Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	8859
Gene name Gene Name - the full gene name approved by the HGNC.	Winged helix repair factor 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	WHR1
Synonyms (NCBI Gene) Gene synonyms aliases	D6S60, D6S60E, G11, HLA-RP1, RP1, STK19, TWH19
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6p21.33

Show/Hide all(193)

miRTarBase ID	miRNA	Experiments	Reference
MIRT044241	hsa-miR-29c-3p	CLASH	23622248
MIRT1397463	hsa-miR-1271	CLIP-seq
MIRT1397464	hsa-miR-15a	CLIP-seq
MIRT1397465	hsa-miR-15b	CLIP-seq
MIRT1397466	hsa-miR-16	CLIP-seq
MIRT1397467	hsa-miR-182	CLIP-seq
MIRT1397468	hsa-miR-195	CLIP-seq
MIRT1397469	hsa-miR-2467-3p	CLIP-seq
MIRT1397470	hsa-miR-3143	CLIP-seq
MIRT1397471	hsa-miR-424	CLIP-seq
MIRT1397472	hsa-miR-4256	CLIP-seq
MIRT1397473	hsa-miR-4257	CLIP-seq
MIRT1397474	hsa-miR-4274	CLIP-seq
MIRT1397475	hsa-miR-4514	CLIP-seq
MIRT1397476	hsa-miR-4692	CLIP-seq
MIRT1397477	hsa-miR-4704-3p	CLIP-seq
MIRT1397478	hsa-miR-497	CLIP-seq
MIRT1397479	hsa-miR-513a-5p	CLIP-seq
MIRT1397480	hsa-miR-590-3p	CLIP-seq
MIRT1397481	hsa-miR-96	CLIP-seq
MIRT1397464	hsa-miR-15a	CLIP-seq
MIRT1397465	hsa-miR-15b	CLIP-seq
MIRT1397466	hsa-miR-16	CLIP-seq
MIRT1397468	hsa-miR-195	CLIP-seq
MIRT1397471	hsa-miR-424	CLIP-seq
MIRT1397474	hsa-miR-4274	CLIP-seq
MIRT1397482	hsa-miR-4470	CLIP-seq
MIRT1397483	hsa-miR-4645-5p	CLIP-seq
MIRT1397484	hsa-miR-4673	CLIP-seq
MIRT1397477	hsa-miR-4704-3p	CLIP-seq
MIRT1397485	hsa-miR-4742-5p	CLIP-seq
MIRT1397478	hsa-miR-497	CLIP-seq
MIRT2341323	hsa-miR-1226	CLIP-seq
MIRT2341324	hsa-miR-1272	CLIP-seq
MIRT2341325	hsa-miR-1277	CLIP-seq
MIRT1397464	hsa-miR-15a	CLIP-seq
MIRT1397465	hsa-miR-15b	CLIP-seq
MIRT1397466	hsa-miR-16	CLIP-seq
MIRT1397468	hsa-miR-195	CLIP-seq
MIRT2341326	hsa-miR-197	CLIP-seq
MIRT2341327	hsa-miR-205	CLIP-seq
MIRT2341328	hsa-miR-28-5p	CLIP-seq
MIRT2341329	hsa-miR-3123	CLIP-seq
MIRT2341330	hsa-miR-3133	CLIP-seq
MIRT2341331	hsa-miR-3139	CLIP-seq
MIRT2341332	hsa-miR-3150b-3p	CLIP-seq
MIRT2341333	hsa-miR-3160-3p	CLIP-seq
MIRT2341334	hsa-miR-3908	CLIP-seq
MIRT2341335	hsa-miR-3921	CLIP-seq
MIRT2341336	hsa-miR-3925-5p	CLIP-seq
MIRT2341337	hsa-miR-412	CLIP-seq
MIRT1397471	hsa-miR-424	CLIP-seq
MIRT1397474	hsa-miR-4274	CLIP-seq
MIRT2341338	hsa-miR-4290	CLIP-seq
MIRT2341339	hsa-miR-4462	CLIP-seq
MIRT1397482	hsa-miR-4470	CLIP-seq
MIRT1397483	hsa-miR-4645-5p	CLIP-seq
