ASAP2 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 2)

Gene

• Entrez ID: 8853
• Gene name: ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
• Gene symbol: ASAP2
• Synonyms (NCBI Gene): AMAP2, CENTB3, DDEF2, PAG3, PAP, Pap-alpha, SHAG1
• Chromosome: 2
• Chromosome location: 2p25.1|2p24
• Summary: This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homol

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019707	hsa-miR-375	Microarray	20215506
MIRT626426	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT626425	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT626424	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT626423	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT626422	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT626421	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT626420	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT626419	hsa-miR-618	HITS-CLIP	23824327
MIRT626418	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT626417	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT626416	hsa-miR-4672	HITS-CLIP	23824327
MIRT441171	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT441171	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT626426	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT626425	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT626424	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT626423	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT626422	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT626421	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT626420	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT626419	hsa-miR-618	HITS-CLIP	23824327
MIRT626418	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT626417	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT626416	hsa-miR-4672	HITS-CLIP	23824327
MIRT801755	hsa-miR-217	CLIP-seq
MIRT801756	hsa-miR-218	CLIP-seq
MIRT801757	hsa-miR-300	CLIP-seq
MIRT801758	hsa-miR-338-5p	CLIP-seq
MIRT801759	hsa-miR-340	CLIP-seq
MIRT801760	hsa-miR-34b	CLIP-seq
MIRT801761	hsa-miR-381	CLIP-seq
MIRT801762	hsa-miR-4477b	CLIP-seq
MIRT801763	hsa-miR-4666-3p	CLIP-seq
MIRT801764	hsa-miR-4789-5p	CLIP-seq
MIRT801765	hsa-miR-582-5p	CLIP-seq
MIRT801766	hsa-miR-944	CLIP-seq
