NOL4 (nucleolar protein 4)

Gene

• Entrez ID: 8715
• Gene name: Nucleolar protein 4
• Gene symbol: NOL4
• Synonyms (NCBI Gene): CT125, HRIHFB2255, NOLP
• Chromosome: 18
• Chromosome location: 18q12.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016812	hsa-miR-335-5p	Microarray	18185580
MIRT025082	hsa-miR-181a-5p	Microarray	17612493
MIRT612725	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT612723	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT612724	hsa-miR-1202	HITS-CLIP	23824327
MIRT612721	hsa-miR-3972	HITS-CLIP	23824327
MIRT612722	hsa-miR-5006-5p	HITS-CLIP	23824327
MIRT612720	hsa-miR-4776-3p	HITS-CLIP	23824327
MIRT612725	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT612723	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT612724	hsa-miR-1202	HITS-CLIP	23824327
MIRT612721	hsa-miR-3972	HITS-CLIP	23824327
MIRT612722	hsa-miR-5006-5p	HITS-CLIP	23824327
MIRT612720	hsa-miR-4776-3p	HITS-CLIP	23824327
MIRT756244	hsa-miR-23a-3p	Luciferase reporter assay	37372085
MIRT756254	hsa-miR-23b-3p	Luciferase reporter assay	37372085
MIRT1188600	hsa-miR-1254	CLIP-seq
MIRT1188601	hsa-miR-1910	CLIP-seq
MIRT1188602	hsa-miR-199a-3p	CLIP-seq
MIRT1188603	hsa-miR-199b-3p	CLIP-seq
MIRT1188604	hsa-miR-3116	CLIP-seq
MIRT1188605	hsa-miR-3117-3p	CLIP-seq
MIRT1188606	hsa-miR-3119	CLIP-seq
MIRT1188607	hsa-miR-3129-5p	CLIP-seq
MIRT1188608	hsa-miR-3973	CLIP-seq
MIRT1188609	hsa-miR-4254	CLIP-seq
MIRT1188610	hsa-miR-455-3p	CLIP-seq
MIRT1188611	hsa-miR-548a-5p	CLIP-seq
MIRT1188612	hsa-miR-548ab	CLIP-seq
MIRT1188613	hsa-miR-548ak	CLIP-seq
MIRT1188614	hsa-miR-548b-5p	CLIP-seq
MIRT1188615	hsa-miR-548c-5p	CLIP-seq
MIRT1188616	hsa-miR-548d-5p	CLIP-seq
MIRT1188617	hsa-miR-548h	CLIP-seq
MIRT1188618	hsa-miR-548i	CLIP-seq
MIRT1188619	hsa-miR-548j	CLIP-seq
MIRT1188620	hsa-miR-548p	CLIP-seq
MIRT1188621	hsa-miR-548w	CLIP-seq
MIRT1188622	hsa-miR-548y	CLIP-seq
MIRT1188623	hsa-miR-559	CLIP-seq
MIRT1188624	hsa-miR-651	CLIP-seq
MIRT1188625	hsa-miR-661	CLIP-seq
MIRT1188626	hsa-miR-936	CLIP-seq
MIRT2054587	hsa-miR-3942-5p	CLIP-seq
MIRT2054588	hsa-miR-4703-5p	CLIP-seq
MIRT2283733	hsa-miR-371-5p	CLIP-seq
MIRT2391629	hsa-miR-3074-3p	CLIP-seq
MIRT2391630	hsa-miR-380	CLIP-seq
MIRT2391631	hsa-miR-4433	CLIP-seq
MIRT2391632	hsa-miR-4459	CLIP-seq
MIRT2391633	hsa-miR-4768-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	TAS	9813152
GO:0005730	Component	Nucleolus	IEA

Other IDs

• MIM: 603577
• HGNC: 7870
• e!Ensembl: ENSG00000101746

Protein

• UniProt ID: O94818
• Protein name: Nucleolar protein 4 (Nucleolar-localized protein)
• Tissue specificity: TISSUE SPECIFICITY: Expressed predominantly in fetal brain, adult brain and testis. {ECO:0000269|PubMed:9813152}.
• Sequence:

  MESERDMYRQFQDWCLRTYGDSGKTKTVTRKKYERIVQLLNGSESSSTDNAKFKFWVKSK
  GFQLGQPDEVRGGGGGAKQVLYVPVKTTDGVGVDEKLSLRRVAVVEDFFDIIYSMHVETG
  PNGEQIRKHAGQKRTYKAISESYAFLPREAVTRFLMSCSECQKRMHLNPDGTDHKDNGKP
  PTLVTSMIDYNMPITMAYMKHMKLQLLNSQQDEDESSIESDEFDMSDSTRMSAVNSDLSS
  NLEERMQSPQNLHGQQDDDSAAESFNGNETLGHSSIASGGTHSREMGDSNSDGKTGLEQD
  EQPLNLSDSPLSAQLTSEYRIDDHNSNGKNKYKNLLISDLKMEREARENGSKSPAHSYSS
  YDSGKNESVDRGAEDLSLNRGDEDEDDHEDHDDSEKVNETDGVEAERLKAFNMFVRLFVD
  ENLDRMVPISKQPKEKIQAIIDSCRRQFPEYQERARKRIRTYLKSCRRMKRSGFEMSRPI
  PSHLTSAVAESILASACESESRNAAKRMRLERQQDESAPADKQCKPEATQATYSTSAVPG
  SQDVLYINGNGTYSYHSYRGLGGGLLNLNDASSSGPTDLSMKRQLATSSGSSSSSNSRPQ
  LSPTEINAVRQLVAGYRESAAFLLRSADELENLILQQN

• Sequence length: 638

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Narcolepsy	Narcolepsy	rs104894574, rs387906655	19629137
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	26198764, 30285260, 28991256

Unknown
Disease term	Disease name	Evidence	References	Source
Neuroticism	Neuroticism			GWAS
Diabetes	Diabetes			GWAS
Metabolic Syndrome	Metabolic Syndrome			GWAS
Mental Depression	Mental Depression			GWAS
Insomnia	Insomnia			GWAS
Restless Legs Syndrome	Restless Legs Syndrome			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Breast Neoplasms	Associate	39199284
Carcinoma Pancreatic Ductal	Associate	31956659
Endometrial Neoplasms	Associate	32074080, 37352078
Head and Neck Neoplasms	Associate	24337411
Neoplasms	Associate	18381458, 24337411
Prostatic Neoplasms	Associate	25733303
Small Cell Lung Carcinoma	Associate	34065612, 37399175
Squamous Cell Carcinoma of Head and Neck	Associate	24337411
Uterine Cervical Neoplasms	Associate	18381458