Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	8836
Gene name Gene Name - the full gene name approved by the HGNC.	Gamma-glutamyl hydrolase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GGH
Synonyms (NCBI Gene) Gene synonyms aliases	GATD10, GH
Chromosome Chromosome number	8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	8q12.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate. [provided by RefSeq, Jul 2008]

Show/Hide all(23)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029881	hsa-miR-26b-5p	Microarray	19088304
MIRT1018148	hsa-miR-3121-3p	CLIP-seq
MIRT1018149	hsa-miR-3185	CLIP-seq
MIRT1018150	hsa-miR-409-3p	CLIP-seq
MIRT1018151	hsa-miR-410	CLIP-seq
MIRT1018152	hsa-miR-4269	CLIP-seq
MIRT1018153	hsa-miR-4528	CLIP-seq
MIRT1018154	hsa-miR-4645-5p	CLIP-seq
MIRT1018155	hsa-miR-4673	CLIP-seq
MIRT1018156	hsa-miR-4755-3p	CLIP-seq
MIRT2001561	hsa-miR-134	CLIP-seq
MIRT2001562	hsa-miR-186	CLIP-seq
MIRT2001563	hsa-miR-3118	CLIP-seq
MIRT2001564	hsa-miR-3164	CLIP-seq
MIRT1018152	hsa-miR-4269	CLIP-seq
MIRT1018153	hsa-miR-4528	CLIP-seq
MIRT1018154	hsa-miR-4645-5p	CLIP-seq
MIRT1018155	hsa-miR-4673	CLIP-seq
MIRT2001565	hsa-miR-4677-3p	CLIP-seq
MIRT2001566	hsa-miR-4679	CLIP-seq
MIRT1018156	hsa-miR-4755-3p	CLIP-seq
MIRT2001567	hsa-miR-617	CLIP-seq
MIRT1018148	hsa-miR-3121-3p	CLIP-seq

Show/Hide all(20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IDA	25645918
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005764	Component	Lysosome	IEA
GO:0005773	Component	Vacuole	IBA
GO:0008238	Function	Exopeptidase activity	TAS	8816764
GO:0008242	Function	Omega peptidase activity	IEA
GO:0008242	Function	Omega peptidase activity	TAS	8816764
GO:0016787	Function	Hydrolase activity	IEA
GO:0034722	Function	Gamma-glutamyl-peptidase activity	IBA
GO:0034722	Function	Gamma-glutamyl-peptidase activity	IDA	11005824
GO:0034722	Function	Gamma-glutamyl-peptidase activity	IEA
GO:0035578	Component	Azurophil granule lumen	TAS
GO:0035580	Component	Specific granule lumen	TAS
GO:0042470	Component	Melanosome	IEA
GO:0046900	Process	Tetrahydrofolylpolyglutamate metabolic process	IBA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:1904724	Component	Tertiary granule lumen	TAS

MIM	HGNC	e!Ensembl
601509	4248	ENSG00000137563

Protein

UniProt ID

Q92820

Protein name

Gamma-glutamyl hydrolase (EC 3.4.19.9) (Conjugase) (GH) (Gamma-Glu-X carboxypeptidase)

Protein function

Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate (PubMed:11005824, PubMed:8816764).

PDB

1L9X

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07722	Peptidase_C26	34 → 246	Peptidase C26	Domain

Sequence

MASPGCLLCVLGLLLCGAASLELSRPHGDTAKKPIIGILMQKCRNKVMKNYGRYYIAASY
VKYLESAGARVVPVRLDLTEKDYEILFKSINGILFPGGSVDLRRSDYAKVAKIFYNLSIQ
SFDDGDYFPVWGTCLGFEELSLLISGECLLTATDTVDVAMPLNFTGGQLHSRMFQNFPTE
LLLSLAVEPLTANFHKWSLSVKNFTMNEKLKKFFNVLTTNTDGKIEFISTMEGYKYPVYG
VQWHPEKAPYEWKNLDGISHAPNAVKTAFYLAEFFVNEARKNNHHFKSESEEEKALIYQF
SPIYTGNISSFQQCYIFD

Sequence length

318

Interactions

View interactions

	KEGG		Reactome
	Folate biosynthesis Biosynthesis of cofactors Antifolate resistance		Neutrophil degranulation

GGH (gamma-glutamyl hydrolase)