MIRT801767	hsa-miR-105	CLIP-seq
MIRT801768	hsa-miR-145	CLIP-seq
MIRT801769	hsa-miR-151-3p	CLIP-seq
MIRT801770	hsa-miR-154	CLIP-seq
MIRT801771	hsa-miR-19a	CLIP-seq
MIRT801772	hsa-miR-19b	CLIP-seq
MIRT801773	hsa-miR-202	CLIP-seq
MIRT801774	hsa-miR-2053	CLIP-seq
MIRT801775	hsa-miR-219-5p	CLIP-seq
MIRT801776	hsa-miR-22	CLIP-seq
MIRT801777	hsa-miR-29a	CLIP-seq
MIRT801778	hsa-miR-29b	CLIP-seq
MIRT801779	hsa-miR-29c	CLIP-seq
MIRT801757	hsa-miR-300	CLIP-seq
MIRT801780	hsa-miR-302a	CLIP-seq
MIRT801781	hsa-miR-302b	CLIP-seq
MIRT801782	hsa-miR-302c	CLIP-seq
MIRT801783	hsa-miR-302d	CLIP-seq
MIRT801784	hsa-miR-302e	CLIP-seq
MIRT801785	hsa-miR-3065-5p	CLIP-seq
MIRT801786	hsa-miR-3120-5p	CLIP-seq
MIRT801787	hsa-miR-3121-3p	CLIP-seq
MIRT801788	hsa-miR-3147	CLIP-seq
MIRT801789	hsa-miR-3153	CLIP-seq
MIRT801758	hsa-miR-338-5p	CLIP-seq
MIRT801759	hsa-miR-340	CLIP-seq
MIRT801790	hsa-miR-3664-3p	CLIP-seq
MIRT801791	hsa-miR-3674	CLIP-seq
MIRT801792	hsa-miR-3685	CLIP-seq
MIRT801793	hsa-miR-372	CLIP-seq
MIRT801794	hsa-miR-373	CLIP-seq
MIRT801761	hsa-miR-381	CLIP-seq
MIRT801795	hsa-miR-384	CLIP-seq
MIRT801796	hsa-miR-3977	CLIP-seq
MIRT801797	hsa-miR-425	CLIP-seq
MIRT801798	hsa-miR-4273	CLIP-seq
MIRT801799	hsa-miR-4275	CLIP-seq
MIRT801800	hsa-miR-4310	CLIP-seq
MIRT801801	hsa-miR-4328	CLIP-seq
MIRT801802	hsa-miR-4425	CLIP-seq
MIRT801803	hsa-miR-4445	CLIP-seq
MIRT801804	hsa-miR-4463	CLIP-seq
MIRT801805	hsa-miR-4499	CLIP-seq
MIRT801806	hsa-miR-4520a-3p	CLIP-seq
MIRT801807	hsa-miR-4645-3p	CLIP-seq
MIRT801763	hsa-miR-4666-3p	CLIP-seq
MIRT801808	hsa-miR-4668-5p	CLIP-seq
MIRT801809	hsa-miR-4677-5p	CLIP-seq
MIRT801810	hsa-miR-4705	CLIP-seq
MIRT801811	hsa-miR-4719	CLIP-seq
MIRT801812	hsa-miR-4772-3p	CLIP-seq
MIRT801813	hsa-miR-4782-3p	CLIP-seq
MIRT801764	hsa-miR-4789-5p	CLIP-seq
MIRT801814	hsa-miR-495	CLIP-seq
MIRT801815	hsa-miR-501-3p	CLIP-seq
MIRT801816	hsa-miR-502-3p	CLIP-seq
MIRT801817	hsa-miR-508-3p	CLIP-seq
MIRT801818	hsa-miR-510	CLIP-seq
MIRT801819	hsa-miR-513b	CLIP-seq
MIRT801820	hsa-miR-519a	CLIP-seq
MIRT801821	hsa-miR-519b-3p	CLIP-seq
MIRT801822	hsa-miR-519c-3p	CLIP-seq
MIRT801823	hsa-miR-520a-3p	CLIP-seq
MIRT801824	hsa-miR-520b	CLIP-seq
MIRT801825	hsa-miR-520c-3p	CLIP-seq
MIRT801826	hsa-miR-520d-3p	CLIP-seq
MIRT801827	hsa-miR-520e	CLIP-seq
