Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	8844
Gene name	Kinase suppressor of ras 1
Gene symbol	KSR1
Synonyms (NCBI Gene)	KSRRSU2
Chromosome	17
Chromosome location	17q11.2

Show/Hide all (64)

miRTarBase ID	miRNA	Experiments	Reference
MIRT437886	hsa-miR-378a-3p	Luciferase reporter assay	23625957
MIRT437886	hsa-miR-378a-3p	Luciferase reporter assay	23625957
MIRT441642	hsa-miR-548e-5p	PAR-CLIP	22100165
MIRT441641	hsa-miR-140-3p	PAR-CLIP	22100165
MIRT441640	hsa-miR-4286	PAR-CLIP	22100165
MIRT440348	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440348	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT441642	hsa-miR-548e-5p	PAR-CLIP	22100165
MIRT441641	hsa-miR-140-3p	PAR-CLIP	22100165
MIRT441640	hsa-miR-4286	PAR-CLIP	22100165
MIRT1102163	hsa-miR-1915	CLIP-seq
MIRT1102164	hsa-miR-198	CLIP-seq
MIRT1102165	hsa-miR-2278	CLIP-seq
MIRT1102166	hsa-miR-3921	CLIP-seq
MIRT1102167	hsa-miR-4251	CLIP-seq
MIRT1102168	hsa-miR-4274	CLIP-seq
MIRT1102169	hsa-miR-4329	CLIP-seq
MIRT1102170	hsa-miR-4476	CLIP-seq
MIRT1102171	hsa-miR-450b-3p	CLIP-seq
MIRT1102172	hsa-miR-4519	CLIP-seq
MIRT1102173	hsa-miR-4524	CLIP-seq
MIRT1102174	hsa-miR-4653-5p	CLIP-seq
MIRT1102175	hsa-miR-4654	CLIP-seq
MIRT1102176	hsa-miR-4704-3p	CLIP-seq
MIRT1102177	hsa-miR-4713-3p	CLIP-seq
MIRT1102178	hsa-miR-4726-3p	CLIP-seq
MIRT1102179	hsa-miR-4769-5p	CLIP-seq
MIRT1102180	hsa-miR-494	CLIP-seq
MIRT1102181	hsa-miR-638	CLIP-seq
MIRT1102182	hsa-miR-665	CLIP-seq
MIRT1102183	hsa-miR-769-3p	CLIP-seq
MIRT1102184	hsa-miR-935	CLIP-seq
MIRT2027853	hsa-miR-224	CLIP-seq
MIRT2027854	hsa-miR-298	CLIP-seq
MIRT2027855	hsa-miR-33a	CLIP-seq
MIRT2027856	hsa-miR-33b	CLIP-seq
MIRT2027857	hsa-miR-3664-3p	CLIP-seq
MIRT2027858	hsa-miR-4433	CLIP-seq
MIRT2027859	hsa-miR-4459	CLIP-seq
MIRT1102173	hsa-miR-4524	CLIP-seq
MIRT2027860	hsa-miR-4768-3p	CLIP-seq
MIRT2027861	hsa-miR-4795-3p	CLIP-seq
MIRT2027862	hsa-miR-657	CLIP-seq
MIRT2259120	hsa-miR-1301	CLIP-seq
MIRT2259121	hsa-miR-219-2-3p	CLIP-seq
MIRT2027853	hsa-miR-224	CLIP-seq
MIRT2027854	hsa-miR-298	CLIP-seq
MIRT2027855	hsa-miR-33a	CLIP-seq
MIRT2027856	hsa-miR-33b	CLIP-seq
MIRT1102173	hsa-miR-4524	CLIP-seq
MIRT2259122	hsa-miR-4687-5p	CLIP-seq
MIRT2259123	hsa-miR-4690-3p	CLIP-seq
MIRT2259124	hsa-miR-5047	CLIP-seq
MIRT2259125	hsa-miR-579	CLIP-seq
MIRT2259126	hsa-miR-602	CLIP-seq
MIRT2390047	hsa-miR-141	CLIP-seq
MIRT2390048	hsa-miR-200a	CLIP-seq
MIRT2390049	hsa-miR-4661-5p	CLIP-seq
MIRT2390050	hsa-miR-4704-5p	CLIP-seq
MIRT2259126	hsa-miR-602	CLIP-seq
MIRT2259120	hsa-miR-1301	CLIP-seq
MIRT2259123	hsa-miR-4690-3p	CLIP-seq
MIRT2259124	hsa-miR-5047	CLIP-seq
MIRT2259125	hsa-miR-579	CLIP-seq

