Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	8805
Gene name Gene Name - the full gene name approved by the HGNC.	Tripartite motif containing 24
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TRIM24
Synonyms (NCBI Gene) Gene synonyms aliases	PTC6, RNF82, TF1A, TIF1, TIF1A, TIF1ALPHA, hTIF1
Chromosome Chromosome number	7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	7q33-q34
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bo

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miRTarBase ID	miRNA	Experiments	Reference
MIRT020969	hsa-miR-155-5p	Proteomics	20584899
MIRT024015	hsa-miR-1-3p	Proteomics	18668040
MIRT032466	hsa-let-7b-5p	Proteomics	18668040
MIRT032466	hsa-let-7b-5p	CLASH	23622248
MIRT509398	hsa-miR-552-3p	PAR-CLIP	23446348
MIRT509397	hsa-miR-3934-5p	PAR-CLIP	23446348
MIRT509396	hsa-miR-1292-3p	PAR-CLIP	23446348
MIRT509395	hsa-miR-5095	PAR-CLIP	23446348
MIRT509394	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT509393	hsa-miR-2355-5p	PAR-CLIP	23446348
MIRT509392	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT495400	hsa-miR-6835-3p	PAR-CLIP	23708386
MIRT495398	hsa-miR-330-3p	PAR-CLIP	23708386
MIRT495399	hsa-miR-548aa	PAR-CLIP	23708386
MIRT495397	hsa-miR-548ap-3p	PAR-CLIP	23708386
MIRT495396	hsa-miR-548t-3p	PAR-CLIP	23708386
MIRT495395	hsa-miR-548as-3p	PAR-CLIP	23708386
MIRT495394	hsa-miR-548at-3p	PAR-CLIP	23708386
MIRT495393	hsa-miR-548ay-3p	PAR-CLIP	23708386
MIRT495392	hsa-miR-548at-5p	PAR-CLIP	23708386
MIRT378711	hsa-miR-4477a	PAR-CLIP	23708386
MIRT509398	hsa-miR-552-3p	PAR-CLIP	23446348
MIRT509397	hsa-miR-3934-5p	PAR-CLIP	23446348
MIRT509396	hsa-miR-1292-3p	PAR-CLIP	23446348
MIRT509395	hsa-miR-5095	PAR-CLIP	23446348
MIRT509394	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT509393	hsa-miR-2355-5p	PAR-CLIP	23446348
MIRT509392	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT495400	hsa-miR-6835-3p	PAR-CLIP	23708386
MIRT495398	hsa-miR-330-3p	PAR-CLIP	23708386
MIRT495399	hsa-miR-548aa	PAR-CLIP	23708386
MIRT495397	hsa-miR-548ap-3p	PAR-CLIP	23708386
MIRT495396	hsa-miR-548t-3p	PAR-CLIP	23708386
MIRT495395	hsa-miR-548as-3p	PAR-CLIP	23708386
MIRT495394	hsa-miR-548at-3p	PAR-CLIP	23708386
MIRT495393	hsa-miR-548ay-3p	PAR-CLIP	23708386
MIRT495392	hsa-miR-548at-5p	PAR-CLIP	23708386
MIRT378711	hsa-miR-4477a	PAR-CLIP	23708386
MIRT2135871	hsa-miR-1305	CLIP-seq
MIRT2135872	hsa-miR-4659a-3p	CLIP-seq
MIRT2135873	hsa-miR-4659b-3p	CLIP-seq
MIRT2135874	hsa-miR-4680-3p	CLIP-seq
MIRT2135875	hsa-miR-580	CLIP-seq
MIRT2135875	hsa-miR-580	CLIP-seq
MIRT2356957	hsa-miR-587	CLIP-seq
MIRT2356958	hsa-miR-101	CLIP-seq
MIRT2356959	hsa-miR-1279	CLIP-seq
MIRT2356960	hsa-miR-139-5p	CLIP-seq
MIRT2356961	hsa-miR-140-5p	CLIP-seq
MIRT2356962	hsa-miR-144	CLIP-seq
MIRT2356963	hsa-miR-1972	CLIP-seq
MIRT2356964	hsa-miR-320a	CLIP-seq
MIRT2356965	hsa-miR-320b	CLIP-seq
MIRT2356966	hsa-miR-320c	CLIP-seq
MIRT2356967	hsa-miR-320d	CLIP-seq
MIRT2356968	hsa-miR-34c-3p	CLIP-seq
MIRT2356969	hsa-miR-3545-5p	CLIP-seq
MIRT2356970	hsa-miR-4429	CLIP-seq
MIRT2356971	hsa-miR-4460	CLIP-seq
MIRT2356972	hsa-miR-4509	CLIP-seq
MIRT2356973	hsa-miR-4650-5p	CLIP-seq
MIRT2356974	hsa-miR-4744	CLIP-seq
MIRT2356975	hsa-miR-4760-3p	CLIP-seq
MIRT2356976	hsa-miR-483-3p	CLIP-seq
MIRT2356958	hsa-miR-101	CLIP-seq
MIRT2356962	hsa-miR-144	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	IBA
GO:0000791	Component	Euchromatin	IEA
GO:0001673	Component	Male germ cell nucleus	IEA
GO:0002039	Function	P53 binding	IEA
GO:0002039	Function	P53 binding	IPI	19556538
GO:0003677	Function	DNA binding	IEA
GO:0003682	Function	Chromatin binding	IDA	21164480
GO:0003682	Function	Chromatin binding	IEA
GO:0003713	Function	Transcription coactivator activity	IDA	21164480
GO:0003713	Function	Transcription coactivator activity	IEA
GO:0003713	Function	Transcription coactivator activity	TAS	9115274
GO:0004672	Function	Protein kinase activity	IEA
GO:0004842	Function	Ubiquitin-protein transferase activity	IEA
GO:0005102	Function	Signaling receptor binding	TAS	9115274
GO:0005515	Function	Protein binding	IPI	19556538, 19909775, 21164480, 21182203, 21531907, 24981860, 26496610, 35271311
GO:0005634	Component	Nucleus	IDA	21164480, 25593309
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	9115274
GO:0005654	Component	Nucleoplasm	IDA
GO:0005726	Component	Perichromatin fibrils	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006325	Process	Chromatin organization	IEA
GO:0006366	Process	Transcription by RNA polymerase II	TAS	9115274
GO:0008270	Function	Zinc ion binding	IDA	21164480
GO:0008270	Function	Zinc ion binding	IEA
GO:0010628	Process	Positive regulation of gene expression	IEA
GO:0016567	Process	Protein ubiquitination	IDA	19556538
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016922	Function	Nuclear receptor binding	IEA
GO:0030163	Process	Protein catabolic process	IEA
GO:0030163	Process	Protein catabolic process	IMP	19556538
GO:0031647	Process	Regulation of protein stability	IEA
GO:0031647	Process	Regulation of protein stability	IMP	19556538
GO:0031981	Component	Nuclear lumen	IEA
GO:0034056	Function	Estrogen response element binding	IDA	21164480
GO:0042981	Process	Regulation of apoptotic process	IMP	19556538
GO:0043434	Process	Response to peptide hormone	IEA
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0050673	Process	Epithelial cell proliferation	IEA
GO:0050680	Process	Negative regulation of epithelial cell proliferation	IEA
GO:0055074	Process	Calcium ion homeostasis	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IDA	19556538
GO:0061630	Function	Ubiquitin protein ligase activity	IEA
GO:0070562	Process	Regulation of vitamin D receptor signaling pathway	IEA
GO:0071391	Process	Cellular response to estrogen stimulus	IDA	21164480
GO:0140118	Function	Histone H3K23ac reader activity	IDA	21164480
GO:1901796	Process	Regulation of signal transduction by p53 class mediator	IEA

