Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	8878
Gene name Gene Name - the full gene name approved by the HGNC.	Sequestosome 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SQSTM1
Synonyms (NCBI Gene) Gene synonyms aliases	A170, DMRV, EBIAP, FTDALS3, NADGP, OSIL, PDB3, ZIP3, p60, p62, p62B
Chromosome Chromosome number	5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	5q35.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to m

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SNP ID	Visualize variation	Clinical significance	Consequence
rs104893941	C>T	Likely-pathogenic, pathogenic, conflicting-interpretations-of-pathogenicity	Coding sequence variant, missense variant
rs200396166	C>G,T	Pathogenic, likely-benign	Intron variant, missense variant, coding sequence variant
rs776749939	C>T	Pathogenic, likely-pathogenic	Coding sequence variant, missense variant
rs796051869	->T	Pathogenic	Coding sequence variant, stop gained
rs796051870	G>A	Pathogenic	Splice donor variant
rs796052213	A>T	Pathogenic	Coding sequence variant, stop gained
rs796052214	GAA>-	Uncertain-significance, pathogenic	Coding sequence variant, inframe deletion
rs886039780	T>A	Pathogenic	Initiator codon variant, intron variant, missense variant
rs886039781	AG>-	Pathogenic	Coding sequence variant, frameshift variant
rs886039782	C>T	Pathogenic	Coding sequence variant, stop gained
rs1064794783	->CGAGGCTGCGGCGGGTCCG	Not-provided, likely-pathogenic	Coding sequence variant, intron variant, frameshift variant
rs1273214757	AG>-	Pathogenic	Coding sequence variant, frameshift variant
rs1331685476	TCTG>-	Pathogenic	Frameshift variant, coding sequence variant

Show/Hide all(587)

