Gene Gene information from NCBI Gene database.
Entrez ID 8837
Gene name CASP8 and FADD like apoptosis regulator
Gene symbol CFLAR
Synonyms (NCBI Gene)
CASHCASP8AP1CLARPCasperFLAMEFLAME-1FLAME1FLIPI-FLICEMRITc-FLIPc-FLIPLc-FLIPRc-FLIPScFLIP
Chromosome 2
Chromosome location 2q33.1
Summary The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encodin
miRNA miRNA information provided by mirtarbase database.
1004
miRTarBase ID miRNA Experiments Reference
MIRT004228 hsa-miR-346 Microarray 16822819
MIRT025744 hsa-miR-7-5p Microarray 19073608
MIRT050158 hsa-miR-26a-5p CLASH 23622248
MIRT053401 hsa-miR-629-5p Microarray 23807165
MIRT887612 hsa-miR-103a CLIP-seq
Transcription factors Transcription factors information provided by TRRUST V2 database.
17
Transcription factor Regulation Reference
ATM Activation 19351839
ATM Repression 20876284
DEDD Unknown 17193921
HDAC9 Activation 20087862
HDAC9 Repression 15540114
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
61
GO ID Ontology Definition Evidence Reference
GO:0001666 Process Response to hypoxia IEA
GO:0002020 Function Protease binding IEA
GO:0002020 Function Protease binding IPI 9208847
GO:0004197 Function Cysteine-type endopeptidase activity IBA
GO:0004197 Function Cysteine-type endopeptidase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603599 1876 ENSG00000003402
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O15519
Protein name CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1)
Protein function Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-i
PDB 2N5R , 3H11 , 3H13 , 6M6O , 7DEE , 7LXC , 8YBX , 8YD7 , 8YD8 , 8YM4 , 8YM5 , 8YM6 , 8YNI , 8YNK , 8YNL , 8YNM , 8YNN
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01335 DED 3 77 Death effector domain Domain
PF01335 DED 93 174 Death effector domain Domain
PF00656 Peptidase_C14 253 477 Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle.
Sequence
Sequence length 480
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  NF-kappa B signaling pathway
Autophagy - animal
Apoptosis
Necroptosis
TNF signaling pathway
Chagas disease
Hepatitis C
  Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
Dimerization of procaspase-8
TRAIL signaling