Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	8728
Gene name Gene Name - the full gene name approved by the HGNC.	ADAM metallopeptidase domain 19
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ADAM19
Synonyms (NCBI Gene) Gene synonyms aliases	FKSG34, MADDAM, MLTNB
Chromosome Chromosome number	5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	5q33.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes

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miRTarBase ID	miRNA	Experiments	Reference
MIRT660931	hsa-miR-4753-5p	HITS-CLIP	23824327
MIRT660930	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT660929	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT660928	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT660927	hsa-miR-3183	HITS-CLIP	23824327
MIRT660926	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT660925	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT660924	hsa-miR-4469	HITS-CLIP	23824327
MIRT660923	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT660922	hsa-miR-4287	HITS-CLIP	23824327
MIRT660920	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT660921	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT660919	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT660918	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT660917	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT660916	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT660915	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT660914	hsa-miR-507	HITS-CLIP	23824327
MIRT660913	hsa-miR-557	HITS-CLIP	23824327
MIRT660912	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT733905	hsa-miR-7973	Luciferase reporter assay, Microarray, qRT-PCR	32042028
MIRT736303	hsa-miR-206	Luciferase reporter assay, RNA-seq, qRT-PCR	32129700
MIRT660931	hsa-miR-4753-5p	HITS-CLIP	23824327
MIRT660930	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT660929	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT660928	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT660927	hsa-miR-3183	HITS-CLIP	23824327
MIRT660926	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT660925	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT660924	hsa-miR-4469	HITS-CLIP	23824327
MIRT660923	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT660922	hsa-miR-4287	HITS-CLIP	23824327
MIRT660920	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT660921	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT660919	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT660918	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT660917	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT660916	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT660915	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT660914	hsa-miR-507	HITS-CLIP	23824327
MIRT660913	hsa-miR-557	HITS-CLIP	23824327
MIRT660912	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT766002	hsa-miR-1178	CLIP-seq
MIRT766003	hsa-miR-1207-5p	CLIP-seq
MIRT766004	hsa-miR-124	CLIP-seq
MIRT766005	hsa-miR-1257	CLIP-seq
MIRT766006	hsa-miR-1273g	CLIP-seq
MIRT766007	hsa-miR-1286	CLIP-seq
MIRT766008	hsa-miR-1288	CLIP-seq
MIRT766009	hsa-miR-1294	CLIP-seq
MIRT766010	hsa-miR-1321	CLIP-seq
MIRT766011	hsa-miR-137	CLIP-seq
MIRT766012	hsa-miR-183	CLIP-seq