MIRT801828	hsa-miR-526b	CLIP-seq
MIRT801829	hsa-miR-543	CLIP-seq
MIRT801830	hsa-miR-548k	CLIP-seq
MIRT801831	hsa-miR-548n	CLIP-seq
MIRT801832	hsa-miR-659	CLIP-seq
MIRT801833	hsa-miR-767-5p	CLIP-seq
MIRT801834	hsa-miR-873	CLIP-seq
MIRT1936732	hsa-miR-1286	CLIP-seq
MIRT801768	hsa-miR-145	CLIP-seq
MIRT1936733	hsa-miR-153	CLIP-seq
MIRT1936734	hsa-miR-1827	CLIP-seq
MIRT801774	hsa-miR-2053	CLIP-seq
MIRT801775	hsa-miR-219-5p	CLIP-seq
MIRT801757	hsa-miR-300	CLIP-seq
MIRT801786	hsa-miR-3120-5p	CLIP-seq
MIRT801787	hsa-miR-3121-3p	CLIP-seq
MIRT1936735	hsa-miR-3163	CLIP-seq
MIRT1936736	hsa-miR-323-5p	CLIP-seq
MIRT801792	hsa-miR-3685	CLIP-seq
MIRT1936737	hsa-miR-3691-3p	CLIP-seq
MIRT801761	hsa-miR-381	CLIP-seq
MIRT801795	hsa-miR-384	CLIP-seq
MIRT1936738	hsa-miR-3908	CLIP-seq
MIRT1936739	hsa-miR-3929	CLIP-seq
MIRT1936740	hsa-miR-3942-5p	CLIP-seq
MIRT801798	hsa-miR-4273	CLIP-seq
MIRT801799	hsa-miR-4275	CLIP-seq
MIRT801801	hsa-miR-4328	CLIP-seq
MIRT1936741	hsa-miR-4419b	CLIP-seq
MIRT801803	hsa-miR-4445	CLIP-seq
MIRT1936742	hsa-miR-4478	CLIP-seq
MIRT1936743	hsa-miR-4640-5p	CLIP-seq
MIRT801763	hsa-miR-4666-3p	CLIP-seq
MIRT801809	hsa-miR-4677-5p	CLIP-seq
MIRT1936744	hsa-miR-4703-5p	CLIP-seq
MIRT801810	hsa-miR-4705	CLIP-seq
MIRT1936745	hsa-miR-4722-5p	CLIP-seq
MIRT1936746	hsa-miR-4726-5p	CLIP-seq
MIRT1936747	hsa-miR-4733-3p	CLIP-seq
MIRT1936748	hsa-miR-4766-3p	CLIP-seq
MIRT801813	hsa-miR-4782-3p	CLIP-seq
MIRT801764	hsa-miR-4789-5p	CLIP-seq
MIRT1936749	hsa-miR-487a	CLIP-seq
MIRT1936750	hsa-miR-488	CLIP-seq
MIRT801817	hsa-miR-508-3p	CLIP-seq
MIRT1936751	hsa-miR-508-5p	CLIP-seq
MIRT801819	hsa-miR-513b	CLIP-seq
MIRT801829	hsa-miR-543	CLIP-seq
MIRT1936752	hsa-miR-548ae	CLIP-seq
MIRT1936753	hsa-miR-548aj	CLIP-seq
MIRT1936754	hsa-miR-548am	CLIP-seq
MIRT801831	hsa-miR-548n	CLIP-seq
MIRT1936755	hsa-miR-548t	CLIP-seq
MIRT1936756	hsa-miR-548x	CLIP-seq
MIRT801834	hsa-miR-873	CLIP-seq
MIRT1936757	hsa-miR-940	CLIP-seq
MIRT801765	hsa-miR-582-5p	CLIP-seq
MIRT801774	hsa-miR-2053	CLIP-seq
MIRT801757	hsa-miR-300	CLIP-seq
MIRT2176529	hsa-miR-3647-3p	CLIP-seq
MIRT801761	hsa-miR-381	CLIP-seq
MIRT801803	hsa-miR-4445	CLIP-seq
MIRT801763	hsa-miR-4666-3p	CLIP-seq
MIRT801812	hsa-miR-4772-3p	CLIP-seq
MIRT801829	hsa-miR-543	CLIP-seq
MIRT801767	hsa-miR-105	CLIP-seq
