ADAM23 (ADAM metallopeptidase domain 23)

Gene

• Entrez ID: 8745
• Gene name: ADAM metallopeptidase domain 23
• Gene symbol: ADAM23
• Synonyms (NCBI Gene): MDC-3, MDC3
• Chromosome: 2
• Chromosome location: 2q33.3
• Summary: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT755376	hsa-miR-372-3p	Luciferase reporter assay, Western blotting, qRT-PCR	35003396
MIRT2167113	hsa-miR-3148	CLIP-seq
MIRT2167114	hsa-miR-3162-5p	CLIP-seq
MIRT2167115	hsa-miR-4313	CLIP-seq
MIRT2167116	hsa-miR-4668-5p	CLIP-seq
MIRT2167117	hsa-miR-885-5p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
SP1	Activation	20851106

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004222	Function	Metalloendopeptidase activity	IBA
GO:0004222	Function	Metalloendopeptidase activity	IEA
GO:0005178	Function	Integrin binding	TAS	9693107
GO:0005515	Function	Protein binding	IPI	20463223
GO:0005576	Component	Extracellular region	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	9693107
GO:0006508	Process	Proteolysis	IBA
GO:0006508	Process	Proteolysis	IEA
GO:0007155	Process	Cell adhesion	IEA
GO:0007417	Process	Central nervous system development	TAS	9693107
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	TAS	9693107
GO:0016020	Component	Membrane	IEA
GO:0042734	Component	Presynaptic membrane	IBA
GO:0042734	Component	Presynaptic membrane	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:1990830	Process	Cellular response to leukemia inhibitory factor	IEA

Other IDs

• MIM: 603710
• HGNC: 202
• e!Ensembl: ENSG00000114948

Protein

• UniProt ID: O75077
• Protein name: Disintegrin and metalloproteinase domain-containing protein 23 (ADAM 23) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3) (MDC-3)
• Protein function: May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01562	Pep_M12B_propep	110 → 249	Reprolysin family propeptide	Family
  PF01421	Reprolysin	299 → 496	Reprolysin (M12B) family zinc metalloprotease	Domain
  PF00200	Disintegrin	511 → 583	Disintegrin	Domain
  PF08516	ADAM_CR	588 → 706	ADAM cysteine-rich	Family

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in the brain and weakly expressed in the heart. In the brain, expressed prominently in the amygdala, caudate nucleus, hypothalamus, thalamus, cerebral cortex and occipital pole. {ECO:0000269|PubMed:14697522}.
• Sequence:

  MKPPGSSSRQPPLAGCSLAGASCGPQRGPAGSVPASAPARTPPCRLLLVLLLLPPLAASS
  RPRAWGAAAPSAPHWNETAEKNLGVLADEDNTLQQNSSSNISYSNAMQKEITLPSRLIYY
  INQDSESPYHVLDTKARHQQKHNKAVHLAQASFQIEAFGSKFILDLILNNGLLSSDYVEI
  HYENGKPQYSKGGEHCYYHGSIRGVKDSKVALSTCNGLHGMFEDDTFVYMIEPLELVHDE
  KSTGRPHIIQKTLAGQYSKQMKNLTMERGDQWPFLSELQWLKRRKRAVNPSRGIFEEMKY
  LELMIVNDHKTYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQID
  ITTNPVQMLHEFSKYRQRIKQHADAVHLISRVTFHYKRSSLSYFGGVCSRTRGVGVNEYG
  LPMAVAQVLSQSLAQNLGIQWEPSSRKPKCDCTESWGGCIMEETGVSHSRKFSKCSILEY
  RDFLQRGGGACLFNRPTKLFEPTECGNGYVEAGEECDCGFHVECYGLCCKKCSLSNGAHC
  SDGPCCNNTSCLFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCY
  NGECKTRDNQCQYIWGTKAAGSDKFCYEKLNTEGTEKGNCGKDGDRWIQCSKHDVFCGFL
  LCTNLTRAPRIGQLQGEIIPTSFYHQGRVIDCSGAHVVLDDDTDVGYVEDGTPCGPSMMC
  LDRKCLQIQALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCSIRDPVRNLHPP
  KDEGPKGPSATNLIIGSIAGAILVAAIVLGGTGWGFKNVKKRRFDPTQQGPI

• Sequence length: 832

Pathways

Reactome:

LGI-ADAM interactions