Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	8863
Gene name	Period circadian regulator 3
Gene symbol	PER3
Synonyms (NCBI Gene)	FASPS3GIG13
Chromosome	1
Chromosome location	1p36.23
Summary	This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomoto

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SNP ID	Visualize variation	Clinical significance	Consequence
rs139315125	A>G	Pathogenic	5 prime UTR variant, missense variant, coding sequence variant
rs150812083	C>G	Pathogenic	Missense variant, 5 prime UTR variant, coding sequence variant
rs1558401132	CTTGC>-	Likely-pathogenic	Frameshift variant, 5 prime UTR variant, coding sequence variant

390

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miRTarBase ID	miRNA	Experiments	Reference
MIRT029909	hsa-miR-26b-5p	Microarray	19088304
MIRT030960	hsa-miR-21-5p	Microarray	18591254
MIRT487823	hsa-miR-320e	PAR-CLIP	23592263
MIRT487822	hsa-miR-3943	PAR-CLIP	23592263
MIRT487821	hsa-miR-6795-3p	PAR-CLIP	23592263
MIRT487819	hsa-miR-4787-5p	PAR-CLIP	23592263
MIRT487820	hsa-miR-4667-5p	PAR-CLIP	23592263
MIRT487818	hsa-miR-4700-5p	PAR-CLIP	23592263
MIRT487817	hsa-miR-8089	PAR-CLIP	23592263
MIRT487816	hsa-miR-1225-3p	PAR-CLIP	23592263
MIRT487815	hsa-miR-4313	PAR-CLIP	23592263
MIRT487814	hsa-miR-4731-5p	PAR-CLIP	23592263
MIRT487813	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT487811	hsa-miR-8085	PAR-CLIP	23592263
MIRT487812	hsa-miR-3175	PAR-CLIP	23592263
MIRT487810	hsa-miR-1343-5p	PAR-CLIP	23592263
MIRT487809	hsa-miR-939-5p	PAR-CLIP	23592263
MIRT487808	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT487807	hsa-miR-328-5p	PAR-CLIP	23592263
MIRT487806	hsa-miR-6885-5p	PAR-CLIP	23592263
MIRT487805	hsa-miR-3150a-3p	PAR-CLIP	23592263
MIRT487804	hsa-miR-6763-5p	PAR-CLIP	23592263
MIRT440003	hsa-miR-154-5p	HITS-CLIP	24374217
MIRT440002	hsa-miR-377-3p	HITS-CLIP	24374217
MIRT440003	hsa-miR-154-5p	HITS-CLIP	24374217
MIRT440002	hsa-miR-377-3p	HITS-CLIP	24374217
MIRT487816	hsa-miR-1225-3p	PAR-CLIP	26701625
MIRT487816	hsa-miR-1225-3p	PAR-CLIP	26701625
MIRT487810	hsa-miR-1343-5p	PAR-CLIP	26701625
MIRT487810	hsa-miR-1343-5p	PAR-CLIP	26701625
MIRT487805	hsa-miR-3150a-3p	PAR-CLIP	26701625
MIRT487805	hsa-miR-3150a-3p	PAR-CLIP	26701625
MIRT487812	hsa-miR-3175	PAR-CLIP	26701625
MIRT487812	hsa-miR-3175	PAR-CLIP	26701625
MIRT487807	hsa-miR-328-5p	PAR-CLIP	26701625
MIRT487807	hsa-miR-328-5p	PAR-CLIP	26701625
MIRT487822	hsa-miR-3943	PAR-CLIP	26701625
MIRT487822	hsa-miR-3943	PAR-CLIP	26701625
MIRT487815	hsa-miR-4313	PAR-CLIP	26701625
MIRT487815	hsa-miR-4313	PAR-CLIP	26701625
MIRT487820	hsa-miR-4667-5p	PAR-CLIP	26701625
MIRT487820	hsa-miR-4667-5p	PAR-CLIP	26701625
MIRT487818	hsa-miR-4700-5p	PAR-CLIP	26701625
MIRT487818	hsa-miR-4700-5p	PAR-CLIP	26701625
MIRT487814	hsa-miR-4731-5p	PAR-CLIP	26701625
MIRT487814	hsa-miR-4731-5p	PAR-CLIP	26701625
MIRT487819	hsa-miR-4787-5p	PAR-CLIP	26701625
MIRT487819	hsa-miR-4787-5p	PAR-CLIP	26701625
MIRT487813	hsa-miR-6731-5p	PAR-CLIP	26701625
MIRT487813	hsa-miR-6731-5p	PAR-CLIP	26701625
