Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8837
Gene name Gene Name - the full gene name approved by the HGNC.
CASP8 and FADD like apoptosis regulator
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CFLAR
Synonyms (NCBI Gene) Gene synonyms aliases
CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, cFLIP
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q33.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encodin
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004228 hsa-miR-346 Microarray 16822819
MIRT025744 hsa-miR-7-5p Microarray 19073608
MIRT050158 hsa-miR-26a-5p CLASH 23622248
MIRT053401 hsa-miR-629-5p Microarray 23807165
MIRT887612 hsa-miR-103a CLIP-seq
Transcription factors
Transcription factor Regulation Reference
ATM Activation 19351839
ATM Repression 20876284
DEDD Unknown 17193921
HDAC9 Activation 20087862
HDAC9 Repression 15540114
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001666 Process Response to hypoxia IEA
GO:0002020 Function Protease binding IEA
GO:0002020 Function Protease binding IPI 9208847
GO:0004197 Function Cysteine-type endopeptidase activity IBA
GO:0004197 Function Cysteine-type endopeptidase activity IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
603599 1876 ENSG00000003402
Protein
UniProt ID O15519
Protein name CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1)
Protein function Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-i
PDB 2N5R , 3H11 , 3H13 , 6M6O , 7DEE , 7LXC , 8YBX , 8YD7 , 8YD8 , 8YM4 , 8YM5 , 8YM6 , 8YNI , 8YNK , 8YNL , 8YNM , 8YNN
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01335 DED 3 77 Death effector domain Domain
PF01335 DED 93 174 Death effector domain Domain
PF00656 Peptidase_C14 253 477 Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle.
Sequence
Sequence length 480
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  NF-kappa B signaling pathway
Autophagy - animal
Apoptosis
Necroptosis
TNF signaling pathway
Chagas disease
Hepatitis C
  Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
Dimerization of procaspase-8
TRAIL signaling
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Breast Cancer Breast cancer N/A N/A GWAS
Lymphocytic Leukemia Chronic lymphocytic leukemia N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 17726263
Adenocarcinoma of Lung Associate 16052233, 26972480, 31638235, 33985619
Arthritis Rheumatoid Associate 12115181, 15457448
Autoimmune Diseases Associate 29222334
Behcet Syndrome Associate 15986355
Breast Neoplasms Associate 15100288, 16080463, 18840411, 20446019, 25168388, 26053096, 28460471, 28670784, 34282169
Breast Neoplasms Inhibit 40211399
Burkitt Lymphoma Associate 15755279
Capsule Opacification Associate 33837174
Carcinogenesis Associate 17726263, 34545139