miRTarBase ID	miRNA	Experiments	Reference
MIRT001410	hsa-miR-16-5p	pSILAC	18668040
MIRT001410	hsa-miR-16-5p	pSILAC	18668040
MIRT018399	hsa-miR-335-5p	Microarray	18185580
MIRT025851	hsa-miR-7-5p	Microarray	19073608
MIRT001410	hsa-miR-16-5p	Proteomics;Other	18668040
MIRT042028	hsa-miR-484	CLASH	23622248
MIRT038085	hsa-miR-423-5p	CLASH	23622248
MIRT038085	hsa-miR-423-5p	CLASH	23622248
MIRT037277	hsa-miR-877-5p	CLASH	23622248
MIRT096298	hsa-miR-548e-5p	PAR-CLIP	21572407
MIRT096299	hsa-miR-1252-3p	PAR-CLIP	21572407
MIRT096300	hsa-miR-3925-5p	PAR-CLIP	21572407
MIRT166151	hsa-miR-7161-3p	PAR-CLIP	21572407
MIRT096296	hsa-miR-646	PAR-CLIP	21572407
MIRT096302	hsa-miR-4712-3p	PAR-CLIP	21572407
MIRT166138	hsa-miR-146a-5p	PAR-CLIP	21572407
MIRT166141	hsa-miR-146b-5p	PAR-CLIP	21572407
MIRT166150	hsa-miR-7153-5p	PAR-CLIP	21572407
MIRT096305	hsa-miR-8069	PAR-CLIP	21572407
MIRT096303	hsa-miR-5093	PAR-CLIP	21572407
MIRT499049	hsa-miR-5087	PAR-CLIP	21572407
MIRT096301	hsa-miR-3978	PAR-CLIP	21572407
MIRT096298	hsa-miR-548e-5p	PAR-CLIP	21572407
MIRT096299	hsa-miR-1252-3p	PAR-CLIP	21572407
MIRT096300	hsa-miR-3925-5p	PAR-CLIP	21572407
MIRT166151	hsa-miR-7161-3p	PAR-CLIP	21572407
MIRT096296	hsa-miR-646	PAR-CLIP	21572407
MIRT096302	hsa-miR-4712-3p	PAR-CLIP	21572407
MIRT166138	hsa-miR-146a-5p	PAR-CLIP	21572407
MIRT166141	hsa-miR-146b-5p	PAR-CLIP	21572407
MIRT166150	hsa-miR-7153-5p	PAR-CLIP	21572407
MIRT096305	hsa-miR-8069	PAR-CLIP	21572407
MIRT096306	hsa-miR-8075	PAR-CLIP	21572407
MIRT096303	hsa-miR-5093	PAR-CLIP	21572407
MIRT499049	hsa-miR-5087	PAR-CLIP	21572407
MIRT096301	hsa-miR-3978	PAR-CLIP	21572407
MIRT096298	hsa-miR-548e-5p	PAR-CLIP	24398324
MIRT096299	hsa-miR-1252-3p	PAR-CLIP	24398324
MIRT096300	hsa-miR-3925-5p	PAR-CLIP	24398324
MIRT166151	hsa-miR-7161-3p	PAR-CLIP	24398324
MIRT096296	hsa-miR-646	PAR-CLIP	24398324
MIRT096302	hsa-miR-4712-3p	PAR-CLIP	24398324
MIRT166138	hsa-miR-146a-5p	PAR-CLIP	24398324
MIRT166141	hsa-miR-146b-5p	PAR-CLIP	24398324
MIRT166150	hsa-miR-7153-5p	PAR-CLIP	24398324
MIRT096305	hsa-miR-8069	PAR-CLIP	24398324
MIRT096306	hsa-miR-8075	PAR-CLIP	24398324
MIRT096303	hsa-miR-5093	PAR-CLIP	24398324
MIRT499049	hsa-miR-5087	PAR-CLIP	24398324
MIRT096301	hsa-miR-3978	PAR-CLIP	24398324
MIRT096312	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT096308	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT439548	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT096312	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT096307	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT096319	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT096309	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT096329	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT096308	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT439548	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT096298	hsa-miR-548e-5p	PAR-CLIP	21572407
MIRT096299	hsa-miR-1252-3p	PAR-CLIP	21572407
MIRT096300	hsa-miR-3925-5p	PAR-CLIP	21572407
MIRT166151	hsa-miR-7161-3p	PAR-CLIP	21572407
MIRT096296	hsa-miR-646	PAR-CLIP	21572407
MIRT096302	hsa-miR-4712-3p	PAR-CLIP	21572407
MIRT166138	hsa-miR-146a-5p	PAR-CLIP	21572407
MIRT166141	hsa-miR-146b-5p	PAR-CLIP	21572407
MIRT166150	hsa-miR-7153-5p	PAR-CLIP	21572407
MIRT096305	hsa-miR-8069	PAR-CLIP	21572407
MIRT096303	hsa-miR-5093	PAR-CLIP	21572407
MIRT499049	hsa-miR-5087	PAR-CLIP	21572407
MIRT096301	hsa-miR-3978	PAR-CLIP	21572407
MIRT096298	hsa-miR-548e-5p	PAR-CLIP	21572407
MIRT096299	hsa-miR-1252-3p	PAR-CLIP	21572407
MIRT096300	hsa-miR-3925-5p	PAR-CLIP	21572407
MIRT166151	hsa-miR-7161-3p	PAR-CLIP	21572407
MIRT096296	hsa-miR-646	PAR-CLIP	21572407
MIRT096302	hsa-miR-4712-3p	PAR-CLIP	21572407
MIRT166138	hsa-miR-146a-5p	PAR-CLIP	21572407
MIRT166141	hsa-miR-146b-5p	PAR-CLIP	21572407
MIRT166150	hsa-miR-7153-5p	PAR-CLIP	21572407
MIRT096305	hsa-miR-8069	PAR-CLIP	21572407
MIRT096306	hsa-miR-8075	PAR-CLIP	21572407
MIRT096303	hsa-miR-5093	PAR-CLIP	21572407
MIRT499049	hsa-miR-5087	PAR-CLIP	21572407
MIRT096301	hsa-miR-3978	PAR-CLIP	21572407
MIRT096298	hsa-miR-548e-5p	PAR-CLIP	24398324
MIRT096299	hsa-miR-1252-3p	PAR-CLIP	24398324
MIRT096300	hsa-miR-3925-5p	PAR-CLIP	24398324
MIRT166151	hsa-miR-7161-3p	PAR-CLIP	24398324
MIRT096296	hsa-miR-646	PAR-CLIP	24398324
MIRT096302	hsa-miR-4712-3p	PAR-CLIP	24398324
MIRT166138	hsa-miR-146a-5p	PAR-CLIP	24398324
MIRT166141	hsa-miR-146b-5p	PAR-CLIP	24398324
MIRT166150	hsa-miR-7153-5p	PAR-CLIP	24398324
MIRT096305	hsa-miR-8069	PAR-CLIP	24398324
MIRT096306	hsa-miR-8075	PAR-CLIP	24398324
MIRT096303	hsa-miR-5093	PAR-CLIP	24398324
MIRT499049	hsa-miR-5087	PAR-CLIP	24398324
MIRT096301	hsa-miR-3978	PAR-CLIP	24398324
MIRT1387478	hsa-miR-135a	CLIP-seq
MIRT1387479	hsa-miR-135b	CLIP-seq
MIRT1387480	hsa-miR-205	CLIP-seq
MIRT1387481	hsa-miR-2052	CLIP-seq
MIRT1387482	hsa-miR-2355-5p	CLIP-seq
MIRT1387483	hsa-miR-3065-3p	CLIP-seq
MIRT1387484	hsa-miR-3157-3p	CLIP-seq
MIRT1387485	hsa-miR-3614-5p	CLIP-seq
MIRT1387486	hsa-miR-370	CLIP-seq
MIRT1387487	hsa-miR-4261	CLIP-seq
MIRT1387488	hsa-miR-4287	CLIP-seq
MIRT1387489	hsa-miR-4496	CLIP-seq
MIRT1387490	hsa-miR-4685-3p	CLIP-seq
MIRT1387491	hsa-miR-4694-3p	CLIP-seq
MIRT1387492	hsa-miR-4757-5p	CLIP-seq
MIRT1387493	hsa-miR-4763-5p	CLIP-seq
MIRT1387494	hsa-miR-494	CLIP-seq
MIRT1387495	hsa-miR-522	CLIP-seq
MIRT1387496	hsa-miR-549	CLIP-seq
MIRT1387497	hsa-miR-596	CLIP-seq
MIRT1387498	hsa-miR-628-5p	CLIP-seq
MIRT1387499	hsa-miR-668	CLIP-seq
