Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene Gene ontology Other IDs Protein Pathways
Entrez ID	8843
Gene name	Hydroxycarboxylic acid receptor 3
Gene symbol	HCAR3
Synonyms (NCBI Gene)	GPR109BHCA3HM74PUMAGPuma-g
Chromosome	12
Chromosome location	12q24.31

Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	TAS	9205127
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	7505609
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	7505609
GO:0016020	Component	Membrane	IEA
GO:0030054	Component	Cell junction	IDA
GO:0070553	Function	Nicotinic acid receptor activity	IBA

MIM	HGNC	e!Ensembl
606039	16824	ENSG00000255398

P49019

Protein name

Hydroxycarboxylic acid receptor 3 (G-protein coupled receptor 109B) (G-protein coupled receptor HM74) (G-protein coupled receptor HM74B) (Niacin receptor 2) (Nicotinic acid receptor 2)

Protein function

Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity rece

PDB

8IHJ , 8IHK , 8JEF , 8JEI

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	44 → 294	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Expression largely restricted to adipose tissue and spleen. {ECO:0000269|PubMed:12522134}.

Sequence

MNRHHLQDHFLEIDKKNCCVFRDDFIAKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFVMDYYVRRSDWKFGDIPCRLVLFMFAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNWTAAIISCLLWGITVGLTVHLLKKKLLIQNGTANVCISF
SICHTFRWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIHIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKITGEPDNNRSTSVELTGDPNKTRGAPEALIANSGEPWSPSYLGP
TSNNHSKKGHCHQEPASLEKQLGCCIE

Sequence length

387

Interactions

View interactions

	KEGG		Reactome
	cAMP signaling pathway		Hydroxycarboxylic acid-binding receptors G alpha (i) signalling events

HCAR3 (hydroxycarboxylic acid receptor 3)