MIRT1936732	hsa-miR-1286	CLIP-seq
MIRT2176530	hsa-miR-199a-3p	CLIP-seq
MIRT2176531	hsa-miR-199b-3p	CLIP-seq
MIRT801774	hsa-miR-2053	CLIP-seq
MIRT801755	hsa-miR-217	CLIP-seq
MIRT2176532	hsa-miR-3129-5p	CLIP-seq
MIRT2176533	hsa-miR-3134	CLIP-seq
MIRT1936735	hsa-miR-3163	CLIP-seq
MIRT1936736	hsa-miR-323-5p	CLIP-seq
MIRT801759	hsa-miR-340	CLIP-seq
MIRT2176529	hsa-miR-3647-3p	CLIP-seq
MIRT801795	hsa-miR-384	CLIP-seq
MIRT1936739	hsa-miR-3929	CLIP-seq
MIRT2176534	hsa-miR-4303	CLIP-seq
MIRT801801	hsa-miR-4328	CLIP-seq
MIRT1936741	hsa-miR-4419b	CLIP-seq
MIRT801803	hsa-miR-4445	CLIP-seq
MIRT1936742	hsa-miR-4478	CLIP-seq
MIRT2176535	hsa-miR-4502	CLIP-seq
MIRT2176536	hsa-miR-4534	CLIP-seq
MIRT2176537	hsa-miR-4666-5p	CLIP-seq
MIRT801810	hsa-miR-4705	CLIP-seq
MIRT1936745	hsa-miR-4722-5p	CLIP-seq
MIRT1936747	hsa-miR-4733-3p	CLIP-seq
MIRT801812	hsa-miR-4772-3p	CLIP-seq
MIRT1936749	hsa-miR-487a	CLIP-seq
MIRT801815	hsa-miR-501-3p	CLIP-seq
MIRT801816	hsa-miR-502-3p	CLIP-seq
MIRT2176538	hsa-miR-570	CLIP-seq
MIRT801765	hsa-miR-582-5p	CLIP-seq
MIRT801833	hsa-miR-767-5p	CLIP-seq
MIRT801834	hsa-miR-873	CLIP-seq
MIRT2176539	hsa-miR-936	CLIP-seq
MIRT1936735	hsa-miR-3163	CLIP-seq
MIRT1936736	hsa-miR-323-5p	CLIP-seq
MIRT1936739	hsa-miR-3929	CLIP-seq
MIRT1936741	hsa-miR-4419b	CLIP-seq
MIRT1936742	hsa-miR-4478	CLIP-seq
MIRT1936747	hsa-miR-4733-3p	CLIP-seq
MIRT801767	hsa-miR-105	CLIP-seq
MIRT801785	hsa-miR-3065-5p	CLIP-seq
MIRT801800	hsa-miR-4310	CLIP-seq
MIRT801800	hsa-miR-4310	CLIP-seq
MIRT2479851	hsa-miR-1283	CLIP-seq
MIRT1936732	hsa-miR-1286	CLIP-seq
MIRT2479852	hsa-miR-1302	CLIP-seq
MIRT801769	hsa-miR-151-3p	CLIP-seq
MIRT2479853	hsa-miR-190	CLIP-seq
MIRT2479854	hsa-miR-190b	CLIP-seq
MIRT801771	hsa-miR-19a	CLIP-seq
MIRT801772	hsa-miR-19b	CLIP-seq
MIRT801774	hsa-miR-2053	CLIP-seq
MIRT801777	hsa-miR-29a	CLIP-seq
MIRT801778	hsa-miR-29b	CLIP-seq
MIRT801779	hsa-miR-29c	CLIP-seq
MIRT801780	hsa-miR-302a	CLIP-seq
MIRT801781	hsa-miR-302b	CLIP-seq
MIRT801782	hsa-miR-302c	CLIP-seq
MIRT801783	hsa-miR-302d	CLIP-seq
MIRT801784	hsa-miR-302e	CLIP-seq
MIRT801787	hsa-miR-3121-3p	CLIP-seq
MIRT2479855	hsa-miR-3122	CLIP-seq
MIRT2479856	hsa-miR-3129-3p	CLIP-seq
MIRT2479857	hsa-miR-3140-3p	CLIP-seq
MIRT2479858	hsa-miR-3148	CLIP-seq
MIRT1936735	hsa-miR-3163	CLIP-seq
MIRT2479859	hsa-miR-3168	CLIP-seq