MIRT487804	hsa-miR-6763-5p	PAR-CLIP	26701625
MIRT487804	hsa-miR-6763-5p	PAR-CLIP	26701625
MIRT487821	hsa-miR-6795-3p	PAR-CLIP	26701625
MIRT487821	hsa-miR-6795-3p	PAR-CLIP	26701625
MIRT487808	hsa-miR-6825-5p	PAR-CLIP	26701625
MIRT487808	hsa-miR-6825-5p	PAR-CLIP	26701625
MIRT487806	hsa-miR-6885-5p	PAR-CLIP	26701625
MIRT487806	hsa-miR-6885-5p	PAR-CLIP	26701625
MIRT487811	hsa-miR-8085	PAR-CLIP	26701625
MIRT487811	hsa-miR-8085	PAR-CLIP	26701625
MIRT487817	hsa-miR-8089	PAR-CLIP	26701625
MIRT487817	hsa-miR-8089	PAR-CLIP	26701625
MIRT487809	hsa-miR-939-5p	PAR-CLIP	26701625
MIRT487809	hsa-miR-939-5p	PAR-CLIP	26701625
MIRT487823	hsa-miR-320e	PAR-CLIP	23592263
MIRT487822	hsa-miR-3943	PAR-CLIP	23592263
MIRT487821	hsa-miR-6795-3p	PAR-CLIP	23592263
MIRT487819	hsa-miR-4787-5p	PAR-CLIP	23592263
MIRT487820	hsa-miR-4667-5p	PAR-CLIP	23592263
MIRT487818	hsa-miR-4700-5p	PAR-CLIP	23592263
MIRT487817	hsa-miR-8089	PAR-CLIP	23592263
MIRT487816	hsa-miR-1225-3p	PAR-CLIP	23592263
MIRT487815	hsa-miR-4313	PAR-CLIP	23592263
MIRT487814	hsa-miR-4731-5p	PAR-CLIP	23592263
MIRT487813	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT487811	hsa-miR-8085	PAR-CLIP	23592263
MIRT487812	hsa-miR-3175	PAR-CLIP	23592263
MIRT487810	hsa-miR-1343-5p	PAR-CLIP	23592263
MIRT487809	hsa-miR-939-5p	PAR-CLIP	23592263
MIRT487808	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT487807	hsa-miR-328-5p	PAR-CLIP	23592263
MIRT487806	hsa-miR-6885-5p	PAR-CLIP	23592263
MIRT487805	hsa-miR-3150a-3p	PAR-CLIP	23592263
MIRT487804	hsa-miR-6763-5p	PAR-CLIP	23592263
MIRT1225121	hsa-miR-1	CLIP-seq
MIRT1225122	hsa-miR-10a	CLIP-seq
MIRT1225123	hsa-miR-10b	CLIP-seq
MIRT1225124	hsa-miR-1205	CLIP-seq
MIRT1225125	hsa-miR-1254	CLIP-seq
MIRT1225126	hsa-miR-1283	CLIP-seq
MIRT1225127	hsa-miR-1286	CLIP-seq
MIRT1225128	hsa-miR-134	CLIP-seq
MIRT1225129	hsa-miR-181a	CLIP-seq
MIRT1225130	hsa-miR-181b	CLIP-seq
MIRT1225131	hsa-miR-181c	CLIP-seq
MIRT1225132	hsa-miR-181d	CLIP-seq
MIRT1225133	hsa-miR-193a-3p	CLIP-seq
MIRT1225134	hsa-miR-193b	CLIP-seq
MIRT1225135	hsa-miR-206	CLIP-seq
MIRT1225136	hsa-miR-3064-5p	CLIP-seq
MIRT1225137	hsa-miR-3116	CLIP-seq
MIRT1225138	hsa-miR-3118	CLIP-seq
MIRT1225139	hsa-miR-3131	CLIP-seq
MIRT1225140	hsa-miR-3134	CLIP-seq
MIRT1225141	hsa-miR-3136-5p	CLIP-seq
MIRT1225142	hsa-miR-3143	CLIP-seq
MIRT1225143	hsa-miR-3153	CLIP-seq
MIRT1225144	hsa-miR-3652	CLIP-seq
MIRT1225145	hsa-miR-3662	CLIP-seq
MIRT1225146	hsa-miR-3690	CLIP-seq
MIRT1225147	hsa-miR-377	CLIP-seq
MIRT1225148	hsa-miR-378g	CLIP-seq
MIRT1225149	hsa-miR-3936	CLIP-seq
MIRT1225150	hsa-miR-4262	CLIP-seq
MIRT1225151	hsa-miR-4265	CLIP-seq
MIRT1225152	hsa-miR-4272	CLIP-seq
MIRT1225153	hsa-miR-4296	CLIP-seq
MIRT1225154	hsa-miR-4322	CLIP-seq
MIRT1225155	hsa-miR-4417	CLIP-seq
MIRT1225156	hsa-miR-4430	CLIP-seq
MIRT1225157	hsa-miR-4437	CLIP-seq
MIRT1225158	hsa-miR-4439	CLIP-seq
MIRT1225159	hsa-miR-4496	CLIP-seq
MIRT1225160	hsa-miR-4505	CLIP-seq
MIRT1225161	hsa-miR-4513	CLIP-seq
MIRT1225162	hsa-miR-4521	CLIP-seq
MIRT1225163	hsa-miR-4534	CLIP-seq
MIRT1225164	hsa-miR-4649-5p	CLIP-seq