Show/Hide all (39)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	IEA
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IBA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005078	Function	MAP-kinase scaffold activity	ISS
GO:0005515	Function	Protein binding	IDA	22572157
GO:0005515	Function	Protein binding	IPI	11909642, 20679487, 22752157, 24929361, 27086506, 29433126, 31980649, 32707033, 35271311, 36931259, 37045861
GO:0005524	Function	ATP binding	IDA	29433126
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IDA	22572157
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IEA
GO:0007265	Process	Ras protein signal transduction	IBA
GO:0007265	Process	Ras protein signal transduction	ISS
GO:0007265	Process	Ras protein signal transduction	NAS	8521512
GO:0008270	Function	Zinc ion binding	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IDA	22572157
GO:0016020	Component	Membrane	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0032587	Component	Ruffle membrane	IEA
GO:0032991	Component	Protein-containing complex	IDA	22572157
GO:0042127	Process	Regulation of cell population proliferation	ISS
GO:0042995	Component	Cell projection	IEA
GO:0043405	Process	Regulation of MAP kinase activity	ISS
GO:0043410	Process	Positive regulation of MAPK cascade	IDA	29433126
GO:0043410	Process	Positive regulation of MAPK cascade	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0071889	Function	14-3-3 protein binding	IDA	29433126
GO:0106310	Function	Protein serine kinase activity	IEA

MIM	HGNC	e!Ensembl
601132	6465	ENSG00000141068

Q8IVT5

Protein name

Kinase suppressor of Ras 1 (EC 2.7.11.1)

Protein function

Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteri

PDB

5VYK , 7JUW , 7JUX , 7JUY , 7JUZ , 7JV0 , 7JV1 , 9AXH

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13543	SAM_KSR1	41 → 168	SAM like domain present in kinase suppressor RAS 1	Domain
PF07714	PK_Tyr_Ser-Thr	613 → 877	Protein tyrosine and serine/threonine kinase	Domain

Sequence

MDRAALRAAAMGEKKEGGGGGDAAAAEGGAGAAASRALQQCGQLQKLIDISIGSLRGLRT
KCAVSNDLTQQEIRTLEAKLVRYICKQRQCKLSVAPGERTPELNSYPRFSDWLYTFNVRP
EVVQEIPRDLTLDALLEMNEAKVKETLRRCGASGDECGRLQYALTCLRKVTGLGGEHKED
SSWSSLDARRESGSGPSTDTLSAASLPWPPGSSQLGRAGNSAQGPRSISVSALPASDSPT
PSFSEGLSDTCIPLHASGRLTPRALHSFITPPTTPQLRRHTKLKPPRTPPPPSRKVFQLL
PSFPTLTRSKSHESQLGNRIDDVSSMRFDLSHGSPQMVRRDIGLSVTHRFSTKSWLSQVC
HVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFLPLTRLRRTESVPSDINNPVDRAAE
PHFGTLPKALTKKEHPPAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSPG
QRDSRFNFPAAYFIHHRQQFIFPVPSAGHCWKCLLIAESLKENAFNISAFAHAAPLPEAA
DGTRLDDQPKADVLEAHEAEAEEPEAGKSEAEDDEDEVDDLPSSRRPWRGPISRKASQTS
VYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGYLHAKGIVHKDLKSKNVFYDNGKVVITDFGLFGISGVVREGRRENQLKLSHDWLCYLA
PEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWPLKNQAAEASIWQIGSGEGMK
RVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLEKLPKLNRRLSHPGHFWKSADIN
SSKVVPRFERFGLGVLESSNPKM

Sequence length

923

Interactions

View interactions

	KEGG		Reactome
	Ras signaling pathway C-type lectin receptor signaling pathway Tuberculosis		RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants

KSR1 (kinase suppressor of ras 1)