ADAM7 (ADAM metallopeptidase domain 7)

Gene

• Entrez ID: 8756
• Gene name: ADAM metallopeptidase domain 7
• Gene symbol: ADAM7
• Synonyms (NCBI Gene): ADAM 7, ADAM-7, EAPI, GP-83, GP83
• Chromosome: 8
• Chromosome location: 8p21.2
• Summary: This gene encodes a member of the ADAMs family of zinc proteases. These transmembrane proteins play roles in multiple processes including cell signaling, adhesion and migration. The encoded protein lacks protease activity and may play roles in protein-pro

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT766181	hsa-miR-1257	CLIP-seq
MIRT766182	hsa-miR-4452	CLIP-seq
MIRT766183	hsa-miR-4455	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003382	Process	Epithelial cell morphogenesis	IEA
GO:0003382	Process	Epithelial cell morphogenesis	ISS
GO:0004175	Function	Endopeptidase activity	IEA
GO:0004222	Function	Metalloendopeptidase activity	IBA
GO:0004222	Function	Metalloendopeptidase activity	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0006508	Process	Proteolysis	IBA
GO:0006508	Process	Proteolysis	IEA
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0009986	Component	Cell surface	IEA
GO:0016020	Component	Membrane	IEA
GO:1902093	Process	Positive regulation of flagellated sperm motility	IEA
GO:1902093	Process	Positive regulation of flagellated sperm motility	ISS
GO:1902492	Process	Positive regulation of sperm capacitation	IEA
GO:1902492	Process	Positive regulation of sperm capacitation	ISS
GO:1905867	Process	Epididymis development	IEA
GO:1905867	Process	Epididymis development	ISS

Other IDs

• MIM: 607310
• HGNC: 214
• e!Ensembl: ENSG00000069206

Protein

• UniProt ID: Q9H2U9
• Protein name: Disintegrin and metalloproteinase domain-containing protein 7 (ADAM 7) (Sperm maturation-related glycoprotein GP-83)
• Protein function: Required for normal male fertility via maintenance of epithelial cell morphology in the caput epididymis and subsequently correct epididymis lumen structure required for sperm development (By similarity). Plays a role in sperm motility, flagella
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01562	Pep_M12B_propep	24 → 156	Reprolysin family propeptide	Family
  PF01421	Reprolysin	199 → 394	Reprolysin (M12B) family zinc metalloprotease	Domain
  PF00200	Disintegrin	411 → 483	Disintegrin	Domain
  PF08516	ADAM_CR	488 → 602	ADAM cysteine-rich	Family

• Sequence:

  MLPGCIFLMILLIPQVKEKFILGVEGQQLVRPKKLPLIQKRDTGHTHDDDILKTYEEELL
  YEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSIVHEYDSA
  ASISTCNGLRGFFRINDQRYLIEPVKYSDEGEHLVFKYNLRVPYGANYSCTELNFTRKTV
  PGDNESEEDSKIKGIHDEKYVELFIVADDTVYRRNGHPHNKLRNRIWGMVNFVNMIYKTL
  NIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVVLLSGKWLYSHV
  QGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHDEFPCTCPSGKCVMD
  SDGSIPALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFCGNKKLDEGEECDCGP
  AQECTNPCCDAHTCVLKPGFTCAEGECCESCQIKKAGSICRPAKDECDFPEMCTGHSPAC
  PKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIESHDICYKMNTKGNKFGYCK
  NKENRFLPCEEKDVRCGKIYCTGGELSSLLGEDKTYHLKDPQKNATVKCKTIFLYHDSTD
  IGLVASGTKCGEGMVCNNGECLNMEKVYISTNCPSQCNENPVDGHGLQCHCEEGQAPVAC
  EETLHVTNITILVVVLVLVIVGIGVLILLVRYRKCIKLKQVQSPPTETLGVENKGYFGDE
  QQIRTEPILPEIHFLNKPASKDSRGIADPNQSAK

• Sequence length: 754