Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8789
Gene name Gene Name - the full gene name approved by the HGNC.
Fructose-bisphosphatase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
FBP2
Synonyms (NCBI Gene) Gene synonyms aliases
CORLK
Disease Acronyms (UniProt) Disease acronyms from UniProt database
CORLK
Chromosome Chromosome number
9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
9q22.32
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a gluconeogenesis regulatory enzyme which catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. [provided by RefSeq, Jul 2008]
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT016705 hsa-miR-335-5p Microarray 18185580
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 25416956, 25910212, 28514442, 31515488, 32296183, 32814053
GO:0005634 Component Nucleus IEA
GO:0005737 Component Cytoplasm IBA 21873635
GO:0005829 Component Cytosol IBA 21873635
GO:0005829 Component Cytosol IDA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
603027 3607 ENSG00000130957
Protein
UniProt ID O00757
Protein name Fructose-1,6-bisphosphatase isozyme 2 (FBPase 2) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 2) (Muscle FBPase)
Protein function Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate. {ECO:0000269|PubMed:17350621, ECO:00
PDB 3IFA , 3IFC , 4HE0 , 4HE1 , 4HE2 , 5ET5 , 5ET6 , 5ET7 , 5ET8 , 5K54 , 5K55 , 5K56 , 5L0A , 5Q0C
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00316 FBPase 12 199 Fructose-1-6-bisphosphatase, N-terminal domain Domain
PF18913 FBPase_C 203 333 Fructose-1-6-bisphosphatase, C-terminal domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in skeletal muscle (at protein level). {ECO:0000269|PubMed:12507293}.
Sequence
Sequence length 339
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Glycolysis / Gluconeogenesis
Pentose phosphate pathway
Fructose and mannose metabolism
Metabolic pathways
Carbon metabolism
AMPK signaling pathway
Insulin signaling pathway
Glucagon signaling pathway
  Gluconeogenesis
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Glycogen storage disease Glycogen Storage Disease rs10250779, rs387906244, rs113994126, rs113994129, rs113994134, rs369973784, rs199922945, rs118203964, rs113994132, rs387906246, rs113994128, rs267606639, rs267606640, rs755419857, rs895690691
View all (721 more)
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 26810065
Carcinoma Hepatocellular Associate 26901106
Encephalitis Viral Associate 30572452
Intervertebral Disc Degeneration Associate 33676464
Liver Neoplasms Associate 26810065
Meningioma Associate 32949309
Mongolian Spot Associate 30572452
Muscular Diseases Associate 39438952
Neoplasms Associate 26810065, 32949309
Sepsis Associate 39438952