MIM	HGNC	e!Ensembl
603406	11812	ENSG00000122779

Protein

UniProt ID

O15164

Protein name

Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24)

Protein function

Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone

PDB

2YYN , 3O33 , 3O34 , 3O35 , 3O36 , 3O37 , 4YAB , 4YAD , 4YAT , 4YAX , 4YBM , 4YBS , 4YBT , 4YC9 , 4ZQL , 5H1T , 5H1U , 5H1V , 7B9X

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00643	zf-B_box	218 → 259	B-box zinc finger	Domain
PF00628	PHD	828 → 873	PHD-finger	Domain
PF00439	Bromodomain	908 → 992	Bromodomain	Domain

Sequence

MEVAVEKAVAAAAAASAAASGGPSAAPSGENEAESRQGPDSERGGEAARLNLLDTCAVCH
QNIQSRAPKLLPCLHSFCQRCLPAPQRYLMLPAPMLGSAETPPPVPAPGSPVSGSSPFAT
QVGVIRCPVCSQECAERHIIDNFFVKDTTEVPSSTVEKSNQVCTSCEDNAEANGFCVECV
EWLCKTCIRAHQRVKFTKDHTVRQKEEVSPEAVGVTSQRPVFCPFHKKEQLKLYCETCDK
LTCRDCQLLEHKEHRYQFIEEAFQNQKVIIDTLITKLMEKTKYIKFTGNQIQNRIIEVNQ
NQKQVEQDIKVAIFTLMVEINKKGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHVM
HFSKWAVSSGSSTALLYSKRLITYRLRHLLRARCDASPVTNNTIQFHCDPSFWAQNIINL
GSLVIEDKESQPQMPKQNPVVEQNSQPPSGLSSNQLSKFPTQISLAQLRLQHMQQQVMAQ
RQQVQRRPAPVGLPNPRMQGPIQQPSISHQQPPPRLINFQNHSPKPNGPVLPPHPQQLRY
PPNQNIPRQAIKPNPLQMAFLAQQAIKQWQISSGQGTPSTTNSTSSTPSSPTITSAAGYD
GKAFGSPMIDLSSPVGGSYNLPSLPDIDCSSTIMLDNIVRKDTNIDHGQPRPPSNRTVQS
PNSSVPSPGLAGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPI
RIKQENSGPPENYDFPVVIVKQESDEESRPQNANYPRSILTSLLLNSSQSSTSEETVLRS
DAPDSTGDQPGLHQDNSSNGKSEWLDPSQKSPLHVGETRKEDDPNEDWCAVCQNGGELLC
CEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDLSKPEVEYDCDAPSHNSEKKKTEGLVKL
TPIDKRKCERLLLFLYCHEMSLAFQDPVPLTVPDYYKIIKNPMDLSTIKKRLQEDYSMYS
KPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLENYFEELLKNLYPEKRFPKPEFRNESE
DNKFSDDSDDDFVQPRKKRLKSIEERQLLK

Sequence length

1050

Interactions

View interactions

	Reactome
			Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Signaling by BRAF and RAF fusions

TRIM24 (tripartite motif containing 24)