Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8741
Gene name Gene Name - the full gene name approved by the HGNC.
TNF superfamily member 13
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TNFSF13
Synonyms (NCBI Gene) Gene synonyms aliases
APRIL, CD256, TALL-2, TALL2, TNLG7B, TRDL-1, UNQ383/PRO715, ZTNF2
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17p13.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell develop
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019711 hsa-miR-375 Microarray 20215506
MIRT026351 hsa-miR-192-5p Microarray 19074876
MIRT054274 hsa-miR-145-5p Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot 25612651
MIRT054274 hsa-miR-145-5p Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot 25612651
MIRT2132687 hsa-miR-4749-3p CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005125 Function Cytokine activity IEA
GO:0005164 Function Tumor necrosis factor receptor binding IEA
GO:0005576 Component Extracellular region TAS
GO:0005615 Component Extracellular space IBA 21873635
GO:0005654 Component Nucleoplasm TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604472 11928 ENSG00000161955
Protein
UniProt ID O75888
Protein name Tumor necrosis factor ligand superfamily member 13 (A proliferation-inducing ligand) (APRIL) (TNF- and APOL-related leukocyte expressed ligand 2) (TALL-2) (TNF-related death ligand 1) (TRDL-1) (CD antigen CD256)
Protein function Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.
PDB 4ZCH
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00229 TNF 139 250 TNF(Tumour Necrosis Factor) family Domain
Tissue specificity TISSUE SPECIFICITY: Expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissues and specifically expressed in monocytes and macrophages.
Sequence
MPASSPFLLAPKGPPGNMGGPVREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRR
EVSRLQGTGGPSQNGEGYPWQSLPEQSSDALEAWENGERSRKRRAVLTQKQKKQHSVLHL
VPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQ
VVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSP
HGTFLGFVKL
Sequence length 250
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
Intestinal immune network for IgA production
Rheumatoid arthritis
  HuR (ELAVL1) binds and stabilizes mRNA
TNFs bind their physiological receptors
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Colorectal cancer Colorectal Carcinoma rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
18423122
Colorectal neoplasms Colorectal Neoplasms rs28929483, rs63751108, rs28929484, rs63749831, rs63750047, rs63751207, rs63749811, rs1553350126, rs63750875, rs63750955, rs587776706, rs63750871, rs587776715, rs63751466, rs63750049
View all (1682 more)
18423122
Glomerulonephritis IGA Glomerulonephritis rs778043831 22197929
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
22545112
Unknown
Disease term Disease name Evidence References Source
Common Variable Immunodeficiency common variable immunodeficiency GenCC
Uterine Fibroids Uterine Fibroids GWAS
Atrial Fibrillation Atrial Fibrillation GWAS
Hypertension Hypertension GWAS
Associations from Text Mining
Disease Name Relationship Type References
Anti N Methyl D Aspartate Receptor Encephalitis Stimulate 36544777
Arthritis Rheumatoid Associate 32998682
Asthma Stimulate 24641287
Atrial Fibrillation Associate 28849223
Behcet Syndrome Associate 25759827
Carcinogenesis Associate 25826583
Celiac Disease Associate 22136669
Colonic Neoplasms Associate 20003335
Colorectal Neoplasms Associate 25826583, 37511338
Crohn Disease Associate 31852111