MIRT1225165	hsa-miR-4668-5p	CLIP-seq
MIRT1225166	hsa-miR-4674	CLIP-seq
MIRT1225167	hsa-miR-4722-5p	CLIP-seq
MIRT1225168	hsa-miR-4725-5p	CLIP-seq
MIRT1225169	hsa-miR-494	CLIP-seq
MIRT1225170	hsa-miR-504	CLIP-seq
MIRT1225171	hsa-miR-520d-5p	CLIP-seq
MIRT1225172	hsa-miR-524-5p	CLIP-seq
MIRT1225173	hsa-miR-539	CLIP-seq
MIRT1225174	hsa-miR-543	CLIP-seq
MIRT1225175	hsa-miR-548c-3p	CLIP-seq
MIRT1225176	hsa-miR-549	CLIP-seq
MIRT1225177	hsa-miR-596	CLIP-seq
MIRT1225178	hsa-miR-611	CLIP-seq
MIRT1225179	hsa-miR-613	CLIP-seq
MIRT1225180	hsa-miR-889	CLIP-seq
MIRT1225181	hsa-miR-892b	CLIP-seq
MIRT2065647	hsa-miR-1185	CLIP-seq
MIRT2065648	hsa-miR-1193	CLIP-seq
MIRT2065649	hsa-miR-1225-5p	CLIP-seq
MIRT2065650	hsa-miR-1255a	CLIP-seq
MIRT2065651	hsa-miR-1255b	CLIP-seq
MIRT1225126	hsa-miR-1283	CLIP-seq
MIRT2065652	hsa-miR-1297	CLIP-seq
MIRT1225129	hsa-miR-181a	CLIP-seq
MIRT1225130	hsa-miR-181b	CLIP-seq
MIRT1225131	hsa-miR-181c	CLIP-seq
MIRT1225132	hsa-miR-181d	CLIP-seq
MIRT2065653	hsa-miR-194	CLIP-seq
MIRT2065654	hsa-miR-2392	CLIP-seq
MIRT2065655	hsa-miR-2467-5p	CLIP-seq
MIRT2065656	hsa-miR-2681	CLIP-seq
MIRT2065657	hsa-miR-2682	CLIP-seq
MIRT2065658	hsa-miR-26a	CLIP-seq
MIRT2065659	hsa-miR-26b	CLIP-seq
MIRT2065660	hsa-miR-29a	CLIP-seq
MIRT2065661	hsa-miR-29b	CLIP-seq
MIRT2065662	hsa-miR-29c	CLIP-seq
MIRT2065663	hsa-miR-30a	CLIP-seq
MIRT2065664	hsa-miR-30b	CLIP-seq
MIRT2065665	hsa-miR-30c	CLIP-seq
MIRT2065666	hsa-miR-30d	CLIP-seq
MIRT2065667	hsa-miR-30e	CLIP-seq
MIRT2065668	hsa-miR-3120-5p	CLIP-seq
MIRT2065669	hsa-miR-3135b	CLIP-seq
MIRT1225142	hsa-miR-3143	CLIP-seq
MIRT2065670	hsa-miR-3149	CLIP-seq
MIRT1225143	hsa-miR-3153	CLIP-seq
MIRT2065671	hsa-miR-3158-3p	CLIP-seq
MIRT2065672	hsa-miR-3160-3p	CLIP-seq
MIRT2065673	hsa-miR-3188	CLIP-seq
MIRT2065674	hsa-miR-3200-5p	CLIP-seq
MIRT2065675	hsa-miR-3202	CLIP-seq
MIRT2065676	hsa-miR-320a	CLIP-seq
MIRT2065677	hsa-miR-320b	CLIP-seq
MIRT2065678	hsa-miR-320c	CLIP-seq
MIRT2065679	hsa-miR-320d	CLIP-seq
MIRT2065680	hsa-miR-34a	CLIP-seq
MIRT2065681	hsa-miR-34c-5p	CLIP-seq
MIRT2065682	hsa-miR-3605-5p	CLIP-seq
MIRT2065683	hsa-miR-3607-3p	CLIP-seq
MIRT2065684	hsa-miR-361-5p	CLIP-seq
MIRT2065685	hsa-miR-3646	CLIP-seq
MIRT1225144	hsa-miR-3652	CLIP-seq
MIRT2065686	hsa-miR-3658	CLIP-seq
MIRT2065687	hsa-miR-3679-5p	CLIP-seq
MIRT2065688	hsa-miR-3685	CLIP-seq
MIRT2065689	hsa-miR-3714	CLIP-seq
MIRT2065690	hsa-miR-384	CLIP-seq
MIRT2065691	hsa-miR-3975	CLIP-seq
MIRT2065692	hsa-miR-3978	CLIP-seq
MIRT2065693	hsa-miR-4256	CLIP-seq
MIRT2065694	hsa-miR-4260	CLIP-seq
MIRT1225150	hsa-miR-4262	CLIP-seq
MIRT2065695	hsa-miR-4270	CLIP-seq
MIRT2065696	hsa-miR-4283	CLIP-seq
MIRT2065697	hsa-miR-4303	CLIP-seq
MIRT2065698	hsa-miR-4420	CLIP-seq
MIRT2065699	hsa-miR-4426	CLIP-seq
MIRT2065700	hsa-miR-4428	CLIP-seq
MIRT2065701	hsa-miR-4429	CLIP-seq
MIRT1225156	hsa-miR-4430	CLIP-seq
MIRT2065702	hsa-miR-4436a	CLIP-seq
MIRT2065703	hsa-miR-4441	CLIP-seq
MIRT2065704	hsa-miR-4446-3p	CLIP-seq
MIRT2065705	hsa-miR-4464	CLIP-seq
MIRT2065706	hsa-miR-4465	CLIP-seq
MIRT2065707	hsa-miR-4487	CLIP-seq
