ADAM18 (ADAM metallopeptidase domain 18)

Gene
Gene miRNA Gene ontology Other IDs Protein
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8749
Gene name Gene Name - the full gene name approved by the HGNC.
ADAM metallopeptidase domain 18
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ADAM18
Synonyms (NCBI Gene) Gene synonyms aliases
ADAM27, tMDCIII
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8p11.22
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes i
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein
Show/Hide all(9)
miRTarBase ID miRNA Experiments Reference
MIRT029408 hsa-miR-26b-5p Microarray 19088304
MIRT765997 hsa-miR-1253 CLIP-seq
MIRT765998 hsa-miR-190 CLIP-seq
MIRT765999 hsa-miR-190b CLIP-seq
MIRT766000 hsa-miR-3140-3p CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein
Show/Hide all(10)
GO ID Ontology Definition Evidence Reference
GO:0004222 Function Metalloendopeptidase activity IEA
GO:0006508 Process Proteolysis IEA
GO:0007155 Process Cell adhesion IBA 21873635
GO:0007275 Process Multicellular organism development IEA
GO:0007283 Process Spermatogenesis IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein
MIM HGNC e!Ensembl
619495 196 ENSG00000168619
Protein
Gene miRNA Gene ontology Other IDs Protein
UniProt ID Q9Y3Q7
Protein name Disintegrin and metalloproteinase domain-containing protein 18 (ADAM 18) (Transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein III) (tMDC III)
Protein function Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein (By similarity).
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01562 Pep_M12B_propep 11 → 141 Reprolysin family propeptide Family
PF01421 Reprolysin 184 → 381 Reprolysin (M12B) family zinc metalloprotease Domain
PF00200 Disintegrin 399 → 474 Disintegrin Domain
PF08516 ADAM_CR 479 → 595 ADAM cysteine-rich Family
Tissue specificity TISSUE SPECIFICITY: Expressed specifically in testis.
Sequence
Sequence length 739
Interactions View interactions