MIRT766013	hsa-miR-22	CLIP-seq
MIRT766014	hsa-miR-2392	CLIP-seq
MIRT766015	hsa-miR-2467-5p	CLIP-seq
MIRT766016	hsa-miR-302f	CLIP-seq
MIRT766017	hsa-miR-3126-5p	CLIP-seq
MIRT766018	hsa-miR-3136-3p	CLIP-seq
MIRT766019	hsa-miR-3148	CLIP-seq
MIRT766020	hsa-miR-3150a-3p	CLIP-seq
MIRT766021	hsa-miR-3150b-3p	CLIP-seq
MIRT766022	hsa-miR-3151	CLIP-seq
MIRT766023	hsa-miR-3169	CLIP-seq
MIRT766024	hsa-miR-3175	CLIP-seq
MIRT766025	hsa-miR-3184	CLIP-seq
MIRT766026	hsa-miR-3194-3p	CLIP-seq
MIRT766027	hsa-miR-345	CLIP-seq
MIRT766028	hsa-miR-3613-3p	CLIP-seq
MIRT766029	hsa-miR-3620	CLIP-seq
MIRT766030	hsa-miR-3650	CLIP-seq
MIRT766031	hsa-miR-3689d	CLIP-seq
MIRT766032	hsa-miR-3974	CLIP-seq
MIRT766033	hsa-miR-423-5p	CLIP-seq
MIRT766034	hsa-miR-4270	CLIP-seq
MIRT766035	hsa-miR-4299	CLIP-seq
MIRT766036	hsa-miR-4316	CLIP-seq
MIRT766037	hsa-miR-4419a	CLIP-seq
MIRT766038	hsa-miR-4434	CLIP-seq
MIRT766039	hsa-miR-4436a	CLIP-seq
MIRT766040	hsa-miR-4441	CLIP-seq
MIRT766041	hsa-miR-4456	CLIP-seq
MIRT766042	hsa-miR-4459	CLIP-seq
MIRT766043	hsa-miR-4489	CLIP-seq
MIRT766044	hsa-miR-4510	CLIP-seq
MIRT766045	hsa-miR-4516	CLIP-seq
MIRT766046	hsa-miR-4652-3p	CLIP-seq
MIRT766047	hsa-miR-4663	CLIP-seq
MIRT766048	hsa-miR-4667-3p	CLIP-seq
MIRT766049	hsa-miR-4677-3p	CLIP-seq
MIRT766050	hsa-miR-4679	CLIP-seq
MIRT766051	hsa-miR-4685-5p	CLIP-seq
MIRT766052	hsa-miR-4704-3p	CLIP-seq
MIRT766053	hsa-miR-4712-3p	CLIP-seq
MIRT766054	hsa-miR-4722-5p	CLIP-seq
MIRT766055	hsa-miR-4728-5p	CLIP-seq
MIRT766056	hsa-miR-4733-3p	CLIP-seq
MIRT766057	hsa-miR-4736	CLIP-seq
MIRT766058	hsa-miR-4739	CLIP-seq
MIRT766059	hsa-miR-4756-5p	CLIP-seq
MIRT766060	hsa-miR-4763-3p	CLIP-seq
MIRT766061	hsa-miR-4784	CLIP-seq
MIRT766062	hsa-miR-486-3p	CLIP-seq
MIRT766063	hsa-miR-491-5p	CLIP-seq
MIRT766064	hsa-miR-493	CLIP-seq
MIRT766065	hsa-miR-506	CLIP-seq
MIRT766066	hsa-miR-516b	CLIP-seq
MIRT766067	hsa-miR-548an	CLIP-seq
MIRT766068	hsa-miR-548q	CLIP-seq
MIRT766069	hsa-miR-765	CLIP-seq
MIRT766070	hsa-miR-767-5p	CLIP-seq
MIRT766071	hsa-miR-877	CLIP-seq
MIRT766072	hsa-miR-939	CLIP-seq
MIRT766073	hsa-miR-943	CLIP-seq
MIRT766005	hsa-miR-1257	CLIP-seq
MIRT766005	hsa-miR-1257	CLIP-seq
MIRT766005	hsa-miR-1257	CLIP-seq
MIRT1925709	hsa-miR-1200	CLIP-seq
MIRT766005	hsa-miR-1257	CLIP-seq
MIRT1925710	hsa-miR-1297	CLIP-seq
MIRT1925711	hsa-miR-2052	CLIP-seq
MIRT1925712	hsa-miR-2110	CLIP-seq
MIRT1925713	hsa-miR-2467-3p	CLIP-seq
MIRT1925714	hsa-miR-26a	CLIP-seq
MIRT1925715	hsa-miR-26b	CLIP-seq
MIRT1925716	hsa-miR-29a	CLIP-seq
MIRT1925717	hsa-miR-29b	CLIP-seq
MIRT1925718	hsa-miR-29c	CLIP-seq
MIRT766018	hsa-miR-3136-3p	CLIP-seq
MIRT1925719	hsa-miR-3176	CLIP-seq
MIRT1925720	hsa-miR-330-3p	CLIP-seq
MIRT1925721	hsa-miR-3649	CLIP-seq
MIRT1925722	hsa-miR-3663-5p	CLIP-seq
MIRT1925723	hsa-miR-3664-5p	CLIP-seq
MIRT1925724	hsa-miR-3678-3p	CLIP-seq
MIRT1925725	hsa-miR-3922-3p	CLIP-seq
MIRT1925726	hsa-miR-4271	CLIP-seq
MIRT1925727	hsa-miR-4307	CLIP-seq
MIRT1925728	hsa-miR-4324	CLIP-seq
MIRT1925729	hsa-miR-4433	CLIP-seq
MIRT1925730	hsa-miR-4465	CLIP-seq
MIRT766053	hsa-miR-4712-3p	CLIP-seq
MIRT1925731	hsa-miR-4714-5p	CLIP-seq
MIRT1925732	hsa-miR-4725-3p	CLIP-seq
MIRT1925733	hsa-miR-4747-5p	CLIP-seq
MIRT1925734	hsa-miR-483-3p	CLIP-seq
MIRT1925735	hsa-miR-488	CLIP-seq
MIRT1925736	hsa-miR-5096	CLIP-seq
