Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	8790
Gene name Gene Name - the full gene name approved by the HGNC.	Fucose-1-phosphate guanylyltransferase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	FPGT
Synonyms (NCBI Gene) Gene synonyms aliases	GFPP
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1p31.1
Summary Summary of gene provided in NCBI Entrez Gene.	L-fucose is a key sugar in glycoproteins and other complex carbohydrates since it may be involved in many of the functional roles of these macromolecules, such as in cell-cell recognition. The fucosyl donor for these fucosylated oligosaccharides is GDP-be

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018371	hsa-miR-335-5p	Microarray	18185580
MIRT445849	hsa-miR-186-5p	PAR-CLIP	22100165
MIRT445848	hsa-miR-4635	PAR-CLIP	22100165
MIRT445847	hsa-miR-302b-5p	PAR-CLIP	22100165
MIRT445846	hsa-miR-302d-5p	PAR-CLIP	22100165
MIRT445849	hsa-miR-186-5p	PAR-CLIP	22100165
MIRT445848	hsa-miR-4635	PAR-CLIP	22100165
MIRT445847	hsa-miR-302b-5p	PAR-CLIP	22100165
MIRT445846	hsa-miR-302d-5p	PAR-CLIP	22100165
MIRT445849	hsa-miR-186-5p	PAR-CLIP	22100165
MIRT445848	hsa-miR-4635	PAR-CLIP	22100165
MIRT445847	hsa-miR-302b-5p	PAR-CLIP	22100165
MIRT445846	hsa-miR-302d-5p	PAR-CLIP	22100165
MIRT445849	hsa-miR-186-5p	PAR-CLIP	22100165
MIRT445848	hsa-miR-4635	PAR-CLIP	22100165
MIRT445847	hsa-miR-302b-5p	PAR-CLIP	22100165
MIRT445846	hsa-miR-302d-5p	PAR-CLIP	22100165
MIRT1003900	hsa-miR-1	CLIP-seq
MIRT1003901	hsa-miR-1226	CLIP-seq
MIRT1003902	hsa-miR-1297	CLIP-seq
MIRT1003903	hsa-miR-186	CLIP-seq
MIRT1003904	hsa-miR-206	CLIP-seq
MIRT1003905	hsa-miR-26a	CLIP-seq
MIRT1003906	hsa-miR-26b	CLIP-seq
MIRT1003907	hsa-miR-3138	CLIP-seq
MIRT1003908	hsa-miR-337-3p	CLIP-seq
MIRT1003909	hsa-miR-338-3p	CLIP-seq
MIRT1003910	hsa-miR-3609	CLIP-seq
MIRT1003911	hsa-miR-3613-3p	CLIP-seq
MIRT1003912	hsa-miR-3617	CLIP-seq
MIRT1003913	hsa-miR-3647-3p	CLIP-seq
MIRT1003914	hsa-miR-3673	CLIP-seq
MIRT1003915	hsa-miR-3685	CLIP-seq
MIRT1003916	hsa-miR-3688-3p	CLIP-seq
MIRT1003917	hsa-miR-384	CLIP-seq
MIRT1003918	hsa-miR-4282	CLIP-seq
MIRT1003919	hsa-miR-4310	CLIP-seq
MIRT1003920	hsa-miR-4465	CLIP-seq
MIRT1003921	hsa-miR-4491	CLIP-seq
MIRT1003922	hsa-miR-4657	CLIP-seq
MIRT1003923	hsa-miR-4733-3p	CLIP-seq
MIRT1003924	hsa-miR-4738-3p	CLIP-seq
MIRT1003925	hsa-miR-4766-5p	CLIP-seq
MIRT1003926	hsa-miR-4800-5p	CLIP-seq
MIRT1003927	hsa-miR-495	CLIP-seq
MIRT1003928	hsa-miR-498	CLIP-seq
MIRT1003929	hsa-miR-513a-3p	CLIP-seq
MIRT1003930	hsa-miR-548ah	CLIP-seq
MIRT1003931	hsa-miR-548g	CLIP-seq
MIRT1003932	hsa-miR-548t	CLIP-seq
MIRT1003933	hsa-miR-613	CLIP-seq
MIRT1003934	hsa-miR-634	CLIP-seq
MIRT1003935	hsa-miR-641	CLIP-seq
MIRT1003936	hsa-miR-802	CLIP-seq
MIRT1003937	hsa-miR-1324	CLIP-seq
MIRT1003938	hsa-miR-3148	CLIP-seq
MIRT1003939	hsa-miR-3153	CLIP-seq
MIRT1003940	hsa-miR-3158-3p	CLIP-seq
MIRT1003941	hsa-miR-3189-3p	CLIP-seq
MIRT1003942	hsa-miR-3662	CLIP-seq
MIRT1003943	hsa-miR-4279	CLIP-seq
MIRT1003944	hsa-miR-4668-5p	CLIP-seq
MIRT1003945	hsa-miR-4698	CLIP-seq
MIRT1003946	hsa-miR-4721	CLIP-seq
MIRT1003947	hsa-miR-548ae	CLIP-seq
MIRT1003948	hsa-miR-548aj	CLIP-seq
MIRT1003949	hsa-miR-548am	CLIP-seq
MIRT1003950	hsa-miR-548x	CLIP-seq
MIRT1003951	hsa-miR-942	CLIP-seq
MIRT1548901	hsa-miR-345	CLIP-seq
MIRT1548902	hsa-miR-4256	CLIP-seq
MIRT1548903	hsa-miR-4762-3p	CLIP-seq
MIRT1997574	hsa-miR-144	CLIP-seq
