Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	8741
Gene name Gene Name - the full gene name approved by the HGNC.	TNF superfamily member 13
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TNFSF13
Synonyms (NCBI Gene) Gene synonyms aliases	APRIL, CD256, TALL-2, TALL2, TNLG7B, TRDL-1, UNQ383/PRO715, ZTNF2
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17p13.1
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell develop

Show/Hide all(80)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019711	hsa-miR-375	Microarray	20215506
MIRT026351	hsa-miR-192-5p	Microarray	19074876
MIRT054274	hsa-miR-145-5p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	25612651
MIRT054274	hsa-miR-145-5p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	25612651
MIRT2132687	hsa-miR-4749-3p	CLIP-seq
MIRT2132687	hsa-miR-4749-3p	CLIP-seq
MIRT2396128	hsa-miR-1247	CLIP-seq
MIRT2396129	hsa-miR-1254	CLIP-seq
MIRT2396130	hsa-miR-3116	CLIP-seq
MIRT2132687	hsa-miR-4749-3p	CLIP-seq
MIRT2396131	hsa-miR-566	CLIP-seq
MIRT2396132	hsa-miR-661	CLIP-seq
MIRT2462086	hsa-miR-185	CLIP-seq
MIRT2462087	hsa-miR-4306	CLIP-seq
MIRT2462088	hsa-miR-4534	CLIP-seq
MIRT2462089	hsa-miR-4644	CLIP-seq
MIRT2462090	hsa-miR-4738-3p	CLIP-seq
MIRT2462091	hsa-miR-615-5p	CLIP-seq
MIRT2647854	hsa-miR-1302	CLIP-seq
MIRT2462086	hsa-miR-185	CLIP-seq
MIRT2647855	hsa-miR-3122	CLIP-seq
MIRT2647856	hsa-miR-3151	CLIP-seq
MIRT2647857	hsa-miR-3189-3p	CLIP-seq
MIRT2647858	hsa-miR-3649	CLIP-seq
MIRT2647859	hsa-miR-3913-5p	CLIP-seq
MIRT2647860	hsa-miR-4265	CLIP-seq
MIRT2647861	hsa-miR-4296	CLIP-seq
MIRT2647862	hsa-miR-4298	CLIP-seq
MIRT2462087	hsa-miR-4306	CLIP-seq
MIRT2647863	hsa-miR-4322	CLIP-seq
MIRT2647864	hsa-miR-4447	CLIP-seq
MIRT2647865	hsa-miR-4472	CLIP-seq
MIRT2462088	hsa-miR-4534	CLIP-seq
MIRT2462089	hsa-miR-4644	CLIP-seq
MIRT2647866	hsa-miR-4671-5p	CLIP-seq
MIRT2462090	hsa-miR-4738-3p	CLIP-seq
MIRT2647867	hsa-miR-491-5p	CLIP-seq
MIRT2647868	hsa-miR-578	CLIP-seq
MIRT2647869	hsa-miR-581	CLIP-seq
MIRT2462091	hsa-miR-615-5p	CLIP-seq
MIRT2693720	hsa-miR-124	CLIP-seq
MIRT2647854	hsa-miR-1302	CLIP-seq
MIRT2693721	hsa-miR-1827	CLIP-seq
MIRT2462086	hsa-miR-185	CLIP-seq
MIRT2693722	hsa-miR-2467-3p	CLIP-seq
MIRT2647855	hsa-miR-3122	CLIP-seq
MIRT2693723	hsa-miR-3136-5p	CLIP-seq
MIRT2647856	hsa-miR-3151	CLIP-seq
MIRT2647857	hsa-miR-3189-3p	CLIP-seq
MIRT2693724	hsa-miR-342-5p	CLIP-seq
MIRT2693725	hsa-miR-3616-3p	CLIP-seq
MIRT2693726	hsa-miR-3622b-5p	CLIP-seq
MIRT2647858	hsa-miR-3649	CLIP-seq
MIRT2693727	hsa-miR-3688-5p	CLIP-seq
MIRT2647859	hsa-miR-3913-5p	CLIP-seq
MIRT2693728	hsa-miR-4254	CLIP-seq
MIRT2647860	hsa-miR-4265	CLIP-seq
MIRT2647861	hsa-miR-4296	CLIP-seq
MIRT2647862	hsa-miR-4298	CLIP-seq
MIRT2462087	hsa-miR-4306	CLIP-seq
MIRT2647863	hsa-miR-4322	CLIP-seq
MIRT2693729	hsa-miR-4439	CLIP-seq
MIRT2647864	hsa-miR-4447	CLIP-seq
MIRT2647865	hsa-miR-4472	CLIP-seq
MIRT2462088	hsa-miR-4534	CLIP-seq
MIRT2462089	hsa-miR-4644	CLIP-seq
MIRT2693730	hsa-miR-4651	CLIP-seq
MIRT2693731	hsa-miR-4664-5p	CLIP-seq
MIRT2647866	hsa-miR-4671-5p	CLIP-seq
MIRT2693732	hsa-miR-4709-3p	CLIP-seq
MIRT2462090	hsa-miR-4738-3p	CLIP-seq
MIRT2647867	hsa-miR-491-5p	CLIP-seq
MIRT2693733	hsa-miR-506	CLIP-seq
MIRT2647868	hsa-miR-578	CLIP-seq
MIRT2647869	hsa-miR-581	CLIP-seq
MIRT2693734	hsa-miR-608	CLIP-seq
MIRT2462091	hsa-miR-615-5p	CLIP-seq
MIRT2693735	hsa-miR-619	CLIP-seq
MIRT2693736	hsa-miR-644	CLIP-seq
MIRT2693737	hsa-miR-943	CLIP-seq

