Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	8714
Gene name	ATP binding cassette subfamily C member 3
Gene symbol	ABCC3
Synonyms (NCBI Gene)	ABC31EST90757MLP2MOAT-DMRP3cMOAT2
Chromosome	17
Chromosome location	17q21.33
Summary	The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, M

Show/Hide all (54)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004155	hsa-miR-192-5p	Microarray	16822819
MIRT003824	hsa-miR-197-3p	Microarray	16822819
MIRT017472	hsa-miR-335-5p	Microarray	18185580
MIRT022500	hsa-miR-124-3p	Microarray	18668037
MIRT732841	hsa-miR-379-3p	Luciferase reporter assayRNA-seqqRT-PCR	31757862
MIRT758372	hsa-miR-1266	CLIP-seq
MIRT758373	hsa-miR-216a	CLIP-seq
MIRT758374	hsa-miR-3065-3p	CLIP-seq
MIRT758375	hsa-miR-3169	CLIP-seq
MIRT758376	hsa-miR-3664-3p	CLIP-seq
MIRT758377	hsa-miR-4459	CLIP-seq
MIRT758378	hsa-miR-4518	CLIP-seq
MIRT758379	hsa-miR-4682	CLIP-seq
MIRT758380	hsa-miR-4700-3p	CLIP-seq
MIRT758381	hsa-miR-4740-5p	CLIP-seq
MIRT758382	hsa-miR-4753-5p	CLIP-seq
MIRT758383	hsa-miR-665	CLIP-seq
MIRT1923662	hsa-miR-3163	CLIP-seq
MIRT1923663	hsa-miR-4530	CLIP-seq
MIRT1923664	hsa-miR-4668-3p	CLIP-seq
MIRT1923665	hsa-miR-4703-3p	CLIP-seq
MIRT1923666	hsa-miR-570	CLIP-seq
MIRT1923667	hsa-miR-591	CLIP-seq
MIRT1923668	hsa-miR-646	CLIP-seq
MIRT2165184	hsa-miR-1246	CLIP-seq
MIRT2165185	hsa-miR-141	CLIP-seq
MIRT2165186	hsa-miR-148a	CLIP-seq
MIRT2165187	hsa-miR-148b	CLIP-seq
MIRT2165188	hsa-miR-149	CLIP-seq
MIRT2165189	hsa-miR-152	CLIP-seq
MIRT2165190	hsa-miR-19a	CLIP-seq
MIRT2165191	hsa-miR-19b	CLIP-seq
MIRT2165192	hsa-miR-200a	CLIP-seq
MIRT2165193	hsa-miR-24	CLIP-seq
MIRT758374	hsa-miR-3065-3p	CLIP-seq
MIRT758375	hsa-miR-3169	CLIP-seq
MIRT2165194	hsa-miR-3186-5p	CLIP-seq
MIRT2165195	hsa-miR-371-5p	CLIP-seq
MIRT2165196	hsa-miR-4269	CLIP-seq
MIRT2165197	hsa-miR-4284	CLIP-seq
MIRT2165198	hsa-miR-4302	CLIP-seq
MIRT2165199	hsa-miR-4320	CLIP-seq
MIRT2165200	hsa-miR-4514	CLIP-seq
MIRT2165201	hsa-miR-4661-5p	CLIP-seq
MIRT758379	hsa-miR-4682	CLIP-seq
MIRT2165202	hsa-miR-4692	CLIP-seq
MIRT758380	hsa-miR-4700-3p	CLIP-seq
MIRT758381	hsa-miR-4740-5p	CLIP-seq
MIRT2165203	hsa-miR-4742-5p	CLIP-seq
MIRT1923666	hsa-miR-570	CLIP-seq
MIRT2165204	hsa-miR-582-3p	CLIP-seq
MIRT2165205	hsa-miR-616	CLIP-seq
MIRT2165206	hsa-miR-648	CLIP-seq
MIRT2165207	hsa-miR-892b	CLIP-seq

Show/Hide all (5)

Transcription factor	Regulation	Reference
RARA	Repression	17272513
RXRA	Repression	17272513
SOX2	Activation	21531766
SP1	Activation	17272513
SP1	Unknown	10772892