MIRT2065708	hsa-miR-4489	CLIP-seq
MIRT2065709	hsa-miR-4492	CLIP-seq
MIRT1225159	hsa-miR-4496	CLIP-seq
MIRT2065710	hsa-miR-4498	CLIP-seq
MIRT2065711	hsa-miR-449a	CLIP-seq
MIRT2065712	hsa-miR-449b	CLIP-seq
MIRT2065713	hsa-miR-449c	CLIP-seq
MIRT2065714	hsa-miR-4528	CLIP-seq
MIRT2065715	hsa-miR-4533	CLIP-seq
MIRT2065716	hsa-miR-4536	CLIP-seq
MIRT2065717	hsa-miR-4647	CLIP-seq
MIRT2065718	hsa-miR-4662b	CLIP-seq
MIRT2065719	hsa-miR-4666-3p	CLIP-seq
MIRT1225165	hsa-miR-4668-5p	CLIP-seq
MIRT2065720	hsa-miR-4670-5p	CLIP-seq
MIRT2065721	hsa-miR-4683	CLIP-seq
MIRT2065722	hsa-miR-4684-5p	CLIP-seq
MIRT2065723	hsa-miR-4693-3p	CLIP-seq
MIRT2065724	hsa-miR-4729	CLIP-seq
MIRT2065725	hsa-miR-4748	CLIP-seq
MIRT2065726	hsa-miR-485-5p	CLIP-seq
MIRT2065727	hsa-miR-488	CLIP-seq
MIRT2065728	hsa-miR-490-5p	CLIP-seq
MIRT1225174	hsa-miR-543	CLIP-seq
MIRT2065729	hsa-miR-548a-3p	CLIP-seq
MIRT2065730	hsa-miR-548e	CLIP-seq
MIRT2065731	hsa-miR-548f	CLIP-seq
MIRT2065732	hsa-miR-548n	CLIP-seq
MIRT2065733	hsa-miR-548t	CLIP-seq
MIRT2065734	hsa-miR-555	CLIP-seq
MIRT2065735	hsa-miR-558	CLIP-seq
MIRT2065736	hsa-miR-568	CLIP-seq
MIRT2065737	hsa-miR-607	CLIP-seq
MIRT2065738	hsa-miR-610	CLIP-seq
MIRT2065739	hsa-miR-624	CLIP-seq
MIRT2065740	hsa-miR-665	CLIP-seq
MIRT2065741	hsa-miR-762	CLIP-seq
MIRT2065742	hsa-miR-942	CLIP-seq
MIRT2293465	hsa-miR-1256	CLIP-seq
MIRT2293466	hsa-miR-1273c	CLIP-seq
MIRT1225129	hsa-miR-181a	CLIP-seq
MIRT1225130	hsa-miR-181b	CLIP-seq
MIRT1225131	hsa-miR-181c	CLIP-seq
MIRT1225132	hsa-miR-181d	CLIP-seq
MIRT2293467	hsa-miR-192	CLIP-seq
MIRT2293468	hsa-miR-215	CLIP-seq
MIRT2065660	hsa-miR-29a	CLIP-seq
MIRT2065661	hsa-miR-29b	CLIP-seq
MIRT2065662	hsa-miR-29c	CLIP-seq
MIRT2293469	hsa-miR-3145-5p	CLIP-seq
MIRT2293470	hsa-miR-3660	CLIP-seq
MIRT2293471	hsa-miR-3671	CLIP-seq
MIRT2293472	hsa-miR-3683	CLIP-seq
MIRT2293473	hsa-miR-3688-3p	CLIP-seq
MIRT1225149	hsa-miR-3936	CLIP-seq
MIRT2065693	hsa-miR-4256	CLIP-seq
MIRT2293474	hsa-miR-4261	CLIP-seq
MIRT1225150	hsa-miR-4262	CLIP-seq
MIRT2293475	hsa-miR-4277	CLIP-seq
MIRT2065699	hsa-miR-4426	CLIP-seq
MIRT1225162	hsa-miR-4521	CLIP-seq
MIRT2293476	hsa-miR-4526	CLIP-seq
MIRT2293477	hsa-miR-4645-3p	CLIP-seq
MIRT2065717	hsa-miR-4647	CLIP-seq
MIRT2293478	hsa-miR-4659a-3p	CLIP-seq
MIRT2293479	hsa-miR-4659b-3p	CLIP-seq
MIRT2065718	hsa-miR-4662b	CLIP-seq
MIRT2293480	hsa-miR-4666-5p	CLIP-seq
MIRT2293481	hsa-miR-4762-5p	CLIP-seq
MIRT2293482	hsa-miR-4797-5p	CLIP-seq
MIRT2065728	hsa-miR-490-5p	CLIP-seq
MIRT2293483	hsa-miR-498	CLIP-seq
MIRT2293484	hsa-miR-508-5p	CLIP-seq
MIRT2293485	hsa-miR-570	CLIP-seq
MIRT2065737	hsa-miR-607	CLIP-seq
MIRT1225180	hsa-miR-889	CLIP-seq
MIRT2293486	hsa-miR-944	CLIP-seq
MIRT2065699	hsa-miR-4426	CLIP-seq
MIRT2065717	hsa-miR-4647	CLIP-seq
MIRT2065718	hsa-miR-4662b	CLIP-seq
MIRT2065647	hsa-miR-1185	CLIP-seq
MIRT2065648	hsa-miR-1193	CLIP-seq
MIRT2591523	hsa-miR-124	CLIP-seq
MIRT2065650	hsa-miR-1255a	CLIP-seq
MIRT2065651	hsa-miR-1255b	CLIP-seq
MIRT2591524	hsa-miR-1261	CLIP-seq
MIRT2293466	hsa-miR-1273c	CLIP-seq