MIRT1925737	hsa-miR-544b	CLIP-seq
MIRT1925738	hsa-miR-665	CLIP-seq
MIRT1925739	hsa-miR-934	CLIP-seq
MIRT2167099	hsa-miR-122	CLIP-seq
MIRT766005	hsa-miR-1257	CLIP-seq
MIRT2167100	hsa-miR-1285	CLIP-seq
MIRT2167101	hsa-miR-1304	CLIP-seq
MIRT2167102	hsa-miR-1343	CLIP-seq
MIRT2167103	hsa-miR-1909	CLIP-seq
MIRT1925711	hsa-miR-2052	CLIP-seq
MIRT2167104	hsa-miR-3065-3p	CLIP-seq
MIRT2167105	hsa-miR-3187-5p	CLIP-seq
MIRT1925727	hsa-miR-4307	CLIP-seq
MIRT2167106	hsa-miR-4481	CLIP-seq
MIRT766055	hsa-miR-4728-5p	CLIP-seq
MIRT2167107	hsa-miR-4745-5p	CLIP-seq
MIRT2167108	hsa-miR-4752	CLIP-seq
MIRT1925735	hsa-miR-488	CLIP-seq
MIRT1925736	hsa-miR-5096	CLIP-seq
MIRT2167109	hsa-miR-612	CLIP-seq
MIRT2167110	hsa-miR-642a	CLIP-seq
MIRT766005	hsa-miR-1257	CLIP-seq
MIRT2383883	hsa-miR-370	CLIP-seq
MIRT1925737	hsa-miR-544b	CLIP-seq
MIRT766069	hsa-miR-765	CLIP-seq
MIRT2167100	hsa-miR-1285	CLIP-seq
MIRT2167102	hsa-miR-1343	CLIP-seq
MIRT2443140	hsa-miR-1976	CLIP-seq
MIRT2167105	hsa-miR-3187-5p	CLIP-seq
MIRT2443141	hsa-miR-3618	CLIP-seq
MIRT2383883	hsa-miR-370	CLIP-seq
MIRT2443142	hsa-miR-4435	CLIP-seq
MIRT2443143	hsa-miR-4691-5p	CLIP-seq
MIRT2167109	hsa-miR-612	CLIP-seq
MIRT2443144	hsa-miR-626	CLIP-seq
MIRT1925739	hsa-miR-934	CLIP-seq
MIRT1925709	hsa-miR-1200	CLIP-seq
MIRT2469623	hsa-miR-1224-5p	CLIP-seq
MIRT766004	hsa-miR-124	CLIP-seq
MIRT2469624	hsa-miR-1253	CLIP-seq
MIRT766005	hsa-miR-1257	CLIP-seq
MIRT2469625	hsa-miR-125a-5p	CLIP-seq
MIRT2469626	hsa-miR-125b	CLIP-seq
MIRT1925710	hsa-miR-1297	CLIP-seq
MIRT2469627	hsa-miR-1301	CLIP-seq
MIRT2469628	hsa-miR-145	CLIP-seq
MIRT2469629	hsa-miR-148a	CLIP-seq
MIRT2469630	hsa-miR-148b	CLIP-seq
MIRT2469631	hsa-miR-150	CLIP-seq
MIRT2469632	hsa-miR-152	CLIP-seq
MIRT2469633	hsa-miR-153	CLIP-seq
MIRT2469634	hsa-miR-1825	CLIP-seq
MIRT2167103	hsa-miR-1909	CLIP-seq
MIRT2469635	hsa-miR-199a-5p	CLIP-seq
MIRT2469636	hsa-miR-199b-5p	CLIP-seq
MIRT766015	hsa-miR-2467-5p	CLIP-seq
MIRT1925714	hsa-miR-26a	CLIP-seq
MIRT1925715	hsa-miR-26b	CLIP-seq
MIRT2469637	hsa-miR-3064-5p	CLIP-seq
MIRT2469638	hsa-miR-3074-5p	CLIP-seq
MIRT2469639	hsa-miR-30a	CLIP-seq
MIRT2469640	hsa-miR-30b	CLIP-seq
MIRT2469641	hsa-miR-30c	CLIP-seq
MIRT2469642	hsa-miR-30d	CLIP-seq
MIRT2469643	hsa-miR-30e	CLIP-seq
MIRT766017	hsa-miR-3126-5p	CLIP-seq
MIRT766018	hsa-miR-3136-3p	CLIP-seq
MIRT2469644	hsa-miR-3138	CLIP-seq
MIRT2469645	hsa-miR-3145-5p	CLIP-seq
MIRT766019	hsa-miR-3148	CLIP-seq
MIRT2469646	hsa-miR-3156-5p	CLIP-seq
MIRT2469647	hsa-miR-3185	CLIP-seq
MIRT766026	hsa-miR-3194-3p	CLIP-seq
MIRT2469648	hsa-miR-320a	CLIP-seq
MIRT2469649	hsa-miR-320b	CLIP-seq
MIRT2469650	hsa-miR-320c	CLIP-seq
MIRT2469651	hsa-miR-320d	CLIP-seq
MIRT2469652	hsa-miR-320e	CLIP-seq
MIRT766027	hsa-miR-345	CLIP-seq
MIRT766029	hsa-miR-3620	CLIP-seq
MIRT2469653	hsa-miR-3915	CLIP-seq
MIRT2469654	hsa-miR-3925-3p	CLIP-seq
MIRT2469655	hsa-miR-3928	CLIP-seq
MIRT2469656	hsa-miR-3940-5p	CLIP-seq
MIRT2469657	hsa-miR-3944-5p	CLIP-seq
MIRT2469658	hsa-miR-3978	CLIP-seq
MIRT2469659	hsa-miR-4263	CLIP-seq
MIRT2469660	hsa-miR-4297	CLIP-seq
MIRT2469661	hsa-miR-4319	CLIP-seq
MIRT1925728	hsa-miR-4324	CLIP-seq
MIRT766037	hsa-miR-4419a	CLIP-seq
MIRT2469662	hsa-miR-4429	CLIP-seq
MIRT1925730	hsa-miR-4465	CLIP-seq
MIRT2469663	hsa-miR-448	CLIP-seq