MIRT2479860	hsa-miR-3179	CLIP-seq
MIRT2479861	hsa-miR-3199	CLIP-seq
MIRT1936736	hsa-miR-323-5p	CLIP-seq
MIRT2479862	hsa-miR-331-5p	CLIP-seq
MIRT2479863	hsa-miR-3646	CLIP-seq
MIRT2176529	hsa-miR-3647-3p	CLIP-seq
MIRT801791	hsa-miR-3674	CLIP-seq
MIRT801792	hsa-miR-3685	CLIP-seq
MIRT801793	hsa-miR-372	CLIP-seq
MIRT801794	hsa-miR-373	CLIP-seq
MIRT801795	hsa-miR-384	CLIP-seq
MIRT2479864	hsa-miR-3913-5p	CLIP-seq
MIRT2479865	hsa-miR-3924	CLIP-seq
MIRT1936739	hsa-miR-3929	CLIP-seq
MIRT2479866	hsa-miR-409-3p	CLIP-seq
MIRT2479867	hsa-miR-4279	CLIP-seq
MIRT2479868	hsa-miR-4298	CLIP-seq
MIRT2479869	hsa-miR-4307	CLIP-seq
MIRT1936741	hsa-miR-4419b	CLIP-seq
MIRT801803	hsa-miR-4445	CLIP-seq
MIRT2479870	hsa-miR-4459	CLIP-seq
MIRT801804	hsa-miR-4463	CLIP-seq
MIRT1936742	hsa-miR-4478	CLIP-seq
MIRT2479871	hsa-miR-4490	CLIP-seq
MIRT801805	hsa-miR-4499	CLIP-seq
MIRT2479872	hsa-miR-450b-5p	CLIP-seq
MIRT2479873	hsa-miR-4515	CLIP-seq
MIRT2479874	hsa-miR-4524	CLIP-seq
MIRT2479875	hsa-miR-4653-3p	CLIP-seq
MIRT2479876	hsa-miR-4678	CLIP-seq
MIRT2479877	hsa-miR-4690-5p	CLIP-seq
MIRT2479878	hsa-miR-4708-3p	CLIP-seq
MIRT2479879	hsa-miR-4712-3p	CLIP-seq
MIRT1936745	hsa-miR-4722-5p	CLIP-seq
MIRT1936747	hsa-miR-4733-3p	CLIP-seq
MIRT2479880	hsa-miR-4753-3p	CLIP-seq
MIRT2479881	hsa-miR-4768-5p	CLIP-seq
MIRT2479882	hsa-miR-4774-5p	CLIP-seq
MIRT2479883	hsa-miR-4775	CLIP-seq
MIRT2479884	hsa-miR-4803	CLIP-seq
MIRT2479885	hsa-miR-494	CLIP-seq
MIRT801820	hsa-miR-519a	CLIP-seq
MIRT801821	hsa-miR-519b-3p	CLIP-seq
MIRT801822	hsa-miR-519c-3p	CLIP-seq
MIRT801823	hsa-miR-520a-3p	CLIP-seq
MIRT801824	hsa-miR-520b	CLIP-seq
MIRT801825	hsa-miR-520c-3p	CLIP-seq
MIRT801826	hsa-miR-520d-3p	CLIP-seq
MIRT801827	hsa-miR-520e	CLIP-seq
MIRT2479886	hsa-miR-539	CLIP-seq
MIRT2479887	hsa-miR-576-5p	CLIP-seq
MIRT2479888	hsa-miR-875-3p	CLIP-seq
MIRT2479889	hsa-miR-889	CLIP-seq
MIRT801787	hsa-miR-3121-3p	CLIP-seq
MIRT2479851	hsa-miR-1283	CLIP-seq
MIRT1936732	hsa-miR-1286	CLIP-seq
MIRT2479852	hsa-miR-1302	CLIP-seq
MIRT801769	hsa-miR-151-3p	CLIP-seq
MIRT2479853	hsa-miR-190	CLIP-seq
MIRT2479854	hsa-miR-190b	CLIP-seq
MIRT801771	hsa-miR-19a	CLIP-seq
MIRT801772	hsa-miR-19b	CLIP-seq
MIRT801774	hsa-miR-2053	CLIP-seq
MIRT801777	hsa-miR-29a	CLIP-seq
MIRT801778	hsa-miR-29b	CLIP-seq
