HCAR3 (hydroxycarboxylic acid receptor 3)

Gene
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8843
Gene name Gene Name - the full gene name approved by the HGNC.
Hydroxycarboxylic acid receptor 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
HCAR3
Synonyms (NCBI Gene) Gene synonyms aliases
GPR109B, HCA3, HM74, PUMAG, Puma-g
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q24.31
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(12)
GO ID Ontology Definition Evidence Reference
GO:0004930 Function G protein-coupled receptor activity IEA
GO:0004930 Function G protein-coupled receptor activity TAS 9205127
GO:0005886 Component Plasma membrane IBA
GO:0005886 Component Plasma membrane IEA
GO:0005886 Component Plasma membrane TAS 7505609
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
606039 16824 ENSG00000255398
Protein
Gene Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P49019
Protein name Hydroxycarboxylic acid receptor 3 (G-protein coupled receptor 109B) (G-protein coupled receptor HM74) (G-protein coupled receptor HM74B) (Niacin receptor 2) (Nicotinic acid receptor 2)
Protein function Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity rece
PDB 8IHJ , 8IHK , 8JEF , 8JEI
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 44 → 294 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Expression largely restricted to adipose tissue and spleen. {ECO:0000269|PubMed:12522134}.
Sequence
Sequence length 387
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  cAMP signaling pathway   Hydroxycarboxylic acid-binding receptors
G alpha (i) signalling events
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (2)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Metabolic Syndrome Metabolic syndrome N/A N/A GWAS
Obsessive-Compulsive Disorder Obsessive-compulsive disorder N/A N/A GWAS
Show/Hide Text Mining Associations (33)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Asthma Associate 34727921
Atherosclerosis Associate 30270326
Bipolar Disorder Associate 19502010
Breast Neoplasms Stimulate 25839160
Breast Neoplasms Associate 34852802, 39375417
Carcinoma Non Small Cell Lung Associate 35170376
Colorectal Neoplasms Associate 34419055
Coronary Artery Disease Associate 33506919
Coronary Disease Associate 32743916
Cytokine Release Syndrome Associate 30270326