Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	8694
Gene name Gene Name - the full gene name approved by the HGNC.	Diacylglycerol O-acyltransferase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	DGAT1
Synonyms (NCBI Gene) Gene synonyms aliases	ARAT, ARGP1, DGAT, DIAR7
Chromosome Chromosome number	8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	8q24.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes an multipass transmembrane protein that functions as a key metabolic enzyme. The encoded protein catalyzes the conversion of diacylglycerol and fatty acyl CoA to triacylglycerol. This enzyme can also transfer acyl CoA to retinol. Activit

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SNP ID	Visualize variation	Clinical significance	Consequence
rs1554847009	C>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1588689245	C>-	Pathogenic	Frameshift variant, initiator codon variant, upstream transcript variant, genic upstream transcript variant

Show/Hide all(225)

miRTarBase ID	miRNA	Experiments	Reference
MIRT006524	hsa-miR-125b-5p	Luciferase reporter assay	19635812
MIRT006524	hsa-miR-125b-5p	Luciferase reporter assay	19635812
MIRT006524	hsa-miR-125b-5p	Luciferase reporter assay	19635812
MIRT006524	hsa-miR-125b-5p	Luciferase reporter assay	19635812
MIRT029044	hsa-miR-26b-5p	Microarray	19088304
MIRT047045	hsa-miR-183-5p	CLASH	23622248
MIRT042201	hsa-miR-484	CLASH	23622248
MIRT723335	hsa-miR-10a-5p	HITS-CLIP	19536157
MIRT723334	hsa-miR-10b-5p	HITS-CLIP	19536157
MIRT723333	hsa-miR-6871-3p	HITS-CLIP	19536157
MIRT723332	hsa-miR-6858-3p	HITS-CLIP	19536157
MIRT723331	hsa-miR-3620-3p	HITS-CLIP	19536157
MIRT723330	hsa-miR-3065-3p	HITS-CLIP	19536157
MIRT723329	hsa-miR-4769-3p	HITS-CLIP	19536157
MIRT723328	hsa-miR-6817-5p	HITS-CLIP	19536157
MIRT723327	hsa-miR-4727-5p	HITS-CLIP	19536157
MIRT723326	hsa-miR-5001-3p	HITS-CLIP	19536157
MIRT723325	hsa-miR-544a	HITS-CLIP	19536157
MIRT723324	hsa-miR-6738-3p	HITS-CLIP	19536157
MIRT529866	hsa-miR-5197-3p	PAR-CLIP	22012620
MIRT529867	hsa-miR-2278	PAR-CLIP	22012620
MIRT529864	hsa-miR-6849-3p	PAR-CLIP	22012620
MIRT529865	hsa-miR-548q	PAR-CLIP	22012620
MIRT529862	hsa-miR-4468	PAR-CLIP	22012620
MIRT723335	hsa-miR-10a-5p	HITS-CLIP	19536157
MIRT723334	hsa-miR-10b-5p	HITS-CLIP	19536157
MIRT723333	hsa-miR-6871-3p	HITS-CLIP	19536157
MIRT723332	hsa-miR-6858-3p	HITS-CLIP	19536157
MIRT723331	hsa-miR-3620-3p	HITS-CLIP	19536157
MIRT723330	hsa-miR-3065-3p	HITS-CLIP	19536157
MIRT723329	hsa-miR-4769-3p	HITS-CLIP	19536157
MIRT723328	hsa-miR-6817-5p	HITS-CLIP	19536157
MIRT723327	hsa-miR-4727-5p	HITS-CLIP	19536157
MIRT723326	hsa-miR-5001-3p	HITS-CLIP	19536157
MIRT723325	hsa-miR-544a	HITS-CLIP	19536157
MIRT723324	hsa-miR-6738-3p	HITS-CLIP	19536157
MIRT529866	hsa-miR-5197-3p	PAR-CLIP	22012620
MIRT529867	hsa-miR-2278	PAR-CLIP	22012620
MIRT529864	hsa-miR-6849-3p	PAR-CLIP	22012620
MIRT529865	hsa-miR-548q	PAR-CLIP	22012620
MIRT529862	hsa-miR-4468	PAR-CLIP	22012620
MIRT756174	hsa-miR-122-5p	Luciferase reporter assay, Western blotting, qRT-PCR, RNA pull down assay	36674813
MIRT933522	hsa-miR-10a	CLIP-seq
MIRT933523	hsa-miR-10b	CLIP-seq