MIRT1387500	hsa-miR-106a	CLIP-seq
MIRT1387501	hsa-miR-106b	CLIP-seq
MIRT1387502	hsa-miR-1205	CLIP-seq
MIRT1387503	hsa-miR-1207-5p	CLIP-seq
MIRT1387504	hsa-miR-1283	CLIP-seq
MIRT1387505	hsa-miR-1321	CLIP-seq
MIRT1387506	hsa-miR-139-5p	CLIP-seq
MIRT1387507	hsa-miR-146a	CLIP-seq
MIRT1387508	hsa-miR-1587	CLIP-seq
MIRT1387509	hsa-miR-17	CLIP-seq
MIRT1387510	hsa-miR-1827	CLIP-seq
MIRT1387511	hsa-miR-1909	CLIP-seq
MIRT1387512	hsa-miR-193a-3p	CLIP-seq
MIRT1387513	hsa-miR-193a-5p	CLIP-seq
MIRT1387514	hsa-miR-193b	CLIP-seq
MIRT1387480	hsa-miR-205	CLIP-seq
MIRT1387481	hsa-miR-2052	CLIP-seq
MIRT1387515	hsa-miR-20a	CLIP-seq
MIRT1387516	hsa-miR-20b	CLIP-seq
MIRT1387482	hsa-miR-2355-5p	CLIP-seq
MIRT1387517	hsa-miR-2392	CLIP-seq
MIRT1387518	hsa-miR-298	CLIP-seq
MIRT1387519	hsa-miR-302a	CLIP-seq
MIRT1387520	hsa-miR-302b	CLIP-seq
MIRT1387521	hsa-miR-302c	CLIP-seq
MIRT1387522	hsa-miR-302d	CLIP-seq
MIRT1387523	hsa-miR-302e	CLIP-seq
MIRT1387524	hsa-miR-3184	CLIP-seq
MIRT1387525	hsa-miR-3185	CLIP-seq
MIRT1387526	hsa-miR-3189-3p	CLIP-seq
MIRT1387527	hsa-miR-3192	CLIP-seq
MIRT1387528	hsa-miR-3199	CLIP-seq
MIRT1387529	hsa-miR-3609	CLIP-seq
MIRT1387530	hsa-miR-3612	CLIP-seq
MIRT1387485	hsa-miR-3614-5p	CLIP-seq
MIRT1387531	hsa-miR-3690	CLIP-seq
MIRT1387486	hsa-miR-370	CLIP-seq
MIRT1387532	hsa-miR-3714	CLIP-seq
MIRT1387533	hsa-miR-372	CLIP-seq
MIRT1387534	hsa-miR-373	CLIP-seq
MIRT1387535	hsa-miR-3919	CLIP-seq
MIRT1387536	hsa-miR-3943	CLIP-seq
MIRT1387537	hsa-miR-4254	CLIP-seq
MIRT1387538	hsa-miR-4264	CLIP-seq
MIRT1387539	hsa-miR-4270	CLIP-seq
MIRT1387540	hsa-miR-4276	CLIP-seq
MIRT1387541	hsa-miR-4311	CLIP-seq
MIRT1387542	hsa-miR-4314	CLIP-seq
MIRT1387543	hsa-miR-4323	CLIP-seq
MIRT1387544	hsa-miR-4433	CLIP-seq
MIRT1387545	hsa-miR-4441	CLIP-seq
MIRT1387546	hsa-miR-4445	CLIP-seq
MIRT1387547	hsa-miR-4459	CLIP-seq
MIRT1387548	hsa-miR-4492	CLIP-seq
MIRT1387549	hsa-miR-4498	CLIP-seq
MIRT1387550	hsa-miR-4515	CLIP-seq
MIRT1387551	hsa-miR-4646-5p	CLIP-seq
MIRT1387552	hsa-miR-4656	CLIP-seq
MIRT1387553	hsa-miR-4660	CLIP-seq
MIRT1387554	hsa-miR-4675	CLIP-seq
MIRT1387555	hsa-miR-4688	CLIP-seq
MIRT1387556	hsa-miR-4695-5p	CLIP-seq
MIRT1387557	hsa-miR-4709-3p	CLIP-seq
MIRT1387558	hsa-miR-4728-5p	CLIP-seq
MIRT1387559	hsa-miR-4736	CLIP-seq
MIRT1387560	hsa-miR-4738-3p	CLIP-seq
MIRT1387561	hsa-miR-4739	CLIP-seq
MIRT1387562	hsa-miR-4741	CLIP-seq
MIRT1387563	hsa-miR-4756-5p	CLIP-seq
MIRT1387492	hsa-miR-4757-5p	CLIP-seq
MIRT1387564	hsa-miR-4760-5p	CLIP-seq
MIRT1387565	hsa-miR-4763-3p	CLIP-seq
MIRT1387493	hsa-miR-4763-5p	CLIP-seq
MIRT1387566	hsa-miR-4768-3p	CLIP-seq
MIRT1387567	hsa-miR-4786-5p	CLIP-seq
MIRT1387568	hsa-miR-4796-3p	CLIP-seq
MIRT1387569	hsa-miR-4797-3p	CLIP-seq
MIRT1387570	hsa-miR-4804-3p	CLIP-seq
MIRT1387571	hsa-miR-512-3p	CLIP-seq
MIRT1387572	hsa-miR-519d	CLIP-seq
MIRT1387573	hsa-miR-520a-3p	CLIP-seq
MIRT1387574	hsa-miR-520b	CLIP-seq
MIRT1387575	hsa-miR-520c-3p	CLIP-seq
MIRT1387576	hsa-miR-520d-3p	CLIP-seq
MIRT1387577	hsa-miR-520d-5p	CLIP-seq
MIRT1387578	hsa-miR-520e	CLIP-seq
MIRT1387579	hsa-miR-524-5p	CLIP-seq
MIRT1387580	hsa-miR-541	CLIP-seq
MIRT1387581	hsa-miR-548ah	CLIP-seq
MIRT1387496	hsa-miR-549	CLIP-seq
MIRT1387497	hsa-miR-596	CLIP-seq
MIRT1387582	hsa-miR-598	CLIP-seq
MIRT1387583	hsa-miR-616	CLIP-seq
MIRT1387498	hsa-miR-628-5p	CLIP-seq
MIRT1387584	hsa-miR-650	CLIP-seq
MIRT1387585	hsa-miR-654-5p	CLIP-seq
MIRT1387586	hsa-miR-657	CLIP-seq
MIRT1387587	hsa-miR-665	CLIP-seq
MIRT1387499	hsa-miR-668	CLIP-seq
MIRT1387588	hsa-miR-7	CLIP-seq
MIRT1387589	hsa-miR-762	CLIP-seq
MIRT1387590	hsa-miR-769-5p	CLIP-seq
MIRT1387591	hsa-miR-93	CLIP-seq
MIRT1387541	hsa-miR-4311	CLIP-seq
MIRT1557123	hsa-miR-4729	CLIP-seq
MIRT1387478	hsa-miR-135a	CLIP-seq
MIRT1387479	hsa-miR-135b	CLIP-seq
MIRT2116105	hsa-miR-1910	CLIP-seq
MIRT1387481	hsa-miR-2052	CLIP-seq
MIRT2116106	hsa-miR-214	CLIP-seq
MIRT1387482	hsa-miR-2355-5p	CLIP-seq
MIRT1387483	hsa-miR-3065-3p	CLIP-seq
MIRT2116107	hsa-miR-3137	CLIP-seq
MIRT1387484	hsa-miR-3157-3p	CLIP-seq
MIRT2116108	hsa-miR-3614-3p	CLIP-seq
MIRT1387485	hsa-miR-3614-5p	CLIP-seq
MIRT2116109	hsa-miR-3619-5p	CLIP-seq
MIRT1387486	hsa-miR-370	CLIP-seq
MIRT1387532	hsa-miR-3714	CLIP-seq
MIRT1387538	hsa-miR-4264	CLIP-seq
MIRT1387539	hsa-miR-4270	CLIP-seq
MIRT1387540	hsa-miR-4276	CLIP-seq
MIRT1387545	hsa-miR-4441	CLIP-seq
MIRT1387547	hsa-miR-4459	CLIP-seq
MIRT2116110	hsa-miR-4530	CLIP-seq
MIRT2116111	hsa-miR-455-3p	CLIP-seq
MIRT1387553	hsa-miR-4660	CLIP-seq
MIRT2116112	hsa-miR-4668-3p	CLIP-seq
MIRT1387491	hsa-miR-4694-3p	CLIP-seq
MIRT1387556	hsa-miR-4695-5p	CLIP-seq
MIRT2116113	hsa-miR-4754	CLIP-seq
MIRT1387492	hsa-miR-4757-5p	CLIP-seq
MIRT1387493	hsa-miR-4763-5p	CLIP-seq
MIRT1387568	hsa-miR-4796-3p	CLIP-seq
MIRT1387569	hsa-miR-4797-3p	CLIP-seq
MIRT1387495	hsa-miR-522	CLIP-seq
MIRT1387496	hsa-miR-549	CLIP-seq
MIRT1387497	hsa-miR-596	CLIP-seq
MIRT1387498	hsa-miR-628-5p	CLIP-seq
MIRT2116114	hsa-miR-645	CLIP-seq
MIRT1387499	hsa-miR-668	CLIP-seq
MIRT2116115	hsa-miR-759	CLIP-seq
MIRT2116116	hsa-miR-761	CLIP-seq
MIRT2116117	hsa-miR-938	CLIP-seq
MIRT1387500	hsa-miR-106a	CLIP-seq
MIRT1387501	hsa-miR-106b	CLIP-seq
MIRT1387504	hsa-miR-1283	CLIP-seq
MIRT1387478	hsa-miR-135a	CLIP-seq
MIRT1387479	hsa-miR-135b	CLIP-seq
MIRT1387506	hsa-miR-139-5p	CLIP-seq
MIRT2338533	hsa-miR-141	CLIP-seq
MIRT1387507	hsa-miR-146a	CLIP-seq
MIRT1387509	hsa-miR-17	CLIP-seq
MIRT1387510	hsa-miR-1827	CLIP-seq
MIRT2116105	hsa-miR-1910	CLIP-seq
