR-4789-3p	HITS-CLIP	27418678
MIRT552019	hsa-miR-4789-3p	HITS-CLIP	27418678
MIRT695997	hsa-miR-4789-5p	HITS-CLIP	27418678
MIRT616827	hsa-miR-5011-5p	HITS-CLIP	27418678
MIRT616827	hsa-miR-5011-5p	HITS-CLIP	27418678
MIRT616828	hsa-miR-603	HITS-CLIP	27418678
MIRT616828	hsa-miR-603	HITS-CLIP	27418678
MIRT616831	hsa-miR-8485	HITS-CLIP	27418678
MIRT616831	hsa-miR-8485	HITS-CLIP	27418678
MIRT519031	hsa-miR-3074-3p	HITS-CLIP	21572407
MIRT519030	hsa-miR-2115-3p	HITS-CLIP	21572407
MIRT519029	hsa-miR-4494	HITS-CLIP	21572407
MIRT519027	hsa-miR-499b-5p	HITS-CLIP	21572407
MIRT519028	hsa-miR-361-5p	HITS-CLIP	21572407
MIRT616831	hsa-miR-8485	HITS-CLIP	21572407
MIRT552019	hsa-miR-4789-3p	HITS-CLIP	21572407
MIRT616827	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT616825	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT616824	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT616831	hsa-miR-8485	HITS-CLIP	23313552
MIRT616830	hsa-miR-329-3p	HITS-CLIP	23313552
MIRT616829	hsa-miR-362-3p	HITS-CLIP	23313552
MIRT616828	hsa-miR-603	HITS-CLIP	23313552
MIRT552019	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT616827	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT616826	hsa-miR-3941	HITS-CLIP	23313552
MIRT695997	hsa-miR-4789-5p	HITS-CLIP	23313552
MIRT616825	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT616824	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT616831	hsa-miR-8485	HITS-CLIP	23824327
MIRT552019	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT616827	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT616825	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT616824	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT519031	hsa-miR-3074-3p	HITS-CLIP	23824327
MIRT519030	hsa-miR-2115-3p	HITS-CLIP	23824327
MIRT519029	hsa-miR-4494	HITS-CLIP	23824327
MIRT519027	hsa-miR-499b-5p	HITS-CLIP	23824327
MIRT519028	hsa-miR-361-5p	HITS-CLIP	23824327
MIRT519031	hsa-miR-3074-3p	HITS-CLIP	23824327
MIRT519030	hsa-miR-2115-3p	HITS-CLIP	23824327
MIRT519029	hsa-miR-4494	HITS-CLIP	23824327
MIRT519027	hsa-miR-499b-5p	HITS-CLIP	23824327
MIRT519028	hsa-miR-361-5p	HITS-CLIP	23824327
MIRT616824	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT616831	hsa-miR-8485	HITS-CLIP	23824327
MIRT552019	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT616827	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT616825	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT616824	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT616831	hsa-miR-8485	HITS-CLIP	23824327
MIRT552019	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT616824	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT519031	hsa-miR-3074-3p	HITS-CLIP	23824327
MIRT519030	hsa-miR-2115-3p	HITS-CLIP	23824327
MIRT519029	hsa-miR-4494	HITS-CLIP	23824327
MIRT519027	hsa-miR-499b-5p	HITS-CLIP	23824327
MIRT519028	hsa-miR-361-5p	HITS-CLIP	23824327
MIRT616824	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT616831	hsa-miR-8485	HITS-CLIP	23824327
MIRT616830	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT616829	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT616828	hsa-miR-603	HITS-CLIP	23824327
MIRT552019	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT616827	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT616826	hsa-miR-3941	HITS-CLIP	23824327
MIRT616825	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT616824	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT552019	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT519031	hsa-miR-3074-3p	PAR-CLIP	21572407
MIRT519030	hsa-miR-2115-3p	PAR-CLIP	21572407
MIRT519029	hsa-miR-4494	PAR-CLIP	21572407
MIRT519027	hsa-miR-499b-5p	PAR-CLIP	21572407
MIRT519028	hsa-miR-361-5p	PAR-CLIP	21572407
MIRT519031	hsa-miR-3074-3p	PAR-CLIP	23446348
MIRT519030	hsa-miR-2115-3p	PAR-CLIP	23446348
MIRT519029	hsa-miR-4494	PAR-CLIP	23446348
MIRT519027	hsa-miR-499b-5p	PAR-CLIP	23446348
MIRT519028	hsa-miR-361-5p	PAR-CLIP	23446348
MIRT1102537	hsa-miR-141	CLIP-seq
MIRT1102538	hsa-miR-200a	CLIP-seq
MIRT1102539	hsa-miR-382	CLIP-seq
MIRT1102540	hsa-miR-4273	CLIP-seq
MIRT1102541	hsa-miR-4677-5p	CLIP-seq
MIRT1102542	hsa-miR-4720-3p	CLIP-seq
MIRT1102543	hsa-miR-4777-5p	CLIP-seq
MIRT1102544	hsa-miR-4804-3p	CLIP-seq
MIRT1102545	hsa-miR-518d-5p	CLIP-seq
MIRT1102546	hsa-miR-519b-5p	CLIP-seq
MIRT1102547	hsa-miR-519c-5p	CLIP-seq
MIRT1102548	hsa-miR-520c-5p	CLIP-seq
MIRT1102549	hsa-miR-526a	CLIP-seq
MIRT1102550	hsa-miR-570	CLIP-seq
MIRT1102551	hsa-miR-140-3p	CLIP-seq
MIRT1102552	hsa-miR-3607-3p	CLIP-seq
MIRT1102553	hsa-miR-3686	CLIP-seq
MIRT1102554	hsa-miR-4652-3p	CLIP-seq
MIRT1102555	hsa-miR-4724-5p	CLIP-seq
MIRT1102556	hsa-miR-4795-3p	CLIP-seq
MIRT1102557	hsa-miR-548ag	CLIP-seq
MIRT1102558	hsa-miR-548ai	CLIP-seq
MIRT1102559	hsa-miR-646	CLIP-seq
MIRT1102560	hsa-miR-656	CLIP-seq
MIRT2259248	hsa-miR-28-3p	CLIP-seq
MIRT2259249	hsa-miR-3065-5p	CLIP-seq
MIRT2259250	hsa-miR-4662a-5p	CLIP-seq
MIRT2259251	hsa-miR-548u	CLIP-seq
MIRT2259252	hsa-miR-576-3p	CLIP-seq