MIRT933524	hsa-miR-1207-3p	CLIP-seq
MIRT933525	hsa-miR-1207-5p	CLIP-seq
MIRT933526	hsa-miR-125a-3p	CLIP-seq
MIRT933527	hsa-miR-125a-5p	CLIP-seq
MIRT933528	hsa-miR-125b	CLIP-seq
MIRT933529	hsa-miR-128	CLIP-seq
MIRT933530	hsa-miR-1286	CLIP-seq
MIRT933531	hsa-miR-1290	CLIP-seq
MIRT933532	hsa-miR-1343	CLIP-seq
MIRT933533	hsa-miR-1909	CLIP-seq
MIRT933534	hsa-miR-1910	CLIP-seq
MIRT933535	hsa-miR-1914	CLIP-seq
MIRT933536	hsa-miR-214	CLIP-seq
MIRT933537	hsa-miR-2355-5p	CLIP-seq
MIRT933538	hsa-miR-299-3p	CLIP-seq
MIRT933539	hsa-miR-3167	CLIP-seq
MIRT933540	hsa-miR-3180	CLIP-seq
MIRT933541	hsa-miR-3180-3p	CLIP-seq
MIRT933542	hsa-miR-3184	CLIP-seq
MIRT933543	hsa-miR-3196	CLIP-seq
MIRT933544	hsa-miR-329	CLIP-seq
MIRT933545	hsa-miR-331-3p	CLIP-seq
MIRT933546	hsa-miR-342-5p	CLIP-seq
MIRT933547	hsa-miR-3619-5p	CLIP-seq
MIRT933548	hsa-miR-362-3p	CLIP-seq
MIRT933549	hsa-miR-3649	CLIP-seq
MIRT933550	hsa-miR-3654	CLIP-seq
MIRT933551	hsa-miR-3681	CLIP-seq
MIRT933552	hsa-miR-371-5p	CLIP-seq
MIRT933553	hsa-miR-3917	CLIP-seq
MIRT933554	hsa-miR-3918	CLIP-seq
MIRT933555	hsa-miR-3941	CLIP-seq
MIRT933556	hsa-miR-3944-5p	CLIP-seq
MIRT933557	hsa-miR-423-5p	CLIP-seq
MIRT933558	hsa-miR-4291	CLIP-seq
MIRT933559	hsa-miR-4319	CLIP-seq
MIRT933560	hsa-miR-4432	CLIP-seq
MIRT933561	hsa-miR-4436a	CLIP-seq
MIRT933562	hsa-miR-4502	CLIP-seq
MIRT933563	hsa-miR-4512	CLIP-seq
MIRT933564	hsa-miR-451b	CLIP-seq
MIRT933565	hsa-miR-4520a-3p	CLIP-seq
MIRT933566	hsa-miR-4532	CLIP-seq
MIRT933567	hsa-miR-4638-3p	CLIP-seq
MIRT933568	hsa-miR-4641	CLIP-seq
MIRT933569	hsa-miR-4642	CLIP-seq
MIRT933570	hsa-miR-466	CLIP-seq
MIRT933571	hsa-miR-4664-5p	CLIP-seq
MIRT933572	hsa-miR-4672	CLIP-seq
MIRT933573	hsa-miR-4696	CLIP-seq
MIRT933574	hsa-miR-4706	CLIP-seq
MIRT933575	hsa-miR-4711-5p	CLIP-seq
MIRT933576	hsa-miR-4720-5p	CLIP-seq
MIRT933577	hsa-miR-4722-5p	CLIP-seq
MIRT933578	hsa-miR-4725-5p	CLIP-seq
MIRT933579	hsa-miR-4731-3p	CLIP-seq
MIRT933580	hsa-miR-4732-3p	CLIP-seq
MIRT933581	hsa-miR-4749-5p	CLIP-seq
MIRT933582	hsa-miR-4755-3p	CLIP-seq
MIRT933583	hsa-miR-4761-5p	CLIP-seq
MIRT933584	hsa-miR-4763-3p	CLIP-seq
MIRT933585	hsa-miR-4789-5p	CLIP-seq
MIRT933586	hsa-miR-4799-3p	CLIP-seq
MIRT933587	hsa-miR-4801	CLIP-seq
MIRT933588	hsa-miR-486-3p	CLIP-seq
MIRT933589	hsa-miR-504	CLIP-seq
MIRT933590	hsa-miR-511	CLIP-seq
MIRT933591	hsa-miR-544	CLIP-seq
MIRT933592	hsa-miR-544b	CLIP-seq
MIRT933593	hsa-miR-545	CLIP-seq
MIRT933594	hsa-miR-552	CLIP-seq
MIRT933595	hsa-miR-603	CLIP-seq
MIRT933596	hsa-miR-628-5p	CLIP-seq
MIRT933597	hsa-miR-657	CLIP-seq
MIRT933598	hsa-miR-670	CLIP-seq
MIRT933599	hsa-miR-744	CLIP-seq
MIRT933600	hsa-miR-761	CLIP-seq
MIRT933601	hsa-miR-876-5p	CLIP-seq
MIRT933602	hsa-miR-922	CLIP-seq
MIRT933524	hsa-miR-1207-3p	CLIP-seq
MIRT933525	hsa-miR-1207-5p	CLIP-seq
MIRT1976358	hsa-miR-3189-5p	CLIP-seq
MIRT933553	hsa-miR-3917	CLIP-seq
MIRT1976359	hsa-miR-4323	CLIP-seq
MIRT933560	hsa-miR-4432	CLIP-seq
MIRT1976360	hsa-miR-4494	CLIP-seq
MIRT933564	hsa-miR-451b	CLIP-seq
MIRT933566	hsa-miR-4532	CLIP-seq
MIRT1976361	hsa-miR-4640-3p	CLIP-seq
MIRT933569	hsa-miR-4642	CLIP-seq
MIRT933573	hsa-miR-4696	CLIP-seq