MIRT1997575	hsa-miR-4682	CLIP-seq
MIRT2449888	hsa-miR-1276	CLIP-seq
MIRT2449889	hsa-miR-330-3p	CLIP-seq
MIRT2449890	hsa-miR-371-5p	CLIP-seq
MIRT2449891	hsa-miR-371b-5p	CLIP-seq
MIRT2449892	hsa-miR-451b	CLIP-seq
MIRT2449893	hsa-miR-548ac	CLIP-seq
MIRT1003947	hsa-miR-548ae	CLIP-seq
MIRT1003948	hsa-miR-548aj	CLIP-seq
MIRT1003949	hsa-miR-548am	CLIP-seq
MIRT2449894	hsa-miR-548d-3p	CLIP-seq
MIRT1003950	hsa-miR-548x	CLIP-seq
MIRT2449895	hsa-miR-548z	CLIP-seq
MIRT1003900	hsa-miR-1	CLIP-seq
MIRT1003901	hsa-miR-1226	CLIP-seq
MIRT2535165	hsa-miR-147	CLIP-seq
MIRT1003904	hsa-miR-206	CLIP-seq
MIRT2535166	hsa-miR-2113	CLIP-seq
MIRT2535167	hsa-miR-216a	CLIP-seq
MIRT2535168	hsa-miR-218	CLIP-seq
MIRT2535169	hsa-miR-2276	CLIP-seq
MIRT2535170	hsa-miR-2355-5p	CLIP-seq
MIRT2535171	hsa-miR-3149	CLIP-seq
MIRT2535172	hsa-miR-323-3p	CLIP-seq
MIRT2535173	hsa-miR-323-5p	CLIP-seq
MIRT2535174	hsa-miR-329	CLIP-seq
MIRT2535175	hsa-miR-331-5p	CLIP-seq
MIRT1003909	hsa-miR-338-3p	CLIP-seq
MIRT2535176	hsa-miR-3606	CLIP-seq
MIRT1003912	hsa-miR-3617	CLIP-seq
MIRT2535177	hsa-miR-362-3p	CLIP-seq
MIRT1003914	hsa-miR-3673	CLIP-seq
MIRT2535178	hsa-miR-3679-3p	CLIP-seq
MIRT1003915	hsa-miR-3685	CLIP-seq
MIRT1003916	hsa-miR-3688-3p	CLIP-seq
MIRT1003917	hsa-miR-384	CLIP-seq
MIRT2535179	hsa-miR-3941	CLIP-seq
MIRT2535180	hsa-miR-4275	CLIP-seq
MIRT2535181	hsa-miR-4286	CLIP-seq
MIRT1003919	hsa-miR-4310	CLIP-seq
MIRT2535182	hsa-miR-4452	CLIP-seq
MIRT2535183	hsa-miR-448	CLIP-seq
MIRT1997575	hsa-miR-4682	CLIP-seq
MIRT2535184	hsa-miR-4705	CLIP-seq
MIRT1003923	hsa-miR-4733-3p	CLIP-seq
MIRT1003925	hsa-miR-4766-5p	CLIP-seq
MIRT2535185	hsa-miR-4772-3p	CLIP-seq
MIRT2535186	hsa-miR-4796-5p	CLIP-seq
MIRT2535187	hsa-miR-4803	CLIP-seq
MIRT2535188	hsa-miR-548c-3p	CLIP-seq
MIRT2535189	hsa-miR-556-3p	CLIP-seq
MIRT2535190	hsa-miR-599	CLIP-seq
MIRT2535191	hsa-miR-603	CLIP-seq
MIRT1003933	hsa-miR-613	CLIP-seq
MIRT1003934	hsa-miR-634	CLIP-seq
MIRT1003935	hsa-miR-641	CLIP-seq
MIRT2535192	hsa-miR-668	CLIP-seq
MIRT2535193	hsa-miR-876-3p	CLIP-seq
MIRT2535194	hsa-miR-944	CLIP-seq
MIRT1003901	hsa-miR-1226	CLIP-seq
MIRT2535166	hsa-miR-2113	CLIP-seq
MIRT2535168	hsa-miR-218	CLIP-seq
MIRT2535170	hsa-miR-2355-5p	CLIP-seq
MIRT2535172	hsa-miR-323-3p	CLIP-seq
MIRT2535173	hsa-miR-323-5p	CLIP-seq
MIRT2535174	hsa-miR-329	CLIP-seq
MIRT2535175	hsa-miR-331-5p	CLIP-seq
MIRT1003909	hsa-miR-338-3p	CLIP-seq
MIRT2535176	hsa-miR-3606	CLIP-seq
MIRT2535177	hsa-miR-362-3p	CLIP-seq
MIRT2535178	hsa-miR-3679-3p	CLIP-seq
MIRT2535179	hsa-miR-3941	CLIP-seq
MIRT2535181	hsa-miR-4286	CLIP-seq
MIRT1003919	hsa-miR-4310	CLIP-seq
MIRT2535182	hsa-miR-4452	CLIP-seq
MIRT1997575	hsa-miR-4682	CLIP-seq
MIRT2681170	hsa-miR-4684-5p	CLIP-seq
MIRT1003923	hsa-miR-4733-3p	CLIP-seq
MIRT2681171	hsa-miR-4762-5p	CLIP-seq
MIRT2681172	hsa-miR-4768-5p	CLIP-seq
MIRT2681173	hsa-miR-4789-3p	CLIP-seq
MIRT2535186	hsa-miR-4796-5p	CLIP-seq
MIRT2535190	hsa-miR-599	CLIP-seq
MIRT2535191	hsa-miR-603	CLIP-seq
MIRT1003934	hsa-miR-634	CLIP-seq
MIRT2535192	hsa-miR-668	CLIP-seq
MIRT2535193	hsa-miR-876-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0003824	Function	Catalytic activity	TAS	9804772
GO:0005525	Function	GTP binding	IEA
GO:0005737	Component	Cytoplasm	TAS	9804772
GO:0005829	Component	Cytosol	TAS
GO:0006004	Process	Fucose metabolic process	TAS	9804772
GO:0047341	Function	Fucose-1-phosphate guanylyltransferase activity	TAS

