INPP4B (inositol polyphosphate-4-phosphatase type II B)

Gene

• Entrez ID: 8821
• Gene name: Inositol polyphosphate-4-phosphatase type II B
• Gene symbol: INPP4B
• Synonyms (NCBI Gene): -
• Chromosome: 4
• Chromosome location: 4q31.21
• Summary: INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is li

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT437679	hsa-miR-222-3p	Microarray, qRT-PCR	22815788
MIRT1067197	hsa-miR-382	CLIP-seq
MIRT1067198	hsa-miR-4477a	CLIP-seq
MIRT1067199	hsa-miR-3691-3p	CLIP-seq
MIRT1067200	hsa-miR-4766-5p	CLIP-seq
MIRT1067201	hsa-miR-759	CLIP-seq
MIRT2016270	hsa-miR-1228	CLIP-seq
MIRT2016271	hsa-miR-1243	CLIP-seq
MIRT2016272	hsa-miR-1255a	CLIP-seq
MIRT2016273	hsa-miR-1255b	CLIP-seq
MIRT2016274	hsa-miR-3136-5p	CLIP-seq
MIRT2016275	hsa-miR-3180-5p	CLIP-seq
MIRT2016276	hsa-miR-3682-3p	CLIP-seq
MIRT2016277	hsa-miR-4424	CLIP-seq
MIRT2016278	hsa-miR-4439	CLIP-seq
MIRT2016279	hsa-miR-4699-5p	CLIP-seq
MIRT2016280	hsa-miR-4761-5p	CLIP-seq
MIRT2016281	hsa-miR-4764-3p	CLIP-seq
MIRT2016282	hsa-miR-4797-3p	CLIP-seq
MIRT2016283	hsa-miR-520a-5p	CLIP-seq
MIRT2016284	hsa-miR-525-5p	CLIP-seq
MIRT2016285	hsa-miR-618	CLIP-seq
MIRT2016286	hsa-miR-943	CLIP-seq
MIRT2248578	hsa-miR-203	CLIP-seq
MIRT2248579	hsa-miR-216a	CLIP-seq
MIRT2248580	hsa-miR-376c	CLIP-seq
MIRT2248581	hsa-miR-4326	CLIP-seq
MIRT2248582	hsa-miR-4705	CLIP-seq
MIRT2248583	hsa-miR-4789-3p	CLIP-seq
MIRT2248584	hsa-miR-599	CLIP-seq
MIRT2248585	hsa-miR-645	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	24407287
GO:0005737	Component	Cytoplasm	IBA
GO:0005829	Component	Cytosol	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006661	Process	Phosphatidylinositol biosynthetic process	IEA
GO:0006661	Process	Phosphatidylinositol biosynthetic process	TAS
GO:0007165	Process	Signal transduction	TAS	9295334
GO:0016316	Function	Phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity	IBA
GO:0016316	Function	Phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity	IEA
GO:0016316	Function	Phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity	TAS	9295334
GO:0016787	Function	Hydrolase activity	IEA
GO:0016791	Function	Phosphatase activity	IEA
GO:0017161	Function	Inositol-1,3,4-trisphosphate 4-phosphatase activity	IEA
GO:0017161	Function	Inositol-1,3,4-trisphosphate 4-phosphatase activity	TAS
GO:0036092	Process	Phosphatidylinositol-3-phosphate biosynthetic process	IEA
GO:0043647	Process	Inositol phosphate metabolic process	TAS
GO:0052828	Function	Inositol-3,4-bisphosphate 4-phosphatase activity	IEA
GO:0052828	Function	Inositol-3,4-bisphosphate 4-phosphatase activity	TAS

Other IDs

• MIM: 607494
• HGNC: 6075
• e!Ensembl: ENSG00000109452

Protein

• UniProt ID: O15327
• Protein name: Inositol polyphosphate 4-phosphatase type II (Type II inositol 3,4-bisphosphate 4-phosphatase) (EC 3.1.3.66)
• Protein function: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate (PubMed:24070612, PubMed:24591580). Plays a role in the late stages of macropinocytosis by
• Tissue specificity: TISSUE SPECIFICITY: Widely expressed with highest levels occurring in the skeletal muscle and heart. {ECO:0000269|PubMed:9295334}.
• Sequence:

  MEIKEEGASEEGQHFLPTAQANDPGDCQFTSIQKTPNEPQLEFILACKDLVAPVRDRKLN
  TLVQISVIHPVEQSLTRYSSTEIVEGTRDPLFLTGVTFPSEYPIYEETKIKLTVYDVKDK
  SHDTVRTSVLPEHKDPPPEVGRSFLGYASFKVGELLKSKEQLLVLSLRTSDGGKVVGTIE
  VSVVKMGEIEDGEADHITTDVQGQKCALVCECTAPESVSGKDNLPFLNSVLKNPVCKLYR
  FPTSDNKWMRIREQMSESILSFHIPKELISLHIKEDLCRNQEIKELGELSPHWDNLRKNV
  LTHCDQMVNMYQDILTELSKETGSSFKSSSSKGEKTLEFVPINLHLQRMQVHSPHLKDAL
  YDVITVGAPAAHFQGFKNGGLRKLLHRFETERRNTGYQFIYYSPENTAKAKEVLSNINQL
  QPLIATHADLLLNSASQHSPDSLKNSLKMLSEKTELFVHAFKDQLVRSALLALYTARPGG
  ILKKPPSPKSSTEESSPQDQPPVMRGQDSIPHHSDYDEEEWDRVWANVGKSLNCIIAMVD
  KLIERDGGSEGSGGNNDGEKEPSLTDAIPSHPREDWYEQLYPLILTLKDCMGEVVNRAKQ
  SLTFVLLQELAYSLPQCLMLTLRRDIVFSQALAGLVCGFIIKLQTSLYDPGFLQQLHTVG
  LIVQYEGLLSTYSDEIGMLEDMAVGISDLKKVAFKIIEAKSNDVLPVITGRREHYVVEVK
  LPARMFESLPLQIKEGQLLHVYPVLFNVGINEQQTLAERFGDVSLQESINQENFELLQEY
  YKIFMEKMPPDYISHFQEQNDLKALLENLLQNIQSKKRKNVEIMWLAATICRKLNGIRFT
  CCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRREGCRIENVLKNIKCRKYAF
  NMLQLMAFPKYYRPPEGTYGKADT

• Sequence length: 924

Pathways

KEGG:

Inositol phosphate metabolism
Metabolic pathways
Phosphatidylinositol signaling system

Reactome:

Synthesis of PIPs at the plasma membrane
Synthesis of PIPs at the early endosome membrane
Synthesis of IP2, IP, and Ins in the cytosol