MIRT1387512	hsa-miR-193a-3p	CLIP-seq
MIRT1387514	hsa-miR-193b	CLIP-seq
MIRT2338534	hsa-miR-200a	CLIP-seq
MIRT1387480	hsa-miR-205	CLIP-seq
MIRT1387481	hsa-miR-2052	CLIP-seq
MIRT1387515	hsa-miR-20a	CLIP-seq
MIRT1387516	hsa-miR-20b	CLIP-seq
MIRT2116106	hsa-miR-214	CLIP-seq
MIRT1387482	hsa-miR-2355-5p	CLIP-seq
MIRT1387517	hsa-miR-2392	CLIP-seq
MIRT1387518	hsa-miR-298	CLIP-seq
MIRT1387519	hsa-miR-302a	CLIP-seq
MIRT1387520	hsa-miR-302b	CLIP-seq
MIRT1387521	hsa-miR-302c	CLIP-seq
MIRT1387522	hsa-miR-302d	CLIP-seq
MIRT1387523	hsa-miR-302e	CLIP-seq
MIRT1387483	hsa-miR-3065-3p	CLIP-seq
MIRT2116107	hsa-miR-3137	CLIP-seq
MIRT1387484	hsa-miR-3157-3p	CLIP-seq
MIRT1387524	hsa-miR-3184	CLIP-seq
MIRT1387525	hsa-miR-3185	CLIP-seq
MIRT1387529	hsa-miR-3609	CLIP-seq
MIRT1387530	hsa-miR-3612	CLIP-seq
MIRT2116108	hsa-miR-3614-3p	CLIP-seq
MIRT1387485	hsa-miR-3614-5p	CLIP-seq
MIRT2116109	hsa-miR-3619-5p	CLIP-seq
MIRT2338535	hsa-miR-3649	CLIP-seq
MIRT1387531	hsa-miR-3690	CLIP-seq
MIRT1387486	hsa-miR-370	CLIP-seq
MIRT1387533	hsa-miR-372	CLIP-seq
MIRT1387534	hsa-miR-373	CLIP-seq
MIRT1387537	hsa-miR-4254	CLIP-seq
MIRT1387487	hsa-miR-4261	CLIP-seq
MIRT1387538	hsa-miR-4264	CLIP-seq
MIRT1387539	hsa-miR-4270	CLIP-seq
MIRT1387540	hsa-miR-4276	CLIP-seq
MIRT1387488	hsa-miR-4287	CLIP-seq
MIRT1387541	hsa-miR-4311	CLIP-seq
MIRT2338536	hsa-miR-4423-3p	CLIP-seq
MIRT1387544	hsa-miR-4433	CLIP-seq
MIRT1387545	hsa-miR-4441	CLIP-seq
MIRT1387546	hsa-miR-4445	CLIP-seq
MIRT1387547	hsa-miR-4459	CLIP-seq
MIRT1387489	hsa-miR-4496	CLIP-seq
MIRT2116110	hsa-miR-4530	CLIP-seq
MIRT2116111	hsa-miR-455-3p	CLIP-seq
MIRT2338537	hsa-miR-455-5p	CLIP-seq
MIRT1387553	hsa-miR-4660	CLIP-seq
MIRT2116112	hsa-miR-4668-3p	CLIP-seq
MIRT1387490	hsa-miR-4685-3p	CLIP-seq
MIRT1387555	hsa-miR-4688	CLIP-seq
MIRT1387491	hsa-miR-4694-3p	CLIP-seq
MIRT1387556	hsa-miR-4695-5p	CLIP-seq
MIRT1387557	hsa-miR-4709-3p	CLIP-seq
MIRT1557123	hsa-miR-4729	CLIP-seq
MIRT1387564	hsa-miR-4760-5p	CLIP-seq
MIRT1387493	hsa-miR-4763-5p	CLIP-seq
MIRT1387566	hsa-miR-4768-3p	CLIP-seq
MIRT1387567	hsa-miR-4786-5p	CLIP-seq
MIRT1387568	hsa-miR-4796-3p	CLIP-seq
MIRT1387569	hsa-miR-4797-3p	CLIP-seq
MIRT2338538	hsa-miR-4797-5p	CLIP-seq
MIRT1387570	hsa-miR-4804-3p	CLIP-seq
MIRT1387494	hsa-miR-494	CLIP-seq
MIRT1387571	hsa-miR-512-3p	CLIP-seq
MIRT1387572	hsa-miR-519d	CLIP-seq
MIRT1387573	hsa-miR-520a-3p	CLIP-seq
MIRT1387574	hsa-miR-520b	CLIP-seq
MIRT1387575	hsa-miR-520c-3p	CLIP-seq
MIRT1387576	hsa-miR-520d-3p	CLIP-seq
MIRT1387577	hsa-miR-520d-5p	CLIP-seq
MIRT1387578	hsa-miR-520e	CLIP-seq
MIRT1387495	hsa-miR-522	CLIP-seq
MIRT1387579	hsa-miR-524-5p	CLIP-seq
MIRT1387580	hsa-miR-541	CLIP-seq
MIRT1387581	hsa-miR-548ah	CLIP-seq
MIRT2338539	hsa-miR-548t	CLIP-seq
MIRT1387496	hsa-miR-549	CLIP-seq
MIRT1387497	hsa-miR-596	CLIP-seq
MIRT1387583	hsa-miR-616	CLIP-seq
MIRT1387498	hsa-miR-628-5p	CLIP-seq
MIRT2116114	hsa-miR-645	CLIP-seq
MIRT1387584	hsa-miR-650	CLIP-seq
MIRT1387585	hsa-miR-654-5p	CLIP-seq
MIRT1387587	hsa-miR-665	CLIP-seq
MIRT1387499	hsa-miR-668	CLIP-seq
MIRT2338540	hsa-miR-671-5p	CLIP-seq
MIRT1387588	hsa-miR-7	CLIP-seq
MIRT2116115	hsa-miR-759	CLIP-seq
MIRT2116116	hsa-miR-761	CLIP-seq
MIRT1387590	hsa-miR-769-5p	CLIP-seq
MIRT1387591	hsa-miR-93	CLIP-seq
MIRT2116117	hsa-miR-938	CLIP-seq
MIRT1387506	hsa-miR-139-5p	CLIP-seq
MIRT1387507	hsa-miR-146a	CLIP-seq
MIRT1387557	hsa-miR-4709-3p	CLIP-seq
MIRT1387567	hsa-miR-4786-5p	CLIP-seq
MIRT1387503	hsa-miR-1207-5p	CLIP-seq
MIRT2460517	hsa-miR-124	CLIP-seq
MIRT2460518	hsa-miR-1258	CLIP-seq
MIRT2460519	hsa-miR-154	CLIP-seq
MIRT1387481	hsa-miR-2052	CLIP-seq
MIRT1387518	hsa-miR-298	CLIP-seq
MIRT2460520	hsa-miR-3126-5p	CLIP-seq
MIRT1387484	hsa-miR-3157-3p	CLIP-seq
MIRT1387485	hsa-miR-3614-5p	CLIP-seq
MIRT2460521	hsa-miR-3664-5p	CLIP-seq
MIRT1387532	hsa-miR-3714	CLIP-seq
MIRT2460522	hsa-miR-3910	CLIP-seq
MIRT2460523	hsa-miR-4266	CLIP-seq
MIRT2460524	hsa-miR-4477a	CLIP-seq
MIRT1387556	hsa-miR-4695-5p	CLIP-seq
MIRT2460525	hsa-miR-4714-5p	CLIP-seq
MIRT1387559	hsa-miR-4736	CLIP-seq
MIRT1387565	hsa-miR-4763-3p	CLIP-seq
MIRT2460526	hsa-miR-4779	CLIP-seq
MIRT2460527	hsa-miR-506	CLIP-seq
MIRT1387580	hsa-miR-541	CLIP-seq
MIRT1387585	hsa-miR-654-5p	CLIP-seq
MIRT1387586	hsa-miR-657	CLIP-seq
MIRT1387499	hsa-miR-668	CLIP-seq
MIRT1387502	hsa-miR-1205	CLIP-seq
MIRT1387503	hsa-miR-1207-5p	CLIP-seq
MIRT2460517	hsa-miR-124	CLIP-seq
MIRT2460518	hsa-miR-1258	CLIP-seq
MIRT1387505	hsa-miR-1321	CLIP-seq
MIRT1387478	hsa-miR-135a	CLIP-seq
MIRT1387479	hsa-miR-135b	CLIP-seq
MIRT2338533	hsa-miR-141	CLIP-seq
MIRT2632051	hsa-miR-1538	CLIP-seq
MIRT2460519	hsa-miR-154	CLIP-seq
MIRT1387508	hsa-miR-1587	CLIP-seq
MIRT1387511	hsa-miR-1909	CLIP-seq
MIRT2116105	hsa-miR-1910	CLIP-seq
MIRT1387512	hsa-miR-193a-3p	CLIP-seq
MIRT1387513	hsa-miR-193a-5p	CLIP-seq
MIRT1387514	hsa-miR-193b	CLIP-seq
MIRT2338534	hsa-miR-200a	CLIP-seq
MIRT1387480	hsa-miR-205	CLIP-seq
MIRT1387481	hsa-miR-2052	CLIP-seq
MIRT2116106	hsa-miR-214	CLIP-seq
MIRT2632052	hsa-miR-2276	CLIP-seq
MIRT1387482	hsa-miR-2355-5p	CLIP-seq
MIRT1387518	hsa-miR-298	CLIP-seq
MIRT1387483	hsa-miR-3065-3p	CLIP-seq
MIRT2460520	hsa-miR-3126-5p	CLIP-seq
MIRT2116107	hsa-miR-3137	CLIP-seq
MIRT1387484	hsa-miR-3157-3p	CLIP-seq
MIRT2632053	hsa-miR-3173-5p	CLIP-seq
MIRT2632054	hsa-miR-3176	CLIP-seq
MIRT1387524	hsa-miR-3184	CLIP-seq
MIRT1387525	hsa-miR-3185	CLIP-seq
MIRT1387526	hsa-miR-3189-3p	CLIP-seq
MIRT2632055	hsa-miR-3607-3p	CLIP-seq
MIRT1387529	hsa-miR-3609	CLIP-seq
