Gene Gene information from NCBI Gene database.
Entrez ID 8766
Gene name RAB11A, member RAS oncogene family
Gene symbol RAB11A
Synonyms (NCBI Gene)
YL8
Chromosome 15
Chromosome location 15q22.31
Summary The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript variants encoding different isof
miRNA miRNA information provided by mirtarbase database.
1192
miRTarBase ID miRNA Experiments Reference
MIRT021133 hsa-miR-186-5p Sequencing 20371350
MIRT049348 hsa-miR-92a-3p CLASH 23622248
MIRT737848 hsa-miR-556-3p HITS-CLIP 33718276
MIRT1280877 hsa-miR-1224-3p CLIP-seq
MIRT1280878 hsa-miR-1260 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
120
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IDA 25673879
GO:0000166 Function Nucleotide binding IEA
GO:0000281 Process Mitotic cytokinesis IC 18511905
GO:0000922 Component Spindle pole IDA 24561039
GO:0003924 Function GTPase activity IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605570 9760 ENSG00000103769
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P62491
Protein name Ras-related protein Rab-11A (Rab-11) (EC 3.6.5.2) (YL8)
Protein function The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to r
PDB 1OIV , 1OIW , 1OIX , 1YZK , 2D7C , 2GZD , 2GZH , 2HV8 , 4C4P , 4D0L , 4D0M , 4LWZ , 4LX0 , 4UJ3 , 4UJ4 , 4UJ5 , 5C46 , 5C4G , 5EUQ , 5EZ5 , 5FBL , 5FBQ , 5FBR , 5FBV , 5FBW , 5JCZ , 6DJL , 6IXV , 8VOF
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 13 174 Ras family Domain
Sequence
Sequence length 216
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Endocytosis
Endocrine and other factor-regulated calcium reabsorption
Vasopressin-regulated water reabsorption
Pancreatic secretion
Influenza A
  Vasopressin regulates renal water homeostasis via Aquaporins
Anchoring of the basal body to the plasma membrane
VxPx cargo-targeting to cilium
TBC/RABGAPs
RAB geranylgeranylation
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
3
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
RAB11A-related disorder Benign rs11556462, rs200883500, rs148440353 RCV003913682
RCV003933452
RCV003911189
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 10780572
Alzheimer Disease Associate 24373285
Amyotrophic Lateral Sclerosis Inhibit 31196199
Atrophy Associate 24413175
Barrett Esophagus Associate 10780572
Body Dysmorphic Disorders Associate 39181022
Calcinosis Cutis Associate 26110570
Carcinoma Non Small Cell Lung Associate 34363324
Carcinoma Squamous Cell Associate 15188492
Colorectal Neoplasms Associate 25117932