Show/Hide all (48)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	18698235
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006805	Process	Xenobiotic metabolic process	IEA
GO:0006805	Process	Xenobiotic metabolic process	TAS
GO:0006855	Process	Xenobiotic transmembrane transport	IMP	11581266, 18245269
GO:0006869	Process	Lipid transport	IEA
GO:0008559	Function	ABC-type xenobiotic transporter activity	IBA
GO:0008559	Function	ABC-type xenobiotic transporter activity	IDA	11581266, 19334674
GO:0008559	Function	ABC-type xenobiotic transporter activity	IEA
GO:0008559	Function	ABC-type xenobiotic transporter activity	IMP	18245269
GO:0009925	Component	Basal plasma membrane	IDA	35307651
GO:0009925	Component	Basal plasma membrane	IEA
GO:0015164	Function	Glucuronoside transmembrane transporter activity	IDA	18698235
GO:0015431	Function	ABC-type glutathione S-conjugate transporter activity	IDA	15083066
GO:0015431	Function	ABC-type glutathione S-conjugate transporter activity	IEA
GO:0015432	Function	ABC-type bile acid transporter activity	ISS
GO:0015432	Function	ABC-type bile acid transporter activity	TAS
GO:0015721	Process	Bile acid and bile salt transport	ISS
GO:0015721	Process	Bile acid and bile salt transport	TAS
GO:0015779	Process	Glucuronoside transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	IBA
GO:0016323	Component	Basolateral plasma membrane	IDA	28408210
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0022857	Function	Transmembrane transporter activity	IEA
GO:0036064	Component	Ciliary basal body	IDA
GO:0042626	Function	ATPase-coupled transmembrane transporter activity	IDA	19334674
GO:0042626	Function	ATPase-coupled transmembrane transporter activity	TAS
GO:0042908	Process	Xenobiotic transport	IDA	18698235, 19334674
GO:0042910	Function	Xenobiotic transmembrane transporter activity	IDA	18698235
GO:0042910	Function	Xenobiotic transmembrane transporter activity	IEA
GO:0043225	Function	ATPase-coupled inorganic anion transmembrane transporter activity	IEA
GO:0043225	Function	ATPase-coupled inorganic anion transmembrane transporter activity	TAS
GO:0046942	Process	Carboxylic acid transport	IEA
GO:0055085	Process	Transmembrane transport	IBA
GO:0055085	Process	Transmembrane transport	IEA
GO:0055085	Process	Transmembrane transport	TAS
GO:0071714	Function	Icosanoid transmembrane transporter activity	IDA	19334674
GO:0071716	Process	Leukotriene transport	IMP	11581266
GO:0098656	Process	Monoatomic anion transmembrane transport	IEA
GO:0140359	Function	ABC-type transporter activity	IEA
GO:0140359	Function	ABC-type transporter activity	TAS
GO:0150104	Process	Transport across blood-brain barrier	NAS	26590417, 30280653

MIM	HGNC	e!Ensembl
604323	54	ENSG00000108846

O15438

Protein name

ATP-binding cassette sub-family C member 3 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (Canalicular multispecific organic anion transporter 2) (Multi-specific organic anion transporter D) (MOAT-D) (Multidrug resistance-associated protein 3)

Protein function

ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes (PubMed:10359813, Pub

PDB

8HVH , 8HW2 , 8HW4 , 8IZP

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00664	ABC_membrane	311 → 582	ABC transporter transmembrane region	Family
PF00005	ABC_tran	644 → 779	ABC transporter	Domain
PF00664	ABC_membrane	971 → 1240	ABC transporter transmembrane region	Family
PF00005	ABC_tran	1306 → 1454	ABC transporter	Domain

Tissue specificity

TISSUE SPECIFICITY: Mainly expressed in the liver. Also expressed in small intestine, colon, prostate, testis, brain and at a lower level in the kidney. In testis, localized to peritubular myoid cells, Leydig cells, along the basal membrane of Sertoli cel

Sequence

MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHC
RGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLAT
LLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFAL
VLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDL
WSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFL
KALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCS
MMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRF
MDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQ
MKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWM
CSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLK
RIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVV
GPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRY
QQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSA
VDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQ
RNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQ
KQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFW
DYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGI
LQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVD
EVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLE
SVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVE
FVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERV
KEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVG
IVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTL
RMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARAL
LRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGV
VAEFDSPANLIAARGIFYGMARDAGLA

Sequence length

1527

Interactions

View interactions

	KEGG		Reactome
	Antifolate resistance ABC transporters Bile secretion Folate transport and metabolism		Recycling of bile acids and salts ABC-family proteins mediated transport

ABCC3 (ATP binding cassette subfamily C member 3)