MIRT2116108	hsa-miR-3614-3p	CLIP-seq
MIRT1387485	hsa-miR-3614-5p	CLIP-seq
MIRT2116109	hsa-miR-3619-5p	CLIP-seq
MIRT2338535	hsa-miR-3649	CLIP-seq
MIRT2460521	hsa-miR-3664-5p	CLIP-seq
MIRT2632056	hsa-miR-3678-5p	CLIP-seq
MIRT2632057	hsa-miR-3686	CLIP-seq
MIRT1387531	hsa-miR-3690	CLIP-seq
MIRT1387486	hsa-miR-370	CLIP-seq
MIRT1387532	hsa-miR-3714	CLIP-seq
MIRT2632058	hsa-miR-378g	CLIP-seq
MIRT2460522	hsa-miR-3910	CLIP-seq
MIRT1387535	hsa-miR-3919	CLIP-seq
MIRT2632059	hsa-miR-3922-3p	CLIP-seq
MIRT1387536	hsa-miR-3943	CLIP-seq
MIRT1387537	hsa-miR-4254	CLIP-seq
MIRT1387487	hsa-miR-4261	CLIP-seq
MIRT1387538	hsa-miR-4264	CLIP-seq
MIRT2460523	hsa-miR-4266	CLIP-seq
MIRT1387539	hsa-miR-4270	CLIP-seq
MIRT1387488	hsa-miR-4287	CLIP-seq
MIRT1387541	hsa-miR-4311	CLIP-seq
MIRT1387543	hsa-miR-4323	CLIP-seq
MIRT2338536	hsa-miR-4423-3p	CLIP-seq
MIRT1387544	hsa-miR-4433	CLIP-seq
MIRT1387545	hsa-miR-4441	CLIP-seq
MIRT1387547	hsa-miR-4459	CLIP-seq
MIRT2460524	hsa-miR-4477a	CLIP-seq
MIRT1387548	hsa-miR-4492	CLIP-seq
MIRT1387489	hsa-miR-4496	CLIP-seq
MIRT1387549	hsa-miR-4498	CLIP-seq
MIRT2116110	hsa-miR-4530	CLIP-seq
MIRT2116111	hsa-miR-455-3p	CLIP-seq
MIRT2338537	hsa-miR-455-5p	CLIP-seq
MIRT1387552	hsa-miR-4656	CLIP-seq
MIRT2116112	hsa-miR-4668-3p	CLIP-seq
MIRT1387554	hsa-miR-4675	CLIP-seq
MIRT1387490	hsa-miR-4685-3p	CLIP-seq
MIRT2632060	hsa-miR-4685-5p	CLIP-seq
MIRT1387555	hsa-miR-4688	CLIP-seq
MIRT1387491	hsa-miR-4694-3p	CLIP-seq
MIRT1387556	hsa-miR-4695-5p	CLIP-seq
MIRT2632061	hsa-miR-4708-3p	CLIP-seq
MIRT2460525	hsa-miR-4714-5p	CLIP-seq
MIRT1387558	hsa-miR-4728-5p	CLIP-seq
MIRT1557123	hsa-miR-4729	CLIP-seq
MIRT2632062	hsa-miR-4731-5p	CLIP-seq
MIRT1387559	hsa-miR-4736	CLIP-seq
MIRT1387560	hsa-miR-4738-3p	CLIP-seq
MIRT1387561	hsa-miR-4739	CLIP-seq
MIRT1387562	hsa-miR-4741	CLIP-seq
MIRT2632063	hsa-miR-4745-3p	CLIP-seq
MIRT2116113	hsa-miR-4754	CLIP-seq
MIRT1387563	hsa-miR-4756-5p	CLIP-seq
MIRT1387492	hsa-miR-4757-5p	CLIP-seq
MIRT1387565	hsa-miR-4763-3p	CLIP-seq
MIRT1387493	hsa-miR-4763-5p	CLIP-seq
MIRT1387566	hsa-miR-4768-3p	CLIP-seq
MIRT2460526	hsa-miR-4779	CLIP-seq
MIRT1387568	hsa-miR-4796-3p	CLIP-seq
MIRT1387569	hsa-miR-4797-3p	CLIP-seq
MIRT2338538	hsa-miR-4797-5p	CLIP-seq
MIRT1387570	hsa-miR-4804-3p	CLIP-seq
MIRT1387494	hsa-miR-494	CLIP-seq
MIRT2460527	hsa-miR-506	CLIP-seq
MIRT1387495	hsa-miR-522	CLIP-seq
MIRT1387580	hsa-miR-541	CLIP-seq
MIRT1387581	hsa-miR-548ah	CLIP-seq
MIRT2338539	hsa-miR-548t	CLIP-seq
MIRT1387496	hsa-miR-549	CLIP-seq
MIRT1387497	hsa-miR-596	CLIP-seq
MIRT1387498	hsa-miR-628-5p	CLIP-seq
MIRT2116114	hsa-miR-645	CLIP-seq
MIRT1387585	hsa-miR-654-5p	CLIP-seq
MIRT1387586	hsa-miR-657	CLIP-seq
MIRT1387499	hsa-miR-668	CLIP-seq
MIRT2338540	hsa-miR-671-5p	CLIP-seq
MIRT1387588	hsa-miR-7	CLIP-seq
MIRT2116115	hsa-miR-759	CLIP-seq
MIRT2116116	hsa-miR-761	CLIP-seq
MIRT1387589	hsa-miR-762	CLIP-seq
MIRT1387590	hsa-miR-769-5p	CLIP-seq
MIRT2116117	hsa-miR-938	CLIP-seq
MIRT1387503	hsa-miR-1207-5p	CLIP-seq
MIRT2460517	hsa-miR-124	CLIP-seq
MIRT2460518	hsa-miR-1258	CLIP-seq
MIRT1387478	hsa-miR-135a	CLIP-seq
MIRT1387479	hsa-miR-135b	CLIP-seq
MIRT2632051	hsa-miR-1538	CLIP-seq
MIRT2460519	hsa-miR-154	CLIP-seq
MIRT2116105	hsa-miR-1910	CLIP-seq
MIRT1387512	hsa-miR-193a-3p	CLIP-seq
MIRT1387514	hsa-miR-193b	CLIP-seq
MIRT1387480	hsa-miR-205	CLIP-seq
MIRT1387481	hsa-miR-2052	CLIP-seq
MIRT2116106	hsa-miR-214	CLIP-seq
MIRT1387518	hsa-miR-298	CLIP-seq
MIRT2460520	hsa-miR-3126-5p	CLIP-seq
MIRT2116107	hsa-miR-3137	CLIP-seq
MIRT1387484	hsa-miR-3157-3p	CLIP-seq
MIRT1387524	hsa-miR-3184	CLIP-seq
MIRT1387525	hsa-miR-3185	CLIP-seq
MIRT1387529	hsa-miR-3609	CLIP-seq
MIRT2116108	hsa-miR-3614-3p	CLIP-seq
MIRT1387485	hsa-miR-3614-5p	CLIP-seq
MIRT2116109	hsa-miR-3619-5p	CLIP-seq
MIRT2338535	hsa-miR-3649	CLIP-seq
MIRT2632056	hsa-miR-3678-5p	CLIP-seq
MIRT1387531	hsa-miR-3690	CLIP-seq
MIRT1387532	hsa-miR-3714	CLIP-seq
MIRT2460522	hsa-miR-3910	CLIP-seq
MIRT1387535	hsa-miR-3919	CLIP-seq
MIRT1387537	hsa-miR-4254	CLIP-seq
MIRT1387538	hsa-miR-4264	CLIP-seq
MIRT2460523	hsa-miR-4266	CLIP-seq
MIRT1387539	hsa-miR-4270	CLIP-seq
MIRT1387488	hsa-miR-4287	CLIP-seq
MIRT1387541	hsa-miR-4311	CLIP-seq
MIRT1387545	hsa-miR-4441	CLIP-seq
MIRT2460524	hsa-miR-4477a	CLIP-seq
MIRT2116110	hsa-miR-4530	CLIP-seq
MIRT2116111	hsa-miR-455-3p	CLIP-seq
MIRT2116112	hsa-miR-4668-3p	CLIP-seq
MIRT1387490	hsa-miR-4685-3p	CLIP-seq
MIRT1387555	hsa-miR-4688	CLIP-seq
MIRT1387491	hsa-miR-4694-3p	CLIP-seq
MIRT1387556	hsa-miR-4695-5p	CLIP-seq
MIRT1557123	hsa-miR-4729	CLIP-seq
MIRT1387559	hsa-miR-4736	CLIP-seq
MIRT1387560	hsa-miR-4738-3p	CLIP-seq
MIRT2632063	hsa-miR-4745-3p	CLIP-seq
MIRT2116113	hsa-miR-4754	CLIP-seq
MIRT1387565	hsa-miR-4763-3p	CLIP-seq
MIRT2460526	hsa-miR-4779	CLIP-seq
MIRT1387568	hsa-miR-4796-3p	CLIP-seq
MIRT1387569	hsa-miR-4797-3p	CLIP-seq
MIRT2338538	hsa-miR-4797-5p	CLIP-seq
MIRT1387570	hsa-miR-4804-3p	CLIP-seq
MIRT2460527	hsa-miR-506	CLIP-seq
MIRT1387495	hsa-miR-522	CLIP-seq
MIRT1387580	hsa-miR-541	CLIP-seq
MIRT1387581	hsa-miR-548ah	CLIP-seq
MIRT2338539	hsa-miR-548t	CLIP-seq
MIRT1387496	hsa-miR-549	CLIP-seq
MIRT2116114	hsa-miR-645	CLIP-seq
MIRT1387585	hsa-miR-654-5p	CLIP-seq
MIRT1387586	hsa-miR-657	CLIP-seq
MIRT1387499	hsa-miR-668	CLIP-seq
MIRT2338540	hsa-miR-671-5p	CLIP-seq
MIRT1387588	hsa-miR-7	CLIP-seq
MIRT2116115	hsa-miR-759	CLIP-seq
MIRT2116116	hsa-miR-761	CLIP-seq
MIRT1387590	hsa-miR-769-5p	CLIP-seq
MIRT2116117	hsa-miR-938	CLIP-seq

