FBP2 (fructose-bisphosphatase 2)

Gene

• Entrez ID: 8789
• Gene name: Fructose-bisphosphatase 2
• Gene symbol: FBP2
• Synonyms (NCBI Gene): CORLK
• Chromosome: 9
• Chromosome location: 9q22.32
• Summary: This gene encodes a gluconeogenesis regulatory enzyme which catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. [provided by RefSeq, Jul 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016705	hsa-miR-335-5p	Microarray	18185580

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003824	Function	Catalytic activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 25910212, 28514442, 31515488, 32296183, 32814053, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA
GO:0005975	Process	Carbohydrate metabolic process	IEA
GO:0006000	Process	Fructose metabolic process	IBA
GO:0006000	Process	Fructose metabolic process	TAS	9678974
GO:0006002	Process	Fructose 6-phosphate metabolic process	IBA
GO:0006094	Process	Gluconeogenesis	IBA
GO:0006094	Process	Gluconeogenesis	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016791	Function	Phosphatase activity	IEA
GO:0030018	Component	Z disc	IEA
GO:0030388	Process	Fructose 1,6-bisphosphate metabolic process	IBA
GO:0042132	Function	Fructose 1,6-bisphosphate 1-phosphatase activity	IBA
GO:0042132	Function	Fructose 1,6-bisphosphate 1-phosphatase activity	IEA
GO:0042578	Function	Phosphoric ester hydrolase activity	IEA
GO:0042802	Function	Identical protein binding	IPI	25416956, 31515488, 32296183
GO:0046872	Function	Metal ion binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0070161	Component	Anchoring junction	IEA

Other IDs

• MIM: 603027
• HGNC: 3607
• e!Ensembl: ENSG00000130957

Protein

• UniProt ID: O00757
• Protein name: Fructose-1,6-bisphosphatase isozyme 2 (FBPase 2) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 2) (Muscle FBPase)
• Protein function: Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate. {ECO:0000269|PubMed:17350621, ECO:00
• PDB: 3IFA, 3IFC, 4HE0, 4HE1, 4HE2, 5ET5, 5ET6, 5ET7, 5ET8, 5K54, 5K55, 5K56, 5L0A, 5Q0C
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00316	FBPase	12 → 199	Fructose-1-6-bisphosphatase, N-terminal domain	Domain
  PF18913	FBPase_C	203 → 333	Fructose-1-6-bisphosphatase, C-terminal domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in skeletal muscle (at protein level). {ECO:0000269|PubMed:12507293}.
• Sequence:

  MTDRSPFETDMLTLTRYVMEKGRQAKGTGELTQLLNSMLTAIKAISSAVRKAGLAHLYGI
  AGSVNVTGDEVKKLDVLSNSLVINMVQSSYSTCVLVSEENKDAIITAKEKRGKYVVCFDP
  LDGSSNIDCLASIGTIFAIYRKTSEDEPSEKDALQCGRNIVAAGYALYGSATLVALSTGQ
  GVDLFMLDPALGEFVLVEKDVKIKKKGKIYSLNEGYAKYFDAATTEYVQKKKFPEDGSAP
  YGARYVGSMVADVHRTLVYGGIFLYPANQKSPKGKLRLLYECNPVAYIIEQAGGLATTGT
  QPVLDVKPEAIHQRVPLILGSPEDVQEYLTCVQKNQAGS

• Sequence length: 339

Pathways

KEGG:

Glycolysis / Gluconeogenesis
Pentose phosphate pathway
Fructose and mannose metabolism
Metabolic pathways
Carbon metabolism
AMPK signaling pathway
Insulin signaling pathway
Glucagon signaling pathway

Reactome:

Gluconeogenesis

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Leukodystrophy, childhood-onset, remitting	Uncertain significance	rs1358711717	RCV002481173
Neurodevelopmental disorder	Uncertain significance	rs769197968	RCV004586497

Associations from Text Mining
Disease Name	Relationship Type	References
Breast Neoplasms	Associate	26810065
Carcinoma Hepatocellular	Associate	26901106
Encephalitis Viral	Associate	30572452
Intervertebral Disc Degeneration	Associate	33676464
Liver Neoplasms	Associate	26810065
Meningioma	Associate	32949309
Mongolian Spot	Associate	30572452
Muscular Diseases	Associate	39438952
Neoplasms	Associate	26810065, 32949309
Sepsis	Associate	39438952