MIRT933575	hsa-miR-4711-5p	CLIP-seq
MIRT933576	hsa-miR-4720-5p	CLIP-seq
MIRT933584	hsa-miR-4763-3p	CLIP-seq
MIRT933586	hsa-miR-4799-3p	CLIP-seq
MIRT933588	hsa-miR-486-3p	CLIP-seq
MIRT1976362	hsa-miR-499a-5p	CLIP-seq
MIRT933593	hsa-miR-545	CLIP-seq
MIRT1976363	hsa-miR-626	CLIP-seq
MIRT1976364	hsa-miR-892a	CLIP-seq
MIRT2211782	hsa-miR-218	CLIP-seq
MIRT2211783	hsa-miR-2467-3p	CLIP-seq
MIRT2211784	hsa-miR-338-3p	CLIP-seq
MIRT2211785	hsa-miR-3616-3p	CLIP-seq
MIRT2211786	hsa-miR-3714	CLIP-seq
MIRT933554	hsa-miR-3918	CLIP-seq
MIRT2211787	hsa-miR-4277	CLIP-seq
MIRT2211788	hsa-miR-4327	CLIP-seq
MIRT933563	hsa-miR-4512	CLIP-seq
MIRT2211789	hsa-miR-4650-5p	CLIP-seq
MIRT2211790	hsa-miR-4708-3p	CLIP-seq
MIRT2211791	hsa-miR-4733-3p	CLIP-seq
MIRT2211792	hsa-miR-634	CLIP-seq
MIRT2211793	hsa-miR-636	CLIP-seq
MIRT2211794	hsa-miR-940	CLIP-seq
MIRT933576	hsa-miR-4720-5p	CLIP-seq
MIRT933586	hsa-miR-4799-3p	CLIP-seq
MIRT933588	hsa-miR-486-3p	CLIP-seq
MIRT2448172	hsa-miR-1324	CLIP-seq
MIRT2448173	hsa-miR-3155	CLIP-seq
MIRT2448174	hsa-miR-3155b	CLIP-seq
MIRT2448175	hsa-miR-4438	CLIP-seq
MIRT2448176	hsa-miR-4514	CLIP-seq
MIRT2448177	hsa-miR-4692	CLIP-seq
MIRT2448178	hsa-miR-4756-3p	CLIP-seq
MIRT2448172	hsa-miR-1324	CLIP-seq
MIRT2448173	hsa-miR-3155	CLIP-seq
MIRT2448174	hsa-miR-3155b	CLIP-seq
MIRT2448175	hsa-miR-4438	CLIP-seq
MIRT2448176	hsa-miR-4514	CLIP-seq
MIRT2448177	hsa-miR-4692	CLIP-seq
MIRT2448178	hsa-miR-4756-3p	CLIP-seq
MIRT933524	hsa-miR-1207-3p	CLIP-seq
MIRT2515572	hsa-miR-1253	CLIP-seq
MIRT2515573	hsa-miR-1254	CLIP-seq
MIRT933526	hsa-miR-125a-3p	CLIP-seq
MIRT2515574	hsa-miR-3116	CLIP-seq
MIRT2515575	hsa-miR-3176	CLIP-seq
MIRT2515576	hsa-miR-346	CLIP-seq
MIRT2515577	hsa-miR-3922-3p	CLIP-seq
MIRT2515578	hsa-miR-3934	CLIP-seq
MIRT933556	hsa-miR-3944-5p	CLIP-seq
MIRT2515579	hsa-miR-4325	CLIP-seq
MIRT2515580	hsa-miR-4488	CLIP-seq
MIRT2515581	hsa-miR-4697-5p	CLIP-seq
MIRT933576	hsa-miR-4720-5p	CLIP-seq
MIRT933582	hsa-miR-4755-3p	CLIP-seq
MIRT2515582	hsa-miR-4786-3p	CLIP-seq
MIRT933586	hsa-miR-4799-3p	CLIP-seq
MIRT2515583	hsa-miR-661	CLIP-seq
MIRT2515584	hsa-miR-764	CLIP-seq
MIRT933524	hsa-miR-1207-3p	CLIP-seq
MIRT933525	hsa-miR-1207-5p	CLIP-seq
MIRT2679241	hsa-miR-1231	CLIP-seq
MIRT2515572	hsa-miR-1253	CLIP-seq
MIRT933526	hsa-miR-125a-3p	CLIP-seq
MIRT2515575	hsa-miR-3176	CLIP-seq
MIRT2679242	hsa-miR-370	CLIP-seq
MIRT933553	hsa-miR-3917	CLIP-seq
MIRT2515577	hsa-miR-3922-3p	CLIP-seq
MIRT2515578	hsa-miR-3934	CLIP-seq
MIRT933556	hsa-miR-3944-5p	CLIP-seq
MIRT933560	hsa-miR-4432	CLIP-seq
MIRT1976360	hsa-miR-4494	CLIP-seq
MIRT933564	hsa-miR-451b	CLIP-seq
MIRT933566	hsa-miR-4532	CLIP-seq
MIRT933569	hsa-miR-4642	CLIP-seq
MIRT933573	hsa-miR-4696	CLIP-seq
MIRT2679243	hsa-miR-4711-3p	CLIP-seq
MIRT933575	hsa-miR-4711-5p	CLIP-seq
MIRT933576	hsa-miR-4720-5p	CLIP-seq
MIRT933582	hsa-miR-4755-3p	CLIP-seq
MIRT933584	hsa-miR-4763-3p	CLIP-seq
MIRT2515582	hsa-miR-4786-3p	CLIP-seq
MIRT933586	hsa-miR-4799-3p	CLIP-seq
MIRT933588	hsa-miR-486-3p	CLIP-seq
MIRT1976362	hsa-miR-499a-5p	CLIP-seq
MIRT933593	hsa-miR-545	CLIP-seq
MIRT1976363	hsa-miR-626	CLIP-seq
MIRT2515584	hsa-miR-764	CLIP-seq
MIRT1976364	hsa-miR-892a	CLIP-seq