MIM	HGNC	e!Ensembl
603609	3825	ENSG00000254685

Protein

UniProt ID

O14772

Protein name

Fucose-1-phosphate guanylyltransferase (EC 2.7.7.30) (GDP-L-fucose diphosphorylase) (GDP-L-fucose pyrophosphorylase)

Protein function

Catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate (PubMed:9804772). Functions as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids (PubMed:9804772). {ECO:0000269|PubMed:980

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07959	Fucokinase	127 → 546	L-fucokinase	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in many tissues.

Sequence

MRAVRRGLREGGAMAAARDPPEVSLREATQRKLRRFSELRGKLVARGEFWDIVAITAADE
KQELAYNQQLSEKLKRKELPLGVQYHVFVDPAGAKIGNGGSTLCALQCLEKLYGDKWNSF
TILLIHSGGYSQRLPNASALGKIFTALPLGNPIYQMLELKLAMYIDFPLNMNPGILVTCA
DDIELYSIGEFEFIRFDKPGFTALAHPSSLTIGTTHGVFVLDPFDDLKHRDLEYRSCHRF
LHKPSIEKMYQFNAVCRPGNFCQQDFAGGDIADLKLDSDYVYTDSLFYMDHKSAKMLLAF
YEKIGTLSCEIDAYGDFLQALGPGATVEYTRNTSNVIKEESELVEMRQRIFHLLKGTSLN
VVVLNNSKFYHIGTTEEYLFYFTSDNSLKSELGLQSITFSIFPDIPECSGKTSCIIQSIL
DSRCSVAPGSVVEYSRLGPDVSVGENCIISGSYILTKAALPAHSFVCSLSLKMNRCLKYA
TMAFGVQDNLKKSVKTLSDIKLLQFFGVCFLSCLDVWNLKVTEELFSGNKTCLSLWTARI
FPVCSSLSDSVITSLKMLNAVKNKSAFSLNSYKLLSIEEMLIYKDVEDMITYREQIFLEI
SLKSSLM

Sequence length

607

Interactions

View interactions

	KEGG		Reactome
	Fructose and mannose metabolism Amino sugar and nucleotide sugar metabolism Metabolic pathways Biosynthesis of nucleotide sugars		GDP-fucose biosynthesis

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Papillary renal carcinoma	Papillary Renal Cell Carcinoma	rs5030823, rs2137087134, rs121913668, rs121913669, rs121913670, rs121913671, rs121913673, rs121913243, rs786202724	23797736
Renal carcinoma	Renal Cell Carcinoma, Conventional (Clear Cell) Renal Cell Carcinoma, Sarcomatoid Renal Cell Carcinoma, Collecting Duct Carcinoma of the Kidney	rs121913668, rs121913670, rs121913243, rs786202724	23797736

Show/Hide Unknown Diseases (5)

Disease term	Disease name	Evidence	References	Source
Unknown
Chromophobe carcinoma	Chromophobe Renal Cell Carcinoma		23797736	ClinVar
Obesity	Obesity			GWAS
Metabolic Syndrome	Metabolic Syndrome			GWAS
Insomnia	Insomnia			GWAS
Glioblastoma	Glioblastoma	CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587		GWAS, CBGDA

FPGT (fucose-1-phosphate guanylyltransferase)