Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8766
Gene name Gene Name - the full gene name approved by the HGNC.
RAB11A, member RAS oncogene family
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RAB11A
Synonyms (NCBI Gene) Gene synonyms aliases
YL8
Chromosome Chromosome number
15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
15q22.31
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript variants encoding different isof
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT021133 hsa-miR-186-5p Sequencing 20371350
MIRT049348 hsa-miR-92a-3p CLASH 23622248
MIRT737848 hsa-miR-556-3p HITS-CLIP 33718276
MIRT1280877 hsa-miR-1224-3p CLIP-seq
MIRT1280878 hsa-miR-1260 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IDA 25673879
GO:0000166 Function Nucleotide binding IEA
GO:0000281 Process Mitotic cytokinesis IC 18511905
GO:0000922 Component Spindle pole IDA 24561039
GO:0003924 Function GTPase activity IBA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605570 9760 ENSG00000103769
Protein
UniProt ID P62491
Protein name Ras-related protein Rab-11A (Rab-11) (EC 3.6.5.2) (YL8)
Protein function The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to r
PDB 1OIV , 1OIW , 1OIX , 1YZK , 2D7C , 2GZD , 2GZH , 2HV8 , 4C4P , 4D0L , 4D0M , 4LWZ , 4LX0 , 4UJ3 , 4UJ4 , 4UJ5 , 5C46 , 5C4G , 5EUQ , 5EZ5 , 5FBL , 5FBQ , 5FBR , 5FBV , 5FBW , 5JCZ , 6DJL , 6IXV , 8VOF
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 13 174 Ras family Domain
Sequence
Sequence length 216
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Endocytosis
Endocrine and other factor-regulated calcium reabsorption
Vasopressin-regulated water reabsorption
Pancreatic secretion
Influenza A
  Vasopressin regulates renal water homeostasis via Aquaporins
Anchoring of the basal body to the plasma membrane
VxPx cargo-targeting to cilium
TBC/RABGAPs
RAB geranylgeranylation
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Neurodevelopmental Disorders neurodevelopmental disorder N/A N/A GenCC
Non-Syndromic Intellectual Disability autosomal dominant non-syndromic intellectual disability N/A N/A GenCC
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 10780572
Alzheimer Disease Associate 24373285
Amyotrophic Lateral Sclerosis Inhibit 31196199
Atrophy Associate 24413175
Barrett Esophagus Associate 10780572
Body Dysmorphic Disorders Associate 39181022
Calcinosis Cutis Associate 26110570
Carcinoma Non Small Cell Lung Associate 34363324
Carcinoma Squamous Cell Associate 15188492
Colorectal Neoplasms Associate 25117932