GGACT (gamma-glutamylamine cyclotransferase)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein
Entrez ID 87769
Gene name Gamma-glutamylamine cyclotransferase
Gene symbol GGACT
Synonyms (NCBI Gene)
A2LD1
Chromosome 13
Chromosome location 13q32.3
Summary The protein encoded by this gene aids in the proteolytic degradation of crosslinked fibrin by breaking down isodipeptide L-gamma-glutamyl-L-epsilon-lysine, a byproduct of fibrin degradation. The reaction catalyzed by the encoded gamma-glutamylaminecyclotr
miRNA miRNA information provided by mirtarbase database.
8
Gene miRNA Gene ontology Other IDs Protein
Show/Hide all (8)
miRTarBase ID miRNA Experiments Reference
MIRT495698 hsa-miR-521 PAR-CLIP 22291592
MIRT495697 hsa-miR-4790-3p PAR-CLIP 22291592
MIRT495696 hsa-miR-3907 PAR-CLIP 22291592
MIRT495695 hsa-miR-5191 PAR-CLIP 22291592
MIRT495698 hsa-miR-521 PAR-CLIP 22291592
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
7
Gene miRNA Gene ontology Other IDs Protein
Show/Hide all (7)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 25416956, 32296183
GO:0005829 Component Cytosol IBA
GO:0016829 Function Lyase activity IEA
GO:0042219 Process Modified amino acid catabolic process IDA 20110353
GO:0061929 Function Gamma-glutamylaminecyclotransferase activity IDA 20110353
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein
MIM HGNC e!Ensembl
613378 25100 ENSG00000134864
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9BVM4
Protein name Gamma-glutamylaminecyclotransferase (GGACT) (EC 4.3.2.8) (AIG2-like domain-containing protein 1) (Gamma-glutamylamine cyclotransferase)
Protein function Contributes to degradation of proteins cross-linked by transglutaminases by degrading the cross-link between a lysine and a glutamic acid residue. Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine. Inactive with L
PDB 3JUB , 3JUC , 3JUD
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06094 GGACT 4 → 140 Gamma-glutamyl cyclotransferase, AIG2-like Family
Sequence
Sequence length 153
Interactions View interactions