Transcription factors

Show/Hide all(4)

Transcription factor	Regulation	Reference
ETS1	Unknown	9762895
NFKB1	Unknown	9762895
SP1	Unknown	9762895
SPDEF	Activation	12700667

Show/Hide all(129)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000407	Component	Phagophore assembly site	IEA
GO:0000422	Process	Autophagy of mitochondrion	NAS	20098416
GO:0000423	Process	Mitophagy	IBA
GO:0000423	Process	Mitophagy	IGI	20457763
GO:0000425	Process	Pexophagy	IDA	26344566
GO:0000932	Component	P-body	IDA	20357094
GO:0001659	Process	Temperature homeostasis	IEA
GO:0002376	Process	Immune system process	IEA
GO:0002931	Process	Response to ischemia	IEA
GO:0005080	Function	Protein kinase C binding	IBA
GO:0005080	Function	Protein kinase C binding	IEA
GO:0005080	Function	Protein kinase C binding	IPI	14676191
GO:0005515	Function	Protein binding	IPI	8618896, 8702753, 14676191, 16169070, 16189514, 16874300, 17389358, 17580304, 18083104, 19229298, 19250911, 19427866, 19615732, 20010802, 20168092, 20173742, 20357094, 20417604, 20452972, 20551902, 20562859, 20808283, 21149568, 21900206, 21988832, 22178386, 22190034, 22421968, 23274
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IC	31281713
GO:0005737	Component	Cytoplasm	IDA	20168092
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IEA
GO:0005764	Component	Lysosome	IEA
GO:0005768	Component	Endosome	IEA
GO:0005770	Component	Late endosome	IEA
GO:0005776	Component	Autophagosome	IDA	30612879, 37802024
GO:0005776	Component	Autophagosome	IDA	17580304, 19640926, 20168092, 22948227, 24954904
GO:0005776	Component	Autophagosome	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005829	Component	Cytosol	IDA	8650207
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS	8650207
GO:0006366	Process	Transcription by RNA polymerase II	IEA
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IDA	15572695
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	TAS	8702753
GO:0006606	Process	Protein import into nucleus	IEA
GO:0006914	Process	Autophagy	IDA	20452972
GO:0006914	Process	Autophagy	IEA
GO:0006914	Process	Autophagy	IMP	17580304
GO:0006914	Process	Autophagy	TAS	19816510
GO:0006915	Process	Apoptotic process	IEA
GO:0007032	Process	Endosome organization	IBA
GO:0007032	Process	Endosome organization	IDA	27368102
GO:0008104	Process	Intracellular protein localization	TAS	8650207
GO:0008270	Function	Zinc ion binding	IEA
GO:0010508	Process	Positive regulation of autophagy	IDA	28871090
GO:0010821	Process	Regulation of mitochondrion organization	NAS	20890124
GO:0016197	Process	Endosomal transport	TAS	12857745
GO:0016234	Component	Inclusion body	IDA	20168092
GO:0016234	Component	Inclusion body	IEA
GO:0016235	Component	Aggresome	IBA
GO:0016235	Component	Aggresome	IEA
GO:0016236	Process	Macroautophagy	IDA	27498865
GO:0016236	Process	Macroautophagy	IMP	20168092, 22622177
GO:0016236	Process	Macroautophagy	ISS
GO:0016605	Component	PML body	IDA	20168092
GO:0016605	Component	PML body	IEA
GO:0019899	Function	Enzyme binding	IPI	27368102
GO:0019901	Function	Protein kinase binding	IDA	8650207
GO:0030017	Component	Sarcomere	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0030163	Process	Protein catabolic process	IDA	36221902
GO:0030163	Process	Protein catabolic process	IDA	27498865, 30612879, 32715615, 36221902
GO:0030674	Function	Protein-macromolecule adaptor activity	IDA	26344566, 31857589, 34893540, 37802024
GO:0030674	Function	Protein-macromolecule adaptor activity	IEA
GO:0030971	Function	Receptor tyrosine kinase binding	TAS	8650207
GO:0031397	Process	Negative regulation of protein ubiquitination	IDA	20452972
GO:0031397	Process	Negative regulation of protein ubiquitination	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0031625	Function	Ubiquitin protein ligase binding	IDA	27368102
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	25127057, 27368102
GO:0033554	Process	Cellular response to stress	IDA	37802024
GO:0033554	Process	Cellular response to stress	IDA	17580304, 37802024
GO:0034142	Process	Toll-like receptor 4 signaling pathway	IDA	25371197
GO:0034144	Process	Negative regulation of toll-like receptor 4 signaling pathway	IDA	31281713
GO:0035255	Function	Ionotropic glutamate receptor binding	IEA
GO:0035255	Function	Ionotropic glutamate receptor binding	ISS
GO:0035556	Process	Intracellular signal transduction	TAS	8650207
GO:0035973	Process	Aggrephagy	IBA
GO:0035973	Process	Aggrephagy	IDA	17580304
GO:0035973	Process	Aggrephagy	IDA	17580304, 22017874, 29343546, 29507397, 31857589, 37306101, 37802024
GO:0035973	Process	Aggrephagy	IEA
GO:0035973	Process	Aggrephagy	IPI	28404643
GO:0038023	Function	Signaling receptor activity	IDA	28871090
GO:0042169	Function	SH2 domain binding	IDA	8650207
GO:0042802	Function	Identical protein binding	IEA
GO:0042802	Function	Identical protein binding	IPI	16169070, 20562859, 21900206, 25416956, 25686248, 32296183
GO:0043065	Process	Positive regulation of apoptotic process	TAS
GO:0043122	Process	Regulation of canonical NF-kappaB signal transduction	IMP	12857745
GO:0043130	Function	Ubiquitin binding	IDA	12857745
GO:0043130	Function	Ubiquitin binding	TAS
GO:0043232	Component	Intracellular membraneless organelle	IDA	22017874, 29343546, 29507397, 31857589, 37802024
GO:0043232	Component	Intracellular membraneless organelle	IEA
GO:0044753	Component	Amphisome	IBA
GO:0044753	Component	Amphisome	IDA	19640926
GO:0044754	Component	Autolysosome	IDA	19640926
GO:0044754	Component	Autolysosome	IEA
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0045202	Component	Synapse	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	TAS	12857745
GO:0046578	Process	Regulation of Ras protein signal transduction	NAS	8618896
GO:0046872	Function	Metal ion binding	IEA
GO:0061635	Process	Regulation of protein complex stability	IDA	25127057
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0070342	Process	Brown fat cell proliferation	IEA
GO:0070530	Function	K63-linked polyubiquitin modification-dependent protein binding	IBA
GO:0070530	Function	K63-linked polyubiquitin modification-dependent protein binding	IDA	28404643, 29343546
GO:0070530	Function	K63-linked polyubiquitin modification-dependent protein binding	IEA
GO:0070534	Process	Protein K63-linked ubiquitination	IDA	33799071
GO:0071211	Process	Protein targeting to vacuole involved in autophagy	IDA	37802024
GO:0071211	Process	Protein targeting to vacuole involved in autophagy	IDA	27498865, 34893540, 36221902, 37802024
GO:0097009	Process	Energy homeostasis	IEA
GO:0097225	Component	Sperm midpiece	IEA
GO:0097413	Component	Lewy body	IEA
GO:0098780	Process	Response to mitochondrial depolarisation	IGI	20457763
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0110076	Process	Negative regulation of ferroptosis	IMP	26403645
GO:0140036	Function	Ubiquitin-modified protein reader activity	IDA	22017874, 27498865, 31857589, 34893540, 36221902
GO:0140036	Function	Ubiquitin-modified protein reader activity	IEA
GO:0140311	Function	Protein sequestering activity	IDA	37306101
GO:0140313	Function	Molecular sequestering activity	IDA	31281713
GO:0140693	Function	Molecular condensate scaffold activity	IDA	29343546, 29507397, 31857589, 37306101, 37802024
GO:0140693	Function	Molecular condensate scaffold activity	IEA
GO:0140694	Process	Membraneless organelle assembly	IDA	29343546, 29507397, 31857589, 37802024
GO:0140694	Process	Membraneless organelle assembly	IEA
GO:1900273	Process	Positive regulation of long-term synaptic potentiation	IEA
GO:1900273	Process	Positive regulation of long-term synaptic potentiation	ISS
GO:1903078	Process	Positive regulation of protein localization to plasma membrane	IEA
GO:1903078	Process	Positive regulation of protein localization to plasma membrane	ISS
GO:1905719	Process	Protein localization to perinuclear region of cytoplasm	IDA	27368102

