ADAM18 (ADAM metallopeptidase domain 18)

Gene

• Entrez ID: 8749
• Gene name: ADAM metallopeptidase domain 18
• Gene symbol: ADAM18
• Synonyms (NCBI Gene): ADAM27, tMDCIII
• Chromosome: 8
• Chromosome location: 8p11.22
• Summary: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes i

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029408	hsa-miR-26b-5p	Microarray	19088304
MIRT765997	hsa-miR-1253	CLIP-seq
MIRT765998	hsa-miR-190	CLIP-seq
MIRT765999	hsa-miR-190b	CLIP-seq
MIRT766000	hsa-miR-3140-3p	CLIP-seq
MIRT766001	hsa-miR-4687-3p	CLIP-seq
MIRT1925706	hsa-miR-4307	CLIP-seq
MIRT1925707	hsa-miR-4670-3p	CLIP-seq
MIRT1925708	hsa-miR-4760-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004222	Function	Metalloendopeptidase activity	IBA
GO:0004222	Function	Metalloendopeptidase activity	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0006508	Process	Proteolysis	IBA
GO:0006508	Process	Proteolysis	IEA
GO:0007155	Process	Cell adhesion	IBA
GO:0007283	Process	Spermatogenesis	IEA
GO:0007283	Process	Spermatogenesis	TAS	10395895
GO:0007339	Process	Binding of sperm to zona pellucida	IBA
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	TAS	10395895
GO:0008584	Process	Male gonad development	IBA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	10395895
GO:0030154	Process	Cell differentiation	IEA

Other IDs

• MIM: 619495
• HGNC: 196
• e!Ensembl: ENSG00000168619

Protein

• UniProt ID: Q9Y3Q7
• Protein name: Disintegrin and metalloproteinase domain-containing protein 18 (ADAM 18) (Transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein III) (tMDC III)
• Protein function: Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein (By similarity).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01562	Pep_M12B_propep	11 → 141	Reprolysin family propeptide	Family
  PF01421	Reprolysin	184 → 381	Reprolysin (M12B) family zinc metalloprotease	Domain
  PF00200	Disintegrin	399 → 474	Disintegrin	Domain
  PF08516	ADAM_CR	479 → 595	ADAM cysteine-rich	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed specifically in testis.
• Sequence:

  MFLLLALLTELGRLQAHEGSEGIFLHVTVPRKIKSNDSEVSERKMIYIITIDGQPYTLHL
  GKQSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSICSGLRGFLQF
  ENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKDQPYKVPLNSQIKNLSK
  LLPQYLEIYIIVEKALYDYMGSEMMAVTQKIVQVIGLVNTMFTQFKLTVILSSLELWSNE
  NQISTSGDADDILQRFLAWKRDYLILRPHDIAYLLVYRKHPKYVGATFPGTVCNKSYDAG
  IAMYPDAIGLEGFSVIIAQLLGLNVGLTYDDITQCFCLRATCIMNHEAVSASGRKIFSNC
  SMHDYRYFVSKFETKCLQKLSNLQPLHQNQPVCGNGILESNEECDCGNKNECQFKKCCDY
  NTCKLKGSVKCGSGPCCTSKCELSIAGTPCRKSIDPECDFTEYCNGTSSNCVPDTYALNG
  RLCKLGTAYCYNGQCQTTDNQCAKIFGKGAQGAPFACFKEVNSLHERSENCGFKNSQPLP
  CERKDVLCGKLACVQPHKNANKSDAQSTVYSYIQDHVCVSIATGSSMRSDGTDNAYVADG
  TMCGPEMYCVNKTCRKVHLMGYNCNATTKCKGKGICNNFGNCQCFPGHRPPDCKFQFGSP
  GGSIDDGNFQKSGDFYTEKGYNTHWNNWFILSFCIFLPFFIVFTTVIFKRNEISKSCNRE
  NAEYNRNSSVVSESDDVGH

• Sequence length: 739