Show/Hide all(44)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001523	Process	Retinoid metabolic process	IEA
GO:0003846	Function	2-acylglycerol O-acyltransferase activity	IEA
GO:0004144	Function	Diacylglycerol O-acyltransferase activity	IBA
GO:0004144	Function	Diacylglycerol O-acyltransferase activity	IDA	18458083, 32433610, 32433611
GO:0004144	Function	Diacylglycerol O-acyltransferase activity	IEA
GO:0004144	Function	Diacylglycerol O-acyltransferase activity	TAS	9789033
GO:0005515	Function	Protein binding	IPI	23420847
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IBA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	ISS
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006640	Process	Monoacylglycerol biosynthetic process	IDA	28420705
GO:0006640	Process	Monoacylglycerol biosynthetic process	IEA
GO:0006641	Process	Triglyceride metabolic process	TAS	9756920
GO:0008374	Function	O-acyltransferase activity	IEA
GO:0016020	Component	Membrane	IDA	32433610, 32433611
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	ISS
GO:0016740	Function	Transferase activity	IEA
GO:0016746	Function	Acyltransferase activity	IEA
GO:0016746	Function	Acyltransferase activity	TAS	9756920
GO:0019432	Process	Triglyceride biosynthetic process	IBA
GO:0019432	Process	Triglyceride biosynthetic process	IDA	18458083
GO:0019432	Process	Triglyceride biosynthetic process	IDA	18238778, 32433610, 32433611
GO:0019432	Process	Triglyceride biosynthetic process	IEA
GO:0019915	Process	Lipid storage	IEA
GO:0019915	Process	Lipid storage	ISS
GO:0034379	Process	Very-low-density lipoprotein particle assembly	IMP	15308631
GO:0035336	Process	Long-chain fatty-acyl-CoA metabolic process	IEA
GO:0035336	Process	Long-chain fatty-acyl-CoA metabolic process	ISS
GO:0035579	Component	Specific granule membrane	TAS
GO:0042572	Process	Retinol metabolic process	IEA
GO:0042802	Function	Identical protein binding	IPI	32433610, 32433611
GO:0043231	Component	Intracellular membrane-bounded organelle	IEA
GO:0046339	Process	Diacylglycerol metabolic process	IDA	32433610, 32433611
GO:0046339	Process	Diacylglycerol metabolic process	IEA
GO:0046339	Process	Diacylglycerol metabolic process	ISS
GO:0046486	Process	Glycerolipid metabolic process	IEA
GO:0050252	Function	Retinol O-fatty-acyltransferase activity	IEA
GO:0055089	Process	Fatty acid homeostasis	IEA