Show/Hide all (32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IDA	6468727
GO:0005829	Component	Cytosol	IDA	6468727
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006569	Process	L-tryptophan catabolic process	IEA
GO:0006569	Process	L-tryptophan catabolic process	IMP	17334708
GO:0006753	Process	Nucleoside phosphate metabolic process	IEA
GO:0009435	Process	NAD+ biosynthetic process	IEA
GO:0009435	Process	NAD+ biosynthetic process	IMP	28792876
GO:0016787	Function	Hydrolase activity	IEA
GO:0019363	Process	Pyridine nucleotide biosynthetic process	IEA
GO:0019441	Process	L-tryptophan catabolic process to kynurenine	IBA
GO:0019805	Process	Quinolinate biosynthetic process	IDA	9291104
GO:0019805	Process	Quinolinate biosynthetic process	IEA
GO:0030170	Function	Pyridoxal phosphate binding	IEA
GO:0030429	Function	Kynureninase activity	IBA
GO:0030429	Function	Kynureninase activity	IDA	9180257, 11985583, 28792876
GO:0030429	Function	Kynureninase activity	IEA
GO:0030429	Function	Kynureninase activity	IMP	17334708
GO:0034341	Process	Response to type II interferon	IDA	9291104
GO:0034354	Process	'de novo' NAD+ biosynthetic process from L-tryptophan	IEA
GO:0034516	Process	Response to vitamin B6	IMP	1939450
GO:0042803	Function	Protein homodimerization activity	IDA	11985583
GO:0043420	Process	Anthranilate metabolic process	IBA
GO:0043420	Process	Anthranilate metabolic process	IDA	11985583
GO:0043420	Process	Anthranilate metabolic process	IEA
GO:0072521	Process	Purine-containing compound metabolic process	IEA
GO:0097053	Process	L-kynurenine catabolic process	IEA

MIM	HGNC	e!Ensembl
605197	6469	ENSG00000115919

Q16719

Protein name

Kynureninase (EC 3.7.1.3) (L-kynurenine hydrolase)

Protein function

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyas

PDB

2HZP , 3E9K , 7S3V

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00266	Aminotran_5	69 → 403	Aminotransferase class-V	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in all tissues tested (heart, brain placenta, lung, liver, skeletal muscle, kidney and pancreas). Highest levels found in placenta, liver and lung. Expressed in all brain regions. {ECO:0000269|PubMed:8706755, ECO:0000269|PubM