MIRT2469664	hsa-miR-4507	CLIP-seq
MIRT766044	hsa-miR-4510	CLIP-seq
MIRT2469665	hsa-miR-4660	CLIP-seq
MIRT2469666	hsa-miR-4689	CLIP-seq
MIRT2469667	hsa-miR-4713-5p	CLIP-seq
MIRT2469668	hsa-miR-4799-5p	CLIP-seq
MIRT2469669	hsa-miR-5047	CLIP-seq
MIRT766065	hsa-miR-506	CLIP-seq
MIRT2469670	hsa-miR-515-5p	CLIP-seq
MIRT2469671	hsa-miR-532-3p	CLIP-seq
MIRT1925737	hsa-miR-544b	CLIP-seq
MIRT766067	hsa-miR-548an	CLIP-seq
MIRT2469672	hsa-miR-576-3p	CLIP-seq
MIRT2469673	hsa-miR-576-5p	CLIP-seq
MIRT2469674	hsa-miR-604	CLIP-seq
MIRT2469675	hsa-miR-633	CLIP-seq
MIRT2469676	hsa-miR-647	CLIP-seq
MIRT2469677	hsa-miR-766	CLIP-seq
MIRT766070	hsa-miR-767-5p	CLIP-seq
MIRT766073	hsa-miR-943	CLIP-seq
MIRT1925709	hsa-miR-1200	CLIP-seq
MIRT2469623	hsa-miR-1224-5p	CLIP-seq
MIRT766004	hsa-miR-124	CLIP-seq
MIRT2469624	hsa-miR-1253	CLIP-seq
MIRT2469625	hsa-miR-125a-5p	CLIP-seq
MIRT2469626	hsa-miR-125b	CLIP-seq
MIRT2167100	hsa-miR-1285	CLIP-seq
MIRT1925710	hsa-miR-1297	CLIP-seq
MIRT2469627	hsa-miR-1301	CLIP-seq
MIRT2674397	hsa-miR-1323	CLIP-seq
MIRT2469628	hsa-miR-145	CLIP-seq
MIRT2469629	hsa-miR-148a	CLIP-seq
MIRT2469630	hsa-miR-148b	CLIP-seq
MIRT2469631	hsa-miR-150	CLIP-seq
MIRT2469632	hsa-miR-152	CLIP-seq
MIRT2469633	hsa-miR-153	CLIP-seq
MIRT2469634	hsa-miR-1825	CLIP-seq
MIRT2469635	hsa-miR-199a-5p	CLIP-seq
MIRT2469636	hsa-miR-199b-5p	CLIP-seq
MIRT766015	hsa-miR-2467-5p	CLIP-seq
MIRT1925714	hsa-miR-26a	CLIP-seq
MIRT1925715	hsa-miR-26b	CLIP-seq
MIRT2469638	hsa-miR-3074-5p	CLIP-seq
MIRT2469639	hsa-miR-30a	CLIP-seq
MIRT2469640	hsa-miR-30b	CLIP-seq
MIRT2469641	hsa-miR-30c	CLIP-seq
MIRT2469642	hsa-miR-30d	CLIP-seq
MIRT2469643	hsa-miR-30e	CLIP-seq
MIRT766017	hsa-miR-3126-5p	CLIP-seq
MIRT766018	hsa-miR-3136-3p	CLIP-seq
MIRT2469644	hsa-miR-3138	CLIP-seq
MIRT2469645	hsa-miR-3145-5p	CLIP-seq
MIRT766019	hsa-miR-3148	CLIP-seq
MIRT2469646	hsa-miR-3156-5p	CLIP-seq
MIRT2469647	hsa-miR-3185	CLIP-seq
MIRT2167105	hsa-miR-3187-5p	CLIP-seq
MIRT766026	hsa-miR-3194-3p	CLIP-seq
MIRT2469648	hsa-miR-320a	CLIP-seq
MIRT2469649	hsa-miR-320b	CLIP-seq
MIRT2469650	hsa-miR-320c	CLIP-seq
MIRT2469651	hsa-miR-320d	CLIP-seq
MIRT2469652	hsa-miR-320e	CLIP-seq
MIRT766027	hsa-miR-345	CLIP-seq
MIRT766029	hsa-miR-3620	CLIP-seq
MIRT2674398	hsa-miR-3647-3p	CLIP-seq
MIRT2674399	hsa-miR-371b-5p	CLIP-seq
MIRT2469653	hsa-miR-3915	CLIP-seq
MIRT2469655	hsa-miR-3928	CLIP-seq
MIRT2469656	hsa-miR-3940-5p	CLIP-seq
MIRT2469657	hsa-miR-3944-5p	CLIP-seq
MIRT2469658	hsa-miR-3978	CLIP-seq
MIRT2469661	hsa-miR-4319	CLIP-seq
MIRT1925728	hsa-miR-4324	CLIP-seq
MIRT766037	hsa-miR-4419a	CLIP-seq
MIRT2469662	hsa-miR-4429	CLIP-seq
MIRT1925730	hsa-miR-4465	CLIP-seq
MIRT2469663	hsa-miR-448	CLIP-seq
MIRT2469664	hsa-miR-4507	CLIP-seq
MIRT766044	hsa-miR-4510	CLIP-seq
MIRT2469665	hsa-miR-4660	CLIP-seq
MIRT2469666	hsa-miR-4689	CLIP-seq
MIRT2469667	hsa-miR-4713-5p	CLIP-seq
MIRT2469669	hsa-miR-5047	CLIP-seq
MIRT766065	hsa-miR-506	CLIP-seq
MIRT2469671	hsa-miR-532-3p	CLIP-seq
MIRT1925737	hsa-miR-544b	CLIP-seq
MIRT766067	hsa-miR-548an	CLIP-seq
MIRT2674400	hsa-miR-548o	CLIP-seq
MIRT2469672	hsa-miR-576-3p	CLIP-seq
MIRT2167109	hsa-miR-612	CLIP-seq
MIRT2469675	hsa-miR-633	CLIP-seq
MIRT766069	hsa-miR-765	CLIP-seq
MIRT766070	hsa-miR-767-5p	CLIP-seq
MIRT2674401	hsa-miR-875-3p	CLIP-seq
MIRT766073	hsa-miR-943	CLIP-seq

