DDX18 (DEAD-box helicase 18)
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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8886 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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DEAD-box helicase 18 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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DDX18 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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Has1, MrDb |
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Chromosome
Chromosome number
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2 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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2q14.1 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and m |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||||||||||||
| UniProt ID | Q9NVP1 | ||||||||||||||||||||
| Protein name | ATP-dependent RNA helicase DDX18 (EC 3.6.4.13) (DEAD box protein 18) (Myc-regulated DEAD box protein) (MrDb) | ||||||||||||||||||||
| Protein function | ATP-dependent RNA helicase that plays a role in the regulation of R-loop homeostasis in both endogenous R-loop-prone regions and at sites of DNA damage. At endogenous loci such as actively transcribed genes, may act as a helicase to resolve the | ||||||||||||||||||||
| PDB | 3LY5 , 8FKP , 8FKQ , 8FKR , 8FKS , 8FKT , 8FKU , 8FKV , 8FKW , 8FKX , 8FKY | ||||||||||||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 670 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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