Gene Gene information from NCBI Gene database.
Entrez ID 890
Gene name Cyclin A2
Gene symbol CCNA2
Synonyms (NCBI Gene)
CCN1CCNA
Chromosome 4
Chromosome location 4q27
Summary The protein encoded by this gene belongs to the highly conserved cyclin family, whose members function as regulators of the cell cycle. This protein binds and activates cyclin-dependent kinase 2 and thus promotes transition through G1/S and G2/M. [provide
miRNA miRNA information provided by mirtarbase database.
578
miRTarBase ID miRNA Experiments Reference
MIRT000119 hsa-miR-24-3p Luciferase reporter assayMicroarrayqRT-PCRWestern blot 19748357
MIRT000119 hsa-miR-24-3p Luciferase reporter assayMicroarrayqRT-PCRWestern blot 19748357
MIRT004017 hsa-miR-146a-5p MicroarrayqRT-PCRWestern blot 19944095
MIRT003999 hsa-let-7b-5p ImmunoblotImmunofluorescenceLuciferase reporter assayqRT-PCR 18379589
MIRT016556 hsa-miR-193b-3p Microarray 20304954
Transcription factors Transcription factors information provided by TRRUST V2 database.
14
Transcription factor Regulation Reference
CREM Repression 9280058
E2F3 Unknown 16909110
E4F1 Repression 15805267
E4F1 Unknown 14645522
ESR1 Activation 17681750
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
53
GO ID Ontology Definition Evidence Reference
GO:0000082 Process G1/S transition of mitotic cell cycle IBA
GO:0000082 Process G1/S transition of mitotic cell cycle NAS 1312467
GO:0000086 Process G2/M transition of mitotic cell cycle IDA 1312467
GO:0000086 Process G2/M transition of mitotic cell cycle NAS 1312467
GO:0000307 Component Cyclin-dependent protein kinase holoenzyme complex IDA 1312467
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
123835 1578 ENSG00000145386
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P20248
Protein name Cyclin-A2 (Cyclin-A) (Cyclin A)
Protein function Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cy
PDB 1E9H , 1FIN , 1FVV , 1GY3 , 1H1P , 1H1Q , 1H1R , 1H1S , 1H24 , 1H25 , 1H26 , 1H27 , 1H28 , 1JST , 1JSU , 1OGU , 1OI9 , 1OIU , 1OIY , 1OKV , 1OKW , 1OL1 , 1OL2 , 1P5E , 1PKD , 1QMZ , 1URC , 1VYW , 2BKZ , 2BPM , 2C4G , 2C5N , 2C5O , 2C5V , 2C5X , 2C6T , 2CCH , 2CCI , 2CJM , 2I40 , 2IW6 , 2IW8 , 2IW9 , 2UUE , 2UZB , 2UZD , 2UZE , 2UZL , 2V22 , 2WEV , 2WFY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF16500 Cyclin_N2 28 166 N-terminal region of cyclin_N Family
PF00134 Cyclin_N 181 307 Cyclin, N-terminal domain Domain
PF02984 Cyclin_C 309 427 Cyclin, C-terminal domain Domain
Sequence
Sequence length 432
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Cell cycle
AMPK signaling pathway
Cellular senescence
Progesterone-mediated oocyte maturation
Hepatitis B
Human papillomavirus infection
Human T-cell leukemia virus 1 infection
Epstein-Barr virus infection
Pathways in cancer
Transcriptional misregulation in cancer
Viral carcinogenesis
Acute myeloid leukemia
  G0 and Early G1
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
Ub-specific processing proteases
Processing of DNA double-strand break ends
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
G2 Phase
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Cyclin A/B1/B2 associated events during G2/M transition
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry