PROZ (protein Z, vitamin K dependent plasma glycoprotein)

Gene
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8858
Gene name Gene Name - the full gene name approved by the HGNC.
Protein Z, vitamin K dependent plasma glycoprotein
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PROZ
Synonyms (NCBI Gene) Gene synonyms aliases
PZ
Chromosome Chromosome number
13
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
13q34
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directl
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(10)
GO ID Ontology Definition Evidence Reference
GO:0004252 Function Serine-type endopeptidase activity IEA
GO:0005509 Function Calcium ion binding IEA
GO:0005515 Function Protein binding IPI 20427285
GO:0005615 Component Extracellular space IBA 21873635
GO:0005788 Component Endoplasmic reticulum lumen TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
176895 9460 ENSG00000126231
Protein
Gene Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P22891
Protein name Vitamin K-dependent protein Z
Protein function Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids.
PDB 3F1S , 3H5C
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00594 Gla 46 → 86 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain Domain
PF00008 EGF 91 → 121 EGF-like domain Domain
PF00089 Trypsin 177 → 395 Trypsin Domain
Tissue specificity TISSUE SPECIFICITY: Plasma.
Sequence
Sequence length 400
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Gamma-carboxylation of protein precursors
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Removal of aminoterminal propeptides from gamma-carboxylated proteins
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (2)
Unknown
Disease term Disease name Evidence References Source
Protein z deficiency PROTEIN Z DEFICIENCY 15638861 ClinVar
Protein Z Deficiency protein Z deficiency GenCC
Show/Hide Text Mining Associations (9)
Associations from Text Mining
Disease Name Relationship Type References
Acute Chest Syndrome Associate 28548215
Anemia Sickle Cell Associate 28548215
Carcinoma Hepatocellular Associate 36140703
Neoplasms Associate 36140703
Pre Eclampsia Associate 35588731
Pulmonary Heart Disease Associate 28548215
Status Asthmaticus Associate 28548215
Thromboembolism Associate 19050305
Thrombophilia Associate 37098010