Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	8844
Gene name Gene Name - the full gene name approved by the HGNC.	Kinase suppressor of ras 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	KSR1
Synonyms (NCBI Gene) Gene synonyms aliases	KSR, RSU2
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17q11.2

Show/Hide all(64)

miRTarBase ID	miRNA	Experiments	Reference
MIRT437886	hsa-miR-378a-3p	Luciferase reporter assay	23625957
MIRT437886	hsa-miR-378a-3p	Luciferase reporter assay	23625957
MIRT441642	hsa-miR-548e-5p	PAR-CLIP	22100165
MIRT441641	hsa-miR-140-3p	PAR-CLIP	22100165
MIRT441640	hsa-miR-4286	PAR-CLIP	22100165
MIRT440348	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440348	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT441642	hsa-miR-548e-5p	PAR-CLIP	22100165
MIRT441641	hsa-miR-140-3p	PAR-CLIP	22100165
MIRT441640	hsa-miR-4286	PAR-CLIP	22100165
MIRT1102163	hsa-miR-1915	CLIP-seq
MIRT1102164	hsa-miR-198	CLIP-seq
MIRT1102165	hsa-miR-2278	CLIP-seq
MIRT1102166	hsa-miR-3921	CLIP-seq
MIRT1102167	hsa-miR-4251	CLIP-seq
MIRT1102168	hsa-miR-4274	CLIP-seq
MIRT1102169	hsa-miR-4329	CLIP-seq
MIRT1102170	hsa-miR-4476	CLIP-seq
MIRT1102171	hsa-miR-450b-3p	CLIP-seq
MIRT1102172	hsa-miR-4519	CLIP-seq
MIRT1102173	hsa-miR-4524	CLIP-seq
MIRT1102174	hsa-miR-4653-5p	CLIP-seq
MIRT1102175	hsa-miR-4654	CLIP-seq
MIRT1102176	hsa-miR-4704-3p	CLIP-seq
MIRT1102177	hsa-miR-4713-3p	CLIP-seq
MIRT1102178	hsa-miR-4726-3p	CLIP-seq
MIRT1102179	hsa-miR-4769-5p	CLIP-seq
MIRT1102180	hsa-miR-494	CLIP-seq
MIRT1102181	hsa-miR-638	CLIP-seq
MIRT1102182	hsa-miR-665	CLIP-seq
MIRT1102183	hsa-miR-769-3p	CLIP-seq
MIRT1102184	hsa-miR-935	CLIP-seq
MIRT2027853	hsa-miR-224	CLIP-seq
MIRT2027854	hsa-miR-298	CLIP-seq
MIRT2027855	hsa-miR-33a	CLIP-seq
MIRT2027856	hsa-miR-33b	CLIP-seq
MIRT2027857	hsa-miR-3664-3p	CLIP-seq
MIRT2027858	hsa-miR-4433	CLIP-seq
MIRT2027859	hsa-miR-4459	CLIP-seq
MIRT1102173	hsa-miR-4524	CLIP-seq
MIRT2027860	hsa-miR-4768-3p	CLIP-seq
MIRT2027861	hsa-miR-4795-3p	CLIP-seq
MIRT2027862	hsa-miR-657	CLIP-seq
MIRT2259120	hsa-miR-1301	CLIP-seq
MIRT2259121	hsa-miR-219-2-3p	CLIP-seq
MIRT2027853	hsa-miR-224	CLIP-seq
MIRT2027854	hsa-miR-298	CLIP-seq
MIRT2027855	hsa-miR-33a	CLIP-seq
MIRT2027856	hsa-miR-33b	CLIP-seq
MIRT1102173	hsa-miR-4524	CLIP-seq
MIRT2259122	hsa-miR-4687-5p	CLIP-seq
MIRT2259123	hsa-miR-4690-3p	CLIP-seq
MIRT2259124	hsa-miR-5047	CLIP-seq
MIRT2259125	hsa-miR-579	CLIP-seq
MIRT2259126	hsa-miR-602	CLIP-seq
MIRT2390047	hsa-miR-141	CLIP-seq
MIRT2390048	hsa-miR-200a	CLIP-seq
MIRT2390049	hsa-miR-4661-5p	CLIP-seq
MIRT2390050	hsa-miR-4704-5p	CLIP-seq
MIRT2259126	hsa-miR-602	CLIP-seq
MIRT2259120	hsa-miR-1301	CLIP-seq
MIRT2259123	hsa-miR-4690-3p	CLIP-seq
MIRT2259124	hsa-miR-5047	CLIP-seq
MIRT2259125	hsa-miR-579	CLIP-seq