MIRT2341340	hsa-miR-4649-3p	CLIP-seq
MIRT2341341	hsa-miR-4653-5p	CLIP-seq
MIRT2341342	hsa-miR-4663	CLIP-seq
MIRT2341343	hsa-miR-4667-3p	CLIP-seq
MIRT1397484	hsa-miR-4673	CLIP-seq
MIRT2341344	hsa-miR-4689	CLIP-seq
MIRT1397477	hsa-miR-4704-3p	CLIP-seq
MIRT2341345	hsa-miR-4714-5p	CLIP-seq
MIRT2341346	hsa-miR-4733-3p	CLIP-seq
MIRT1397485	hsa-miR-4742-5p	CLIP-seq
MIRT2341347	hsa-miR-4784	CLIP-seq
MIRT1397478	hsa-miR-497	CLIP-seq
MIRT2341348	hsa-miR-548b-3p	CLIP-seq
MIRT2341349	hsa-miR-708	CLIP-seq
MIRT2635296	hsa-miR-10a	CLIP-seq
MIRT2635297	hsa-miR-10b	CLIP-seq
MIRT2635298	hsa-miR-1178	CLIP-seq
MIRT2635299	hsa-miR-1224-3p	CLIP-seq
MIRT2341323	hsa-miR-1226	CLIP-seq
MIRT2635300	hsa-miR-1260	CLIP-seq
MIRT2635301	hsa-miR-1260b	CLIP-seq
MIRT1397463	hsa-miR-1271	CLIP-seq
MIRT2341325	hsa-miR-1277	CLIP-seq
MIRT2635302	hsa-miR-1280	CLIP-seq
MIRT2635303	hsa-miR-1301	CLIP-seq
MIRT2635304	hsa-miR-149	CLIP-seq
MIRT2635305	hsa-miR-150	CLIP-seq
MIRT2341326	hsa-miR-197	CLIP-seq
MIRT2341327	hsa-miR-205	CLIP-seq
MIRT2635306	hsa-miR-2114	CLIP-seq
MIRT2635307	hsa-miR-2355-5p	CLIP-seq
MIRT2341328	hsa-miR-28-5p	CLIP-seq
MIRT2635308	hsa-miR-29a	CLIP-seq
MIRT2635309	hsa-miR-29b	CLIP-seq
MIRT2635310	hsa-miR-29c	CLIP-seq
MIRT2635311	hsa-miR-3065-3p	CLIP-seq
MIRT2341329	hsa-miR-3123	CLIP-seq
MIRT2341330	hsa-miR-3133	CLIP-seq
MIRT2341331	hsa-miR-3139	CLIP-seq
MIRT2341332	hsa-miR-3150b-3p	CLIP-seq
MIRT2635312	hsa-miR-3157-5p	CLIP-seq
MIRT2341333	hsa-miR-3160-3p	CLIP-seq
MIRT2635313	hsa-miR-3202	CLIP-seq
MIRT2635314	hsa-miR-337-3p	CLIP-seq
MIRT2635315	hsa-miR-339-5p	CLIP-seq
MIRT2635316	hsa-miR-3614-3p	CLIP-seq
MIRT2635317	hsa-miR-3667-3p	CLIP-seq
MIRT2635318	hsa-miR-371-5p	CLIP-seq
MIRT2635319	hsa-miR-3919	CLIP-seq
MIRT2341335	hsa-miR-3921	CLIP-seq
MIRT2341336	hsa-miR-3925-5p	CLIP-seq
MIRT2341337	hsa-miR-412	CLIP-seq
MIRT2341338	hsa-miR-4290	CLIP-seq
MIRT2635320	hsa-miR-4297	CLIP-seq
MIRT2635321	hsa-miR-4421	CLIP-seq
MIRT2635322	hsa-miR-4436b-3p	CLIP-seq
MIRT2635323	hsa-miR-4436b-5p	CLIP-seq
MIRT2341339	hsa-miR-4462	CLIP-seq
MIRT2635324	hsa-miR-4533	CLIP-seq
MIRT1397483	hsa-miR-4645-5p	CLIP-seq
MIRT2341340	hsa-miR-4649-3p	CLIP-seq
MIRT2341341	hsa-miR-4653-5p	CLIP-seq
MIRT2635325	hsa-miR-4660	CLIP-seq
MIRT2341342	hsa-miR-4663	CLIP-seq
MIRT2341343	hsa-miR-4667-3p	CLIP-seq
MIRT1397484	hsa-miR-4673	CLIP-seq
MIRT2341344	hsa-miR-4689	CLIP-seq
MIRT2635326	hsa-miR-4691-3p	CLIP-seq