MIRT1225133	hsa-miR-193a-3p	CLIP-seq
MIRT1225134	hsa-miR-193b	CLIP-seq
MIRT2065654	hsa-miR-2392	CLIP-seq
MIRT2065656	hsa-miR-2681	CLIP-seq
MIRT2065660	hsa-miR-29a	CLIP-seq
MIRT2065661	hsa-miR-29b	CLIP-seq
MIRT2065662	hsa-miR-29c	CLIP-seq
MIRT1225136	hsa-miR-3064-5p	CLIP-seq
MIRT2293469	hsa-miR-3145-5p	CLIP-seq
MIRT2591525	hsa-miR-3148	CLIP-seq
MIRT2065674	hsa-miR-3200-5p	CLIP-seq
MIRT2065682	hsa-miR-3605-5p	CLIP-seq
MIRT1225144	hsa-miR-3652	CLIP-seq
MIRT2065686	hsa-miR-3658	CLIP-seq
MIRT2293471	hsa-miR-3671	CLIP-seq
MIRT2065687	hsa-miR-3679-5p	CLIP-seq
MIRT2293472	hsa-miR-3683	CLIP-seq
MIRT2293473	hsa-miR-3688-3p	CLIP-seq
MIRT2591526	hsa-miR-369-3p	CLIP-seq
MIRT2065689	hsa-miR-3714	CLIP-seq
MIRT2591527	hsa-miR-374c	CLIP-seq
MIRT1225147	hsa-miR-377	CLIP-seq
MIRT2591528	hsa-miR-3910	CLIP-seq
MIRT2591529	hsa-miR-3942-3p	CLIP-seq
MIRT2293475	hsa-miR-4277	CLIP-seq
MIRT2065697	hsa-miR-4303	CLIP-seq
MIRT2065698	hsa-miR-4420	CLIP-seq
MIRT2065699	hsa-miR-4426	CLIP-seq
MIRT2065700	hsa-miR-4428	CLIP-seq
MIRT1225156	hsa-miR-4430	CLIP-seq
MIRT2591530	hsa-miR-4432	CLIP-seq
MIRT1225160	hsa-miR-4505	CLIP-seq
MIRT2591531	hsa-miR-4639-5p	CLIP-seq
MIRT2591532	hsa-miR-4641	CLIP-seq
MIRT2293477	hsa-miR-4645-3p	CLIP-seq
MIRT2065717	hsa-miR-4647	CLIP-seq
MIRT2591533	hsa-miR-4662a-3p	CLIP-seq
MIRT2065718	hsa-miR-4662b	CLIP-seq
MIRT2065721	hsa-miR-4683	CLIP-seq
MIRT2065722	hsa-miR-4684-5p	CLIP-seq
MIRT2591534	hsa-miR-4738-3p	CLIP-seq
MIRT2591535	hsa-miR-4747-3p	CLIP-seq
MIRT2293481	hsa-miR-4762-5p	CLIP-seq
MIRT2065727	hsa-miR-488	CLIP-seq
MIRT2065728	hsa-miR-490-5p	CLIP-seq
MIRT2591536	hsa-miR-499-5p	CLIP-seq
MIRT2591537	hsa-miR-506	CLIP-seq
MIRT2293484	hsa-miR-508-5p	CLIP-seq
MIRT2591538	hsa-miR-548ad	CLIP-seq
MIRT2591539	hsa-miR-548p	CLIP-seq
MIRT2065737	hsa-miR-607	CLIP-seq
MIRT2065738	hsa-miR-610	CLIP-seq
MIRT2591540	hsa-miR-655	CLIP-seq
MIRT1225181	hsa-miR-892b	CLIP-seq
MIRT2591523	hsa-miR-124	CLIP-seq
MIRT2591524	hsa-miR-1261	CLIP-seq
MIRT2293466	hsa-miR-1273c	CLIP-seq
MIRT1225133	hsa-miR-193a-3p	CLIP-seq
MIRT1225134	hsa-miR-193b	CLIP-seq
MIRT2065660	hsa-miR-29a	CLIP-seq
MIRT2065661	hsa-miR-29b	CLIP-seq
MIRT2065662	hsa-miR-29c	CLIP-seq
MIRT1225136	hsa-miR-3064-5p	CLIP-seq
MIRT2293469	hsa-miR-3145-5p	CLIP-seq
MIRT1225144	hsa-miR-3652	CLIP-seq
MIRT2293471	hsa-miR-3671	CLIP-seq
MIRT2293472	hsa-miR-3683	CLIP-seq
MIRT2065689	hsa-miR-3714	CLIP-seq
MIRT2591528	hsa-miR-3910	CLIP-seq
MIRT2293475	hsa-miR-4277	CLIP-seq
MIRT2065699	hsa-miR-4426	CLIP-seq
MIRT2065700	hsa-miR-4428	CLIP-seq
MIRT1225156	hsa-miR-4430	CLIP-seq
MIRT1225160	hsa-miR-4505	CLIP-seq
MIRT2591531	hsa-miR-4639-5p	CLIP-seq
MIRT2293477	hsa-miR-4645-3p	CLIP-seq
MIRT2065717	hsa-miR-4647	CLIP-seq
MIRT2065718	hsa-miR-4662b	CLIP-seq
MIRT2065721	hsa-miR-4683	CLIP-seq
MIRT2065722	hsa-miR-4684-5p	CLIP-seq
MIRT2293481	hsa-miR-4762-5p	CLIP-seq
MIRT2065727	hsa-miR-488	CLIP-seq
MIRT2591537	hsa-miR-506	CLIP-seq
MIRT2293484	hsa-miR-508-5p	CLIP-seq
MIRT2591538	hsa-miR-548ad	CLIP-seq
MIRT2065737	hsa-miR-607	CLIP-seq
MIRT1225181	hsa-miR-892b	CLIP-seq