MIRT801779	hsa-miR-29c	CLIP-seq
MIRT801780	hsa-miR-302a	CLIP-seq
MIRT801781	hsa-miR-302b	CLIP-seq
MIRT801782	hsa-miR-302c	CLIP-seq
MIRT801783	hsa-miR-302d	CLIP-seq
MIRT801784	hsa-miR-302e	CLIP-seq
MIRT801787	hsa-miR-3121-3p	CLIP-seq
MIRT2479855	hsa-miR-3122	CLIP-seq
MIRT2479856	hsa-miR-3129-3p	CLIP-seq
MIRT2479857	hsa-miR-3140-3p	CLIP-seq
MIRT2479858	hsa-miR-3148	CLIP-seq
MIRT1936735	hsa-miR-3163	CLIP-seq
MIRT2479859	hsa-miR-3168	CLIP-seq
MIRT2479860	hsa-miR-3179	CLIP-seq
MIRT2479861	hsa-miR-3199	CLIP-seq
MIRT1936736	hsa-miR-323-5p	CLIP-seq
MIRT2479862	hsa-miR-331-5p	CLIP-seq
MIRT2479863	hsa-miR-3646	CLIP-seq
MIRT2176529	hsa-miR-3647-3p	CLIP-seq
MIRT801791	hsa-miR-3674	CLIP-seq
MIRT801792	hsa-miR-3685	CLIP-seq
MIRT801793	hsa-miR-372	CLIP-seq
MIRT801794	hsa-miR-373	CLIP-seq
MIRT801795	hsa-miR-384	CLIP-seq
MIRT2479864	hsa-miR-3913-5p	CLIP-seq
MIRT2479865	hsa-miR-3924	CLIP-seq
MIRT1936739	hsa-miR-3929	CLIP-seq
MIRT2479866	hsa-miR-409-3p	CLIP-seq
MIRT2479868	hsa-miR-4298	CLIP-seq
MIRT2479869	hsa-miR-4307	CLIP-seq
MIRT1936741	hsa-miR-4419b	CLIP-seq
MIRT801803	hsa-miR-4445	CLIP-seq
MIRT2479870	hsa-miR-4459	CLIP-seq
MIRT801804	hsa-miR-4463	CLIP-seq
MIRT1936742	hsa-miR-4478	CLIP-seq
MIRT801805	hsa-miR-4499	CLIP-seq
MIRT2479872	hsa-miR-450b-5p	CLIP-seq
MIRT2479873	hsa-miR-4515	CLIP-seq
MIRT2479874	hsa-miR-4524	CLIP-seq
MIRT2479875	hsa-miR-4653-3p	CLIP-seq
MIRT2479876	hsa-miR-4678	CLIP-seq
MIRT2479877	hsa-miR-4690-5p	CLIP-seq
MIRT2479878	hsa-miR-4708-3p	CLIP-seq
MIRT2479879	hsa-miR-4712-3p	CLIP-seq
MIRT1936745	hsa-miR-4722-5p	CLIP-seq
MIRT1936747	hsa-miR-4733-3p	CLIP-seq
MIRT2479880	hsa-miR-4753-3p	CLIP-seq
MIRT2479881	hsa-miR-4768-5p	CLIP-seq
MIRT2479883	hsa-miR-4775	CLIP-seq
MIRT2479884	hsa-miR-4803	CLIP-seq
MIRT2479885	hsa-miR-494	CLIP-seq
MIRT801820	hsa-miR-519a	CLIP-seq
MIRT801821	hsa-miR-519b-3p	CLIP-seq
MIRT801822	hsa-miR-519c-3p	CLIP-seq
MIRT801823	hsa-miR-520a-3p	CLIP-seq
MIRT801824	hsa-miR-520b	CLIP-seq
MIRT801825	hsa-miR-520c-3p	CLIP-seq
MIRT801826	hsa-miR-520d-3p	CLIP-seq
MIRT801827	hsa-miR-520e	CLIP-seq
MIRT2479886	hsa-miR-539	CLIP-seq
MIRT2479887	hsa-miR-576-5p	CLIP-seq
MIRT2479888	hsa-miR-875-3p	CLIP-seq
MIRT2479889	hsa-miR-889	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
CTCF	Unknown	23999061
VDR	Unknown	23999061