Show/Hide all(28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002260	Process	Lymphocyte homeostasis	IBA
GO:0002376	Process	Immune system process	IEA
GO:0005102	Function	Signaling receptor binding	IEA
GO:0005102	Function	Signaling receptor binding	TAS	9743536
GO:0005125	Function	Cytokine activity	IBA
GO:0005125	Function	Cytokine activity	IEA
GO:0005164	Function	Tumor necrosis factor receptor binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183, 32814053
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	19828625
GO:0005829	Component	Cytosol	TAS
GO:0006955	Process	Immune response	IBA
GO:0006955	Process	Immune response	IEA
GO:0007154	Process	Cell communication	IEA
GO:0007165	Process	Signal transduction	TAS	9743536
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	TAS	9743536
GO:0016020	Component	Membrane	IEA
GO:0023052	Process	Signaling	IEA
GO:0030890	Process	Positive regulation of B cell proliferation	IBA
GO:0048298	Process	Positive regulation of isotype switching to IgA isotypes	IBA
GO:0048298	Process	Positive regulation of isotype switching to IgA isotypes	IDA	14988498
GO:0048298	Process	Positive regulation of isotype switching to IgA isotypes	IEA
GO:0070062	Component	Extracellular exosome	HDA	19199708

MIM	HGNC	e!Ensembl
604472	11928	ENSG00000161955

Protein

UniProt ID

O75888

Protein name

Tumor necrosis factor ligand superfamily member 13 (A proliferation-inducing ligand) (APRIL) (TNF- and APOL-related leukocyte expressed ligand 2) (TALL-2) (TNF-related death ligand 1) (TRDL-1) (CD antigen CD256)

Protein function

Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.

PDB

4ZCH

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00229	TNF	139 → 250	TNF(Tumour Necrosis Factor) family	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissues and specifically expressed in monocytes and macrophages.

Sequence

MPASSPFLLAPKGPPGNMGGPVREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRR
EVSRLQGTGGPSQNGEGYPWQSLPEQSSDALEAWENGERSRKRRAVLTQKQKKQHSVLHL
VPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQ
VVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSP
HGTFLGFVKL

Sequence length

250

Interactions

View interactions

	KEGG		Reactome
	Cytokine-cytokine receptor interaction Intestinal immune network for IgA production Rheumatoid arthritis		HuR (ELAVL1) binds and stabilizes mRNA TNFs bind their physiological receptors

Show/Hide Unknown Diseases (4)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Atrial Fibrillation	Atrial fibrillation	N/A	N/A	GWAS
Common Variable Immunodeficiency	common variable immunodeficiency	N/A	N/A	GenCC
Hypertension	Hypertension	N/A	N/A	GWAS
Uterine Fibroids	Uterine fibroids	N/A	N/A	GWAS

Show/Hide Text Mining Associations (32)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Anti N Methyl D Aspartate Receptor Encephalitis	Stimulate	36544777
Arthritis Rheumatoid	Associate	32998682
Asthma	Stimulate	24641287
Atrial Fibrillation	Associate	28849223
Behcet Syndrome	Associate	25759827
Carcinogenesis	Associate	25826583
Celiac Disease	Associate	22136669
Colonic Neoplasms	Associate	20003335
Colorectal Neoplasms	Associate	25826583, 37511338
Crohn Disease	Associate	31852111
Drug Hypersensitivity	Stimulate	24641287
Glioma	Associate	34712225
Glomerulonephritis IGA	Associate	27068226
Glomerulonephritis IGA	Stimulate	27920152
Inflammation	Associate	34712225
Kidney Failure Chronic	Stimulate	27068226
Kidney Failure Chronic	Associate	27068226
Laryngeal Neoplasms	Associate	26395262
Lupus Erythematosus Systemic	Associate	21250838
Lymphoma	Stimulate	23775715
Lymphoma	Associate	31852111
Melanoma	Associate	37435077
Neoplasm Metastasis	Associate	25826583
Neoplasms	Associate	23775715, 25826583, 26395262, 34712225, 37435077
Neoplasms	Stimulate	25612651
Peri Implantitis	Associate	35886240
Primary Immunodeficiency Diseases	Associate	27920152
Proteinuria	Associate	27920152
Schizophrenia	Stimulate	22545112
Sjogren's Syndrome	Associate	22562936
Squamous Cell Carcinoma of Head and Neck	Associate	26395262
Stomach Neoplasms	Associate	25612651

TNFSF13 (TNF superfamily member 13)