Show/Hide all (2)

Transcription factor	Regulation	Reference
ARNTL	Activation	22750052
CLOCK	Activation	22750052

Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IBA
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	26903630
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000976	Function	Transcription cis-regulatory region binding	IBA
GO:0001222	Function	Transcription corepressor binding	IBA
GO:0005515	Function	Protein binding	IPI	21070773, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	26903630
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	26903630
GO:0005737	Component	Cytoplasm	IEA
GO:0007623	Process	Circadian rhythm	IEA
GO:0019900	Function	Kinase binding	IEA
GO:0031625	Function	Ubiquitin protein ligase binding	IEA
GO:0032922	Process	Circadian regulation of gene expression	IBA
GO:0043153	Process	Entrainment of circadian clock by photoperiod	IBA
GO:0045187	Process	Regulation of circadian sleep/wake cycle, sleep	IEA
GO:0045187	Process	Regulation of circadian sleep/wake cycle, sleep	IMP	17346965, 19716732, 24439663, 24577121, 26903630
GO:0048511	Process	Rhythmic process	IEA
GO:0050821	Process	Protein stabilization	IMP	26903630

MIM	HGNC	e!Ensembl
603427	8847	ENSG00000049246

P56645

Protein name

Period circadian protein homolog 3 (hPER3) (Cell growth-inhibiting gene 13 protein) (Circadian clock protein PERIOD 3)

Protein function

Originally described as a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08447	PAS_3	284 → 374	PAS fold	Domain
PF12114	Period_C	1029 → 1195	Period protein 2/3C-terminal region	Family

