Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8863
Gene name Gene Name - the full gene name approved by the HGNC.
Period circadian regulator 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PER3
Synonyms (NCBI Gene) Gene synonyms aliases
FASPS3, GIG13
Disease Acronyms (UniProt) Disease acronyms from UniProt database
FASPS3
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p36.23
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomoto
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs139315125 A>G Pathogenic 5 prime UTR variant, missense variant, coding sequence variant
rs150812083 C>G Pathogenic Missense variant, 5 prime UTR variant, coding sequence variant
rs1558401132 CTTGC>- Likely-pathogenic Frameshift variant, 5 prime UTR variant, coding sequence variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT029909 hsa-miR-26b-5p Microarray 19088304
MIRT030960 hsa-miR-21-5p Microarray 18591254
MIRT487823 hsa-miR-320e PAR-CLIP 23592263
MIRT487822 hsa-miR-3943 PAR-CLIP 23592263
MIRT487821 hsa-miR-6795-3p PAR-CLIP 23592263
Transcription factors
Transcription factor Regulation Reference
ARNTL Activation 22750052
CLOCK Activation 22750052
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 26903630
GO:0000976 Function Transcription regulatory region sequence-specific DNA binding IBA 21873635
GO:0001222 Function Transcription corepressor binding IBA 21873635
GO:0005515 Function Protein binding IPI 21070773
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
603427 8847 ENSG00000049246
Protein
UniProt ID P56645
Protein name Period circadian protein homolog 3 (hPER3) (Cell growth-inhibiting gene 13 protein) (Circadian clock protein PERIOD 3)
Protein function Originally described as a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08447 PAS_3 284 374 PAS fold Domain
PF12114 Period_C 1029 1195 Period protein 2/3C-terminal region Family
Sequence
MPRGEAPGPGRRGAKDEALGEESGERWSPEFHLQRKLADSSHSEQQDRNRVSEELIMVVQ
EMKKYFPSERRNKPSTLDALNYALRCVHSVQANSEFFQILSQNGAPQADVSMYSLEELAT
IASEHTSKNTDTFVAVFSFLSGRLVHISEQAALILNRKKDVLASSHFVDLLAPQDMRVFY
AHTARAQLPFWNNWTQRAARYECAPVKPFFCRIRGGEDRKQEKCHSPFRIIPYLIHVHHP
AQPELESEPCCLTVVEKIHSGYEAPRIPVNKRIFTTTHTPGCVFLEVDEKAVPLLGYLPQ
DLIGTSILSYLHPEDRSLMVAIHQKVLKYAGHPPFEHSPIRFCTQNGDYIILDSSWSSFV
NPWSRKISFIIGRH
KVRTSPLNEDVFATKIKKMNDNDKDITELQEQIYKLLLQPVHVSVS
SGYGSLGSSGSQEQLVSIASSSEASGHRVEETKAEQMTLQQVYASVNKIKNLGQQLYIES
MTKSSFKPVTGTRTEPNGGGECKTFTSFHQTLKNNSVYTEPCEDLRNDEHSPSYQQINCI
DSVIRYLKSYNIPALKRKCISCTNTTSSSSEEDKQNHKADDVQALQAGLQIPAIPKSEMP
TNGRSIDTGGGAPQILSTAMLSLGSGISQCGYSSTIVHVPPPETARDATLFCEPWTLNMQ
PAPLTSEEFKHVGLTAAVLSAHTQKEEQNYVDKFREKILSSPYSSYLQQESRSKAKYSYF
QGDSTSKQTRSAGCRKGKHKRKKLPEPPDSSSSNTGSGPRRGAHQNAQPCCPSAASSPHT
SSPTFPPAAMVPSQAPYLVPAFPLPAATSPGREYAAPGTAPEGLHGLPLSEGLQPYPAFP
FPYLDTFMTVFLPDPPVCPLLSPSFLPCPFLGATASSAISPSMSSAMSPTLDPPPSVTSQ
RREEEKWEAQSEGHPFITSRSSSPLQLNLLQEEMPRPSESPDQMRRNTCPQTEYCVTGNN
GSESSPATTGALSTGSPPRENPSHPTASALSTGSPPMKNPSHPTASALSTGSPPMKNPSH
PTASTLSMGLPPSRTPSHPTATVLSTGSPPSESPSRTGSAASGSSDSSIYLTSSVYSSKI
SQNGQQSQDVQKKETFPNVAEEPIWRMIRQTPERILMTYQVPERVKEVVLKEDLEKLESM
RQQQPQFSHGQKEELAKVYNWIQSQTVTQEIDIQACVTCENEDSADGAATSCGQV
LVEDS
C
Sequence length 1201
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  Circadian rhythm
Circadian entrainment
 
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Advanced sleep phase syndrome Familial advanced sleep-phase syndrome, Advanced Sleep-Phase Syndrome, Familial rs121908635, rs104894561, rs397514693, rs1559332542 26903630
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
20625127
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
20625127
Marfan syndrome Mammary Carcinoma, Human rs137854456, rs137854457, rs267606796, rs137854458, rs137854459, rs137854460, rs137854470, rs137854471, rs267606797, rs137854461, rs137854462, rs137854463, rs869025419, rs137854464, rs137854465
View all (942 more)
20625127
Unknown
Disease term Disease name Evidence References Source
Crohn disease Crohn Disease 21102463 ClinVar
Mental depression Mental Depression, Depressive disorder 19708722, 19926609 ClinVar
Advanced Sleep Phase Syndrome advanced sleep phase syndrome GenCC
Crohn Disease Crohn Disease GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 36385012
Adenoma Associate 25501848, 27771773
Alcoholism Associate 22467995
Alzheimer Disease Associate 36901420
Anxiety Associate 28860482, 35365695, 38102312
Atrophy Associate 36130474
Attention Deficit and Disruptive Behavior Disorders Associate 19926609
Attention Deficit and Disruptive Behavior Disorders Inhibit 31708917
Attention Deficit Disorder with Hyperactivity Associate 34273025, 34275001, 34275002
Bipolar Disorder Associate 16528748, 36548883