Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	8872
Gene name Gene Name - the full gene name approved by the HGNC.	Cell division cycle 123
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CDC123
Synonyms (NCBI Gene) Gene synonyms aliases	C10orf7, D123
Chromosome Chromosome number	10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	10p14-p13

Show/Hide all(67)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020104	hsa-miR-361-5p	Sequencing	20371350
MIRT027249	hsa-miR-101-3p	Sequencing	20371350
MIRT028390	hsa-miR-30a-5p	Proteomics	18668040
MIRT031400	hsa-miR-16-5p	Proteomics	18668040
MIRT043215	hsa-miR-324-5p	CLASH	23622248
MIRT039270	hsa-miR-671-5p	CLASH	23622248
MIRT036838	hsa-miR-877-3p	CLASH	23622248
MIRT036838	hsa-miR-877-3p	CLASH	23622248
MIRT036407	hsa-miR-1227-3p	CLASH	23622248
MIRT876762	hsa-miR-1257	CLIP-seq
MIRT876763	hsa-miR-125a-3p	CLIP-seq
MIRT876764	hsa-miR-1468	CLIP-seq
MIRT876765	hsa-miR-1470	CLIP-seq
MIRT876766	hsa-miR-2114	CLIP-seq
MIRT876767	hsa-miR-2355-5p	CLIP-seq
MIRT876768	hsa-miR-2964a-5p	CLIP-seq
MIRT876769	hsa-miR-3156-5p	CLIP-seq
MIRT876770	hsa-miR-3679-3p	CLIP-seq
MIRT876771	hsa-miR-4446-5p	CLIP-seq
MIRT876772	hsa-miR-4667-3p	CLIP-seq
MIRT876773	hsa-miR-4726-3p	CLIP-seq
MIRT876774	hsa-miR-4795-3p	CLIP-seq
MIRT876775	hsa-miR-4796-3p	CLIP-seq
MIRT876776	hsa-miR-548p	CLIP-seq
MIRT876777	hsa-miR-548t	CLIP-seq
MIRT876778	hsa-miR-562	CLIP-seq
MIRT876762	hsa-miR-1257	CLIP-seq
MIRT876763	hsa-miR-125a-3p	CLIP-seq
MIRT876764	hsa-miR-1468	CLIP-seq
MIRT876765	hsa-miR-1470	CLIP-seq
MIRT876766	hsa-miR-2114	CLIP-seq
MIRT876767	hsa-miR-2355-5p	CLIP-seq
MIRT876770	hsa-miR-3679-3p	CLIP-seq
MIRT1959802	hsa-miR-376a	CLIP-seq
MIRT1959803	hsa-miR-376b	CLIP-seq
MIRT1959804	hsa-miR-4422	CLIP-seq
MIRT876771	hsa-miR-4446-5p	CLIP-seq
MIRT876772	hsa-miR-4667-3p	CLIP-seq
MIRT876773	hsa-miR-4726-3p	CLIP-seq
MIRT876774	hsa-miR-4795-3p	CLIP-seq
MIRT876776	hsa-miR-548p	CLIP-seq
MIRT876778	hsa-miR-562	CLIP-seq
MIRT876762	hsa-miR-1257	CLIP-seq
MIRT876763	hsa-miR-125a-3p	CLIP-seq
MIRT2196849	hsa-miR-145	CLIP-seq
MIRT876764	hsa-miR-1468	CLIP-seq
MIRT876765	hsa-miR-1470	CLIP-seq
MIRT876766	hsa-miR-2114	CLIP-seq
MIRT876767	hsa-miR-2355-5p	CLIP-seq
MIRT876768	hsa-miR-2964a-5p	CLIP-seq
MIRT2196850	hsa-miR-3163	CLIP-seq
MIRT876770	hsa-miR-3679-3p	CLIP-seq
MIRT2196851	hsa-miR-3925-3p	CLIP-seq
MIRT2196852	hsa-miR-423-3p	CLIP-seq
MIRT876771	hsa-miR-4446-5p	CLIP-seq
MIRT876772	hsa-miR-4667-3p	CLIP-seq
MIRT2196853	hsa-miR-4712-5p	CLIP-seq
MIRT876773	hsa-miR-4726-3p	CLIP-seq
MIRT876774	hsa-miR-4795-3p	CLIP-seq
MIRT876775	hsa-miR-4796-3p	CLIP-seq
MIRT2196854	hsa-miR-515-5p	CLIP-seq
MIRT876776	hsa-miR-548p	CLIP-seq
MIRT876777	hsa-miR-548t	CLIP-seq
MIRT2196855	hsa-miR-574-3p	CLIP-seq
MIRT2196856	hsa-miR-766	CLIP-seq
MIRT2196857	hsa-miR-770-5p	CLIP-seq
MIRT2196858	hsa-miR-942	CLIP-seq