Sequence

MPRGEAPGPGRRGAKDEALGEESGERWSPEFHLQRKLADSSHSEQQDRNRVSEELIMVVQ
EMKKYFPSERRNKPSTLDALNYALRCVHSVQANSEFFQILSQNGAPQADVSMYSLEELAT
IASEHTSKNTDTFVAVFSFLSGRLVHISEQAALILNRKKDVLASSHFVDLLAPQDMRVFY
AHTARAQLPFWNNWTQRAARYECAPVKPFFCRIRGGEDRKQEKCHSPFRIIPYLIHVHHP
AQPELESEPCCLTVVEKIHSGYEAPRIPVNKRIFTTTHTPGCVFLEVDEKAVPLLGYLPQ
DLIGTSILSYLHPEDRSLMVAIHQKVLKYAGHPPFEHSPIRFCTQNGDYIILDSSWSSFV
NPWSRKISFIIGRHKVRTSPLNEDVFATKIKKMNDNDKDITELQEQIYKLLLQPVHVSVS
SGYGSLGSSGSQEQLVSIASSSEASGHRVEETKAEQMTLQQVYASVNKIKNLGQQLYIES
MTKSSFKPVTGTRTEPNGGGECKTFTSFHQTLKNNSVYTEPCEDLRNDEHSPSYQQINCI
DSVIRYLKSYNIPALKRKCISCTNTTSSSSEEDKQNHKADDVQALQAGLQIPAIPKSEMP
TNGRSIDTGGGAPQILSTAMLSLGSGISQCGYSSTIVHVPPPETARDATLFCEPWTLNMQ
PAPLTSEEFKHVGLTAAVLSAHTQKEEQNYVDKFREKILSSPYSSYLQQESRSKAKYSYF
QGDSTSKQTRSAGCRKGKHKRKKLPEPPDSSSSNTGSGPRRGAHQNAQPCCPSAASSPHT
SSPTFPPAAMVPSQAPYLVPAFPLPAATSPGREYAAPGTAPEGLHGLPLSEGLQPYPAFP
FPYLDTFMTVFLPDPPVCPLLSPSFLPCPFLGATASSAISPSMSSAMSPTLDPPPSVTSQ
RREEEKWEAQSEGHPFITSRSSSPLQLNLLQEEMPRPSESPDQMRRNTCPQTEYCVTGNN
GSESSPATTGALSTGSPPRENPSHPTASALSTGSPPMKNPSHPTASALSTGSPPMKNPSH
PTASTLSMGLPPSRTPSHPTATVLSTGSPPSESPSRTGSAASGSSDSSIYLTSSVYSSKI
SQNGQQSQDVQKKETFPNVAEEPIWRMIRQTPERILMTYQVPERVKEVVLKEDLEKLESM
RQQQPQFSHGQKEELAKVYNWIQSQTVTQEIDIQACVTCENEDSADGAATSCGQVLVEDS
C

Sequence length

1201

Interactions

View interactions

	KEGG
	Circadian rhythm Circadian entrainment

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
See cases	Likely pathogenic	rs2151127625	RCV001420256

Show/Hide Unknown Diseases (14)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Advanced sleep phase syndrome 3	Uncertain significance; Conflicting classifications of pathogenicity	rs772840416, rs139315125, rs150812083, rs200862765, rs2524417481, rs556093537	RCV001839395 RCV000494693 RCV000495971 RCV005399205 RCV003990337 RCV005392557
Cervical cancer	Benign	rs116369722	RCV005908616
Clear cell carcinoma of kidney	Benign; Likely benign	rs12121492, rs116369722	RCV005906781 RCV005908617
Colorectal cancer	Benign; Likely benign	rs12121492	RCV005906782
Familial cancer of breast	Benign; Likely benign	rs12121492	RCV005906778
Gastric cancer	Benign	rs116369722	RCV005908619
Lung cancer	Benign	rs116369722	RCV005908622
Malignant tumor of esophagus	Benign; Likely benign	rs12121492	RCV005906779
Nonpapillary renal cell carcinoma	Benign; Likely benign	rs12121492	RCV005906780
Ovarian serous cystadenocarcinoma	Benign; Likely benign	rs12121492, rs116369722	RCV005906784 RCV005908620
PER3-related disorder	Likely benign; Benign; Uncertain significance; Conflicting classifications of pathogenicity	rs41278956, rs1480760882, rs765289714, rs2640909, rs555771796, rs554573019, rs2859387, rs12023156, rs182687404, rs374450338, rs140044547, rs35802556, rs113009468, rs191955069, rs10462020 View all (8 more)	RCV003929822 RCV003981733 RCV003981756 RCV003974568 RCV003897314 RCV003904284 RCV003984663 RCV003977268 RCV003909602 RCV003909765 RCV003924613 RCV003931539 RCV003959140 RCV003922206 RCV003974742 RCV003982173 RCV003926012 RCV003926167 RCV003926168 RCV003916153 RCV003958005 RCV003913112 RCV003925799
Sarcoma	Benign; Likely benign	rs12121492, rs116369722	RCV005906783 RCV005908618
Thyroid cancer, nonmedullary, 1	Benign	rs116369722	RCV005908621
Uterine corpus endometrial carcinoma	Benign	rs116369722	RCV005908623

