GGACT (gamma-glutamylamine cyclotransferase)

Gene
Gene miRNA Gene ontology Other IDs Protein
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
87769
Gene name Gene Name - the full gene name approved by the HGNC.
Gamma-glutamylamine cyclotransferase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
GGACT
Synonyms (NCBI Gene) Gene synonyms aliases
A2LD1
Chromosome Chromosome number
13
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
13q32.3
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene aids in the proteolytic degradation of crosslinked fibrin by breaking down isodipeptide L-gamma-glutamyl-L-epsilon-lysine, a byproduct of fibrin degradation. The reaction catalyzed by the encoded gamma-glutamylaminecyclotr
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein
Show/Hide all(8)
miRTarBase ID miRNA Experiments Reference
MIRT495698 hsa-miR-521 PAR-CLIP 22291592
MIRT495697 hsa-miR-4790-3p PAR-CLIP 22291592
MIRT495696 hsa-miR-3907 PAR-CLIP 22291592
MIRT495695 hsa-miR-5191 PAR-CLIP 22291592
MIRT495698 hsa-miR-521 PAR-CLIP 22291592
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein
Show/Hide all(7)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 25416956, 32296183
GO:0005829 Component Cytosol IBA
GO:0016829 Function Lyase activity IEA
GO:0042219 Process Modified amino acid catabolic process IDA 20110353
GO:0061929 Function Gamma-glutamylaminecyclotransferase activity IDA 20110353
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein
MIM HGNC e!Ensembl
613378 25100 ENSG00000134864
Protein
Gene miRNA Gene ontology Other IDs Protein
UniProt ID Q9BVM4
Protein name Gamma-glutamylaminecyclotransferase (GGACT) (EC 4.3.2.8) (AIG2-like domain-containing protein 1) (Gamma-glutamylamine cyclotransferase)
Protein function Contributes to degradation of proteins cross-linked by transglutaminases by degrading the cross-link between a lysine and a glutamic acid residue. Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine. Inactive with L
PDB 3JUB , 3JUC , 3JUD
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06094 GGACT 4 → 140 Gamma-glutamyl cyclotransferase, AIG2-like Family
Sequence
Sequence length 153
Interactions View interactions
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