Show/Hide all(13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000287	Function	Magnesium ion binding	IDA	37507029
GO:0005515	Function	Protein binding	IPI	28514442, 33961781, 35271311, 37507029
GO:0005524	Function	ATP binding	IDA	37507029
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	10942595
GO:0005737	Component	Cytoplasm	IEA
GO:0006457	Process	Protein folding	IEA
GO:0044183	Function	Protein folding chaperone	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:1905143	Process	Eukaryotic translation initiation factor 2 complex assembly	IDA	37507029
GO:1905143	Process	Eukaryotic translation initiation factor 2 complex assembly	IMP	37507029

MIM	HGNC	e!Ensembl
617708	16827	ENSG00000151465

Protein

UniProt ID

O75794

Protein name

Translation initiation factor eIF2 assembly protein (Cell division cycle protein 123 homolog) (Protein D123) (HT-1080) (PZ32)

Protein function

ATP-dependent protein-folding chaperone for the eIF2 complex (PubMed:35031321, PubMed:37507029). Binds to the gamma subunit of the eIF2 complex which allows the subunit to assemble with the alpha and beta subunits (By similarity). {ECO:0000250|U

PDB

8PHD , 8PHV

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07065	D123	14 → 314	D123	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes with the highest expression in testis. {ECO:0000269|PubMed:9683532}.

Sequence

MKKEHVLHCQFSAWYPFFRGVTIKSVILPLPQNVKDYLLDDGTLVVSGRDDPPTHSQPDS
DDEAEEIQWSDDENTATLTAPEFPEFATKVQEAINSLGGSVFPKLNWSAPRDAYWIAMNS
SLKCKTLSDIFLLFKSSDFITRDFTQPFIHCTDDSPDPCIEYELVLRKWCELIPGAEFRC
FVKENKLIGISQRDYTQYYDHISKQKEEIRRCIQDFFKKHIQYKFLDEDFVFDIYRDSRG
KVWLIDFNPFGEVTDSLLFTWEELISENNLNGDFSEVDAQEQDSPAFRCTNSEVTVQPSP
YLSYRLPKDFVDLSTGEDAHKLIDFLKLKRNQQEDD

Sequence length

336

Interactions

View interactions

Show/Hide Unknown Diseases (3)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Coronary artery disease	Coronary artery disease	N/A	N/A	GWAS
Diabetes	Type 2 diabetes (PheCode 250.2), Type 2 diabetes, Type 2 diabetes mellitus adjusted for BMI or coronary artery disease (pleiotropy), Circulating leptin levels or type 2 diabetes, Childhood onset type 2 diabetes, Body fat percentage and type 2 diabetes (pairwise), Type ii diabetes, Type 2 diabetes (adjusted for BMI), Type 2 diabetes with neurological manifestations (PheCode 250.24), Type 2 diabetes with ophthalmic manifestations (PheCode 250.23)	N/A	N/A	GWAS
Myocardial Infarction	Myocardial infarction	N/A	N/A	GWAS

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Diabetes Mellitus	Associate	18567820, 19833888, 24135527, 33479058
Diabetes Mellitus Type 2	Associate	18567820, 19833888, 22923468, 22961080, 24637646, 27281091, 29412141, 33706321
Glaucoma Open Angle	Associate	9497264
Obesity	Associate	18567820

CDC123 (cell division cycle 123)