Gene Gene information from NCBI Gene database.
Entrez ID 8886
Gene name DEAD-box helicase 18
Gene symbol DDX18
Synonyms (NCBI Gene)
Has1MrDb
Chromosome 2
Chromosome location 2q14.1
Summary DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and m
miRNA miRNA information provided by mirtarbase database.
409
miRTarBase ID miRNA Experiments Reference
MIRT052470 hsa-let-7a-5p CLASH 23622248
MIRT052091 hsa-let-7b-5p CLASH 23622248
MIRT051780 hsa-let-7c-5p CLASH 23622248
MIRT048605 hsa-miR-99a-5p CLASH 23622248
MIRT045851 hsa-miR-128-3p CLASH 23622248
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
MYC Unknown 8861962
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
20
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0000463 Process Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
GO:0003676 Function Nucleic acid binding IEA
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003723 Function RNA binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
606355 2741 ENSG00000088205
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NVP1
Protein name ATP-dependent RNA helicase DDX18 (EC 3.6.4.13) (DEAD box protein 18) (Myc-regulated DEAD box protein) (MrDb)
Protein function ATP-dependent RNA helicase that plays a role in the regulation of R-loop homeostasis in both endogenous R-loop-prone regions and at sites of DNA damage. At endogenous loci such as actively transcribed genes, may act as a helicase to resolve the
PDB 3LY5 , 8FKP , 8FKQ , 8FKR , 8FKS , 8FKT , 8FKU , 8FKV , 8FKW , 8FKX , 8FKY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00270 DEAD 203 374 DEAD/DEAH box helicase Domain
PF00271 Helicase_C 411 520 Helicase conserved C-terminal domain Family
PF13959 DUF4217 561 621 Domain of unknown function (DUF4217) Domain
Sequence
MSHLPMKLLRKKIEKRNLKLRQRNLKFQGASNLTLSETQNGDVSEETMGSRKVKKSKQKP
MNVGLSETQNGGMSQEAVGNIKVTKSPQKSTVLTNGEAAMQSSNSESKKKKKKKRKMVND
AEPDTKKAKTENKGKSEEESAETTKETENNVEKPDNDEDESEVPSLPLGLTGAFEDTSFA
SLCNLVNENTLKAIKEMGFTNMTEIQHKSIRPLLEGRDLLAAAKTGSGKTLAFLIPAVEL
IVKLRFMPRNGTGVLILSPTRELAMQTFGVLKELMTHHVHTYGLIMGGSNRSAEAQKLGN
GINIIVATPGRLLDHMQNTPGFMYKNLQCLVIDEADRILDVGFEEELKQIIKLLPTRRQT
MLFSATQTRKVEDL
ARISLKKEPLYVGVDDDKANATVDGLEQGYVVCPSEKRFLLLFTFL
KKNRKKKLMVFFSSCMSVKYHYELLNYIDLPVLAIHGKQKQNKRTTTFFQFCNADSGTLL
CTDVAARGLDIPEVDWIVQYDPPDDPKEYIHRVGRTARGL
NGRGHALLILRPEELGFLRY
LKQSKVPLSEFDFSWSKISDIQSQLEKLIEKNYFLHKSAQEAYKSYIRAYDSHSLKQIFN
VNNLNLPQVALSFGFKVPPFV
DLNVNSNEGKQKKRGGGGGFGYQKTKKVEKSKIFKHISK
KSSDSRQFSH
Sequence length 670
Interactions View interactions