Show/Hide all(21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001890	Process	Placenta development	IEP	19727588
GO:0004222	Function	Metalloendopeptidase activity	IBA
GO:0004222	Function	Metalloendopeptidase activity	IEA
GO:0004222	Function	Metalloendopeptidase activity	IMP	11162584, 17112471
GO:0005515	Function	Protein binding	IPI	11162584, 17112471, 25825872, 33961781
GO:0005634	Component	Nucleus	IDA	19727588
GO:0005886	Component	Plasma membrane	TAS
GO:0006508	Process	Proteolysis	IEA
GO:0006509	Process	Membrane protein ectodomain proteolysis	IBA
GO:0008233	Function	Peptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0010628	Process	Positive regulation of gene expression	IDA	19727588
GO:0016020	Component	Membrane	IEA
GO:0016485	Process	Protein processing	IMP	17112471
GO:0016787	Function	Hydrolase activity	IEA
GO:0017124	Function	SH3 domain binding	IEA
GO:0031012	Component	Extracellular matrix	HDA	28344315
GO:0042987	Process	Amyloid precursor protein catabolic process	IMP	17112471
GO:0046872	Function	Metal ion binding	IEA
GO:1902945	Function	Metalloendopeptidase activity involved in amyloid precursor protein catabolic process	IMP	17112471
GO:2000049	Process	Positive regulation of cell-cell adhesion mediated by cadherin	IDA	19727588

