Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	8673
Gene name	Vesicle associated membrane protein 8
Gene symbol	VAMP8
Synonyms (NCBI Gene)	EDBVAMP-8
Chromosome	2
Chromosome location	2p11.2
Summary	This gene encodes an integral membrane protein that belongs to the synaptobrevin/vesicle-associated membrane protein subfamily of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). The encoded protein is involved in the fusio

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016522	hsa-miR-193b-3p	Microarray	20304954
MIRT016522	hsa-miR-193b-3p	Proteomics	21512034
MIRT022696	hsa-miR-124-3p	Microarray	18668037
MIRT025757	hsa-miR-7-5p	Microarray	17612493
MIRT031767	hsa-miR-16-5p	Proteomics	18668040
MIRT649546	hsa-miR-449b-3p	HITS-CLIP	23824327
MIRT649545	hsa-miR-4691-3p	HITS-CLIP	23824327
MIRT649544	hsa-miR-455-3p	HITS-CLIP	23824327
MIRT649543	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT649542	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT649541	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT649540	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT649539	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT649538	hsa-miR-7156-3p	HITS-CLIP	23824327
MIRT649537	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT649536	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT649534	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT303877	hsa-miR-4428	PAR-CLIP	20371350
MIRT303878	hsa-miR-4524b-3p	PAR-CLIP	20371350
MIRT303875	hsa-miR-3125	PAR-CLIP	20371350
MIRT303876	hsa-miR-3916	PAR-CLIP	20371350
MIRT303879	hsa-miR-6859-5p	PAR-CLIP	20371350
MIRT561100	hsa-miR-3137	PAR-CLIP	20371350
MIRT561099	hsa-miR-20b-3p	PAR-CLIP	20371350
MIRT025757	hsa-miR-7-5p	PAR-CLIP	20371350
MIRT561098	hsa-miR-6832-5p	PAR-CLIP	20371350
MIRT561097	hsa-miR-4732-5p	PAR-CLIP	20371350
MIRT303874	hsa-miR-877-5p	PAR-CLIP	20371350
MIRT649546	hsa-miR-449b-3p	HITS-CLIP	23824327
MIRT649545	hsa-miR-4691-3p	HITS-CLIP	23824327
MIRT649544	hsa-miR-455-3p	HITS-CLIP	23824327
MIRT649543	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT649542	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT649541	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT649540	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT649539	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT649538	hsa-miR-7156-3p	HITS-CLIP	23824327
MIRT649537	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT649536	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT649534	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT303877	hsa-miR-4428	PAR-CLIP	20371350
MIRT303878	hsa-miR-4524b-3p	PAR-CLIP	20371350
MIRT303875	hsa-miR-3125	PAR-CLIP	20371350
MIRT303876	hsa-miR-3916	PAR-CLIP	20371350
MIRT303879	hsa-miR-6859-5p	PAR-CLIP	20371350
MIRT561100	hsa-miR-3137	PAR-CLIP	20371350
MIRT561099	hsa-miR-20b-3p	PAR-CLIP	20371350
MIRT025757	hsa-miR-7-5p	PAR-CLIP	20371350
MIRT561098	hsa-miR-6832-5p	PAR-CLIP	20371350
MIRT561097	hsa-miR-4732-5p	PAR-CLIP	20371350
MIRT303874	hsa-miR-877-5p	PAR-CLIP	20371350
MIRT1481910	hsa-miR-103a	CLIP-seq
MIRT1481911	hsa-miR-107	CLIP-seq
MIRT1481912	hsa-miR-1179	CLIP-seq
MIRT1481913	hsa-miR-125a-5p	CLIP-seq
MIRT1481914	hsa-miR-125b	CLIP-seq
MIRT1481915	hsa-miR-15a	CLIP-seq
MIRT1481916	hsa-miR-15b	CLIP-seq
MIRT1481917	hsa-miR-16	CLIP-seq
MIRT1481918	hsa-miR-195	CLIP-seq
MIRT1481919	hsa-miR-214	CLIP-seq
MIRT1481920	hsa-miR-296-3p	CLIP-seq
MIRT1481921	hsa-miR-323b-5p	CLIP-seq
MIRT1481922	hsa-miR-3619-5p	CLIP-seq
MIRT1481923	hsa-miR-3918	CLIP-seq
MIRT1481924	hsa-miR-424	CLIP-seq
MIRT1481925	hsa-miR-4266	CLIP-seq
MIRT1481926	hsa-miR-4310	CLIP-seq
MIRT1481927	hsa-miR-4319	CLIP-seq
MIRT1481928	hsa-miR-4512	CLIP-seq
MIRT1481929	hsa-miR-4646-3p	CLIP-seq
MIRT1481930	hsa-miR-4695-5p	CLIP-seq
MIRT1481931	hsa-miR-4709-3p	CLIP-seq
MIRT1481932	hsa-miR-4729	CLIP-seq
MIRT1481933	hsa-miR-4732-3p	CLIP-seq
MIRT1481934	hsa-miR-4751	CLIP-seq
MIRT1481935	hsa-miR-4779	CLIP-seq
MIRT1481936	hsa-miR-4802-5p	CLIP-seq
MIRT1481937	hsa-miR-497	CLIP-seq
MIRT1481938	hsa-miR-670	CLIP-seq
MIRT1481939	hsa-miR-761	CLIP-seq
MIRT1481940	hsa-miR-885-3p	CLIP-seq
MIRT1481920	hsa-miR-296-3p	CLIP-seq
MIRT2144951	hsa-miR-296-5p	CLIP-seq
MIRT2144952	hsa-miR-3144-5p	CLIP-seq
MIRT1481921	hsa-miR-323b-5p	CLIP-seq
MIRT2144953	hsa-miR-3667-3p	CLIP-seq
MIRT2144954	hsa-miR-3925-3p	CLIP-seq
MIRT2144955	hsa-miR-4497	CLIP-seq
MIRT2144956	hsa-miR-4521	CLIP-seq
MIRT1481929	hsa-miR-4646-3p	CLIP-seq