MIRT2341345	hsa-miR-4714-5p	CLIP-seq
MIRT2635327	hsa-miR-4725-5p	CLIP-seq
MIRT2341346	hsa-miR-4733-3p	CLIP-seq
MIRT1397485	hsa-miR-4742-5p	CLIP-seq
MIRT2635328	hsa-miR-4761-5p	CLIP-seq
MIRT2341347	hsa-miR-4784	CLIP-seq
MIRT2635329	hsa-miR-4793-5p	CLIP-seq
MIRT2635330	hsa-miR-4797-5p	CLIP-seq
MIRT2635331	hsa-miR-498	CLIP-seq
MIRT2635332	hsa-miR-504	CLIP-seq
MIRT2635333	hsa-miR-5047	CLIP-seq
MIRT2341348	hsa-miR-548b-3p	CLIP-seq
MIRT2635334	hsa-miR-554	CLIP-seq
MIRT2635335	hsa-miR-587	CLIP-seq
MIRT2635336	hsa-miR-605	CLIP-seq
MIRT2341349	hsa-miR-708	CLIP-seq
MIRT2635337	hsa-miR-767-5p	CLIP-seq
MIRT1397481	hsa-miR-96	CLIP-seq
MIRT2635296	hsa-miR-10a	CLIP-seq
MIRT2635297	hsa-miR-10b	CLIP-seq
MIRT2635298	hsa-miR-1178	CLIP-seq
MIRT2635299	hsa-miR-1224-3p	CLIP-seq
MIRT2341323	hsa-miR-1226	CLIP-seq
MIRT2635300	hsa-miR-1260	CLIP-seq
MIRT2635301	hsa-miR-1260b	CLIP-seq
MIRT2341325	hsa-miR-1277	CLIP-seq
MIRT2635302	hsa-miR-1280	CLIP-seq
MIRT2635304	hsa-miR-149	CLIP-seq
MIRT2635305	hsa-miR-150	CLIP-seq
MIRT2341326	hsa-miR-197	CLIP-seq
MIRT2341327	hsa-miR-205	CLIP-seq
MIRT2635307	hsa-miR-2355-5p	CLIP-seq
MIRT2635308	hsa-miR-29a	CLIP-seq
MIRT2635309	hsa-miR-29b	CLIP-seq
MIRT2635310	hsa-miR-29c	CLIP-seq
MIRT2635311	hsa-miR-3065-3p	CLIP-seq
MIRT2341329	hsa-miR-3123	CLIP-seq
MIRT2341330	hsa-miR-3133	CLIP-seq
MIRT2635312	hsa-miR-3157-5p	CLIP-seq
MIRT2635313	hsa-miR-3202	CLIP-seq
MIRT2635314	hsa-miR-337-3p	CLIP-seq
MIRT2635315	hsa-miR-339-5p	CLIP-seq
MIRT2635316	hsa-miR-3614-3p	CLIP-seq
MIRT2635317	hsa-miR-3667-3p	CLIP-seq
MIRT2635318	hsa-miR-371-5p	CLIP-seq
MIRT2635319	hsa-miR-3919	CLIP-seq
MIRT2341336	hsa-miR-3925-5p	CLIP-seq
MIRT2341337	hsa-miR-412	CLIP-seq
MIRT2341338	hsa-miR-4290	CLIP-seq
MIRT2635320	hsa-miR-4297	CLIP-seq
MIRT2635321	hsa-miR-4421	CLIP-seq
MIRT2635322	hsa-miR-4436b-3p	CLIP-seq
MIRT2635323	hsa-miR-4436b-5p	CLIP-seq
MIRT2341339	hsa-miR-4462	CLIP-seq
MIRT2635324	hsa-miR-4533	CLIP-seq
MIRT2341343	hsa-miR-4667-3p	CLIP-seq
MIRT2635326	hsa-miR-4691-3p	CLIP-seq
MIRT2635327	hsa-miR-4725-5p	CLIP-seq
MIRT2341346	hsa-miR-4733-3p	CLIP-seq
MIRT2635328	hsa-miR-4761-5p	CLIP-seq
MIRT2635329	hsa-miR-4793-5p	CLIP-seq
MIRT2635330	hsa-miR-4797-5p	CLIP-seq
MIRT2635331	hsa-miR-498	CLIP-seq
MIRT2635332	hsa-miR-504	CLIP-seq
MIRT2341348	hsa-miR-548b-3p	CLIP-seq
MIRT2635335	hsa-miR-587	CLIP-seq
MIRT2635336	hsa-miR-605	CLIP-seq
MIRT2635337	hsa-miR-767-5p	CLIP-seq

