Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8886
Gene name Gene Name - the full gene name approved by the HGNC.
DEAD-box helicase 18
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
DDX18
Synonyms (NCBI Gene) Gene synonyms aliases
Has1, MrDb
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q14.1
Summary Summary of gene provided in NCBI Entrez Gene.
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and m
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT052470 hsa-let-7a-5p CLASH 23622248
MIRT052091 hsa-let-7b-5p CLASH 23622248
MIRT051780 hsa-let-7c-5p CLASH 23622248
MIRT048605 hsa-miR-99a-5p CLASH 23622248
MIRT045851 hsa-miR-128-3p CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
MYC Unknown 8861962
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0000463 Process Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
GO:0003676 Function Nucleic acid binding IEA
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003723 Function RNA binding IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
606355 2741 ENSG00000088205
Protein
UniProt ID Q9NVP1
Protein name ATP-dependent RNA helicase DDX18 (EC 3.6.4.13) (DEAD box protein 18) (Myc-regulated DEAD box protein) (MrDb)
Protein function ATP-dependent RNA helicase that plays a role in the regulation of R-loop homeostasis in both endogenous R-loop-prone regions and at sites of DNA damage. At endogenous loci such as actively transcribed genes, may act as a helicase to resolve the
PDB 3LY5 , 8FKP , 8FKQ , 8FKR , 8FKS , 8FKT , 8FKU , 8FKV , 8FKW , 8FKX , 8FKY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00270 DEAD 203 374 DEAD/DEAH box helicase Domain
PF00271 Helicase_C 411 520 Helicase conserved C-terminal domain Family
PF13959 DUF4217 561 621 Domain of unknown function (DUF4217) Domain
Sequence
MSHLPMKLLRKKIEKRNLKLRQRNLKFQGASNLTLSETQNGDVSEETMGSRKVKKSKQKP
MNVGLSETQNGGMSQEAVGNIKVTKSPQKSTVLTNGEAAMQSSNSESKKKKKKKRKMVND
AEPDTKKAKTENKGKSEEESAETTKETENNVEKPDNDEDESEVPSLPLGLTGAFEDTSFA
SLCNLVNENTLKAIKEMGFTNMTEIQHKSIRPLLEGRDLLAAAKTGSGKTLAFLIPAVEL
IVKLRFMPRNGTGVLILSPTRELAMQTFGVLKELMTHHVHTYGLIMGGSNRSAEAQKLGN
GINIIVATPGRLLDHMQNTPGFMYKNLQCLVIDEADRILDVGFEEELKQIIKLLPTRRQT
MLFSATQTRKVEDL
ARISLKKEPLYVGVDDDKANATVDGLEQGYVVCPSEKRFLLLFTFL
KKNRKKKLMVFFSSCMSVKYHYELLNYIDLPVLAIHGKQKQNKRTTTFFQFCNADSGTLL
CTDVAARGLDIPEVDWIVQYDPPDDPKEYIHRVGRTARGL
NGRGHALLILRPEELGFLRY
LKQSKVPLSEFDFSWSKISDIQSQLEKLIEKNYFLHKSAQEAYKSYIRAYDSHSLKQIFN
VNNLNLPQVALSFGFKVPPFV
DLNVNSNEGKQKKRGGGGGFGYQKTKKVEKSKIFKHISK
KSSDSRQFSH
Sequence length 670
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Diabetes Type 2 diabetes N/A N/A GWAS
Glioblastoma Glioblastoma N/A N/A GWAS
Insomnia Insomnia N/A N/A GWAS
Oligodendroglioma Oligodendroglioma N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Colorectal Neoplasms Associate 32815531, 39577603
Esophageal Squamous Cell Carcinoma Associate 33345608
Renal Insufficiency Chronic Associate 35571562