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IEA
GO:0005515	Function	Protein binding	IPI	11716503, 17255943, 17474147, 18786926, 20936779, 21706016, 25416956, 31980649, 33961781
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0032580	Component	Golgi cisterna membrane	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 603817
• HGNC: 2721
• e!Ensembl: ENSG00000151693

Protein

• UniProt ID: O43150
• Protein name: Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 (Development and differentiation-enhancing factor 2) (Paxillin-associated protein with ARF GAP activity 3) (PAG3) (Pyk2 C-terminus-associated protein) (PAP)
• Protein function: Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF16746	BAR_3	31 → 266		Domain
  PF00169	PH	306 → 397	PH domain	Domain
  PF01412	ArfGap	421 → 539	Putative GTPase activating protein for Arf	Domain
  PF00023	Ank	620 → 652	Ankyrin repeat	Repeat
  PF14604	SH3_9	951 → 1002	Variant SH3 domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Detected in heart, brain, placenta, kidney, monocytes and pancreas. {ECO:0000269|PubMed:10022920}.
• Sequence:

  MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKA
  INSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMN
  NIISFPLDSLLKGDLKGVKGDLKKPFDKAWKDYETKITKIEKEKKEHAKLHGMIRTEISG
  AEIAEEMEKERRFFQLQMCEYLLKVNEIKIKKGVDLLQNLIKYFHAQCNFFQDGLKAVES
  LKPSIETLSTDLHTIKQAQDEERRQLIQLRDILKSALQVEQKEDSQIRQSTAYSLHQPQG
  NKEHGTERNGSLYKKSDGIRKVWQKRKCSVKNGFLTISHGTANRPPAKLNLLTCQVKTNP
  EEKKCFDLISHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELT
  KEIISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDV
  LGTSELLLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKKH
  ADNAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTS
  LHIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEIANESGETPLDI
  AKRLKHEHCEELLTQALSGRFNSHVHVEYEWRLLHEDLDESDDDMDEKLQPSPNRREDRP
  ISFYQLGSNQLQSNAVSLARDAANLAKEKQRAFMPSILQNETYGALLSGSPPPAQPAAPS
  TTSAPPLPPRNVGKVQTASSANTLWKTNSVSVDGGSRQRSSSDPPAVHPPLPPLRVTSTN
  PLTPTPPPPVAKTPSVMEALSQPSKPAPPGISQIRPPPLPPQPPSRLPQKKPAPGADKST
  PLTNKGQPRGPVDLSATEALGPLSNAMVLQPPAPMPRKSQATKLKPKRVKALYNCVADNP
  DELTFSEGDVIIVDGEEDQEWWIGHIDGDPGRKGAFPVSFVHFIAD

• Sequence length: 1006

Pathways

KEGG:

Endocytosis
Fc gamma R-mediated phagocytosis

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Colon adenocarcinoma	Benign	rs34464740	RCV005908126
Colorectal cancer	Benign	rs34464740	RCV005908128
Gastric cancer	Uncertain significance; Benign	rs752573155, rs34464740	RCV005930889 RCV005908129
Nonpapillary renal cell carcinoma	Benign	rs34464740	RCV005908127
Ovarian serous cystadenocarcinoma	Benign	rs34464740	RCV005908130
Thyroid cancer, nonmedullary, 1	Benign	rs34464740	RCV005908131

Associations from Text Mining
Disease Name	Relationship Type	References
Amyotrophic Lateral Sclerosis	Stimulate	40033250
Anemia Sickle Cell	Associate	39209956
Carcinoma Hepatocellular	Associate	38320622
Carcinoma Renal Cell	Associate	25230976
Episodic Ataxia	Associate	39209956
Neoplasm Metastasis	Associate	34486534
Neoplasms	Associate	37914932
Pituitary Neoplasms	Associate	24198235
Stomach Neoplasms	Associate	34486534