Gene Gene information from NCBI Gene database.
Entrez ID 8675
Gene name Syntaxin 16
Gene symbol STX16
Synonyms (NCBI Gene)
SYN-16SYN16
Chromosome 20
Chromosome location 20q13.32
Summary This gene encodes a protein that is a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for V-SNARES (vesicle-SNAP receptors) permitting specific synaptic vesicle docking a
miRNA miRNA information provided by mirtarbase database.
827
miRTarBase ID miRNA Experiments Reference
MIRT028613 hsa-miR-30a-5p Proteomics 18668040
MIRT030553 hsa-miR-24-3p Western blot;Other 17150773
MIRT048767 hsa-miR-93-5p CLASH 23622248
MIRT043405 hsa-miR-331-3p CLASH 23622248
MIRT042882 hsa-miR-324-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
37
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0000139 Component Golgi membrane TAS
GO:0000149 Function SNARE binding IBA
GO:0005484 Function SNAP receptor activity IBA
GO:0005484 Function SNAP receptor activity IDA 15215310
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603666 11431 ENSG00000124222
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O14662
Protein name Syntaxin-16 (Syn16)
Protein function SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.
PDB 8QQF
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00804 Syntaxin 78 265 Syntaxin Domain
PF05739 SNARE 266 318 SNARE domain Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous.
Sequence
Sequence length 325
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  SNARE interactions in vesicular transport   Intra-Golgi traffic
Retrograde transport at the Trans-Golgi-Network
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
147
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Autosomal dominant pseudohypoaldosteronism type 1 Uncertain significance; Benign; Likely benign rs761666161, rs886056865, rs35295928, rs545095749, rs10695175, rs886056863, rs566135029 RCV000401194
RCV000393063
RCV000293916
RCV000300454
RCV000393086
RCV000349488
RCV000296705
RCV000330075
Pseudohypoparathyroidism type 1B Uncertain significance; Conflicting classifications of pathogenicity; Benign; Likely benign rs781763936, rs371863588, rs775032938, rs370006614, rs921011114, rs754524705, rs2516022199, rs115536505, rs151312981, rs749300349, rs149351460, rs886056843, rs368572667, rs139859128, rs115046538
View all (115 more)
RCV005038122
RCV005038121
RCV005034654
RCV005027956
RCV005036852
RCV005030254
RCV003990902
RCV005038683
RCV005038684
RCV005023538
RCV000373969
RCV000296561
RCV000307996
RCV000321261
RCV000262733
RCV000280288
RCV000332957
RCV000388897
RCV000292251
RCV000291165
RCV000342710
RCV000386908
RCV000341743
RCV000379967
RCV000340213
RCV000274184
RCV000365155
RCV000382526
RCV000377104
RCV000285004
RCV000279185
RCV000361149
RCV000319835
RCV000374406
RCV000282745
RCV000334544
RCV000309301
RCV000366315
RCV000268540
RCV000319973
RCV000372356
RCV000263427
RCV000381000
RCV000313463
RCV000370509
RCV000312898
RCV000319038
RCV000362207
RCV000304097
RCV000268338
RCV000323420
RCV000281742
RCV000401873
RCV000349157
RCV000392999
RCV000392989
RCV000360413
RCV000359761
RCV000349407
RCV000398773
RCV000391187
RCV000303498
RCV000355915
RCV000354633
RCV000276364
RCV000328981
RCV000282808
RCV000399462
RCV000334449
RCV000325558
RCV000324452
RCV000376010
RCV000336557
RCV000309865
RCV000354854
RCV000321471
RCV000343736
RCV000304168
RCV000391193
RCV000297545
RCV000271521
RCV000289142
RCV000392781
RCV000272951
RCV000267008
RCV000259945
RCV002495350
RCV001137592
RCV002495501
RCV001139711
RCV001139712
RCV001140478
RCV001140479
RCV001142332
RCV001142333
RCV001137590
RCV001137591
RCV001139816
RCV001139817
RCV001139818
RCV001140592
RCV001140593
RCV001142447
RCV001142448
RCV001142449
RCV001142450
RCV001137701
RCV001137702
RCV001137703
RCV001137704
RCV001139927
RCV001139928
RCV001139929
RCV001140689
RCV001140690
RCV001142566
RCV001142567
RCV001137819
RCV001137820
RCV001137821
RCV001140055
RCV001140056
RCV001140810
RCV001140811
RCV001140812
RCV001140813
RCV001142660
RCV001142661
RCV001142662
RCV001142663
STX16-related disorder Uncertain significance; Likely benign; Conflicting classifications of pathogenicity rs960434917, rs768436138, rs202102691 RCV003392820
RCV003947045
RCV004755888
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Abnormalities Drug Induced Associate 35859320
Alzheimer Disease Associate 28084650, 28711660
Autism Spectrum Disorder Associate 27404287
Calcium Metabolism Disorders Associate 34477200
Gastrointestinal Stromal Tumors Associate 25987131
Heart Failure Associate 35128826
Obesity Associate 28453643
Pseudohypoaldosteronism Associate 25603460, 25997889, 28084650, 33247854, 34477200, 34791361
Pseudohypoparathyroidism Associate 15800843, 20538864, 20965295, 21062889, 23087324, 24438374, 25843330, 26819647, 33247854, 34477200, 39894498
Pseudohypoparathyroidism Type 1B Associate 21062889, 28453643, 34157100, 39894498