Sequence

MEPSSLELPADTVQRIAAELKCHPTDERVALHLDEEDKLRHFRECFYIPKIQDLPPVDLS
LVNKDENAIYFLGNSLGLQPKMVKTYLEEELDKWAKIAAYGHEVGKRPWITGDESIVGLM
KDIVGANEKEIALMNALTVNLHLLMLSFFKPTPKRYKILLEAKAFPSDHYAIESQLQLHG
LNIEESMRMIKPREGEETLRIEDILEVIEKEGDSIAVILFSGVHFYTGQHFNIPAITKAG
QAKGCYVGFDLAHAVGNVELYLHDWGVDFACWCSYKYLNAGAGGIAGAFIHEKHAHTIKP
ALVGWFGHELSTRFKMDNKLQLIPGVCGFRISNPPILLVCSLHASLEIFKQATMKALRKK
SVLLTGYLEYLIKHNYGKDKAATKKPVVNIITPSHVEERGCQLTITFSVPNKDVFQELEK
RGVVCDKRNPNGIRVAPVPLYNSFHDVYKFTNLLTSILDSAETKN

Sequence length

465

Interactions

View interactions

	KEGG		Reactome
	Tryptophan metabolism Metabolic pathways Biosynthesis of cofactors		Tryptophan catabolism

Show/Hide Causal Diseases (6)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Catel-Manzke syndrome	Pathogenic; Likely pathogenic	rs780720490, rs142934146, rs147475752	RCV001256675 RCV001256674 RCV001256673
Clear cell carcinoma of kidney	Likely pathogenic	rs754953201	RCV005922639
Congenital NAD deficiency disorder	Pathogenic; Likely pathogenic	rs1135401744, rs758865880, rs770642379, rs147475752, rs767060858, rs752269711, rs765122670, rs1458654786, rs771131526	RCV000496147 RCV000496184 RCV000496114 RCV001391067 RCV001391064 RCV001391066 RCV001391063 RCV001391062 RCV001391065
Hydroxykynureninuria	Pathogenic	rs606231307	RCV000148021
KYNU-related disorder	Likely pathogenic	rs2467839682, rs1685164393, rs1683090143	RCV003335880 RCV003335881 RCV004550769
Vertebral, cardiac, renal, and limb defects syndrome 2	Likely pathogenic; Pathogenic	rs550079487, rs754953201, rs2467829103, rs1135401744, rs758865880, rs770642379, rs142934146, rs767060858, rs765122670, rs1458654786, rs771131526	RCV003326157 RCV001808860 RCV002265065 RCV000505804 RCV000505808 RCV000505812 RCV006272094 RCV003883468 RCV003883467 RCV003883466 RCV003883469

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Intellectual disability	Benign; Likely benign	rs373196560	RCV005622042
Squamous cell carcinoma of the head and neck	-	rs893482697	RCV005930236
Squamous cell lung carcinoma	Uncertain significance	rs1483044652	RCV005931251

Show/Hide Text Mining Associations (37)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	37799714, 39735553
Amyotrophic lateral sclerosis 1	Associate	34194442
Aneurysm	Associate	33298635
Arthritis Reactive	Associate	32934294
Arthritis Rheumatoid	Associate	30123050, 34177888
Breast Neoplasms	Associate	33109232
Carcinoma Ductal	Associate	37221310
Colitis Ulcerative	Associate	38303405, 39596612
COVID 19	Associate	36499104
Depressive Disorder	Associate	30718454
Developmental Disabilities	Associate	31923704
Diabetes Mellitus	Associate	29746559
Glioblastoma	Associate	26936918
Growth Disorders	Associate	31923704
Hand Injuries	Associate	31923704
Heart Defects Congenital	Associate	31923704
Heart Diseases	Associate	31923704
Hidradenitis Suppurativa	Associate	37997679
Holt Oram syndrome	Associate	31923704
Hydroxykynureninuria	Associate	31923704
Ichthyosis	Associate	29803800
Infections	Associate	36499104
Inflammation	Inhibit	33298635
Inflammatory Bowel Diseases	Associate	32934294, 34948292
Leiomyoma	Associate	35715314
Meningitis Bacterial	Associate	21473761
Mowat Wilson syndrome	Associate	20145308
Multiple System Atrophy	Associate	31923704
Obesity	Associate	26347385
Pancreatic Neoplasms	Associate	34632851
Plaque Atherosclerotic	Associate	27684644
Psoriasis	Associate	29803800, 38303405
Sjogren Larsson Syndrome	Associate	31923704
Syndrome	Associate	34200361
Tn Syndrome	Stimulate	33109232
Triple Negative Breast Neoplasms	Stimulate	37221310
Uniparental Disomy	Associate	34200361

KYNU (kynureninase)