MIRT2144957	hsa-miR-4690-3p	CLIP-seq
MIRT2144958	hsa-miR-4709-5p	CLIP-seq
MIRT2144959	hsa-miR-4724-3p	CLIP-seq
MIRT2144960	hsa-miR-4731-5p	CLIP-seq
MIRT1481936	hsa-miR-4802-5p	CLIP-seq
MIRT2144961	hsa-miR-766	CLIP-seq
MIRT2144951	hsa-miR-296-5p	CLIP-seq
MIRT2144954	hsa-miR-3925-3p	CLIP-seq
MIRT2144957	hsa-miR-4690-3p	CLIP-seq
MIRT2144960	hsa-miR-4731-5p	CLIP-seq
MIRT2144961	hsa-miR-766	CLIP-seq
MIRT2396780	hsa-miR-3154	CLIP-seq
MIRT2396781	hsa-miR-3665	CLIP-seq
MIRT2396782	hsa-miR-4436b-3p	CLIP-seq
MIRT1481931	hsa-miR-4709-3p	CLIP-seq
MIRT2396783	hsa-miR-4736	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005484	Function	SNAP receptor activity	IBA
GO:0005515	Function	Protein binding	IPI	19557002, 22118466, 23217709, 25419848, 31806350, 33422265, 33947832, 33961781, 35271311, 37821429
GO:0005737	Component	Cytoplasm	IDA	18253931
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IDA	23217709
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	TAS	9614193
GO:0005829	Component	Cytosol	IDA	22589474
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	18253931
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006906	Process	Vesicle fusion	IBA
GO:0006914	Process	Autophagy	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IDA	16677249
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	9614193
GO:0016192	Process	Vesicle-mediated transport	IEA
GO:0016240	Process	Autophagosome membrane docking	IDA	25686604
GO:0019869	Function	Chloride channel inhibitor activity	IDA	18570918
GO:0019905	Function	Syntaxin binding	IBA
GO:0030667	Component	Secretory granule membrane	IDA	16677249
GO:0030667	Component	Secretory granule membrane	TAS
GO:0030669	Component	Clathrin-coated endocytic vesicle membrane	TAS
GO:0030670	Component	Phagocytic vesicle membrane	TAS
GO:0031201	Component	SNARE complex	IBA
GO:0031201	Component	SNARE complex	IDA	12130530, 18253931, 23217709, 24550300
GO:0031201	Component	SNARE complex	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0031901	Component	Early endosome membrane	IEA
GO:0031902	Component	Late endosome membrane	IDA	23217709
GO:0031902	Component	Late endosome membrane	IEA
GO:0031982	Component	Vesicle	IDA	18570918
GO:0035493	Process	SNARE complex assembly	IBA
GO:0035577	Component	Azurophil granule membrane	IDA	16677249
GO:0035577	Component	Azurophil granule membrane	TAS
GO:0035579	Component	Specific granule membrane	TAS
GO:0042589	Component	Zymogen granule membrane	IEA
GO:0043308	Process	Eosinophil degranulation	IMP	16677249
GO:0043312	Process	Neutrophil degranulation	IMP	16677249
GO:0043933	Process	Protein-containing complex organization	IEA
GO:0046718	Process	Symbiont entry into host cell	IMP	24550300
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	18570918
GO:0051607	Process	Defense response to virus	IEA
GO:0055037	Component	Recycling endosome	IDA	18570918
GO:0055038	Component	Recycling endosome membrane	TAS
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337
GO:0070254	Process	Mucus secretion	IBA
GO:0070254	Process	Mucus secretion	IMP	22144578
GO:0070821	Component	Tertiary granule membrane	TAS
GO:0097352	Process	Autophagosome maturation	IMP	23217709
GO:0098594	Component	Mucin granule	IBA
GO:0098594	Component	Mucin granule	IDA	22144578
GO:1903076	Process	Regulation of protein localization to plasma membrane	IDA	18570918
GO:1903531	Process	Negative regulation of secretion by cell	IDA	12130530
GO:1903595	Process	Positive regulation of histamine secretion by mast cell	IMP	18253931

MIM	HGNC	e!Ensembl
603177	12647	ENSG00000118640

Q9BV40

Protein name

Vesicle-associated membrane protein 8 (VAMP-8) (Endobrevin) (EDB)

Protein function

SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four al

PDB

4WY4 , 7BV6

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00957	Synaptobrevin	9 → 97	Synaptobrevin	Family

Tissue specificity

TISSUE SPECIFICITY: Platelets. {ECO:0000269|PubMed:12130530}.

Sequence

MEEASEGGGNDRVRNLQSEVEGVKNIMTQNVERILARGENLEHLRNKTEDLEATSEHFKT
TSQKVARKFWWKNVKMIVLICVIVFIIILFIVLFATGAFS

Sequence length

100

Interactions

View interactions

	KEGG		Reactome
	SNARE interactions in vesicular transport Autophagy - animal Platelet activation		ER-Phagosome pathway trans-Golgi Network Vesicle Budding Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Neutrophil degranulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis

VAMP8 (vesicle associated membrane protein 8)