CCK (cholecystokinin)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
885
Gene name Gene Name - the full gene name approved by the HGNC.
Cholecystokinin
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CCK
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3p22.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the gastrin/cholecystokinin family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the peptide hormones cholecystokinin-8, -12, -33, and others. The encoded
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(3)
miRTarBase ID miRNA Experiments Reference
MIRT870835 hsa-miR-1245b-3p CLIP-seq
MIRT870836 hsa-miR-3185 CLIP-seq
MIRT870837 hsa-miR-570 CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(10)
Transcription factor Regulation Reference
CREB1 Unknown 15030385;15073527
CREBBP Unknown 15030385
EWSR1 Unknown 17438102
FLI1 Unknown 17438102
FOS Activation 1360635
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0001764 Process Neuron migration IEA
GO:0001764 Process Neuron migration ISS 15152034
GO:0005179 Function Hormone activity IEA
GO:0005179 Function Hormone activity TAS 10320330
GO:0005184 Function Neuropeptide hormone activity IBA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
118440 1569 ENSG00000187094
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P06307
Protein name Cholecystokinin (CCK) [Cleaved into: Cholecystokinin-58 (CCK58); Cholecystokinin-58 desnonopeptide ((1-49)-CCK58); Cholecystokinin-39 (CCK39); Cholecystokinin-33 (CCK33); Cholecystokinin-25 (CCK25); Cholecystokinin-18 (CCK18); Cholecystokinin-12 (CCK12);
Protein function This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors s
PDB 7EZH , 7EZK , 7EZM , 7MBX , 7MBY , 7XOU , 8IA7 , 9BKJ , 9BKK
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00918 Gastrin 3 → 115 Gastrin/cholecystokinin family Family
Tissue specificity TISSUE SPECIFICITY: Detected in cerebrospinal fluid and urine (at protein level). {ECO:0000269|PubMed:25326458, ECO:0000269|PubMed:37453717}.
Sequence
Sequence length 115
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Neuroactive ligand-receptor interaction
Hormone signaling
Insulin secretion
Pancreatic secretion 		  Peptide ligand-binding receptors
G alpha (q) signalling events
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (3)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Diabetes Type 2 diabetes N/A N/A GWAS
Glioblastoma Glioblastoma N/A N/A GWAS
Metabolic Syndrome Metabolic syndrome N/A N/A GWAS
Show/Hide Text Mining Associations (36)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Alzheimer Disease Associate 36635346
Anxiety Associate 26454231
Bicuspid Aortic Valve Disease Associate 36071494
Biliary Tract Neoplasms Associate 15682471, 23701593
Breast Neoplasms Associate 26395295, 26472474
Carcinogenesis Associate 9239407
Colonic Neoplasms Associate 26508021
Desmoplastic Small Round Cell Tumor Associate 1631063
Diabetes Mellitus Associate 28592602
Diabetes Mellitus Type 2 Associate 31691451