Gene Gene information from NCBI Gene database.
Entrez ID 8804
Gene name Cellular repressor of E1A stimulated genes 1
Gene symbol CREG1
Synonyms (NCBI Gene)
CREG
Chromosome 1
Chromosome location 1q24.2
Summary The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein
miRNA miRNA information provided by mirtarbase database.
400
miRTarBase ID miRNA Experiments Reference
MIRT007367 hsa-miR-31-5p ImmunofluorescenceLuciferase reporter assayqRT-PCRWestern blot 23518389
MIRT028971 hsa-miR-26b-5p Microarray 19088304
MIRT036577 hsa-miR-941 CLASH 23622248
MIRT727936 hsa-miR-15a-5p HITS-CLIP 22473208
MIRT727937 hsa-miR-15b-5p HITS-CLIP 22473208
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
19
GO ID Ontology Definition Evidence Reference
GO:0003714 Function Transcription corepressor activity TAS 9710587
GO:0005576 Component Extracellular region IEA
GO:0005576 Component Extracellular region TAS
GO:0005615 Component Extracellular space IBA
GO:0005615 Component Extracellular space IDA 25645918
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
618055 2351 ENSG00000143162
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O75629
Protein name Protein CREG1 (Cellular repressor of E1A-stimulated genes 1)
Protein function May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires inte
PDB 1XHN
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13883 Pyrid_oxidase_2 50 216 Domain
Sequence
Sequence length 220
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Neutrophil degranulation
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
2
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
CREG1-related disorder Likely benign rs547663782, rs781036042 RCV003977270
RCV003954560
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Atherosclerosis Inhibit 27139506, 32067910
Carcinoma Non Small Cell Lung Associate 26722374
Diabetes Mellitus Type 2 Inhibit 27139506
Endometrial Neoplasms Associate 17451460
Li Fraumeni Syndrome Associate 21263217
Macular Degeneration Associate 39487449
Osteosarcoma Associate 21263217
Uveal melanoma Associate 31903983
Vascular Diseases Associate 32067910