Show/Hide all(18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003677	Function	DNA binding	IEA
GO:0003690	Function	Double-stranded DNA binding	IDA	38252411, 38890355
GO:0003723	Function	RNA binding	IEA
GO:0003725	Function	Double-stranded RNA binding	IDA	38890355
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	32531245, 38252411
GO:0005515	Function	Protein binding	IPI	33961781
GO:0005634	Component	Nucleus	IDA	32531245, 38252411
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	9812991
GO:0005737	Component	Cytoplasm	IDA	32531245
GO:0005737	Component	Cytoplasm	IEA
GO:0006281	Process	DNA repair	IEA
GO:0006974	Process	DNA damage response	IEA
GO:0016607	Component	Nuclear speck	IDA
GO:0042803	Function	Protein homodimerization activity	IDA	38252411
GO:0046579	Process	Positive regulation of Ras protein signal transduction	IBA
GO:0046579	Process	Positive regulation of Ras protein signal transduction	IDA	30712867
GO:1903518	Process	Positive regulation of single strand break repair	IMP	38252411

MIM	HGNC	e!Ensembl
604977	11398	ENSG00000204344

Protein

UniProt ID

P49842

Protein name

Winged helix repair factor 1 (Inactive serine/threonine-protein kinase 19) (Protein G11) (Protein RP1) (Tandem winged helix protein formerly known as STK19)

Protein function

DNA-binding protein which is required for efficient transcription-coupled nucleotide excision repair (TC-NER) (PubMed:38252411, PubMed:38890355, PubMed:39353615, PubMed:39547223, PubMed:39547228, PubMed:39547229). Acts as part of a TC-NER comple

PDB

7XRB , 8YCM , 9BZ0 , 9ER2 , 9FD2

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10494	Stk19	147 → 365	Serine-threonine protein kinase 19	Family

Tissue specificity

TISSUE SPECIFICITY: Monocytes, hepatocytes, epithelial cells, T- and B-lymphocytes. {ECO:0000269|PubMed:8012361}.

Sequence

MQKWFSAFDDAIIQRQWRANPSRGGGGVSFTKEVDTNVATGAPPRRQRVPGRACPWREPI
RGRRGARPGGGDAGGTPGETVRHCSAPEDPIFRFSSLHSYPFPGTIKSRDMSWKRHHLIP
ETFGVKRRRKRGPVESDPLRGEPGSARAAVSELMQLFPRGLFEDALPPIVLRSQVYSLVP
DRTVADRQLKELQEQGEIRIVQLGFDLDAHGIIFTEDYRTRVCDCVLKACDGRPYAGAVQ
KFLASVLPACGDLSFQQDQMTQTFGFRDSEITHLVNAGVLTVRDAGSWWLAVPGAGRFIK
YFVKGRQAVLSMVRKAKYRELLLSELLGRRAPVVVRLGLTYHVHDLIGAQLVDCISTTSG
TLLRLPET

Sequence length

368

Interactions

View interactions

WHR1 (winged helix repair factor 1)