Show/Hide Text Mining Associations (73)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	36385012
Adenoma	Associate	25501848, 27771773
Alcoholism	Associate	22467995
Alzheimer Disease	Associate	36901420
Anxiety	Associate	28860482, 35365695, 38102312
Atrophy	Associate	36130474
Attention Deficit and Disruptive Behavior Disorders	Associate	19926609
Attention Deficit and Disruptive Behavior Disorders	Inhibit	31708917
Attention Deficit Disorder with Hyperactivity	Associate	34273025, 34275001, 34275002
Bipolar Disorder	Associate	16528748, 36548883
Breast Neoplasms	Associate	23822714, 25485508, 25501848, 29958276, 31739444, 39193850, 39201344
Carcinoma Non Small Cell Lung	Associate	25550826, 35575281
Chronobiology Disorders	Associate	11306557, 36901420
Cognition Disorders	Associate	19516903
Colonic Neoplasms	Inhibit	35116071
Colorectal Neoplasms	Associate	23712462, 27492458
Colorectal Neoplasms	Inhibit	24393525, 27983919
Coronavirus Infections	Associate	34542826
COVID 19	Associate	34542826
Death	Associate	34542826
Dental Caries	Associate	15869869
Depressive Disorder	Associate	26926884
Depressive Disorder Major	Associate	26926884
Diabetes Gestational	Associate	23323702
Disorders of Excessive Somnolence	Associate	27102916
Drug Related Side Effects and Adverse Reactions	Associate	36130474
Endometrial Neoplasms	Associate	36748323
Erythema	Associate	36130474
Esophageal Neoplasms	Inhibit	32503923
Glioblastoma	Associate	24135790
Hereditary Breast and Ovarian Cancer Syndrome	Associate	31739444, 36130474
Hypertension	Associate	37814975
Insulin Resistance	Associate	37768516
Iron Overload	Associate	37768516
Leukemia Myelogenous Chronic BCR ABL Positive	Inhibit	16999817
Lung Neoplasms	Inhibit	25550826
Lung Neoplasms	Associate	35575281
Lymphoma Large B Cell Diffuse	Associate	26406960
Major Affective Disorder 2	Associate	16528748
Melanoma Cutaneous Malignant	Associate	37373286
Mental Disorders	Associate	36901420
Mental Retardation Autosomal Dominant 1	Associate	25271084
Metabolic Syndrome	Associate	28296937, 36497566
Mood Disorders	Associate	16528748, 28860482
Mouth Breathing	Associate	37814975
Multiple Myeloma	Inhibit	38642856
Multiple Sclerosis	Associate	35008743
Neoplasm Metastasis	Associate	27492458
Neoplasms	Associate	19926609, 22081375, 23712462, 24393525, 25485508, 31708917, 34604590
Neoplasms	Inhibit	29958276, 38642856
Neoplasms Adipose Tissue	Associate	37768516
Osteosarcoma	Associate	30575220
Pain	Associate	31249322
Pre Eclampsia	Associate	36284122
Prostatic Neoplasms	Associate	19934327, 29771413, 34604590, 35154101
Prostatitis	Associate	19934327
Psychological Trauma	Associate	23524621, 36901420
Refractive Errors	Associate	36596879
REM Sleep Behavior Disorder	Associate	31538609
Seasonal Affective Disorder	Associate	28860482
Sleep Apnea Obstructive	Associate	37814975
Sleep Apnea Syndromes	Inhibit	30657733
Sleep Deprivation	Associate	18714788, 18835917, 19360490, 19516903, 23029352, 23440187, 33920292
Sleep Disorders Circadian Rhythm	Associate	11306557, 12841365, 15961535, 16528748, 17309758, 20469812, 25201053
Sleep Initiation and Maintenance Disorders	Associate	22467995
Sleep Wake Disorders	Associate	17346965, 18835917, 19516903, 23029352, 25501848, 28860482, 32737280, 36137075, 36901420
Sleepiness	Associate	21533241, 25325466
Snoring	Associate	37814975
Squamous Cell Carcinoma of Head and Neck	Associate	22081375, 36505439, 37968308
Squamous Cell Carcinoma of Head and Neck	Inhibit	37342762
Stomach Neoplasms	Associate	24708606
Stomach Neoplasms	Inhibit	34162762
Triple Negative Breast Neoplasms	Associate	39193850

PER3 (period circadian regulator 3)