MIM	HGNC	e!Ensembl
601530	11280	ENSG00000161011

Protein

UniProt ID

Q13501

Protein name

Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62)

Protein function

Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:2201787

PDB

1Q02 , 2JY7 , 2JY8 , 2K0B , 2KNV , 4MJS , 4UF8 , 4UF9 , 5YP7 , 5YP8 , 5YPA , 5YPB , 5YPC , 5YPE , 5YPF , 5YPG , 5YPH , 6JM4 , 6KHZ , 6MJ7 , 6TGY , 6TH3 , 7R1O

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00564	PB1	21 → 102	PB1 domain	Domain
PF00569	ZZ	122 → 165	Zinc finger, ZZ type	Domain
PF16577	UBA_5	379 → 440	UBA domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed. {ECO:0000269|PubMed:8650207}.

Sequence

MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRP
GGFQAHYRDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPPCAQEAPRN
MVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNV
GESVAAALSPLGIEVDIDVEHGGKRSRLTPVSPESSSTEEKSSSQPSSCCSDPSKPGGNV
EGATQSLAEQMRKIALESEGRPEEQMESDNCSGGDDDWTHLSSKEVDPSTGELQSLQMPE
SEGPSSLDPSQEGPTGLKEAALYPHLPPEADPRLIESLSQMLSMGFSDEGGWLTRLLQTK
NYDIGAALDTIQYSKHPPPL

Sequence length

440

Interactions

View interactions

	KEGG		Reactome
	Mitophagy - animal Autophagy - animal Necroptosis Cellular senescence Osteoclast differentiation Amyotrophic lateral sclerosis Pathways of neurodegeneration - multiple diseases Shigellosis Fluid shear stress and atherosclerosis		NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival Pink/Parkin Mediated Mitophagy Interleukin-1 signaling Pexophagy

Show/Hide Causal Diseases (2)

Disease merge term	Disease name	dbSNP ID	References
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Neurodegeneration With Ataxia, Dystonia, And Gaze Palsy	neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset	rs886039780, rs886039781, rs886039782	N/A
Paget disease	paget disease of bone 3	rs796051869, rs796051870, rs796052213	N/A

Show/Hide Unknown Diseases (4)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Amyotrophic Lateral Sclerosis	amyotrophic lateral sclerosis	N/A	N/A	GenCC, ClinVar
Behavioral Variant Of Frontotemporal Dementia	behavioral variant of frontotemporal dementia	N/A	N/A	GenCC
Frontotemporal Dementia With Motor Neuron Disease	frontotemporal dementia with motor neuron disease	N/A	N/A	GenCC
Frontotemporal Dementia With Or Without Amyotrophic Lateral Sclerosis	frontotemporal dementia and/or amyotrophic lateral sclerosis 3	N/A	N/A	ClinVar