MIM	HGNC	e!Ensembl
604900	2843	ENSG00000185000

Protein

UniProt ID

O75907

Protein name

Diacylglycerol O-acyltransferase 1 (EC 2.3.1.20) (ACAT-related gene product 1) (Acyl-CoA retinol O-fatty-acyltransferase) (ARAT) (Retinol O-fatty-acyltransferase) (EC 2.3.1.76) (Diglyceride acyltransferase)

Protein function

Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates (PubMed:16214399, PubMed:18768481, PubMed:28420705, PubMed:32433610, PubMed:32433611, PubMed:9756920). Highly ex

PDB

6VP0 , 6VYI , 6VZ1 , 8ESM , 8ETM

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03062	MBOAT	153 → 474	MBOAT, membrane-bound O-acyltransferase family	Family

Sequence

MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVG
SGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQV
VSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPA
AVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHT
VSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWM
VPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREF
YRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVS
VPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLN
YEAPAAEA

Sequence length

488

Interactions

View interactions

	KEGG		Reactome
	Glycerolipid metabolism Retinol metabolism Metabolic pathways Fat digestion and absorption		Acyl chain remodeling of DAG and TAG Neutrophil degranulation Triglyceride biosynthesis

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Diabetes	Type 2 diabetes, Type 2 diabetes (PheCode 250.2)	N/A	N/A	GWAS

Show/Hide Text Mining Associations (36)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	33050938
Carcinogenesis	Associate	35764091
Carcinoma Renal Cell	Associate	35764091, 36728187
Colorectal Neoplasms	Associate	37705049
Diabetes Gestational	Inhibit	24262292
Diabetes Mellitus	Associate	26883093
Diabetes Mellitus Type 2	Associate	26493024
Diarrhea	Associate	29604290, 33261563, 36315449
Diarrhea 5 With Tufting Enteropathy Congenital	Associate	36315449
Dysentery	Associate	29604290
Failure to Thrive	Associate	36315449
Fibrosis	Inhibit	26493024
Glioblastoma	Associate	36603576
Graves Ophthalmopathy	Associate	36465658
Growth Disorders	Associate	36315449
Hypertriglyceridemia	Associate	33261563
Hypoalbuminemia	Associate	36315449
Intestinal Failure	Associate	29604290
Leukemia	Associate	36084349
Leukemia Myeloid Acute	Associate	36084349
Lipoma	Associate	26493024
Metabolic Diseases	Associate	26493024, 26883093
Mitochondrial Diseases	Associate	36084349
Mitochondrial Diseases	Inhibit	36603576
Necrosis	Associate	33750350
Neoplasms	Inhibit	30816200
Neoplasms	Associate	33750350, 33824421
Obesity	Associate	14569040, 26493024, 26883093, 30816200
Obesity	Stimulate	28541534
Obesity Maternal	Inhibit	24262292
Ovarian Neoplasms	Associate	40554491
Prostatic Neoplasms	Associate	28877685, 30816200, 33824421
Prostatitis	Associate	30816200
Protein Losing Enteropathies	Associate	26883093
Stomach Neoplasms	Associate	33750350
Vomiting	Associate	36315449

DGAT1 (diacylglycerol O-acyltransferase 1)