ADAM7 (ADAM metallopeptidase domain 7)

Gene
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8756
Gene name Gene Name - the full gene name approved by the HGNC.
ADAM metallopeptidase domain 7
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ADAM7
Synonyms (NCBI Gene) Gene synonyms aliases
ADAM 7, ADAM-7, EAPI, GP-83, GP83
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8p21.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the ADAMs family of zinc proteases. These transmembrane proteins play roles in multiple processes including cell signaling, adhesion and migration. The encoded protein lacks protease activity and may play roles in protein-pro
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(3)
miRTarBase ID miRNA Experiments Reference
MIRT766181 hsa-miR-1257 CLIP-seq
MIRT766182 hsa-miR-4452 CLIP-seq
MIRT766183 hsa-miR-4455 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(6)
GO ID Ontology Definition Evidence Reference
GO:0004175 Function Endopeptidase activity IBA 21873635
GO:0004222 Function Metalloendopeptidase activity IEA
GO:0005886 Component Plasma membrane IBA 21873635
GO:0006508 Process Proteolysis IEA
GO:0008237 Function Metallopeptidase activity IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
607310 214 ENSG00000069206
Protein
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Q9H2U9
Protein name Disintegrin and metalloproteinase domain-containing protein 7 (ADAM 7) (Sperm maturation-related glycoprotein GP-83)
Protein function Required for normal male fertility via maintenance of epithelial cell morphology in the caput epididymis and subsequently correct epididymis lumen structure required for sperm development (By similarity). Plays a role in sperm motility, flagella
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01562 Pep_M12B_propep 24 → 156 Reprolysin family propeptide Family
PF01421 Reprolysin 199 → 394 Reprolysin (M12B) family zinc metalloprotease Domain
PF00200 Disintegrin 411 → 483 Disintegrin Domain
PF08516 ADAM_CR 488 → 602 ADAM cysteine-rich Family
Sequence
Sequence length 754
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (1)
Unknown
Disease term Disease name Evidence References Source
Ankylosing Spondylitis Ankylosing Spondylitis GWAS
Show/Hide Text Mining Associations (2)
Associations from Text Mining
Disease Name Relationship Type References
Melanoma Associate 21618342
Prostatic Neoplasms Associate 25519703