Show/Hide Text Mining Associations (157)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma	Associate	28544335
Adenocarcinoma	Stimulate	29383752
Adenoma	Associate	28544335
Adrenocortical Carcinoma	Associate	36292980
Alzheimer Disease	Inhibit	19481605
Alzheimer Disease	Associate	25796131, 36516243
Alzheimer Disease	Stimulate	28984607
Amyotrophic Lateral Sclerosis	Associate	22972638, 23942205, 24042580, 25114083, 25681989, 25700176, 26208961, 27156075, 27163810, 27318084, 27545679, 28490746, 29653597, 30514811, 31362587 View all (9 more)
Amyotrophic lateral sclerosis 1	Associate	23942205
Apraxias	Associate	25114083
Ataxia	Associate	27545679, 34130600
Atherosclerosis	Associate	34360560
Atrophy	Associate	27163810
Autism Spectrum Disorder	Associate	33159718
Bipolar Disorder	Inhibit	30575805
Bone Diseases	Associate	17129171, 17187080
Bone Diseases Metabolic	Associate	29148034
Bone Neoplasms	Associate	31991009
Bone Resorption	Associate	12857745
Brain Diseases	Associate	34130600
Breast Neoplasms	Associate	23026799, 28855742, 30653426, 31311202, 33213267, 35436939
Calcinosis Cutis	Associate	35436939
Carcinogenesis	Stimulate	26743088
Carcinogenesis	Associate	28498503, 30281815
Carcinoma Hepatocellular	Associate	24287900, 32807131, 33712023, 34691238, 34921137, 35892599, 36028814, 36231045, 36292980
Carcinoma Merkel Cell	Associate	31180579
Carcinoma Non Small Cell Lung	Associate	27250032, 35713446
Carcinoma Ovarian Epithelial	Stimulate	28498503
Carcinoma Pancreatic Ductal	Associate	31177911, 35354432
Carcinoma Renal Cell	Associate	31959887
Carcinoma Squamous Cell	Associate	24618016, 31221127
Carcinoma Squamous Cell	Inhibit	30653445
Cardiomyopathies	Associate	33605084
CD59 Deficiency	Associate	31376301
Chediak Higashi Syndrome	Associate	34130600
Chromosomal Instability	Associate	39208097
Cognition Disorders	Associate	27545679
Colonic Neoplasms	Associate	36127676
Colorectal Neoplasms	Associate	20930850, 22652752, 27444698, 28544335, 32342935, 33076720, 39208097
Crohn Disease	Associate	33973626
Death	Associate	26713335, 35354432
Demyelinating Diseases	Associate	36622429
Diabetes Mellitus	Associate	29518789
Diffuse Lewy Body Disease with Gaze Palsy	Associate	27545679
Distal Myopathies	Associate	26208961, 30514811
Distal myopathy Nonaka type	Associate	26208961
Drug Related Side Effects and Adverse Reactions	Associate	30067838, 7797464
Dysarthria	Associate	27545679
Dystonia	Associate	27545679
Familial Paget's disease of bone	Associate	14584883, 15176995, 17181397, 17187080
Fibrous Dysplasia Polyostotic	Associate	16277682, 21987421
Fractures Bone	Associate	20499339, 31991009
Fragile X Tremor Ataxia Syndrome	Associate	31481131
Frontotemporal Dementia	Associate	19481605, 24042580, 25114083, 26208961, 27163810, 27545679, 27632209, 28490746, 30514811, 33891871, 34130600, 35964197, 37243816
Frontotemporal Lobar Degeneration	Associate	22972638, 27163810, 27554286, 31362587
Gait Disorders Neurologic	Associate	27545679
Gastrointestinal Neoplasms	Associate	34484469
Gaucher Disease	Associate	34130600
Gerstmann Straussler Scheinker Disease	Associate	34130600
Glaucoma	Associate	27275741
Glioblastoma	Associate	30718520
Glioma	Associate	24039914, 38203743
Glycogen Storage Disease	Associate	34130600
Hereditary Breast and Ovarian Cancer Syndrome	Associate	12368243
Heredodegenerative Disorders Nervous System	Associate	32233732
Herpes Simplex	Associate	31375597
Histiocytoma	Associate	29747676
Histiocytoma Benign Fibrous	Associate	29327718
HIV Infections	Associate	30344003, 30653393, 30746609
HTLV I Infections	Associate	29962265, 31142734
Huntington Disease	Associate	34130600, 36971475
Hyperostosis corticalis deformans juvenilis	Associate	15125799, 17181397, 17187080, 19589897, 23658060, 32176830, 32978683, 35241069
Hypoxia	Inhibit	24200883, 36481701
Hypoxia Brain	Inhibit	26553068, 36481701
Infections	Associate	35891458
Inflammation	Associate	29148034, 30746609, 31824497, 36361795
Inflammatory Breast Neoplasms	Associate	30514811
Intellectual Disability	Associate	28539120
Kidney Neoplasms	Associate	26743088, 31810986
Leiomyoma	Associate	31843092
Leukemia	Associate	22898604, 27613868, 30563411
Leukemia Lymphocytic Chronic B Cell	Associate	23537217, 31992855
Leukemia Myeloid Acute	Associate	25034783, 39519080, 39702290
Leukemia Myeloid Acute	Inhibit	30563411
Leukoencephalopathies	Associate	27163810
Light Fixation Seizure Syndrome	Associate	27085974
Livedoid Vasculopathy	Associate	27163810
Liver Diseases	Associate	36055749
Liver Neoplasms	Associate	27158844
Lung Diseases	Associate	26565381
Lung Neoplasms	Associate	22412944, 26553068, 28183697, 30697967
Lymphatic Metastasis	Associate	35713446
Lymphoma Non Hodgkin	Associate	23537217
Lymphoma Non Hodgkin	Stimulate	38203743
Lymphoma Primary Effusion	Associate	30586869
Lysosomal Storage Diseases	Associate	19787053
Macular Degeneration	Associate	29576851, 33172148
Malignant mesenchymal tumor	Associate	35149769
Melanoma	Associate	24553345, 29212029
Mental Disorders	Associate	25114083
Mesothelioma	Associate	36292980
Migraine Disorders	Associate	32233732
Mitochondrial Diseases	Associate	27545679, 29938581
Mouth Neoplasms	Associate	22882088
Multiple Acyl Coenzyme A Dehydrogenase Deficiency	Associate	27085974
Multiple Myeloma	Associate	26043024, 26109433, 27626179
Muscular Diseases	Associate	31376301
Muscular Disorders Atrophic	Associate	27085974
Myopathy with Giant Abnormal Mitochondria	Associate	26509433
Myositis Inclusion Body	Associate	27594680, 29653597
Nasopharyngeal Carcinoma	Associate	27145374, 30459351
Neoplasm Metastasis	Associate	28544335, 29383752
Neoplasms	Stimulate	20018885
Neoplasms	Associate	20441585, 23192274, 24039914, 24553345, 24599075, 24618016, 24655592, 26020424, 26553068, 26743088, 27250032, 27345151, 27444698, 27466985, 28880214 View all (16 more)
Neoplasms	Inhibit	31180579
Neoplasms Cystic Mucinous and Serous	Associate	28455291
Nervous System Diseases	Associate	30669930
Neuroblastoma	Associate	19787053, 26509433
Neurodegenerative Diseases	Associate	17580304, 19481605, 23922739, 26008206, 27545679, 27594680, 30827875, 31362587, 31824497, 33891871, 34130600, 34987184, 35355568
Neurologic Manifestations	Associate	25114083, 32233732
Neuronal Ceroid Lipofuscinoses	Associate	34130600
Neurotoxicity Syndromes	Associate	31362587, 36527420
Neutropenia Nonimmune Chronic Idiopathic Adult	Associate	31841566
Niemann Pick Disease Type A	Associate	34130600
Non alcoholic Fatty Liver Disease	Associate	36055749
Osteitis Deformans	Associate	11473345, 11992264, 12857745, 14584883, 15125799, 15176995, 15312251, 15647816, 15765181, 16277682, 17129171, 17229007, 17907922, 19016598, 19049332 View all (32 more)
Osteoarthritis	Associate	28801211
Osteosarcoma	Associate	19016598, 32054506
Ovarian Neoplasms	Associate	28455291, 28498503, 29410485, 30081720, 30941888, 36328147
Pancreatic Neoplasms	Associate	30782064, 35354432, 36835048
Parkinson Disease	Associate	34130600
Personality Disorders	Associate	24655592, 27250032
Pigmentation Disorders	Associate	33591357
Polycystic Ovary Syndrome	Inhibit	31056990
Progeria	Associate	28229933
Prostatic Neoplasms	Associate	24655592, 25103771, 29383752, 34987184, 35438056
Prostatic Neoplasms	Stimulate	26423274
Protein Aggregation Pathological	Associate	12857745
Protein Deficiency	Associate	20018885
Pulmonary Disease Chronic Obstructive	Associate	38110986
Purpura Thrombocytopenic Idiopathic	Associate	33140452
Reperfusion Injury	Associate	28334711
Retinoblastoma	Associate	27466985
Seizures	Associate	32233732
Spastic paraplegia 11 autosomal recessive	Associate	30081747
Spastic paraplegia 15 autosomal recessive	Associate	30081747
Spastic Paraplegia Hereditary	Associate	30081747
Spinal Stenosis	Associate	26713335
Squamous Cell Carcinoma of Head and Neck	Associate	22882088, 24599075, 24983366, 25338734, 33318468, 34830108
Stomach Neoplasms	Associate	28109268, 29989092
Systemic carnitine deficiency	Associate	27085974
Thyroid Cancer Papillary	Associate	28507274, 35713446, 37175943
Thyroid Neoplasms	Associate	32457407, 32737449
Tuberculosis Meningeal	Associate	30586869
Vacuolar myopathy	Associate	26208961
Vitiligo	Associate	35406685
Zellweger Syndrome	Associate	17129171, 21987421

SQSTM1 (sequestosome 1)