Show/Hide all(39)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	IEA
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IBA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005078	Function	MAP-kinase scaffold activity	ISS
GO:0005515	Function	Protein binding	IDA	22572157
GO:0005515	Function	Protein binding	IPI	11909642, 20679487, 22752157, 24929361, 27086506, 29433126, 31980649, 32707033, 35271311, 36931259, 37045861
GO:0005524	Function	ATP binding	IDA	29433126
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IDA	22572157
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IEA
GO:0007265	Process	Ras protein signal transduction	IBA
GO:0007265	Process	Ras protein signal transduction	ISS
GO:0007265	Process	Ras protein signal transduction	NAS	8521512
GO:0008270	Function	Zinc ion binding	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IDA	22572157
GO:0016020	Component	Membrane	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0032587	Component	Ruffle membrane	IEA
GO:0032991	Component	Protein-containing complex	IDA	22572157
GO:0042127	Process	Regulation of cell population proliferation	ISS
GO:0042995	Component	Cell projection	IEA
GO:0043405	Process	Regulation of MAP kinase activity	ISS
GO:0043410	Process	Positive regulation of MAPK cascade	IDA	29433126
GO:0043410	Process	Positive regulation of MAPK cascade	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0071889	Function	14-3-3 protein binding	IDA	29433126
GO:0106310	Function	Protein serine kinase activity	IEA

MIM	HGNC	e!Ensembl
601132	6465	ENSG00000141068

Protein

UniProt ID

Q8IVT5

Protein name

Kinase suppressor of Ras 1 (EC 2.7.11.1)

Protein function

Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteri

PDB

5VYK , 7JUW , 7JUX , 7JUY , 7JUZ , 7JV0 , 7JV1 , 9AXH

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13543	SAM_KSR1	41 → 168	SAM like domain present in kinase suppressor RAS 1	Domain
PF07714	PK_Tyr_Ser-Thr	613 → 877	Protein tyrosine and serine/threonine kinase	Domain

Sequence

MDRAALRAAAMGEKKEGGGGGDAAAAEGGAGAAASRALQQCGQLQKLIDISIGSLRGLRT
KCAVSNDLTQQEIRTLEAKLVRYICKQRQCKLSVAPGERTPELNSYPRFSDWLYTFNVRP
EVVQEIPRDLTLDALLEMNEAKVKETLRRCGASGDECGRLQYALTCLRKVTGLGGEHKED
SSWSSLDARRESGSGPSTDTLSAASLPWPPGSSQLGRAGNSAQGPRSISVSALPASDSPT
PSFSEGLSDTCIPLHASGRLTPRALHSFITPPTTPQLRRHTKLKPPRTPPPPSRKVFQLL
PSFPTLTRSKSHESQLGNRIDDVSSMRFDLSHGSPQMVRRDIGLSVTHRFSTKSWLSQVC
HVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFLPLTRLRRTESVPSDINNPVDRAAE
PHFGTLPKALTKKEHPPAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSPG
QRDSRFNFPAAYFIHHRQQFIFPVPSAGHCWKCLLIAESLKENAFNISAFAHAAPLPEAA
DGTRLDDQPKADVLEAHEAEAEEPEAGKSEAEDDEDEVDDLPSSRRPWRGPISRKASQTS
VYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMN
YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
MGYLHAKGIVHKDLKSKNVFYDNGKVVITDFGLFGISGVVREGRRENQLKLSHDWLCYLA
PEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWPLKNQAAEASIWQIGSGEGMK
RVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLEKLPKLNRRLSHPGHFWKSADIN
SSKVVPRFERFGLGVLESSNPKM

Sequence length

923

Interactions

View interactions

	KEGG		Reactome
	Ras signaling pathway C-type lectin receptor signaling pathway Tuberculosis		RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants

Show/Hide Unknown Diseases (4)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Crohn Disease	Crohn's disease	N/A	N/A	GWAS
Inflammatory Bowel Disease	Inflammatory bowel disease	N/A	N/A	GWAS
Rheumatoid arthritis	Rheumatoid arthritis	N/A	N/A	GWAS
Systemic lupus erythematosus	Systemic lupus erythematosus	N/A	N/A	GWAS

Show/Hide Text Mining Associations (18)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Arthritis Juvenile	Associate	24886659
Asthma	Associate	32512817
Breast Neoplasms	Associate	15684389, 24129246, 26022350
Carcinogenesis	Associate	21435442
Colonic Neoplasms	Associate	27273865
Colorectal Neoplasms	Associate	27273865, 33970103
Endometrial Neoplasms	Stimulate	21435442
Fibrosarcoma	Associate	35313064
Inflammatory Bowel Diseases	Associate	34758847
Leukemia Myeloid Acute	Associate	38511641
Melanoma	Associate	37511580
Negative rheumatoid factor polyarthritis	Associate	24886659
Neoplasm Metastasis	Associate	15684389
Neoplasms	Inhibit	26022350
Neoplasms	Associate	27273865, 27556948, 35313064, 37511580, 37972068
Neurilemmoma	Associate	26549023
Pancreatic Carcinoma	Associate	26022350
Thymic epithelial tumor	Associate	30832724

KSR1 (kinase suppressor of ras 1)