Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
890
Gene name Gene Name - the full gene name approved by the HGNC.
Cyclin A2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CCNA2
Synonyms (NCBI Gene) Gene synonyms aliases
CCN1, CCNA
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q27
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members function as regulators of the cell cycle. This protein binds and activates cyclin-dependent kinase 2 and thus promotes transition through G1/S and G2/M. [provide
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT000119 hsa-miR-24-3p Luciferase reporter assay, Microarray, qRT-PCR, Western blot 19748357
MIRT000119 hsa-miR-24-3p Luciferase reporter assay, Microarray, qRT-PCR, Western blot 19748357
MIRT004017 hsa-miR-146a-5p Microarray, qRT-PCR, Western blot 19944095
MIRT003999 hsa-let-7b-5p Immunoblot, Immunofluorescence, Luciferase reporter assay, qRT-PCR 18379589
MIRT016556 hsa-miR-193b-3p Microarray 20304954
Transcription factors
Transcription factor Regulation Reference
CREM Repression 9280058
E2F3 Unknown 16909110
E4F1 Repression 15805267
E4F1 Unknown 14645522
ESR1 Activation 17681750
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000079 Process Regulation of cyclin-dependent protein serine/threonine kinase activity IBA 21873635
GO:0000086 Process G2/M transition of mitotic cell cycle IDA 1312467
GO:0000307 Component Cyclin-dependent protein kinase holoenzyme complex IBA 21873635
GO:0000307 Component Cyclin-dependent protein kinase holoenzyme complex IDA 1312467
GO:0001939 Component Female pronucleus IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
123835 1578 ENSG00000145386
Protein
UniProt ID P20248
Protein name Cyclin-A2 (Cyclin-A) (Cyclin A)
Protein function Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cy
PDB 1E9H , 1FIN , 1FVV , 1GY3 , 1H1P , 1H1Q , 1H1R , 1H1S , 1H24 , 1H25 , 1H26 , 1H27 , 1H28 , 1JST , 1JSU , 1OGU , 1OI9 , 1OIU , 1OIY , 1OKV , 1OKW , 1OL1 , 1OL2 , 1P5E , 1PKD , 1QMZ , 1URC , 1VYW , 2BKZ , 2BPM , 2C4G , 2C5N , 2C5O , 2C5V , 2C5X , 2C6T , 2CCH , 2CCI , 2CJM , 2I40 , 2IW6 , 2IW8 , 2IW9 , 2UUE , 2UZB , 2UZD , 2UZE , 2UZL , 2V22 , 2WEV , 2WFY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF16500 Cyclin_N2 28 166 N-terminal region of cyclin_N Family
PF00134 Cyclin_N 181 307 Cyclin, N-terminal domain Domain
PF02984 Cyclin_C 309 427 Cyclin, C-terminal domain Domain
Sequence
Sequence length 432
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Cell cycle
AMPK signaling pathway
Cellular senescence
Progesterone-mediated oocyte maturation
Hepatitis B
Human papillomavirus infection
Human T-cell leukemia virus 1 infection
Epstein-Barr virus infection
Pathways in cancer
Transcriptional misregulation in cancer
Viral carcinogenesis
Acute myeloid leukemia
  G0 and Early G1
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
Ub-specific processing proteases
Processing of DNA double-strand break ends
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
G2 Phase
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Cyclin A/B1/B2 associated events during G2/M transition
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Carcinoma of the head and neck Squamous cell carcinoma of the head and neck rs121909237, rs121909250, rs121909251, rs121909252, rs28934571, rs28934574, rs28934576, rs28934578, rs121912664, rs397516436, rs121912666, rs397514495, rs587782705, rs193920774, rs730882001
View all (7 more)
29464035
Mental retardation Profound Mental Retardation, Mental deficiency, Intellectual Disability rs5742905, rs267607136, rs267607137, rs2131714307, rs267607038, rs267607042, rs80338685, rs137853127, rs80338815, rs28940893, rs387906309, rs121908096, rs121908099, rs587784365, rs121918315
View all (1024 more)
21937992
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
17608974
Unknown
Disease term Disease name Evidence References Source
Neurodevelopmental Disorders neurodevelopmental disorder GenCC
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 17255290, 27893678
Adenocarcinoma of Lung Associate 23874428, 32121037, 33187219, 33627711, 34039308, 34304612, 34880385, 35783192, 35929837, 37254219, 37537521
Adenocarcinoma of Lung Stimulate 33398330
Adrenocortical Carcinoma Associate 32147961, 37535572, 38053725
Anthropophobia Associate 39466061
Astrocytoma Associate 10656729
Ataxia Telangiectasia Associate 35782055
Barrett Esophagus Associate 17255290, 27893678
Behcet Syndrome Associate 37335738
Breast Neoplasms Associate 10934345, 11875707, 12429812, 12627500, 12719458, 15187102, 16670718, 16823179, 17201163, 19706846, 22918167, 23446853, 24207091, 24622579, 25220500
View all (9 more)