MIM	HGNC	e!Ensembl
603640	197	ENSG00000135074

Protein

UniProt ID

Q9H013

Protein name

Disintegrin and metalloproteinase domain-containing protein 19 (ADAM 19) (EC 3.4.24.-) (Meltrin-beta) (Metalloprotease and disintegrin dendritic antigen marker) (MADDAM)

Protein function

Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast diff

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01562	Pep_M12B_propep	34 → 162	Reprolysin family propeptide	Family
PF01421	Reprolysin	210 → 408	Reprolysin (M12B) family zinc metalloprotease	Domain
PF00200	Disintegrin	425 → 497	Disintegrin	Domain
PF08516	ADAM_CR	502 → 624	ADAM cysteine-rich	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in many normal organ tissues and several cancer cell lines.

Sequence

MPGGAGAARLCLLAFALQPLRPRAAREPGWTRGSEEGSPKLQHELIIPQWKTSESPVREK
HPLKAELRVMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVR
ETELSSVTLSTCRGIRGLITVSSNLSYVIEPLPDSKGQHLIYRSEHLKPPPGNCGFEHSK
PTTRDWALQFTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQKNRRDQDATKHKLIEI
ANYVDKFYRSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRKLLAQKYHDNAQL
ITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTHDSADC
CSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPDTRMLYGGRRCG
NGYLEDGEECDCGEEEECNNPCCNASNCTLRPGAECAHGSCCHQCKLLAPGTLCREQARQ
CDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPAPDLC
FEKVNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARPLESNAVPIDTTIIMNG
RQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFETEGCGKKCNG
HGVCNNNQNCHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPVVAGVLVAILVLAVLMLM
YYCCRQNNKLGQLKPSALPSKLRQQFSCPFRVSQNSGTGHANPTFKLQTPQGKRKVINTP
EILRKPSQPPPRPPPDYLRGGSPPAPLPAHLSRAARNSPGPGSQIERTESSRRPPPSRPI
PPAPNCIVSQDFSRPRPPQKALPANPVPGRRSLPRPGGASPLRPPGAGPQQSRPLAALAP
KVSPREALKVKAGTRGLQGGRCRVEKTKQFMLLVVWTELPEQKPRAKHSCFLVPA

Sequence length

955

Interactions

View interactions

	Reactome
			Invadopodia formation

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Asthma	Age of onset of adult onset asthma, Asthma in any disease, Nonatopic asthma, Asthma	N/A	N/A	GWAS
Coronary artery disease	Coronary artery disease	N/A	N/A	GWAS

Show/Hide Text Mining Associations (30)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Acute Kidney Injury	Associate	16900093
Alzheimer Disease	Associate	25114068
Asthma	Associate	29692868
Asthma	Inhibit	37809092
Bipolar Disorder	Associate	19319892
Breast Neoplasms	Associate	33548228
Carcinoma Non Small Cell Lung	Associate	31298334
Carcinoma Renal Cell	Associate	38149560
Depressive Disorder	Associate	22590542
Dermatitis Herpetiformis	Associate	22991566
Epstein Barr Virus Infections	Associate	16948840
Fibrosis	Associate	16827870, 16900093
Glomerulonephritis	Associate	16900093
Glycogen Storage Disease Type IV	Associate	31675985
Hernias Diaphragmatic Congenital	Associate	32039782
Hypotension	Associate	19319892
Inflammation	Associate	16827870, 35902972
Kidney Diseases	Associate	16900093
Lung Diseases	Associate	20010835
Lymphoma	Stimulate	21239057
Lymphoma	Associate	21239057
Lymphoma Non Hodgkin	Associate	21239057
Neoplasms	Associate	18714391, 33548228
Ovarian Neoplasms	Associate	18714391
Prostatic Neoplasms	Associate	26912236
Psychotic Disorders	Associate	22590542
Pulmonary Disease Chronic Obstructive	Associate	21659657, 27078193
Renal Insufficiency Chronic	Stimulate	16827870
Retinoblastoma	Associate	26823772
Stomach Neoplasms	Associate	31675985

ADAM19 (ADAM metallopeptidase domain 19)